Motif ID: EWSR1-FLI1.p2

Z-value: 1.213


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1



Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_10520264 4.478 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr6_-_10520592 4.071 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr5_-_148422799 2.472 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr4_+_183302105 2.065 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr1_-_68071635 1.956 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr11_-_117628211 1.941 NM_198275
MPZL3
myelin protein zero-like 3
chrX_+_107569671 1.900 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chrX_-_148394570 1.526 NM_000202
NM_001166550
NM_006123
IDS


iduronate 2-sulfatase


chr11_+_101485946 1.515 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr7_+_16759845 1.487 NM_014399
TSPAN13
tetraspanin 13
chr1_-_6468600 1.295 NM_001042665
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr16_+_67697622 1.290 NM_138612
HAS3
hyaluronan synthase 3
chr17_-_31146660 1.276 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chr1_-_150276064 1.273 S100A11
S100 calcium binding protein A11
chr1_-_150276091 1.186 S100A11
S100 calcium binding protein A11
chr1_-_150276114 1.184 NM_005620
S100A11
S100 calcium binding protein A11
chr1_-_68470585 1.169 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr7_-_106991941 1.145 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chrX_-_107569256 1.141 NM_001847
COL4A6
collagen, type IV, alpha 6
chr3_-_65999548 1.120 NM_001033057
NM_004742
NM_015520
MAGI1


membrane associated guanylate kinase, WW and PDZ domain containing 1


chr9_+_77695334 1.099 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr17_+_2443983 1.068 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr18_+_44319365 1.059 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr10_+_114700775 1.052 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr17_+_45488356 1.007 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr17_+_45488330 0.990 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr1_-_223907283 0.934 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr2_+_113532685 0.930 NM_173170
IL1F5
interleukin 1 family, member 5 (delta)
chr17_+_2443652 0.922 NM_000430
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr19_-_242168 0.905 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr2_+_37425240 0.897 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr5_+_156819782 0.876 NIPAL4
NIPA-like domain containing 4
chr7_+_36395913 0.862 NM_018685
ANLN
anillin, actin binding protein
chr21_+_39099624 0.831 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr17_-_71385651 0.825 TRIM47
tripartite motif containing 47
chr10_+_88708267 0.819 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr1_+_221955876 0.817 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr20_+_6696744 0.817 NM_001200
BMP2
bone morphogenetic protein 2
chr1_+_185064654 0.812 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr1_-_236120844 0.808 NM_021186
ZP4
zona pellucida glycoprotein 4
chr4_-_86106567 0.798 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr19_+_12996830 0.798 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_-_231498081 0.797 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr6_+_139055244 0.788 FLJ46906
hypothetical LOC441172
chr16_-_48960186 0.777 NM_001173984
NM_013263
BRD7

bromodomain containing 7

chr21_+_39099717 0.747 NM_005239
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr9_-_83494198 0.733 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr3_-_48446405 0.694 NM_001130082
PLXNB1
plexin B1
chr19_-_55763091 0.694 NM_001080457
LRRC4B
leucine rich repeat containing 4B
chr18_+_54682261 0.683 ZNF532
zinc finger protein 532
chr2_+_113533155 0.664 NM_012275
IL1F5
interleukin 1 family, member 5 (delta)
chr8_-_145530639 0.633 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr12_+_14409875 0.628 NM_018179
ATF7IP
activating transcription factor 7 interacting protein
chr19_-_1966628 0.624 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr19_+_12996745 0.595 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr19_+_53466465 0.586 NM_153608
ZNF114
zinc finger protein 114
chr2_-_26395420 0.586 NM_001145168
NM_001145169
GPR113

