Motif ID: SPI1.p2

Z-value: 4.917


Transcription factors associated with SPI1.p2:

Gene SymbolEntrez IDGene Name
SPI1 6688 spleen focus forming virus (SFFV) proviral integration oncogene spi1



Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_35586950 10.552 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr6_-_32268267 6.105 GPSM3
G-protein signaling modulator 3
chr10_+_49562866 5.709 WDFY4
WDFY family member 4
chr5_-_88215034 5.671 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr16_-_87570716 5.598 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr3_-_113334657 5.478 NM_001190259
NM_001190260
NM_152785
GCET2


germinal center expressed transcript 2


chr11_+_63864263 5.448 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr6_-_32268615 4.813 GPSM3
G-protein signaling modulator 3
chr16_-_29664765 4.632 NM_175900
C16orf54
chromosome 16 open reading frame 54
chr21_+_25856311 4.617 MIR155HG
MIR155 host gene (non-protein coding)
chr1_+_159899528 4.613 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr5_+_118719591 4.595 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr11_+_65164767 4.476 SIPA1
signal-induced proliferation-associated 1
chr5_-_88214720 4.325 MEF2C
myocyte enhancer factor 2C
chr6_-_33016561 4.316 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr1_+_111544469 4.273


chr19_-_7672978 4.223 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr19_-_55091942 4.097 NM_152899
IL4I1
interleukin 4 induced 1
chr11_+_66927976 4.093 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr10_+_26767698 3.970 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr11_+_66927955 3.962 TBC1D10C
TBC1 domain family, member 10C
chr11_+_61352348 3.931 FADS2
fatty acid desaturase 2
chr1_-_111544603 3.827


chr6_+_31648071 3.824 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr6_-_32265489 3.792 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr14_+_20319049 3.746 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr11_+_107304344 3.700 NM_017516
RAB39
RAB39, member RAS oncogene family
chr17_-_31441390 3.684 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr1_-_111544784 3.674 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr12_+_25096472 3.654 NM_006152
LRMP
lymphoid-restricted membrane protein
chr11_+_61352209 3.586 NM_004265
FADS2
fatty acid desaturase 2
chr1_-_111544820 3.582 DENND2D
DENN/MADD domain containing 2D
chr17_+_44643067 3.557 ABI3
ABI family, member 3
chr17_+_44642587 3.537 NM_001135186
NM_016428
ABI3

ABI family, member 3

chr19_-_10311262 3.516 NM_002162
ICAM3
intercellular adhesion molecule 3
chr2_-_231498184 3.501 NM_005683
GPR55
G protein-coupled receptor 55
chr16_-_87244896 3.499 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr1_+_149309703 3.494 NM_144618
GABPB2
GA binding protein transcription factor, beta subunit 2
chr1_+_159817752 3.462 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr4_-_105631915 3.386 NM_025212
CXXC4
CXXC finger protein 4
chr7_-_86686754 3.351 NM_024315
C7orf23
chromosome 7 open reading frame 23
chr12_+_25096755 3.338 LRMP
lymphoid-restricted membrane protein
chr17_+_1906262 3.327 NM_001098202
HIC1
hypermethylated in cancer 1
chr3_+_195889845 3.320 FAM43A
family with sequence similarity 43, member A
chr7_+_114350144 3.288 MDFIC
MyoD family inhibitor domain containing
chr17_-_40843530 3.287 ARHGAP27
Rho GTPase activating protein 27
chr19_-_6432765 3.263 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr2_+_143603368 3.251 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr9_-_129707392 3.241 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr2_+_143603439 3.201 ARHGAP15
Rho GTPase activating protein 15
chr7_+_128367961 3.159 NM_001098627
IRF5
interferon regulatory factor 5
chr6_+_31647854 3.158 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr15_+_72861767 3.154 CSK
c-src tyrosine kinase
chr3_+_120495906 3.144 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr2_+_218790364 3.116 NM_005731
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr14_-_22354457 3.110 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr19_+_41085221 3.093 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chr1_-_31003260 3.068 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr19_-_43800374 3.028 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr22_+_42908612 3.005 PARVG
parvin, gamma
chr12_-_51887266 2.991 NM_000889
ITGB7
integrin, beta 7
chr15_+_72861470 2.976 NM_001127190
NM_004383
CSK

