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• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: HIC1.p2

Z-value: 1.768

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr11_+_101485946	8.940	NM_001130145 NM_001195044 NM_006106	YAP1	Yes-associated protein 1
chr14_+_105012106	8.757	NM_001312	CRIP2	cysteine-rich protein 2
chr21_-_43671355	7.680	NM_173354	SIK1	salt-inducible kinase 1
chr6_+_147871477	6.955	NM_001030060	SAMD5	sterile alpha motif domain containing 5
chr6_-_112301123	6.725	NM_002037	FYN	FYN oncogene related to SRC, FGR, YES
chr5_+_14196287	6.700	NM_007118	TRIO	triple functional domain (PTPRF interacting)
chr13_-_109757442	6.519	NM_001845	COL4A1	collagen, type IV, alpha 1
chr13_+_109757593	6.451	NM_001846	COL4A2	collagen, type IV, alpha 2
chr2_-_112907577	6.385	NM_001164463	RGPD8 RGPD5	RANBP2-like and GRIP domain containing 8 RANBP2-like and GRIP domain containing 5
chr17_+_52026058	6.244	NM_005450	NOG	noggin
chr20_+_8997660	6.208	NM_001172646	PLCB4	phospholipase C, beta 4
chr2_-_160972606	6.018		RBMS1	RNA binding motif, single stranded interacting protein 1
chr18_+_7557313	5.760	NM_001105244 NM_002845	PTPRM	protein tyrosine phosphatase, receptor type, M
chr2_+_9532087	5.713	NM_001039613	IAH1	isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)
chr2_+_241586927	5.471	NM_001080437	SNED1	sushi, nidogen and EGF-like domains 1
chr2_+_238200922	5.434	NM_001137550	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1
chr12_+_26003218	5.399	NM_001164748 NM_007211	RASSF8	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr9_-_135847106	5.386	NM_001134398 NM_003371	VAV2	vav 2 guanine nucleotide exchange factor
chr1_-_8008934	5.309		ERRFI1	ERBB receptor feedback inhibitor 1
chrX_+_9943793	5.290	NM_015691	WWC3	WWC family member 3
chr12_-_41269679	5.215	NM_153026	PRICKLE1	prickle homolog 1 (Drosophila)
chr4_+_184257337	5.196	NM_024949	WWC2	WW and C2 domain containing 2
chr14_+_54104099	5.081		SAMD4A	sterile alpha motif domain containing 4A
chr20_+_8997791	4.908		PLCB4	phospholipase C, beta 4
chr21_+_45318861	4.849	NM_001112 NM_001160230 NM_015833 NM_015834	ADARB1	adenosine deaminase, RNA-specific, B1
chr1_-_85703198	4.691		DDAH1	dimethylarginine dimethylaminohydrolase 1
chr20_+_39199542	4.649	NM_002660 NM_182811	PLCG1	phospholipase C, gamma 1
chr6_-_105691235	4.619	NM_007073	BVES	blood vessel epicardial substance
chr6_+_3696224	4.573
chr16_-_71639670	4.348	NM_006885	ZFHX3	zinc finger homeobox 3
chr4_-_141896920	4.303	NM_015130	TBC1D9	TBC1 domain family, member 9 (with GRAM domain)
chr9_-_13269562	4.280		MPDZ	multiple PDZ domain protein
chr1_-_95165089	4.139	NM_001839	CNN3	calponin 3, acidic
chr15_-_49174107	4.137		TNFAIP8L3	tumor necrosis factor, alpha-induced protein 8-like 3
chr14_+_63389360	4.029	NM_015180 NM_182914	SYNE2	spectrin repeat containing, nuclear envelope 2
chr12_-_26166485	4.024		BHLHE41	basic helix-loop-helix family, member e41
chr21_+_45649719	4.023
chr9_-_88751923	3.999	NM_002048	GAS1	growth arrest-specific 1
chr14_+_58174489	3.995	NM_001079520 NM_016651	DACT1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
chr8_+_144420939	3.982	NM_138465	GLI4	GLI family zinc finger 4
chr18_+_75540786	3.940	NM_004715 NM_048368	CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr8_+_17398940	3.876	NM_001008539	SLC7A2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr1_+_10193267	3.847	NM_015074 NM_183416	KIF1B	kinesin family member 1B
chr1_-_8008979	3.760	NM_018948	ERRFI1	ERBB receptor feedback inhibitor 1
chr10_+_11100075	3.759		CELF2	CUGBP, Elav-like family member 2
