Motif ID: TBP.p2

Z-value: 2.109


Transcription factors associated with TBP.p2:

Gene SymbolEntrez IDGene Name
TBP 6908 TATA box binding protein



Activity profile for motif TBP.p2.

activity profile for motif TBP.p2


Sorted Z-values histogram for motif TBP.p2

Sorted Z-values for motif TBP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_151052391 3.581 NM_005168
RND3
Rho family GTPase 3
chr7_+_100557098 3.373 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr9_+_123088217 3.293 GSN
gelsolin
chr5_-_57791544 3.275 NM_006622
PLK2
polo-like kinase 2
chr21_-_27139143 3.235 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr21_-_27139563 3.086 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr4_-_75183700 2.894 CXCL2
chemokine (C-X-C motif) ligand 2
chr10_-_62373828 2.879 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr3_+_195336625 2.718 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr14_+_74815233 2.661 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr11_-_2907169 2.655 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr2_-_216009015 2.576 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr12_+_12935759 2.559 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr8_-_23077392 2.508 NM_003840
TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr17_-_36469869 2.491 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr10_+_53744043 2.487 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr16_+_55217085 2.307 NM_175617
MT1E
metallothionein 1E
chr20_-_43410437 2.293 NM_002999
SDC4
syndecan 4
chr17_+_29606408 2.255 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr16_+_55217180 2.241 MT1E
metallothionein 1E
chr15_-_58477407 2.233 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr14_-_52487558 2.221 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr3_+_195336631 2.199 HES1
hairy and enhancer of split 1, (Drosophila)
chr12_+_12935619 2.158 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr15_+_37660568 2.132 NM_003246
THBS1
thrombospondin 1
chr20_+_29656744 2.119 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr4_-_75123193 2.076 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr1_-_151784889 2.023 NM_002961
NM_019554
S100A4

S100 calcium binding protein A4

chr3_-_130517759 1.993 NM_006026
H1FX
H1 histone family, member X
chr17_-_45633986 1.943 NM_000088
COL1A1
collagen, type I, alpha 1
chr17_-_45633873 1.873 COL1A1
collagen, type I, alpha 1
chr17_+_30594192 1.785 NM_144975
SLFN5
schlafen family member 5
chr4_+_74953971 1.785 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr9_+_91409746 1.765 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr8_-_134378630 1.718 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr10_-_92670764 1.692 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_+_85819004 1.651 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr1_-_8008934 1.627 ERRFI1
ERBB receptor feedback inhibitor 1
chr10_+_17311282 1.617 VIM
vimentin
chr9_-_116920232 1.608 NM_002160
TNC
tenascin C
chr6_-_134540666 1.523 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr8_-_48813256 1.503 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr17_+_36493927 1.477 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr8_-_124622434 1.467 NM_058229
FBXO32
F-box protein 32
chr1_+_200775864 1.449 NM_001197131
PPP1R12B
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr12_+_50686990 1.443 NM_181711
GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
chr12_-_123568781 1.411


chr17_-_68100537 1.408 LOC100499467
hypothetical LOC100499467
chr17_-_10265991 1.336 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr1_-_94779727 1.322 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr1_-_16355013 1.301 NM_004431
EPHA2
EPH receptor A2
chr10_+_17311283 1.286 VIM
vimentin
chr2_+_65517316 1.251 FLJ16124
FLJ16124 protein
chr7_-_526005 1.218 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr8_-_23317571 1.210 LOXL2
lysyl oxidase-like 2
chr4_-_75183860 1.190 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chr1_-_32940850 1.188 SYNC
syncoilin, intermediate filament protein
chr19_+_627346 1.158 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr1_-_85816520 1.151 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr8_-_23317577 1.140 LOXL2
lysyl oxidase-like 2
chr8_-_23317536 1.107 LOXL2
lysyl oxidase-like 2
chr7_+_93862137 1.105 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr3_+_52504391 1.066 NM_015136
STAB1
stabilin 1
chrX_+_152699616 1.049 NM_001170760
NM_001170761
NM_014370
SRPK3