c-src tyrosine kinase

chr14_-_22354389 2.957 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr1_-_26517342 2.945 NM_145345
UBXN11
UBX domain protein 11
chrX_-_47374187 2.931 NM_001145252
CFP
complement factor properdin
chr6_-_31658044 2.923 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr6_+_31651319 2.893 NM_000594
TNF
tumor necrosis factor
chr11_-_60475558 2.877 NM_016582
SLC15A3
solute carrier family 15, member 3
chr16_+_28413421 2.843 NM_018690
APOBR
apolipoprotein B receptor
chrX_-_74062005 2.836 NM_001008537
KIAA2022
KIAA2022
chr1_+_111217314 2.771 CD53
CD53 molecule
chr22_-_35970230 2.756 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr1_+_111217244 2.754 NM_000560
CD53
CD53 molecule
chr5_+_49998528 2.723 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr10_+_26767657 2.720 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr6_-_30760413 2.658 KIAA1949
KIAA1949
chr5_+_49998677 2.630 PARP8
poly (ADP-ribose) polymerase family, member 8
chrX_+_72699834 2.618 CHIC1
cysteine-rich hydrophobic domain 1
chrX_-_47374647 2.614 NM_002621
CFP
complement factor properdin
chr17_+_53769562 2.612 LOC100506779
hypothetical LOC100506779
chr11_+_120828058 2.600 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr10_-_98021144 2.599 NM_001114094
NM_013314
BLNK

B-cell linker

chr6_+_43004837 2.595 NM_006586
CNPY3
canopy 3 homolog (zebrafish)
chr6_+_31690957 2.592 NM_004847
NM_001623
AIF1

allograft inflammatory factor 1

chr5_-_142795269 2.586 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr12_-_50004208 2.586 BIN2
bridging integrator 2
chr1_-_25128951 2.579 RUNX3
runt-related transcription factor 3
chr12_-_50004172 2.575 NM_016293
BIN2
bridging integrator 2
chr17_-_73640082 2.569 NM_007267
TMC6
transmembrane channel-like 6
chr19_+_40895669 2.555 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr4_+_8251818 2.553 NM_018986
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr12_-_50004102 2.551 BIN2
bridging integrator 2
chr1_-_159306037 2.542 ARHGAP30
Rho GTPase activating protein 30
chr12_-_53664722 2.528 NM_001136030
KIAA0748
KIAA0748
chr22_-_35970133 2.524 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr1_-_181826292 2.499 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr2_-_96174865 2.497 NM_004418
DUSP2
dual specificity phosphatase 2
chr17_+_53769659 2.497 LOC100506779
hypothetical LOC100506779
chr12_+_55018925 2.486 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr14_-_22358752 2.477 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chrX_+_48427103 2.449 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr1_-_205161821 2.440 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr12_-_47605478 2.409 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr6_-_144427340 2.403 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chrX_+_48427137 2.377 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr11_+_65164167 2.365 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr12_+_81605289 2.308 TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr6_+_31661934 2.305 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr19_-_15436333 2.296 NM_022904
RASAL3
RAS protein activator like 3
chr19_-_40925151 2.282 NM_024660
TMEM149
transmembrane protein 149
chr17_-_44642934 2.282 NM_001198754
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr17_-_59363352 2.276 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr18_-_50004770 2.272 MBD2
methyl-CpG binding domain protein 2
chr2_-_197883569 2.263 ANKRD44
ankyrin repeat domain 44
chr9_-_129580732 2.259 NM_170600
SH2D3C
SH2 domain containing 3C
chr6_+_31662454 2.255 NM_205837
LST1
leukocyte specific transcript 1
chr3_-_16530132 2.254 NM_015150
RFTN1
raftlin, lipid raft linker 1
chr10_-_121292139 2.254 NM_001005339
RGS10
regulator of G-protein signaling 10
chr2_+_68445936 2.239 PLEK
pleckstrin
chr14_-_50367513 2.228 NM_016350
NM_020921
NM_182944
NM_182946
NIN