G protein-coupled receptor 113

chr11_+_9736408 0.571 LOC283104
hypothetical LOC283104
chr8_+_30361485 0.562 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr14_-_53493198 0.558 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr16_-_2848106 0.557 NM_022119
PRSS22
protease, serine, 22
chr10_+_119292699 0.557


chr1_-_72521079 0.540


chr15_+_39310693 0.515 NM_007236
CHP
calcium binding protein P22
chr15_+_39310757 0.515 CHP
calcium binding protein P22
chr17_-_10574370 0.512 NM_001004313
TMEM220
transmembrane protein 220
chr6_-_24827265 0.495 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr17_+_35390607 0.495 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr19_-_242335 0.489 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr21_+_38550739 0.471 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr21_+_38550533 0.470 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr20_+_42807901 0.469 NM_022358
KCNK15
potassium channel, subfamily K, member 15
chr10_-_35143900 0.468 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr17_+_35390614 0.467 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr2_+_182464910 0.463 SSFA2
sperm specific antigen 2
chr10_-_90601655 0.462 NM_144590
ANKRD22
ankyrin repeat domain 22
chr8_-_22982435 0.443 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr10_+_70553993 0.439 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr1_+_117253882 0.430 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr15_+_88345612 0.414 NM_198526
ZNF710
zinc finger protein 710
chr9_+_34169023 0.414 UBAP1
ubiquitin associated protein 1
chr5_+_156819604 0.413 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr1_-_155336223 0.409 NM_001004341
ETV3L
ets variant 3-like
chr17_+_35390579 0.407 NM_002809
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr14_+_22845851 0.398 NM_004050
BCL2L2-PABPN1
BCL2L2
BCL2L2-PABPN1 read-through transcript
BCL2-like 2
chr9_+_34169036 0.397 UBAP1
ubiquitin associated protein 1
chr9_+_34169058 0.394 UBAP1
ubiquitin associated protein 1
chr11_-_66897584 0.355 NM_013246
CLCF1
cardiotrophin-like cytokine factor 1
chr9_+_34169047 0.354 UBAP1
ubiquitin associated protein 1
chr17_-_76919068 0.354 NM_178520
TMEM105
transmembrane protein 105
chr10_+_70553983 0.349 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr17_+_35390632 0.348 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr9_+_34169002 0.343 NM_001171201
NM_001171202
NM_001171203
NM_001171204
NM_016525
UBAP1




ubiquitin associated protein 1




chr6_+_117044334 0.335 NM_001010892
NM_001161664
RSPH4A

radial spoke head 4 homolog A (Chlamydomonas)

chr6_-_134538762 0.334 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr8_-_29262240 0.328 NM_057158
DUSP4
dual specificity phosphatase 4
chr5_-_64100176 0.316 SREK1IP1
SREK1-interacting protein 1
chr11_-_74120077 0.316 CHRDL2
chordin-like 2
chrX_+_505078 0.311 NM_000451
NM_006883
SHOX

short stature homeobox

chr11_-_8788765 0.311 NM_213618
ST5
suppression of tumorigenicity 5
chr17_+_35390641 0.310 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr6_+_31698447 0.304


chr12_+_52060689 0.302 NM_003109
SP1
Sp1 transcription factor
chr12_+_10222823 0.296 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr19_-_56164628 0.292 NM_002774
KLK6
kallikrein-related peptidase 6
chr5_+_35892747 0.288 NM_002185
IL7R
interleukin 7 receptor
chr11_+_10433241 0.286 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr17_+_582406 0.282 NM_024792
FAM57A
family with sequence similarity 57, member A
chr4_+_110956085 0.272 NM_018983
NM_032993
GAR1

GAR1 ribonucleoprotein homolog (yeast)

chr1_-_26070330 0.268 NM_178422
PAQR7
progestin and adipoQ receptor family member VII
chr5_-_64100239 0.265 NM_173829
SREK1IP1
SREK1-interacting protein 1
chrX_-_109448083 0.260 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr6_-_134538526 0.257 SGK1
serum/glucocorticoid regulated kinase 1
chrX_-_109447970 0.257 NM_001025580
NM_015365
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chrX_-_62891712 0.254 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr11_-_8789457 0.248 NM_139157
ST5
suppression of tumorigenicity 5
chr1_-_224993498 0.243 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr18_-_44189625 0.241 ZBTB7C
zinc finger and BTB domain containing 7C
chrX_-_109447954 0.229 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr19_-_9098625 0.229 NM_001001958
OR7G3
olfactory receptor, family 7, subfamily G, member 3
chr9_-_83493415 0.225 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr12_+_83954229 0.222 NM_001079910
NM_032165
LRRIQ1