SRSF protein kinase 3


chr21_+_46342440 1.048 NM_001849
NM_058174
NM_058175
COL6A2


collagen, type VI, alpha 2


chr15_+_78858763 1.042 NM_018689
KIAA1199
KIAA1199
chr9_+_130354490 1.035 NM_001130438
NM_001195532
NM_003127
SPTAN1


spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)


chr17_-_30724732 1.032 NM_001104587
NM_001104588
NM_001104589
NM_001104590
NM_152270
SLFN11




schlafen family member 11




chr12_-_87498225 1.030 NM_000899
NM_003994
KITLG

KIT ligand

chr2_-_238813365 1.018 NM_001142853
NM_018645
HES6

hairy and enhancer of split 6 (Drosophila)

chr9_+_138677197 1.004 NM_201446
NM_016215
EGFL7

EGF-like-domain, multiple 7

chr1_-_201411533 0.983 NM_004997
MYBPH
myosin binding protein H
chr5_-_179712920 0.935 NM_005110
GFPT2
glutamine-fructose-6-phosphate transaminase 2
chr15_-_32875040 0.933 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr2_+_88148413 0.933 NM_198274
SMYD1
SET and MYND domain containing 1
chr5_+_53787187 0.930 NM_006308
HSPB3
heat shock 27kDa protein 3
chr12_-_47869134 0.917 TUBA1A
tubulin, alpha 1a
chr11_+_64946848 0.912


chr12_+_8866416 0.889 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr10_+_96512447 0.873 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr10_+_17311307 0.873 VIM
vimentin
chr19_-_40939756 0.856 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr17_+_35425139 0.856 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr11_+_64946820 0.848 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr1_+_15957832 0.846 NM_017556
FBLIM1
filamin binding LIM protein 1
chr9_-_33437527 0.845 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr17_-_36436979 0.829 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr10_+_17311242 0.821 VIM
vimentin
chr1_+_78126787 0.795 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr17_-_36792161 0.782 NM_021013
KRT34
keratin 34
chr2_-_238813284 0.780 HES6
hairy and enhancer of split 6 (Drosophila)
chr6_-_3102690 0.772 NM_001069
TUBB2A
tubulin, beta 2A
chr6_-_74287483 0.771 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr12_-_47869067 0.768 NM_006009
TUBA1A
tubulin, alpha 1a
chr4_-_140317686 0.763 ELF2
E74-like factor 2 (ets domain transcription factor)
chr6_-_134537699 0.759 NM_005627
SGK1
serum/glucocorticoid regulated kinase 1
chr6_+_32021831 0.747 CFB
complement factor B
chr8_-_23317620 0.739 NM_002318
LOXL2
lysyl oxidase-like 2
chr17_-_36475652 0.738 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr1_-_154941861 0.725 NM_001878
CRABP2
cellular retinoic acid binding protein 2
chr1_-_226202210 0.719 NM_003395
WNT9A
wingless-type MMTV integration site family, member 9A
chr19_+_18357966 0.712 NM_004864
GDF15
growth differentiation factor 15
chr17_-_37034288 0.710 NM_000422
KRT17
keratin 17
chr2_-_179380301 0.694 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr1_-_202432165 0.692 NM_002256
KISS1
KiSS-1 metastasis-suppressor
chr17_-_36807322 0.690 NM_002277
KRT31
keratin 31
chr8_-_27528105 0.690 CLU
clusterin
chr1_-_23758503 0.684 ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr5_+_15553288 0.678 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr6_-_74287453 0.676 NM_001402
EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr12_-_51173238 0.665 NM_005554
KRT6A
keratin 6A
chr17_-_77411695 0.662 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr7_+_44802798 0.662 PPIA
peptidylprolyl isomerase A (cyclophilin A)
chr6_+_12398514 0.662 NM_001168319
NM_001955
EDN1

