Motif ID: TLX2.p2

Z-value: 0.795


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2



Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_14266200 1.182 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chrX_-_73429101 1.054 MIR374AHG
mir-374a-545 cluster host gene (non-protein coding)
chr4_-_38534802 0.982 NM_006068
TLR6
toll-like receptor 6
chr13_-_40491491 0.976 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr17_+_55269974 0.906


chr13_-_40491405 0.906 ELF1
E74-like factor 1 (ets domain transcription factor)
chr11_-_62379788 0.829 SNHG1
small nucleolar RNA host gene 1 (non-protein coding)
chr3_+_69216747 0.812 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr12_+_14429499 0.777 ATF7IP
activating transcription factor 7 interacting protein
chr6_+_26548678 0.772 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr3_-_15814678 0.768 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr1_-_114925734 0.752 NM_005872
BCAS2
breast carcinoma amplified sequence 2
chr10_-_46593923 0.742 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr9_-_124715392 0.734 NM_006626
ZBTB6
zinc finger and BTB domain containing 6
chr22_-_35914200 0.732 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr10_+_86174665 0.720 FAM190B
family with sequence similarity 190, member B
chr4_-_35922288 0.693 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr10_+_47216925 0.679 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr1_-_154837855 0.670 NM_015590
NM_182679
GPATCH4

G patch domain containing 4

chr18_+_54013575 0.666 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr5_+_68746694 0.659 NM_001038603
MARVELD2
MARVEL domain containing 2
chr11_-_95715976 0.653 NM_032427
MAML2
mastermind-like 2 (Drosophila)
chr6_-_33862690 0.651 NM_001143944
LEMD2
LEM domain containing 2
chr1_+_160002746 0.644 ATF6
activating transcription factor 6
chr13_-_98428244 0.641 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr12_-_52960168 0.632 NM_012117
CBX5
chromobox homolog 5
chr12_+_84198015 0.630 NM_006982
ALX1
ALX homeobox 1
chr10_+_96295511 0.624 NM_018063
HELLS
helicase, lymphoid-specific
chr1_+_160002733 0.622 ATF6
activating transcription factor 6
chr12_-_52960146 0.619 CBX5
chromobox homolog 5
chr12_-_52960206 0.618 CBX5
chromobox homolog 5
chr8_+_120289735 0.617 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr14_-_22825072 0.598 HOMEZ
homeobox and leucine zipper encoding
chr14_-_22825148 0.592 NM_020834
HOMEZ
homeobox and leucine zipper encoding
chr6_-_31658044 0.592 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr2_+_219141761 0.591 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr1_-_114215768 0.580 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr1_+_160002693 0.578 NM_007348
ATF6
activating transcription factor 6
chr2_-_188021117 0.575 NM_005795
CALCRL
calcitonin receptor-like
chr18_+_27332024 0.571 NM_001943
DSG2
desmoglein 2
chr5_-_102483680 0.562 NM_017676
GIN1
gypsy retrotransposon integrase 1
chr14_-_20807346 0.553 NM_001077442
NM_001077443
NM_004500
NM_031314
HNRNPC



heterogeneous nuclear ribonucleoprotein C (C1/C2)



chr6_+_134800533 0.550 LOC154092
hypothetical LOC154092
chr13_-_32658215 0.544 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr1_-_233391129 0.544 NM_001161533
NM_015014
RBM34

RNA binding motif protein 34

chr18_-_26935883 0.542 NM_004949
NM_024422
DSC2

desmocollin 2

chr2_-_225519974 0.542 DOCK10
dedicator of cytokinesis 10
chr10_+_47875229 0.541 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr7_-_33047042 0.537 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr12_+_55018925 0.535 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr1_-_159257486 0.527 F11R
F11 receptor
chr3_+_42107711 0.525 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr10_-_32707549 0.523 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr2_+_63669596 0.519 NM_005917
MDH1
malate dehydrogenase 1, NAD (soluble)
chr1_-_159257567 0.517 F11R
F11 receptor
chr10_+_80672842 0.512 ZMIZ1
zinc finger, MIZ-type containing 1
chr1_-_95311031 0.510 NM_144988
ALG14
asparagine-linked glycosylation 14 homolog (S. cerevisiae)
chr1_-_68470585 0.506 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr16_-_27982277 0.504 NM_001109763
GSG1L
GSG1-like
chr4_-_139382672 0.502 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr20_+_36867708 0.501 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory (inhibitor) subunit 16B

