Motif ID: HLF.p2

Z-value: 3.872


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
HLF 3131 hepatic leukemia factor



Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_113601608 7.838 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr2_-_113310796 5.271 NM_000576
IL1B
interleukin 1, beta
chr9_+_116131889 4.978 NM_000608
ORM2
orosomucoid 2
chr2_+_113601616 4.919 IL1RN
interleukin 1 receptor antagonist
chr12_-_28016182 4.749 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr9_+_116125123 4.635 NM_000607
ORM1
orosomucoid 1
chr16_+_70654625 4.472 NM_020995
HPR
haptoglobin-related protein
chr11_+_93394025 4.383 NM_001098672
HEPHL1
hephaestin-like 1
chr9_-_129752687 4.345 NM_203305
FAM102A
family with sequence similarity 102, member A
chr3_-_12561962 4.240 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr3_-_49701085 4.040 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr16_+_55963899 3.814 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr4_-_87989291 3.792 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr16_+_70646008 3.778 NM_001126102
NM_005143
HP

haptoglobin

chr2_+_65517316 3.673 FLJ16124
FLJ16124 protein
chr9_+_676640 3.405


chr1_+_149221122 3.403 NM_003568
ANXA9
annexin A9
chr17_-_38978772 3.380 NM_001986
ETV4
ets variant 4
chr12_-_51132129 3.174 NM_005555
KRT6B
keratin 6B
chr3_-_121883647 3.084 HGD
homogentisate 1,2-dioxygenase
chr10_-_95350949 3.009 NM_006744
RBP4
retinol binding protein 4, plasma
chr8_+_124264054 2.889 FAM83A
family with sequence similarity 83, member A
chr1_-_177106702 2.877 NM_004673
ANGPTL1
angiopoietin-like 1
chr10_-_52315436 2.847 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr8_+_124263932 2.819 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr3_-_58175437 2.814 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr1_-_228916486 2.764 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr17_-_31352643 2.737 CCL14-CCL15
CCL15
CCL14-CCL15 read-through transcript
chemokine (C-C motif) ligand 15
chr17_-_31352720 2.712 CCL14-CCL15
CCL14-CCL15 read-through transcript
chr1_+_205328834 2.703 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr6_-_2785682 2.628 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr9_-_98421894 2.606 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr19_-_6410735 2.574 NM_024103
SLC25A23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr19_+_50663089 2.523 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr17_-_38530935 2.482 NM_007297
NM_007299
NM_007294
NM_007300
BRCA1



breast cancer 1, early onset



chr5_+_150612805 2.479 NM_000405
NM_001167607
GM2A

GM2 ganglioside activator

chr1_+_239762179 2.365 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr5_+_73145098 2.296 RGNEF
190 kDa guanine nucleotide exchange factor
chr20_+_61842880 2.244 SLC2A4RG
SLC2A4 regulator
chr1_-_228916470 2.236 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr3_+_42107711 2.171 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr4_-_153493133 2.168 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr14_+_101345878 2.108 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr14_+_23633101 2.089 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr6_-_24491498 2.089 NM_001195610
DCDC2
doublecortin domain containing 2
chr1_-_228916559 2.079 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr3_+_187813538 2.060 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr8_-_145187553 2.047 NM_017570
OPLAH
5-oxoprolinase (ATP-hydrolysing)
chr11_-_66431910 2.047 NM_022172
PC
pyruvate carboxylase
chr19_-_52308848 2.043 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr10_-_82039158 2.030 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr17_-_75427644 2.025 NM_003655
CBX4
chromobox homolog 4
chr2_-_213723298 2.019 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr13_-_45577144 1.995 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr9_-_68552337 1.991 NM_001085457
CBWD5
CBWD3
CBWD1
CBWD6
COBW domain containing 5
COBW domain containing 3
COBW domain containing 1
COBW domain containing 6
chr6_-_30151526 1.987 NM_170769
NM_025236
RNF39

ring finger protein 39

chr17_-_36346240 1.986 KRT23
keratin 23 (histone deacetylase inducible)
chr11_-_76862197 1.908 NM_001128620
NM_002576
PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr17_-_17426416 1.874 PEMT
phosphatidylethanolamine N-methyltransferase
chr1_-_21373816 1.874 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr19_+_40465249 1.852 NM_021175
HAMP
hepcidin antimicrobial peptide
chr6_+_32003180 1.832 NM_000063
NM_001145903
C2

complement component 2

chr11_+_65023038 1.810 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr7_+_45899621 1.798


chr13_+_96726415 1.791 MBNL2
muscleblind-like 2 (Drosophila)
chr17_-_31353196 1.788 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr14_-_19871267 1.760 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr9_-_94095787 1.745 NM_013417
IARS
isoleucyl-tRNA synthetase
chr1_-_62557655 1.702 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr11_-_116168316 1.702 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr1_-_114925734 1.689 NM_005872
BCAS2
breast carcinoma amplified sequence 2
chr6_+_32003380 1.675 C2
complement component 2
chr9_+_674193 1.641