chr14_+_92049396	3.752	NM_024832	RIN3	Ras and Rab interactor 3
chr2_-_175578156	3.729	NM_001025201 NM_001822	CHN1	chimerin (chimaerin) 1
chr6_-_105691675	3.720		BVES	blood vessel epicardial substance
chr8_-_145090892	3.661	NM_201381	PLEC	plectin
chr20_+_56701224	3.660	NM_024663	NPEPL1	aminopeptidase-like 1
chr16_+_85158357	3.625	NM_005251	FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr1_-_223907283	3.613	NM_001008493 NM_018212	ENAH	enabled homolog (Drosophila)
chr12_+_3056781	3.610	NM_001168320 NM_006675	TSPAN9	tetraspanin 9
chr19_-_61324456	3.609	NM_001002836	ZNF787	zinc finger protein 787
chr8_-_48813236	3.583		CEBPD	CCAAT/enhancer binding protein (C/EBP), delta
chr4_-_174327377	3.577
chr10_-_13381751	3.576	NM_001037537	PHYH	phytanoyl-CoA 2-hydroxylase
chr19_+_748444	3.552		PTBP1	polypyrimidine tract binding protein 1
chr19_+_748390	3.546	NM_002819 NM_031990 NM_031991 NM_175847	PTBP1	polypyrimidine tract binding protein 1
chr7_-_81910956	3.543	NM_000722	CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr8_+_32525269	3.482	NM_001160002 NM_001160004 NM_001160005 NM_001160007 NM_001160008 NM_004495 NM_013956 NM_013957 NM_013958 NM_013960 NM_013964	NRG1	neuregulin 1
chr18_-_75540727	3.432		FLJ25715	hypothetical protein FLJ25715
chr8_+_90983934	3.427	NM_001126111	OSGIN2	oxidative stress induced growth inhibitor family member 2
chr13_-_109236897	3.427	NM_003749	IRS2	insulin receptor substrate 2
chr11_+_109469296	3.419	NM_033390	ZC3H12C	zinc finger CCCH-type containing 12C
chr19_-_61324412	3.405		ZNF787	zinc finger protein 787
chr4_+_151218862	3.373	NM_001040260 NM_001040261	DCLK2	doublecortin-like kinase 2
chr19_+_748448	3.356		PTBP1	polypyrimidine tract binding protein 1
chr2_+_9264360	3.356		ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr12_+_66328760	3.337	NM_003583 NM_006482	DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr1_-_95165037	3.329		CNN3	calponin 3, acidic
chr7_-_29995809	3.305	NM_001145515 NM_014766 NM_001145513	SCRN1	secernin 1
chr17_+_58058774	3.301		MRC2	mannose receptor, C type 2
chr15_+_29406335	3.300	NM_015995	KLF13	Kruppel-like factor 13
chr5_+_10617431	3.293	NM_001164440	ANKRD33B	ankyrin repeat domain 33B
chr14_-_29466562	3.276	NM_002742	PRKD1	protein kinase D1
chr2_+_9264327	3.275	NM_001135191 NM_003887	ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr5_-_58370693	3.241	NM_001197221 NM_001197222	PDE4D	phosphodiesterase 4D, cAMP-specific
chr13_-_100866706	3.234	NM_052867	NALCN	sodium leak channel, non-selective
chr8_+_26491317	3.228	NM_001386	DPYSL2	dihydropyrimidinase-like 2
chr11_+_19691397	3.212	NM_145117 NM_182964	NAV2	neuron navigator 2
chr8_-_7200278	3.191		FAM66B	family with sequence similarity 66, member B
chr14_+_54104383	3.159	NM_001161576 NM_015589	SAMD4A	sterile alpha motif domain containing 4A
chr4_-_177950658	3.151	NM_005429	VEGFC	vascular endothelial growth factor C
chr9_-_21549696	3.134		LOC554202	hypothetical LOC554202
chr10_-_42953787	3.130
chr3_+_61522310	3.129		PTPRG	protein tyrosine phosphatase, receptor type, G
chr16_+_415630	3.125	NM_014700	RAB11FIP3	RAB11 family interacting protein 3 (class II)
chr2_+_235525355	3.108	NM_014521	SH3BP4	SH3-domain binding protein 4
chr14_+_51188289	3.091	NM_152330	FRMD6	FERM domain containing 6
chr18_+_75540831	3.088		CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr9_-_110815542	3.064	NM_003798	CTNNAL1	catenin (cadherin-associated protein), alpha-like 1