ninein (GSK3B interacting protein)



chr17_-_40655347 2.214 LOC339192
hypothetical LOC339192
chr5_+_88220846 2.190


chr17_-_8809656 2.189 NM_001142633
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chr2_+_68445821 2.179 NM_002664
PLEK
pleckstrin
chr12_-_51887318 2.179 ITGB7
integrin, beta 7
chr1_-_181826086 2.178 NCF2
neutrophil cytosolic factor 2
chr16_+_56134077 2.175 NM_153837
GPR114
G protein-coupled receptor 114
chr7_+_73826244 2.166 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr1_-_158883666 2.163 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr12_-_6611075 2.160 NM_001142961
LPAR5
lysophosphatidic acid receptor 5
chr2_-_96174502 2.155 DUSP2
dual specificity phosphatase 2
chr16_+_27320983 2.147 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr7_-_44985175 2.143 MYO1G
myosin IG
chr7_-_44985202 2.142 NM_033054
MYO1G
myosin IG
chr2_+_227737524 2.112 NM_000091
COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen)
chr16_+_56134037 2.108 GPR114
G protein-coupled receptor 114
chr7_-_44985084 2.085 MYO1G
myosin IG
chr11_-_64403712 2.082 EHD1
EH-domain containing 1
chr14_-_22354851 2.082 NM_001126105
NM_003982
SLC7A7

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

chr6_-_32920387 2.079 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr12_+_6930815 2.076 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr16_-_73292188 2.050 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr22_-_36212160 2.050 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr17_+_40655060 2.047 NM_005892
FMNL1
formin-like 1
chr6_-_32920689 2.022 NM_004159
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr1_+_26517032 2.022 CD52
CD52 molecule
chr7_-_3049872 2.022 NM_032415
CARD11
caspase recruitment domain family, member 11
chr19_-_47328399 2.009 NM_002698
POU2F2
POU class 2 homeobox 2
chr12_-_109611277 1.989 NM_032369
HVCN1
hydrogen voltage-gated channel 1
chr5_+_140871107 1.987


chr7_-_99914690 1.986 NM_030935
TSC22D4
TSC22 domain family, member 4
chr14_+_74964261 1.984 NM_001135047
JDP2
Jun dimerization protein 2
chr10_-_13789628 1.970 FRMD4A
FERM domain containing 4A
chr11_-_66961709 1.965 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr1_-_31003181 1.955 LAPTM5
lysosomal protein transmembrane 5
chr12_+_48443232 1.954 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr2_-_225519974 1.933 DOCK10
dedicator of cytokinesis 10
chr10_+_26767288 1.927 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr22_-_16080265 1.916 CECR1
cat eye syndrome chromosome region, candidate 1
chr12_+_91620749 1.909 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr16_+_29582069 1.908 NM_003123
SPN
sialophorin
chr6_+_73388713 1.906 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr12_+_110328126 1.904 NM_005475
SH2B3
SH2B adaptor protein 3
chr16_+_48865521 1.902 ADCY7
adenylate cyclase 7
chrX_-_83644054 1.901 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr4_-_25473528 1.901 NM_015187
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr6_-_30762385 1.893 KIAA1949
KIAA1949
chr1_-_154215558 1.892 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr9_+_263025 1.888 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr11_-_66877519 1.884 NM_021173
POLD4
polymerase (DNA-directed), delta 4
chr1_-_142535878 1.882 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr12_-_56159631 1.878 NM_001080157
ARHGAP9
Rho GTPase activating protein 9
chr22_-_30071761 1.867 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr1_-_159306327 1.866 ARHGAP30
Rho GTPase activating protein 30
chr10_-_7493418 1.864 NM_001029880
SFMBT2
Scm-like with four mbt domains 2
chr1_-_27825178 1.857 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr10_+_26767268 1.852 NM_019043
APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chrX_-_70248022 1.847 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr19_-_46504831 1.846