leucine-rich repeats and IQ motif containing 1

chr6_-_143307976 0.220 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr19_-_53515143 0.220 NM_144577
CCDC114
coiled-coil domain containing 114
chr3_-_129852345 0.219 RPN1
ribophorin I
chr4_+_120029426 0.217 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr3_-_193928038 0.216 NM_004113
FGF12
fibroblast growth factor 12
chr1_-_20684858 0.213 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr1_+_151596953 0.212 NM_002965
S100A9
S100 calcium binding protein A9
chr1_-_20685314 0.210 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr10_+_70553949 0.209 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr10_+_70553862 0.208 NM_001035260
NM_004896
VPS26A

vacuolar protein sorting 26 homolog A (S. pombe)

chr10_+_70553945 0.204 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr10_+_70553962 0.202 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr4_-_184662604 0.199 LOC389247
hypothetical LOC389247
chr10_+_70553936 0.198 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr1_+_242691295 0.197 NM_001130957
NM_173807
C1orf101

chromosome 1 open reading frame 101

chrX_+_56606686 0.194 NM_013444
UBQLN2
ubiquilin 2
chr15_-_71712605 0.189 NPTN
neuroplastin
chr1_-_48235148 0.183 NM_001194986
LOC388630
UPF0632 protein A
chr2_+_182464713 0.183 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chr14_+_31616196 0.179 NM_001030055
NM_001173
ARHGAP5

Rho GTPase activating protein 5

chr2_+_96269703 0.176 NM_001037228
LOC285033
hypothetical protein LOC285033
chr10_+_114699953 0.176 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr3_+_33130563 0.176 CRTAP
cartilage associated protein
chr4_+_84676280 0.175 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr13_+_56626195 0.174 NM_198441
NM_001130404
NM_001130405
NM_001130406
NM_001130407
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
proline rich 20A
proline rich 20B
proline rich 20C
proline rich 20D
proline rich 20E
chr17_-_60483346 0.173 NM_006572
GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr22_+_38296703 0.169 NM_001003406
NM_021096
CACNA1I

calcium channel, voltage-dependent, T type, alpha 1I subunit

chr12_+_121803255 0.164 NM_003677
DENR
density-regulated protein
chr9_+_33807168 0.162 NM_017811
UBE2R2
ubiquitin-conjugating enzyme E2R 2
chr11_-_122571198 0.161 NM_024769
CLMP
CXADR-like membrane protein
chr1_-_72520735 0.161 NM_173808
NEGR1
neuronal growth regulator 1
chr11_-_65244718 0.152 NM_032193
RNASEH2C
ribonuclease H2, subunit C
chr14_-_20636568 0.148 NM_016423
ZNF219
zinc finger protein 219
chrX_-_49851743 0.146 NM_139289
AKAP4
A kinase (PRKA) anchor protein 4
chr17_-_70901303 0.144 GRB2
growth factor receptor-bound protein 2
chr12_-_40824699 0.143 NM_001099650
NM_173601
GXYLT1

glucoside xylosyltransferase 1

chr2_-_60634271 0.140 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr19_+_54786723 0.139 NM_020719
PRR12
proline rich 12
chr2_+_79593679 0.139 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr19_+_17972923 0.139 NM_001025604
ARRDC2
arrestin domain containing 2
chr3_-_42282665 0.138 NM_000729
CCK
cholecystokinin
chr16_+_66438348 0.137 NUTF2
nuclear transport factor 2
chr15_-_56829225 0.135 NM_001110
ADAM10
ADAM metallopeptidase domain 10
chr3_-_15875932 0.135 NM_015199
ANKRD28
ankyrin repeat domain 28
chr10_-_103864579 0.135 LDB1
LIM domain binding 1
chr17_+_35372751 0.134 NM_178171
GSDMA
gasdermin A
chr11_+_10480891 0.134 AMPD3
adenosine monophosphate deaminase 3
chr7_+_21434818 0.131