endothelin 1

chr13_-_44048391 0.661 TSC22D1
TSC22 domain family, member 1
chr16_+_84202515 0.659 NM_001134473
KIAA0182
KIAA0182
chr7_+_44802834 0.649 PPIA
peptidylprolyl isomerase A (cyclophilin A)
chr5_-_141981083 0.648 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr17_-_36456949 0.643 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr11_-_5204769 0.642 NM_000518
HBB
hemoglobin, beta
chr7_+_44802691 0.632 NM_021130
PPIA
peptidylprolyl isomerase A (cyclophilin A)
chr4_+_71330797 0.631 NM_001145006
MUC7
mucin 7, secreted
chr11_-_6418705 0.614 NM_000613
HPX
hemopexin
chrX_-_106846684 0.611 TSC22D3
TSC22 domain family, member 3
chr3_+_150675169 0.606 TM4SF4
transmembrane 4 L six family member 4
chr13_+_30378311 0.603 NM_032849
C13orf33
chromosome 13 open reading frame 33
chr3_+_150065732 0.601 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr5_-_54504590 0.594 NM_001145734
NM_001170402
NM_152623
CDC20B


cell division cycle 20 homolog B (S. cerevisiae)


chr7_-_6490375 0.590 KDELR2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr12_+_79634820 0.589 NM_005593
MYF5
myogenic factor 5
chr17_-_71287417 0.587 NM_005324
H3F3B
H3 histone, family 3B (H3.3B)
chr17_+_36647795 0.584 NM_031963
KRTAP9-8
keratin associated protein 9-8
chr2_-_121759237 0.579 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr18_-_42810446 0.572 NM_145653
TCEB3C
transcription elongation factor B polypeptide 3C (elongin A3)
chr4_+_75529716 0.572 NM_001657
AREG
amphiregulin
chr8_-_48813236 0.571 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr10_+_89409332 0.566 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr6_-_133076873 0.565 NM_004666
VNN1
vanin 1
chr7_+_127668566 0.564 NM_000230
LEP
leptin
chr19_-_14490235 0.552 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr15_-_60244773 0.552 NM_001007595
C2CD4B
C2 calcium-dependent domain containing 4B
chr3_-_81893604 0.548 NM_000158
GBE1
glucan (1,4-alpha-), branching enzyme 1
chr7_-_45927263 0.547 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr8_+_70567634 0.547 SULF1
sulfatase 1
chr8_-_27528215 0.543 NM_001831
CLU
clusterin
chr5_-_16795336 0.536 MYO10
myosin X
chr11_-_8982107 0.533 NM_020645
NRIP3
nuclear receptor interacting protein 3
chr5_+_176744037 0.531 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr19_+_16296734 0.526 KLF2
Kruppel-like factor 2 (lung)
chr7_+_75769927 0.526 HSPB1
heat shock 27kDa protein 1
chr5_-_42847716 0.521 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr12_-_51153788 0.520 NM_173086
KRT6C
keratin 6C
chr21_+_18539016 0.516 NM_024944
CHODL
chondrolectin
chr12_+_50913274 0.514 KRT7
keratin 7
chr8_+_70541412 0.513 NM_001128204
NM_015170
SULF1

sulfatase 1

chr1_+_144183811 0.513 ANKRD34A
ankyrin repeat domain 34A
chr7_+_111908143 0.513 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr11_-_2863536 0.512 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr1_-_8008979 0.511 NM_018948
ERRFI1
ERBB receptor feedback inhibitor 1
chrX_-_106846924 0.510 NM_004089
TSC22D3
TSC22 domain family, member 3
chr7_+_134114701 0.509 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr11_-_60886038 0.509 NM_001161454
NM_153611
CYBASC3

cytochrome b, ascorbate dependent 3

chr7_+_107088315 0.505 NM_000441
SLC26A4
solute carrier family 26, member 4
chr7_+_75769765 0.504 NM_001540
HSPB1
heat shock 27kDa protein 1
chr20_-_1922701 0.496 NM_001190899
NM_001190898
NM_024411
PDYN


prodynorphin


chr12_-_47868563 0.493 TUBA1A
tubulin, alpha 1a
chr6_-_52968035 0.486 NM_001512
GSTA4
glutathione S-transferase alpha 4
chr6_-_74287506 0.484 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr6_-_169395847 0.482 THBS2
thrombospondin 2
chr9_+_129951552 0.482 NM_005564
LCN2
lipocalin 2
chr6_-_33879734 0.481 NM_001040109
NM_001184698
NM_002418
MLN