chr6_-_32920167 1.835 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr16_+_29582065 1.834 SPN
sialophorin
chr6_-_32605898 1.829 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr12_-_24993260 1.822 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr1_+_207995999 1.820 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr1_+_26517045 1.819 CD52
CD52 molecule
chr1_+_9634368 1.808 NM_005026
PIK3CD
phosphoinositide-3-kinase, catalytic, delta polypeptide
chr19_-_55104875 1.799 NUP62
nucleoporin 62kDa
chr12_-_24993190 1.794 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr22_+_23153529 1.794 NM_000675
ADORA2A
adenosine A2a receptor
chr2_-_175207521 1.788 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr18_-_59137488 1.781 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chr1_+_172395277 1.772 RABGAP1L
RAB GTPase activating protein 1-like
chr3_-_122862447 1.756 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr19_-_46550788 1.750 TGFB1
transforming growth factor, beta 1
chr3_-_15348811 1.734 SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr9_-_35640852 1.722 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr6_-_30762957 1.711 KIAA1949
KIAA1949
chr22_-_28992787 1.709 NM_020530
OSM
oncostatin M
chr13_-_45654292 1.701 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_-_149586298 1.695 RFX5
regulatory factor X, 5 (influences HLA class II expression)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.15 1.97e-16 GO:0050794 regulation of cellular process
1.13 5.31e-15 GO:0065007 biological regulation
1.13 6.40e-15 GO:0050789 regulation of biological process
1.19 6.84e-13 GO:0044260 cellular macromolecule metabolic process
1.07 5.26e-11 GO:0009987 cellular process
1.16 9.20e-11 GO:0043170 macromolecule metabolic process
1.17 8.05e-10 GO:0051716 cellular response to stimulus
1.27 1.91e-09 GO:0048583 regulation of response to stimulus
1.54 7.32e-09 GO:0001775 cell activation
1.19 1.23e-08 GO:0007165 signal transduction
1.22 1.70e-08 GO:0048522 positive regulation of cellular process
1.20 7.84e-08 GO:0048518 positive regulation of biological process
1.17 9.53e-08 GO:0023052 signaling
1.22 2.35e-07 GO:0090304 nucleic acid metabolic process
1.26 3.27e-07 GO:0023051 regulation of signaling
1.71 3.53e-07 GO:0045321 leukocyte activation
1.19 4.10e-07 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.28 4.71e-07 GO:0009966 regulation of signal transduction
1.16 5.37e-07 GO:0019222 regulation of metabolic process
1.16 8.12e-07 GO:0031323 regulation of cellular metabolic process
1.28 3.22e-06 GO:0035556 intracellular signal transduction
1.16 5.09e-06 GO:0080090 regulation of primary metabolic process
1.23 1.03e-05 GO:0006464 protein modification process
1.28 1.48e-05 GO:0002376 immune system process
1.40 1.49e-05 GO:0051726 regulation of cell cycle
1.43 2.59e-05 GO:0006974 response to DNA damage stimulus
1.71 3.15e-05 GO:0046649 lymphocyte activation
1.21 3.20e-05 GO:0043412 macromolecule modification
1.36 5.54e-05 GO:0002682 regulation of immune system process
1.51 6.29e-05 GO:0006917 induction of apoptosis
1.18 7.03e-05 GO:0044267 cellular protein metabolic process
1.51 7.93e-05 GO:0012502 induction of programmed cell death
1.18 8.48e-05 GO:0048519 negative regulation of biological process
1.23 1.11e-04 GO:0006996 organelle organization
1.15 1.27e-04 GO:0060255 regulation of macromolecule metabolic process
1.41 1.38e-04 GO:0043065 positive regulation of apoptosis
1.41 1.38e-04 GO:0043068 positive regulation of programmed cell death
1.95 2.82e-04 GO:0050851 antigen receptor-mediated signaling pathway
1.09 2.94e-04 GO:0044237 cellular metabolic process
1.09 3.38e-04 GO:0044238 primary metabolic process