chrX_+_122923279 0.128 STAG2
stromal antigen 2
chr4_+_84676414 0.127 NM_032717
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr14_+_69415880 0.127 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chr9_-_103397023 0.123 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr12_+_29193399 0.122 FAR2
fatty acyl CoA reductase 2
chr10_-_14412813 0.119 NM_018027
FRMD4A
FERM domain containing 4A
chr1_-_27802688 0.118 NM_001029882
AHDC1
AT hook, DNA binding motif, containing 1
chr9_+_33807213 0.116 UBE2R2
ubiquitin-conjugating enzyme E2R 2
chr12_-_92489652 0.115 LOC144481
hypothetical protein LOC144481
chr9_-_106705867 0.111 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr15_-_56829104 0.111 ADAM10
ADAM metallopeptidase domain 10
chr3_-_129852182 0.111 RPN1
ribophorin I
chr11_-_74119833 0.110 NM_015424
CHRDL2
chordin-like 2
chr15_-_86600658 0.109 NM_001007156
NM_001012338
NM_002530
NTRK3


neurotrophic tyrosine kinase, receptor, type 3


chrX_-_62891667 0.107 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr8_-_37943143 0.106 NM_000025
ADRB3
adrenergic, beta-3-, receptor
chr19_-_11234117 0.106 NM_020812
DOCK6
dedicator of cytokinesis 6
chr3_-_129852400 0.105 NM_002950
RPN1
ribophorin I
chrX_-_62891730 0.104 NM_001173480
NM_015185
ARHGEF9

Cdc42 guanine nucleotide exchange factor (GEF) 9

chr4_+_166519392 0.101 NM_001873
CPE
carboxypeptidase E
chr4_-_74343169 0.100


chr17_-_60483278 0.100


chr3_-_166397142 0.100 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr1_+_156229934 0.100 KIRREL
kin of IRRE like (Drosophila)
chr1_+_109036431 0.099 NM_018061
PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr19_-_47451119 0.098 NM_006494
ERF
Ets2 repressor factor
chr3_-_121295663 0.098 NM_001146156
NM_002093
GSK3B

glycogen synthase kinase 3 beta

chr3_-_188936941 0.096 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr2_+_79593567 0.096 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr4_+_110956360 0.094 GAR1
GAR1 ribonucleoprotein homolog (yeast)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.49 1.01e-05 GO:0000902 cell morphogenesis
3.98 1.03e-05 GO:0048812 neuron projection morphogenesis
4.02 1.75e-05 GO:0007409 axonogenesis
3.72 1.96e-05 GO:0000904 cell morphogenesis involved in differentiation
3.69 2.33e-05 GO:0048858 cell projection morphogenesis
3.65 2.76e-05 GO:0032990 cell part morphogenesis
3.31 3.21e-05 GO:0032989 cellular component morphogenesis
3.88 3.39e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
3.61 6.72e-05 GO:0031175 neuron projection development
2.31 7.34e-05 GO:0009653 anatomical structure morphogenesis
3.00 2.41e-04 GO:0030182 neuron differentiation
3.25 2.69e-04 GO:0048666 neuron development
2.70 5.44e-04 GO:0048699 generation of neurons
3.03 5.69e-04 GO:0030030 cell projection organization
2.63 6.37e-04 GO:0022008 neurogenesis
2.19 9.76e-04 GO:0007399 nervous system development
2.52 2.38e-03 GO:0048468 cell development
1.75 2.74e-03 GO:0048731 system development
3.73 3.90e-03 GO:0007411 axon guidance
3.13 1.32e-02 GO:0051094 positive regulation of developmental process
1.64 1.42e-02 GO:0048856 anatomical structure development
1.59 2.13e-02 GO:0007275 multicellular organismal development
1.80 3.39e-02 GO:0030154 cell differentiation
1.79 3.39e-02 GO:0048869 cellular developmental process
40.38 3.45e-02 GO:0061036 positive regulation of cartilage development
2.40 3.74e-02 GO:0048584 positive regulation of response to stimulus
1.84 3.84e-02 GO:0048583 regulation of response to stimulus

Nothing significant found in compartment category.

Nothing significant found in function category.