chr4_-_147662318 0.497 NM_001029998
NM_032128
SLC10A7

solute carrier family 10 (sodium/bile acid cotransporter family), member 7

chr12_-_32940931 0.496 NM_001005242
NM_004572
PKP2

plakophilin 2

chr2_+_61098355 0.495 PEX13
peroxisomal biogenesis factor 13
chr3_-_150578023 0.493 TM4SF1
transmembrane 4 L six family member 1
chr18_+_27281729 0.491 NM_001944
DSG3
desmoglein 3
chr3_-_145049853 0.491 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr20_-_1321571 0.489 FKBP1A
FK506 binding protein 1A, 12kDa
chr1_+_86662356 0.489 NM_006536
CLCA2
chloride channel accessory 2
chr5_+_40877053 0.483 NM_032587
CARD6
caspase recruitment domain family, member 6
chr12_+_74160779 0.481 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr2_+_64535114 0.480 HSPC159
galectin-related protein
chr20_+_33223434 0.478 NM_006404
PROCR
protein C receptor, endothelial
chr16_-_84342129 0.478 NM_206967
C16orf74
chromosome 16 open reading frame 74
chr9_-_32563057 0.477 NM_002493
NM_182739
NDUFB6

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa

chr1_-_17638797 0.476 NM_018715
RCC2
regulator of chromosome condensation 2
chr11_-_57054756 0.471 NM_012456
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr5_-_64100176 0.469 SREK1IP1
SREK1-interacting protein 1
chr6_+_26473376 0.468 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr11_-_8572321 0.467 STK33
serine/threonine kinase 33
chr12_+_52960745 0.465 NM_002136
NM_031157
HNRNPA1

heterogeneous nuclear ribonucleoprotein A1

chr1_+_28705041 0.464 NM_001048199
RCC1
regulator of chromosome condensation 1
chr10_+_82163568 0.463 C10orf58
chromosome 10 open reading frame 58
chr1_+_169549996 0.463 NM_002022
FMO4
flavin containing monooxygenase 4
chrX_-_131181141 0.456 RAP2C
RAP2C, member of RAS oncogene family
chr19_+_56766342 0.454 NM_007147
ZNF175
zinc finger protein 175
chrX_-_70755023 0.448 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr12_+_52960798 0.444 HNRNPA1L2
HNRNPA1
HNRNPA1P10
heterogeneous nuclear ribonucleoprotein A1-like 2
heterogeneous nuclear ribonucleoprotein A1
heterogeneous nuclear ribonucleoprotein A1 pseudogene 10
chr2_-_63669265 0.443 NM_015910
WDPCP
WD repeat containing planar cell polarity effector
chrX_+_24393264 0.439 NM_001142386
NM_005391
PDK3

pyruvate dehydrogenase kinase, isozyme 3

chr18_+_50646616 0.437 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr6_-_139654807 0.437 NM_153235
TXLNB
taxilin beta
chr7_-_22363036 0.434 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr15_-_24569201 0.434 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr11_+_8660913 0.433 RPL27A
ribosomal protein L27a
chrX_+_15428820 0.431 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr3_-_178396892 0.426 TBL1XR1
transducin (beta)-like 1 X-linked receptor 1
chr7_+_130445394 0.424 NM_001145354
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr11_-_8572277 0.424 STK33
serine/threonine kinase 33
chr6_+_54819527 0.422 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr1_-_159257595 0.421 NM_016946
F11R
F11 receptor
chr5_-_64100239 0.421 NM_173829
SREK1IP1
SREK1-interacting protein 1
chr8_-_97316933 0.415 NM_006294
UQCRB
ubiquinol-cytochrome c reductase binding protein
chr14_-_22610572 0.412 ACIN1
apoptotic chromatin condensation inducer 1
chr7_+_133982070 0.410 NM_001724
NM_199186
BPGM

2,3-bisphosphoglycerate mutase

chrX_+_84145487 0.408 NM_198450
APOOL
apolipoprotein O-like
chr12_-_69317441 0.408 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr17_-_46140015 0.406 NM_052855
ANKRD40
ankyrin repeat domain 40
chr7_-_11838260 0.406 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr2_+_32244406 0.406 NM_001193513
NM_001193514
NM_001193515
NM_017964
SLC30A6



solute carrier family 30 (zinc transporter), member 6



chr2_+_61098200 0.405 NM_002618
PEX13
peroxisomal biogenesis factor 13
chr19_+_49943773 0.405 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr3_-_12858006 0.401 NM_000994
NM_001007073
RPL32

ribosomal protein L32

chr15_+_42808611 0.399 TRIM69
tripartite motif containing 69
chr10_-_12124778 0.399 NM_015542
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr19_-_48771449 0.399 XRCC1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr10_-_96112609 0.397 NM_022451
NOC3L
nucleolar complex associated 3 homolog (S. cerevisiae)
chr9_+_102231616 0.397 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr15_+_42808510 0.396 TRIM69
tripartite motif containing 69
chr17_+_7532391 0.395 NM_001143992
NM_018081
WRAP53