chr18_+_59405513 1.611 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr20_+_41621079 1.581 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr18_+_59705918 1.559 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr9_+_110664366 1.558 NM_006687
ACTL7A
actin-like 7A
chr14_-_49399317 1.548 RN7SL2
RNA, 7SL, cytoplasmic 2
chr3_+_187813553 1.527 AHSG
alpha-2-HS-glycoprotein
chr9_+_70046658 1.525 NM_201453
CBWD5
CBWD3
CBWD1
CBWD6
COBW domain containing 5
COBW domain containing 3
COBW domain containing 1
COBW domain containing 6
chr2_-_31491102 1.492 NM_000379
XDH
xanthine dehydrogenase
chr17_-_17426469 1.472 NM_007169
PEMT
phosphatidylethanolamine N-methyltransferase
chr14_+_59785723 1.470 PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr6_+_131936057 1.465 NM_000045
ARG1
arginase, liver
chr5_-_147266257 1.456 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr20_+_31613800 1.454 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr2_-_98646367 1.452 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr17_+_38575939 1.441 NM_031862
NM_031858
NBR1

neighbor of BRCA1 gene 1

chr14_+_59785703 1.437 NM_021003
NM_177951
PPM1A

protein phosphatase, Mg2+/Mn2+ dependent, 1A

chr2_-_31491057 1.435 XDH
xanthine dehydrogenase
chr19_-_50779924 1.408 NM_001017989
NM_025136
OPA3

optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)

chr12_-_121946635 1.384 NM_024667
VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr3_+_138132006 1.381 NM_001190796
NCK1
NCK adaptor protein 1
chr9_-_69729965 1.378 CBWD5
COBW domain containing 5
chr12_-_119451303 1.378 NM_032314
COQ5
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
chr7_+_89870707 1.362 CLDN12
claudin 12
chr4_+_75449720 1.361 NM_001432
EREG
epiregulin
chr9_+_102987137 1.360 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr18_+_54039779 1.355 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chrX_-_15530112 1.354 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr14_+_95740916 1.349 BDKRB2
bradykinin receptor B2
chr22_+_23309717 1.335 NM_013430
GGT1
gamma-glutamyltransferase 1
chr9_-_69729958 1.293 CBWD6
COBW domain containing 6
chr20_+_4614796 1.292 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr18_-_41932255 1.274 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr19_-_50779914 1.271 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr17_+_38531134 1.261 NBR2
neighbor of BRCA1 gene 2 (non-protein coding)
chr18_-_41932249 1.259 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr19_-_50779861 1.255 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr20_+_41621119 1.255 SGK2
serum/glucocorticoid regulated kinase 2
chr17_-_38530830 1.252 BRCA1
breast cancer 1, early onset
chr11_+_9552809 1.250 NM_001143976
WEE1
WEE1 homolog (S. pombe)
chr17_-_53849888 1.239 RNF43
ring finger protein 43
chr18_-_41932185 1.236 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr18_-_41932228 1.234 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr3_+_123526700 1.233 NM_005213
CSTA
cystatin A (stefin A)
chr18_-_41932231 1.227 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr6_-_32206029 1.225 NM_022110
FKBPL
FK506 binding protein like
chr17_-_53849929 1.198 NM_017763
RNF43
ring finger protein 43
chr2_+_113119985 1.189 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr2_-_73723001 1.185 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr9_-_94095807 1.182 IARS
isoleucyl-tRNA synthetase
chr2_+_113542017 1.168 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr4_+_187424336 1.151 F11
coagulation factor XI
chr12_-_121767272 1.151 NM_006018
GPR109B
G protein-coupled receptor 109B
chr16_-_4528739 1.150 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr3_+_63928459 1.132 NM_001128149
ATXN7
ataxin 7
chr2_-_43676603 1.128 NM_001083953
NM_022065
THADA

thyroid adenoma associated

chr20_+_47328575 1.121 NCRNA00275
non-protein coding RNA 275
chr7_+_89870647 1.121 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr12_-_121946581 1.105 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr9_-_69729926 1.104 CBWD5
CBWD3
CBWD6
COBW domain containing 5
COBW domain containing 3
COBW domain containing 6
chrX_-_77037563 1.089 NM_032121
MAGT1
magnesium transporter 1
chr10_+_5228756 1.072 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr1_-_62557559 1.067 KANK4
KN motif and ankyrin repeat domains 4
chr2_-_27566024 1.064 NM_015662
IFT172
intraflagellar transport 172 homolog (Chlamydomonas)
chr6_+_20642665 1.059 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr18_+_54039730 1.053 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_+_149165438 1.049 NM_001145415
NM_012432
SETDB1