motilin


chr15_+_30797466 0.477 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr2_-_216944911 0.476 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr17_-_77411733 0.475 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr11_-_111287657 0.473 NM_001885
CRYAB
crystallin, alpha B
chr4_+_75699652 0.472 NM_001657
AREG
amphiregulin
chr1_-_35431329 0.470 NM_005066
SFPQ
splicing factor proline/glutamine-rich
chr8_+_1980564 0.467 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr22_-_34566276 0.465 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr12_-_51132129 0.463 NM_005555
KRT6B
keratin 6B
chr6_+_112775224 0.459 NM_001013734
RFPL4B
ret finger protein-like 4B
chr10_+_17311347 0.459 VIM
vimentin
chr10_+_6284845 0.456 NM_004566
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr19_+_45914755 0.456 NM_025194
ITPKC
inositol 1,4,5-trisphosphate 3-kinase C
chr7_+_30917939 0.452 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chr1_-_180627512 0.450 GLUL
glutamate-ammonia ligase
chr7_+_100399409 0.442


chr6_-_130224108 0.432 NM_001010876
C6orf191
chromosome 6 open reading frame 191
chr17_-_76622967 0.432 FLJ90757
hypothetical LOC440465
chr8_+_23016271 0.431 NM_003841
TNFRSF10C
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
chr1_-_35431318 0.429 SFPQ
splicing factor proline/glutamine-rich
chr17_-_77411659 0.425 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr3_+_62279707 0.424 C3orf14
chromosome 3 open reading frame 14
chr7_-_41709191 0.422 NM_002192
INHBA
inhibin, beta A
chr11_+_60886407 0.420 TMEM138
transmembrane protein 138
chr11_-_60885928 0.420 CYBASC3
cytochrome b, ascorbate dependent 3
chr15_-_61461127 0.419 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr3_-_81893506 0.418 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr11_+_60885983 0.418 NM_016464
TMEM138
transmembrane protein 138
chr15_+_76952398 0.418 MORF4L1
mortality factor 4 like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.63 8.65e-10 GO:0009888 tissue development
1.49 2.79e-09 GO:0032501 multicellular organismal process
10.30 4.58e-08 GO:0034614 cellular response to reactive oxygen species
1.92 5.03e-08 GO:0048513 organ development
1.81 8.31e-08 GO:0042221 response to chemical stimulus
3.70 5.73e-07 GO:0010035 response to inorganic substance
12.14 8.28e-07 GO:0070301 cellular response to hydrogen peroxide
1.61 8.36e-07 GO:0048856 anatomical structure development
4.23 8.65e-07 GO:0008544 epidermis development
7.73 8.72e-07 GO:0034599 cellular response to oxidative stress
1.70 2.73e-06 GO:0006950 response to stress
1.52 4.31e-06 GO:0032502 developmental process
5.90 5.41e-06 GO:0000302 response to reactive oxygen species
1.61 8.31e-06 GO:0048731 system development
2.20 1.29e-05 GO:0070887 cellular response to chemical stimulus
2.25 3.55e-05 GO:0006952 defense response
1.51 5.71e-05 GO:0007275 multicellular organismal development
8.09 1.10e-04 GO:0031424 keratinization
3.76 1.67e-04 GO:0006979 response to oxidative stress
6.18 2.23e-04 GO:0042542 response to hydrogen peroxide
2.34 6.95e-04 GO:0009887 organ morphogenesis
10.30 9.26e-04 GO:0042743 hydrogen peroxide metabolic process
3.01 1.01e-03 GO:0006954 inflammatory response
5.43 1.09e-03 GO:0009913 epidermal cell differentiation
12.02 1.46e-03 GO:0042744 hydrogen peroxide catabolic process
4.50 1.87e-03 GO:0008217 regulation of blood pressure
1.82 2.18e-03 GO:0010033 response to organic substance
2.44 2.76e-03 GO:0072358 cardiovascular system development
2.44 2.76e-03 GO:0072359 circulatory system development
1.73 3.10e-03 GO:0009653 anatomical structure morphogenesis
4.02 3.83e-03 GO:0051789 response to protein stimulus
1.97 3.84e-03 GO:0009611 response to wounding
1.28 3.93e-03 GO:0050896 response to stimulus
2.42 4.77e-03 GO:0048646 anatomical structure formation involved in morphogenesis
2.33 5.36e-03 GO:0009607 response to biotic stimulus
6.95 7.07e-03 GO:0072593 reactive oxygen species metabolic process
5.31 1.00e-02 GO:0030216 keratinocyte differentiation
5.72 1.34e-02 GO:0002526 acute inflammatory response
6.87 2.71e-02 GO:0044236 multicellular organismal metabolic process
8.01 3.16e-02 GO:0031032 actomyosin structure organization
8.01 3.16e-02 GO:0044243 multicellular organismal catabolic process
7.73 4.10e-02 GO:0032963 collagen metabolic process
2.07 4.21e-02 GO:0009725 response to hormone stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.61 2.53e-30 GO:0005576 extracellular region
3.52 2.80e-30 GO:0044421 extracellular region part
8.88 4.52e-30 GO:0005882 intermediate filament
3.86 2.72e-28 GO:0005615 extracellular space
7.69 6.64e-27 GO:0045111 intermediate filament cytoskeleton
10.82 1.14e-19 GO:0045095 keratin filament
2.00 7.21e-09 GO:0005856 cytoskeleton
2.18 7.19e-08 GO:0044430 cytoskeletal part
3.08 4.23e-07 GO:0031012 extracellular matrix
2.94 4.51e-05 GO:0005578 proteinaceous extracellular matrix
12.02 1.76e-04 GO:0032982 myosin filament
1.49 3.99e-04 GO:0043228 non-membrane-bounded organelle
1.49 3.99e-04 GO:0043232 intracellular non-membrane-bounded organelle
4.02 4.61e-04 GO:0043292 contractile fiber
5.48 8.73e-04 GO:0000786 nucleosome
4.00 1.03e-03 GO:0030016 myofibril
3.83 3.50e-03 GO:0044449 contractile fiber part
5.15 2.90e-02 GO:0031674 I band