WD repeat containing, antisense to TP53

chr22_-_44015248 0.390 NM_001009880
KIAA0930
KIAA0930
chr17_+_40494201 0.389 NM_021079
NMT1
N-myristoyltransferase 1
chr5_+_36642213 0.385 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr19_+_55614006 0.384 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr2_+_64534774 0.383 NM_014181
HSPC159
galectin-related protein
chr6_+_106653429 0.383 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr1_-_87152372 0.383 SEP15
15 kDa selenoprotein
chr3_-_168935287 0.383 NM_007217
NM_145860
NM_145859
PDCD10


programmed cell death 10


chr1_+_155052094 0.381 NM_001007792
NTRK1
neurotrophic tyrosine kinase, receptor, type 1
chr6_-_33028790 0.380 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr17_+_40494167 0.379 NMT1
N-myristoyltransferase 1
chr14_+_101346032 0.378 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr4_-_90977149 0.378 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr1_-_6368324 0.378 NM_181864
ACOT7
acyl-CoA thioesterase 7
chr7_-_112545847 0.377 LOC401397
hypothetical LOC401397
chr1_-_87152396 0.377 SEP15
15 kDa selenoprotein
chr15_-_24569253 0.377 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr20_-_1420004 0.374 SIRPB2
signal-regulatory protein beta 2
chr14_-_22610610 0.371 NM_001164816
NM_001164817
ACIN1

apoptotic chromatin condensation inducer 1

chr11_-_107234733 0.371 SLC35F2
solute carrier family 35, member F2
chr1_+_28705139 0.370 SNHG3
small nucleolar RNA host gene 3 (non-protein coding)
chr17_+_7180571 0.370 NM_014716
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr16_-_66827449 0.362 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr22_+_29808845 0.362 SMTN
smoothelin
chr8_-_99126927 0.358 RPL30
ribosomal protein L30
chr11_+_59979857 0.358 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr3_+_123279439 0.357 NM_006889
CD86
CD86 molecule
chr5_-_159778621 0.356 NM_006425
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chr1_+_205561632 0.356 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chrX_+_117364444 0.354 WDR44
WD repeat domain 44
chr19_+_48772791 0.352 NM_001193621
LOC390940
hypothetical protein LOC390940
chr7_-_112545840 0.352 LOC401397
hypothetical LOC401397
chr3_+_115258270 0.351 NM_024638
QTRTD1
queuine tRNA-ribosyltransferase domain containing 1
chr16_+_80036275 0.350 NM_198390
CMIP
c-Maf-inducing protein
chr1_+_205561709 0.348 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr6_-_112033752 0.348 TRAF3IP2
TRAF3 interacting protein 2
chr1_-_26197121 0.344 NM_000437
PAFAH2
platelet-activating factor acetylhydrolase 2, 40kDa
chr18_+_59405513 0.344 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr17_-_40493837 0.343 NM_024819
DCAKD
dephospho-CoA kinase domain containing
chr1_+_151147646 0.342 NM_005547
IVL
involucrin
chr1_-_36387653 0.341 NM_014408
TRAPPC3
trafficking protein particle complex 3
chr5_+_36642424 0.341 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr19_-_50601406 0.338 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr3_-_180805104 0.337 NM_020409
NM_177988
MRPL47

mitochondrial ribosomal protein L47

chr1_-_52642646 0.336 NM_001190818
NM_001190819
NM_004153
ORC1


origin recognition complex, subunit 1


chr8_-_10550026 0.334 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr6_+_133177399 0.333 NM_001016
SNORA33
RPS12
small nucleolar RNA, H/ACA box 33
ribosomal protein S12
chr17_+_16283025 0.333 NCRNA00188
non-protein coding RNA 188
chr1_+_205561693 0.331 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr19_+_51796330 0.330 NM_005184
CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr2_+_231968578 0.330 NM_145236
B3GNT7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr6_-_32665409 0.328 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chrX_+_108666725 0.328 NXT2
nuclear transport factor 2-like export factor 2
chr8_-_99126770 0.328 RPL30
ribosomal protein L30
chr7_-_107953795 0.327 PNPLA8
patatin-like phospholipase domain containing 8
chr15_-_24569309 0.326 NM_000814
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr9_-_19368815 0.324 RPS6
ribosomal protein S6
chr20_-_1420168 0.321 NM_001122962
NM_001134836
SIRPB2