SET domain, bifurcated 1

chr3_+_120984246 1.046 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr19_-_56147971 1.042 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr14_+_59785739 1.040 PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr12_+_56424930 1.036 NM_005981
TSPAN31
tetraspanin 31
chr7_+_55987046 1.033 NM_015969
MRPS17
mitochondrial ribosomal protein S17
chr16_-_66614599 1.017 DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr17_-_36792161 1.011 NM_021013
KRT34
keratin 34
chr8_+_40130143 1.005 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr9_-_6005602 1.005 NM_012416
RANBP6
RAN binding protein 6
chr21_-_29286982 0.987 NM_015565
LTN1
listerin E3 ubiquitin protein ligase 1
chr3_-_150422474 0.981 NM_000096
CP
ceruloplasmin (ferroxidase)
chr5_+_56507029 0.981 NM_001127235
GPBP1
GC-rich promoter binding protein 1
chr17_+_632262 0.978 NM_018146
RNMTL1
RNA methyltransferase like 1
chr20_+_47328585 0.978 NCRNA00275
non-protein coding RNA 275
chr2_+_160180049 0.977 LOC643072
hypothetical LOC643072
chr2_+_201464884 0.971 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. pombe)
chr8_-_101384633 0.966 NM_015435
RNF19A
ring finger protein 19A
chr9_-_94095810 0.965 NM_002161
IARS
isoleucyl-tRNA synthetase
chr18_-_41932271 0.964 NM_004046
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr2_-_32344192 0.958 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr17_-_61655915 0.945 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr19_-_411995 0.942 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr8_-_10550026 0.939 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr8_-_6722848 0.935 NM_005218
DEFB1
defensin, beta 1
chr2_-_190336168 0.932 NM_022353
OSGEPL1
O-sialoglycoprotein endopeptidase-like 1
chr15_-_61461127 0.924 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr22_-_29197944 0.919 NM_174975
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr15_+_91244563 0.918 CHD2
chromodomain helicase DNA binding protein 2
chr11_+_62893836 0.915 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr19_-_4491078 0.911 LRG1
leucine-rich alpha-2-glycoprotein 1
chr9_-_106705867 0.910 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr22_+_33792125 0.899 NM_001008494
ISX
intestine-specific homeobox
chr3_+_187813405 0.887 AHSG
alpha-2-HS-glycoprotein
chr19_-_45611110 0.883 NM_020956
NM_181882
PRX

periaxin

chr17_-_38575737 0.882 BRCA1
breast cancer 1, early onset
chr5_-_42847716 0.870 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr1_-_228916958 0.868 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr15_-_64577122 0.865 NM_006049
SNAPC5
small nuclear RNA activating complex, polypeptide 5, 19kDa
chr3_-_40469668 0.863 FLJ36665
hypothetical protein FLJ36665
chr20_-_43177137 0.858 NM_145652
WFDC5
WAP four-disulfide core domain 5
chr16_+_66614645 0.856 NM_017803
DUS2L
dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)
chr2_+_68548173 0.850 NM_173545
APLF
aprataxin and PNKP like factor
chr12_+_16391342 0.850 NM_145792
MGST1
microsomal glutathione S-transferase 1
chr12_+_54838408 0.833 MYL6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr9_-_69729887 0.831


chr3_+_46591048 0.830 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr16_-_66614621 0.826 DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr19_-_47638890 0.824 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr2_-_110319828 0.821 NPHP1
nephronophthisis 1 (juvenile)
chr3_-_16281287 0.819 NM_001047434
NM_206831
DPH3

DPH3, KTI11 homolog (S. cerevisiae)

chr9_+_96528814 0.812 C9orf3
chromosome 9 open reading frame 3
chr10_-_46593923 0.803 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr2_-_20115269 0.797 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chrX_+_9391314 0.793 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr17_+_59205289 0.791 NM_007372
NM_203499
DDX42

DEAD (Asp-Glu-Ala-Asp) box polypeptide 42

chr2_+_3683660 0.790 NM_018436
ALLC
allantoicase
chr13_-_24643778 0.789 NM_152704
NM_199138
FAM123A

family with sequence similarity 123A

chr11_-_102219450 0.787 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr11_-_67795903 0.786 C11orf24
chromosome 11 open reading frame 24
chr11_-_67796022 0.781 NM_022338
C11orf24
chromosome 11 open reading frame 24
chr10_-_101180191 0.780 NM_002079
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.91 2.03e-03 GO:0005615 extracellular space
1.65 3.99e-02 GO:0044421 extracellular region part
7.04 4.16e-02 GO:0034364 high-density lipoprotein particle

Nothing significant found in function category.