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.20 3.81e-13 GO:0005198 structural molecule activity
7.18 2.20e-11 GO:0005179 hormone activity
2.42 2.66e-10 GO:0005102 receptor binding
4.04 4.84e-07 GO:0005125 cytokine activity
4.25 7.84e-05 GO:0046906 tetrapyrrole binding
4.27 1.56e-04 GO:0020037 heme binding
3.51 2.10e-04 GO:0005126 cytokine receptor binding
7.19 2.98e-04 GO:0008307 structural constituent of muscle
3.42 1.09e-03 GO:0001664 G-protein-coupled receptor binding
3.50 1.39e-03 GO:0008083 growth factor activity
24.72 1.89e-03 GO:0046870 cadmium ion binding
4.64 3.31e-03 GO:0005201 extracellular matrix structural constituent
6.18 4.02e-03 GO:0019825 oxygen binding
6.05 4.85e-03 GO:0008009 chemokine activity
2.02 5.30e-03 GO:0005509 calcium ion binding
4.79 5.69e-03 GO:0005200 structural constituent of cytoskeleton
5.45 1.16e-02 GO:0042379 chemokine receptor binding
11.89 1.29e-02 GO:0005344 oxygen transporter activity
2.82 1.65e-02 GO:0005506 iron ion binding
2.27 2.36e-02 GO:0030246 carbohydrate binding
15.45 2.45e-02 GO:0015250 water channel activity
3.13 3.21e-02 GO:0005539 glycosaminoglycan binding
13.73 4.29e-02 GO:0005372 water transmembrane transporter activity
1.19 4.47e-02 GO:0005515 protein binding
23.18 4.72e-02 GO:0015168 glycerol transmembrane transporter activity