signal-regulatory protein beta 2

chr11_-_26550243 0.321 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr1_+_101263989 0.320


chr9_+_132558972 0.318 NM_014285
EXOSC2
exosome component 2
chr9_+_74956614 0.315 ANXA1
annexin A1
chr15_-_46890475 0.315 NM_001194998
NM_014985
CEP152

centrosomal protein 152kDa

chr7_-_107953814 0.314 NM_015723
PNPLA8
patatin-like phospholipase domain containing 8
chr1_-_167603623 0.314 NM_013330
NM_197972
NME7

non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)

chr2_+_33554824 0.313 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr12_+_6472782 0.313 NCAPD2
non-SMC condensin I complex, subunit D2
chr17_+_69721095 0.311 NM_032646
TTYH2
tweety homolog 2 (Drosophila)
chr17_-_78391178 0.311 NM_024702
ZNF750
zinc finger protein 750
chr22_+_40559214 0.310 SREBF2
sterol regulatory element binding transcription factor 2
chr10_-_134940315 0.310 NM_001109
NM_001164489
NM_001164490
ADAM8


ADAM metallopeptidase domain 8


chr9_-_127043455 0.309 NM_005347
HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr12_-_55013713 0.309 NM_001127460
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr13_-_32757835 0.308 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr12_-_6472669 0.307 NM_016497
MRPL51
mitochondrial ribosomal protein L51
chr8_-_99126942 0.306 NM_000989
RPL30
ribosomal protein L30
chr12_+_97513644 0.305 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chrX_+_73080887 0.305 NCRNA00183
non-protein coding RNA 183
chr3_-_12856948 0.304 NM_001007074
RPL32
ribosomal protein L32
chr6_-_30693003 0.304 PPP1R10
protein phosphatase 1, regulatory (inhibitor) subunit 10

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.10 1.01e-03 GO:0009987 cellular process
2.98 2.13e-03 GO:0019080 viral genome expression
2.98 2.13e-03 GO:0019083 viral transcription
2.50 2.74e-03 GO:0019058 viral infectious cycle
1.36 3.72e-03 GO:0010467 gene expression
2.71 5.68e-03 GO:0006414 translational elongation
1.20 1.47e-02 GO:0044260 cellular macromolecule metabolic process
2.76 1.57e-02 GO:0006415 translational termination
2.61 2.87e-02 GO:0043241 protein complex disassembly
2.61 2.87e-02 GO:0043624 cellular protein complex disassembly
1.15 3.20e-02 GO:0044238 primary metabolic process
1.60 3.31e-02 GO:0071822 protein complex subunit organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 1.53e-08 GO:0005737 cytoplasm
1.21 1.89e-06 GO:0044446 intracellular organelle part
1.20 8.30e-06 GO:0044422 organelle part
1.37 1.93e-05 GO:0005829 cytosol
1.31 3.05e-05 GO:0043228 non-membrane-bounded organelle
1.31 3.05e-05 GO:0043232 intracellular non-membrane-bounded organelle
1.09 5.07e-05 GO:0005622 intracellular
1.10 6.58e-05 GO:0044424 intracellular part
1.11 8.19e-05 GO:0043226 organelle
1.11 9.31e-05 GO:0043229 intracellular organelle
1.17 3.67e-04 GO:0044444 cytoplasmic part
2.20 9.71e-04 GO:0005840 ribosome
3.21 1.37e-03 GO:0015934 large ribosomal subunit
3.90 2.12e-03 GO:0022625 cytosolic large ribosomal subunit
2.93 2.22e-03 GO:0022626 cytosolic ribosome
2.24 3.80e-03 GO:0044445 cytosolic part
5.89 6.38e-03 GO:0042613 MHC class II protein complex
1.27 9.05e-03 GO:0031974 membrane-enclosed lumen
1.27 1.13e-02 GO:0070013 intracellular organelle lumen
1.26 1.33e-02 GO:0043233 organelle lumen
1.10 1.66e-02 GO:0043231 intracellular membrane-bounded organelle
1.10 2.00e-02 GO:0043227 membrane-bounded organelle
1.20 2.33e-02 GO:0032991 macromolecular complex
1.56 4.19e-02 GO:0030529 ribonucleoprotein complex
2.24 4.43e-02 GO:0005765 lysosomal membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 8.93e-05 GO:0005515 protein binding
2.37 1.15e-03 GO:0003735 structural constituent of ribosome