chr10_-_35143900	3.063	NM_001184785 NM_001184786 NM_001184787 NM_001184788 NM_001184789 NM_001184790 NM_001184791 NM_001184792 NM_001184793 NM_001184794 NM_019619	PARD3	par-3 partitioning defective 3 homolog (C. elegans)
chr10_+_49184658	3.046		MAPK8	mitogen-activated protein kinase 8
chr18_-_24011349	3.006	NM_001792	CDH2	cadherin 2, type 1, N-cadherin (neuronal)
chr2_-_127580975	2.991	NM_004305 NM_139343 NM_139344 NM_139345 NM_139346 NM_139347 NM_139348 NM_139349 NM_139350 NM_139351	BIN1	bridging integrator 1
chr12_+_95112131	2.976	NM_005230	ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)
chr1_+_6767968	2.964	NM_001195563 NM_015215	CAMTA1	calmodulin binding transcription activator 1
chr1_+_181258952	2.955	NM_002293	LAMC1	laminin, gamma 1 (formerly LAMB2)
chr12_-_94708477	2.951		NTN4	netrin 4
chr10_+_128583984	2.933	NM_001380	DOCK1	dedicator of cytokinesis 1
chr2_+_54537842	2.929		SPTBN1	spectrin, beta, non-erythrocytic 1
chr10_+_42953886	2.926	NM_018590	CSGALNACT2	chondroitin sulfate N-acetylgalactosaminyltransferase 2
chr4_+_86615275	2.924	NM_001025616	ARHGAP24	Rho GTPase activating protein 24
chr11_+_72765044	2.921	NM_152222	RELT	RELT tumor necrosis factor receptor
chr15_-_88446543	2.919		IDH2	isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr17_+_58058783	2.888		MRC2	mannose receptor, C type 2
chr8_+_94781910	2.866	NM_145269	FAM92A1	family with sequence similarity 92, member A1
chr11_+_86189138	2.864	NM_007173	PRSS23	protease, serine, 23
chr19_-_11234117	2.859	NM_020812	DOCK6	dedicator of cytokinesis 6
chr1_-_56817823	2.854	NM_003713	PPAP2B	phosphatidic acid phosphatase type 2B
chr5_-_171643399	2.844	NM_152277	UBTD2	ubiquitin domain containing 2
chr16_+_87765661	2.837	NM_004933	CDH15	cadherin 15, type 1, M-cadherin (myotubule)
chr2_+_109112428	2.813	NM_001099289	SH3RF3	SH3 domain containing ring finger 3
chr16_+_415606	2.801		RAB11FIP3	RAB11 family interacting protein 3 (class II)
chr6_-_56816403	2.788		DST	dystonin
chr20_+_60151868	2.787	NM_198935	SS18L1	synovial sarcoma translocation gene on chromosome 18-like 1
chr2_+_241023908	2.764		GPC1	glypican 1
chr14_+_85069217	2.760
chr10_+_112247614	2.709	NM_004419	DUSP5	dual specificity phosphatase 5
chr12_+_63958949	2.707	NM_001193461	MSRB3	methionine sulfoxide reductase B3
chr17_+_11864841	2.702	NM_003010	MAP2K4	mitogen-activated protein kinase kinase 4
chr22_+_36286350	2.679	NM_152243	CDC42EP1	CDC42 effector protein (Rho GTPase binding) 1
chr11_-_67737275	2.678	NM_016028 NM_017635	SUV420H1	suppressor of variegation 4-20 homolog 1 (Drosophila)
chr10_+_124124196	2.677		PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr18_+_12397894	2.647	NM_001142405 NM_006553	SLMO1	slowmo homolog 1 (Drosophila)
chr13_+_30672122	2.632		B3GALTL	beta 1,3-galactosyltransferase-like
chr20_-_60151835	2.625	NM_002792	PSMA7	proteasome (prosome, macropain) subunit, alpha type, 7
chr19_+_748452	2.622		PTBP1	polypyrimidine tract binding protein 1
chr12_-_10766965	2.615		CSDA	cold shock domain protein A
chr7_-_81910740	2.613		CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr17_+_78303317	2.608		TBCD	tubulin folding cofactor D
chr1_-_1540904	2.602		MIB2	mindbomb homolog 2 (Drosophila)
chr8_-_48813256	2.597	NM_005195	CEBPD	CCAAT/enhancer binding protein (C/EBP), delta
chr11_+_109468734	2.594		ZC3H12C	zinc finger CCCH-type containing 12C
chr7_-_107883929	2.590	NM_001193582 NM_001193583 NM_001193584 NM_005010	NRCAM	neuronal cell adhesion molecule
chr3_+_41215999	2.584		CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa
chr17_+_43127628	2.569	NM_014726	TBKBP1	TBK1 binding protein 1
chr2_-_175255717	2.555	NM_001077269	WIPF1	WAS/WASL interacting protein family, member 1