1.14 3.39e-04 GO:0016043 cellular component organization
1.68 3.47e-04 GO:0002757 immune response-activating signal transduction
1.21 4.21e-04 GO:0016070 RNA metabolic process
1.16 5.69e-04 GO:0071842 cellular component organization at cellular level
1.39 5.81e-04 GO:0010942 positive regulation of cell death
1.18 5.92e-04 GO:0048523 negative regulation of cellular process
1.27 6.25e-04 GO:0043067 regulation of programmed cell death
1.14 6.36e-04 GO:0071840 cellular component organization or biogenesis
1.27 7.47e-04 GO:0042981 regulation of apoptosis
1.27 7.76e-04 GO:0007049 cell cycle
1.27 8.68e-04 GO:0006793 phosphorus metabolic process
1.27 8.68e-04 GO:0006796 phosphate metabolic process
1.59 9.01e-04 GO:0051249 regulation of lymphocyte activation
1.44 1.17e-03 GO:0007264 small GTPase mediated signal transduction
1.64 1.19e-03 GO:0002764 immune response-regulating signaling pathway
1.16 1.56e-03 GO:0006950 response to stress
1.57 1.63e-03 GO:0071156 regulation of cell cycle arrest
1.87 2.08e-03 GO:0030098 lymphocyte differentiation
1.40 2.30e-03 GO:0002684 positive regulation of immune system process
1.24 2.38e-03 GO:0050790 regulation of catalytic activity
1.21 2.42e-03 GO:0065009 regulation of molecular function
1.25 2.49e-03 GO:0010941 regulation of cell death
1.77 3.19e-03 GO:0042110 T cell activation
1.15 3.29e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.57 3.75e-03 GO:0000075 cell cycle checkpoint
1.37 3.82e-03 GO:0007599 hemostasis
1.15 3.83e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25 3.93e-03 GO:0051246 regulation of protein metabolic process
1.43 4.24e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.45 4.53e-03 GO:0070647 protein modification by small protein conjugation or removal
1.28 4.90e-03 GO:0033554 cellular response to stress
1.33 5.07e-03 GO:0006259 DNA metabolic process
1.53 5.34e-03 GO:0002694 regulation of leukocyte activation
1.62 5.78e-03 GO:0051251 positive regulation of lymphocyte activation
1.14 5.87e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.51 5.94e-03 GO:0050865 regulation of cell activation
1.32 6.23e-03 GO:0051276 chromosome organization
1.36 6.30e-03 GO:0007596 blood coagulation
1.36 6.30e-03 GO:0050817 coagulation
1.79 8.29e-03 GO:0002429 immune response-activating cell surface receptor signaling pathway
1.33 9.94e-03 GO:0050878 regulation of body fluid levels
1.24 1.05e-02 GO:0032268 regulation of cellular protein metabolic process
1.18 1.24e-02 GO:0010467 gene expression
1.27 1.46e-02 GO:0031399 regulation of protein modification process
1.42 1.46e-02 GO:0006281 DNA repair
1.22 1.50e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.37 1.51e-02 GO:0050776 regulation of immune response
1.26 1.82e-02 GO:0008219 cell death
1.26 2.00e-02 GO:0016265 death
1.58 2.17e-02 GO:0050863 regulation of T cell activation
1.48 2.27e-02 GO:0016567 protein ubiquitination
1.07 2.39e-02 GO:0008152 metabolic process
1.26 2.47e-02 GO:0016310 phosphorylation
1.45 2.54e-02 GO:0032446 protein modification by small protein conjugation
1.13 2.90e-02 GO:0019538 protein metabolic process
2.80 2.98e-02 GO:0050853 B cell receptor signaling pathway
1.21 3.42e-02 GO:0031325 positive regulation of cellular metabolic process
1.55 3.45e-02 GO:0050867 positive regulation of cell activation
1.72 3.51e-02 GO:0002768 immune response-regulating cell surface receptor signaling pathway
1.27 3.73e-02 GO:0006955 immune response
1.66 3.81e-02 GO:0002521 leukocyte differentiation
1.30 3.93e-02 GO:0042060 wound healing
1.27 4.32e-02 GO:0006468 protein phosphorylation
1.40 4.39e-02 GO:0010564 regulation of cell cycle process
1.36 4.97e-02 GO:0007243 intracellular protein kinase cascade
1.36 4.97e-02 GO:0023014 signal transduction via phosphorylation event