chr14_+_104226769	2.549	NM_001031714 NM_022489 NM_032714	INF2	inverted formin, FH2 and WH2 domain containing
chr5_-_57791544	2.548	NM_006622	PLK2	polo-like kinase 2
chr6_+_72055197	2.542	NM_024576	OGFRL1	opioid growth factor receptor-like 1
chr6_-_119079712	2.538	NM_001042475 NM_206921	C6orf204	chromosome 6 open reading frame 204
chr16_-_62573	2.531	NM_022450	RHBDF1	rhomboid 5 homolog 1 (Drosophila)
chr1_+_1541067	2.529	NM_001170689	MIB2	mindbomb homolog 2 (Drosophila)
chr5_+_149845503	2.523		NDST1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr16_+_19032744	2.521	NM_001034841	ITPRIPL2	inositol 1,4,5-triphosphate receptor interacting protein-like 2
chr3_-_126088819	2.513	NM_002213	ITGB5	integrin, beta 5
chr2_+_232281491	2.505		PTMA	prothymosin, alpha
chr15_-_81744469	2.500	NM_001717	BNC1	basonuclin 1
chr13_-_100866839	2.487		NALCN	sodium leak channel, non-selective
chr2_-_238813284	2.481		HES6	hairy and enhancer of split 6 (Drosophila)
chr2_-_238813365	2.471	NM_001142853 NM_018645	HES6	hairy and enhancer of split 6 (Drosophila)
chr6_+_72055235	2.464		OGFRL1	opioid growth factor receptor-like 1
chr8_-_144770838	2.455		TSTA3	tissue specific transplantation antigen P35B
chr17_+_26322081	2.444	NM_001184992 NM_032322 NM_197939	RNF135	ring finger protein 135
chr16_-_79395379	2.444	NM_152342	CDYL2	chromodomain protein, Y-like 2
chr8_-_94781836	2.441		LOC642924	hypothetical LOC642924
chr6_+_3697328	2.436
chr13_-_39075304	2.428		LHFP	lipoma HMGIC fusion partner
chr14_+_95575319	2.412		C14orf132	chromosome 14 open reading frame 132
chr20_-_34925483	2.405	NM_080627	KIAA0889	KIAA0889
chr17_+_26322168	2.393		RNF135	ring finger protein 135
chr3_-_130807865	2.389	NM_015103	PLXND1	plexin D1
chr3_+_44878380	2.379	NM_144638	TMEM42	transmembrane protein 42
chr15_-_90999606	2.374	NM_207446	FAM174B	family with sequence similarity 174, member B
chr18_-_24010944	2.373		CDH2	cadherin 2, type 1, N-cadherin (neuronal)
chr8_-_96030719	2.362	NM_001135733 NM_033285	TP53INP1	tumor protein p53 inducible nuclear protein 1
chr13_-_39075355	2.354	NM_005780	LHFP	lipoma HMGIC fusion partner
chrX_+_1670485	2.345	NM_005088	AKAP17A	A kinase (PRKA) anchor protein 17A
chr12_+_95112385	2.339		ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)
chr3_+_61522219	2.338	NM_002841	PTPRG	protein tyrosine phosphatase, receptor type, G
chr10_-_118022707	2.338	NM_001145453	GFRA1	GDNF family receptor alpha 1
chr8_-_33544184	2.335	NM_024787	RNF122	ring finger protein 122
chr9_+_127549437	2.333	NM_006195	PBX3	pre-B-cell leukemia homeobox 3
chr1_-_158091760	2.324	NM_001134233	C1orf204	chromosome 1 open reading frame 204
chr1_-_56817568	2.322		PPAP2B	phosphatidic acid phosphatase type 2B
chr20_+_11819364	2.316	NM_181443	BTBD3	BTB (POZ) domain containing 3
chr5_+_53849518	2.310		SNX18	sorting nexin 18
chr2_+_54536780	2.305	NM_003128	SPTBN1	spectrin, beta, non-erythrocytic 1
chr17_-_20886680	2.287	NM_015276	USP22	ubiquitin specific peptidase 22
chr7_+_98084531	2.284	NM_002523	NPTX2	neuronal pentraxin II
chr5_+_67547357	2.280		PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr12_+_112107747	2.279	NM_032848	C12orf52	chromosome 12 open reading frame 52
chr10_+_124210980	2.271	NM_002775	HTRA1	HtrA serine peptidase 1
chr6_+_72055229	2.252		OGFRL1	opioid growth factor receptor-like 1
chrX_+_149282097	2.250	NM_001177465	MAMLD1	mastermind-like domain containing 1
chr5_-_107744971	2.241		FBXL17	F-box and leucine-rich repeat protein 17
chr10_+_171410	2.240		ZMYND11	zinc finger, MYND-type containing 11