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 3.75e-15 GO:0005634 nucleus
1.38 1.78e-14 GO:0005654 nucleoplasm
1.08 1.81e-14 GO:0005622 intracellular
1.08 3.09e-14 GO:0044424 intracellular part
1.27 3.43e-12 GO:0044428 nuclear part
1.28 2.31e-11 GO:0031981 nuclear lumen
1.24 2.62e-09 GO:0005829 cytosol
1.47 1.66e-08 GO:0005694 chromosome
1.07 2.68e-08 GO:0043229 intracellular organelle
1.07 3.76e-08 GO:0043226 organelle
1.08 9.84e-08 GO:0043231 intracellular membrane-bounded organelle
1.08 1.11e-07 GO:0043227 membrane-bounded organelle
1.21 1.97e-07 GO:0043233 organelle lumen
1.20 2.46e-07 GO:0031974 membrane-enclosed lumen
1.38 3.32e-07 GO:0044451 nucleoplasm part
1.12 4.32e-07 GO:0044446 intracellular organelle part
1.11 5.19e-07 GO:0044422 organelle part
1.20 7.22e-07 GO:0070013 intracellular organelle lumen
1.03 6.80e-06 GO:0044464 cell part
1.03 7.35e-06 GO:0005623 cell
1.08 8.86e-06 GO:0005737 cytoplasm
1.14 2.60e-05 GO:0032991 macromolecular complex
1.60 5.20e-05 GO:0016604 nuclear body
1.40 1.06e-04 GO:0044427 chromosomal part
1.13 1.54e-03 GO:0043234 protein complex
1.13 4.18e-03 GO:0043228 non-membrane-bounded organelle
1.13 4.18e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.96 1.30e-02 GO:0016605 PML body
1.45 1.67e-02 GO:0000785 chromatin
1.83 3.87e-02 GO:0030117 membrane coat
1.83 3.87e-02 GO:0048475 coated membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 2.88e-30 GO:0005515 protein binding
1.06 1.00e-09 GO:0005488 binding
1.47 7.53e-07 GO:0060589 nucleoside-triphosphatase regulator activity
1.46 2.38e-06 GO:0030695 GTPase regulator activity
1.53 4.94e-04 GO:0005096 GTPase activator activity
1.27 5.00e-04 GO:0030234 enzyme regulator activity
1.41 7.34e-04 GO:0008047 enzyme activator activity
1.29 1.15e-03 GO:0019899 enzyme binding
1.24 1.82e-03 GO:0030528 transcription regulator activity
1.39 3.63e-03 GO:0000988 protein binding transcription factor activity
1.39 3.63e-03 GO:0000989 transcription factor binding transcription factor activity
1.15 4.13e-03 GO:0003677 DNA binding
1.39 5.14e-03 GO:0003712 transcription cofactor activity
1.12 7.85e-03 GO:0003676 nucleic acid binding
1.42 8.17e-03 GO:0016564 transcription repressor activity
1.28 1.03e-02 GO:0043565 sequence-specific DNA binding
1.42 1.38e-02 GO:0005083 small GTPase regulator activity
1.85 1.88e-02 GO:0047485 protein N-terminus binding
1.54 3.67e-02 GO:0005085 guanyl-nucleotide exchange factor activity
1.56 4.84e-02 GO:0003714 transcription corepressor activity