chr10_+_11099860	2.216	NM_006561	CELF2	CUGBP, Elav-like family member 2
chr11_+_64838882	2.214	NM_006779	CDC42EP2	CDC42 effector protein (Rho GTPase binding) 2
chr2_-_239987557	2.213	NM_006037	HDAC4	histone deacetylase 4
chr1_-_85703321	2.209	NM_012137	DDAH1	dimethylarginine dimethylaminohydrolase 1
chr17_-_8006979	2.208	NM_014232	VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)
chr20_+_23290844	2.208		GZF1	GDNF-inducible zinc finger protein 1
chr2_+_241023880	2.200
chr20_-_7948370	2.194	NM_021156	TMX4	thioredoxin-related transmembrane protein 4
chr8_+_1936549	2.191		KBTBD11	kelch repeat and BTB (POZ) domain containing 11
chr4_-_1692574	2.186		TMEM129	transmembrane protein 129
chr11_+_35596310	2.184	NM_014344	FJX1	four jointed box 1 (Drosophila)

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.10	3.88e-17	GO:0009987	cellular process
1.22	6.36e-14	GO:0032502	developmental process
1.24	1.08e-13	GO:0007275	multicellular organismal development
1.14	8.43e-13	GO:0050794	regulation of cellular process
1.48	3.01e-12	GO:0022008	neurogenesis
1.30	9.34e-12	GO:0030154	cell differentiation
1.36	2.48e-11	GO:0007399	nervous system development
1.29	2.75e-11	GO:0048869	cellular developmental process
1.36	2.96e-11	GO:0009966	regulation of signal transduction
1.13	3.23e-11	GO:0050789	regulation of biological process
1.35	3.32e-11	GO:0009653	anatomical structure morphogenesis
1.33	8.34e-11	GO:0023051	regulation of signaling
1.47	1.02e-10	GO:0048699	generation of neurons
1.25	1.12e-10	GO:0071842	cellular component organization at cellular level
1.12	1.62e-10	GO:0065007	biological regulation
1.21	5.78e-10	GO:0016043	cellular component organization
1.26	7.44e-10	GO:0048519	negative regulation of biological process
1.43	9.83e-10	GO:0048468	cell development
1.27	1.94e-09	GO:0048523	negative regulation of cellular process
1.63	2.99e-09	GO:0007409	axonogenesis
1.58	3.40e-09	GO:0000904	cell morphogenesis involved in differentiation
1.61	3.49e-09	GO:0048812	neuron projection morphogenesis
1.23	4.53e-09	GO:0071841	cellular component organization or biogenesis at cellular level
1.21	5.63e-09	GO:0048856	anatomical structure development
1.53	7.09e-09	GO:0048666	neuron development
1.57	8.68e-09	GO:0031175	neuron projection development
1.61	1.17e-08	GO:0048667	cell morphogenesis involved in neuron differentiation
1.28	1.63e-08	GO:0006464	protein modification process
1.13	1.71e-08	GO:0044237	cellular metabolic process
1.22	1.98e-08	GO:0048731	system development
1.19	3.04e-08	GO:0071840	cellular component organization or biogenesis
1.49	3.24e-08	GO:0030030	cell projection organization
1.55	3.54e-08	GO:0048858	cell projection morphogenesis
1.23	3.84e-08	GO:0048522	positive regulation of cellular process
1.54	4.44e-08	GO:0032990	cell part morphogenesis
1.50	4.69e-08	GO:0000902	cell morphogenesis
1.18	6.07e-08	GO:0031323	regulation of cellular metabolic process
1.26	8.81e-08	GO:0043412	macromolecule modification
1.47	1.04e-07	GO:0007167	enzyme linked receptor protein signaling pathway
1.19	1.23e-07	GO:0060255	regulation of macromolecule metabolic process
1.45	2.10e-07	GO:0030182	neuron differentiation
1.18	3.00e-07	GO:0080090	regulation of primary metabolic process
1.21	6.28e-07	GO:0048518	positive regulation of biological process
1.63	7.42e-07	GO:0007411	axon guidance
1.45	8.22e-07	GO:0032989	cellular component morphogenesis
1.15	1.65e-06	GO:0044260	cellular macromolecule metabolic process
1.25	2.10e-06	GO:0048583	regulation of response to stimulus
1.51	2.43e-06	GO:0072358	cardiovascular system development
1.51	2.43e-06	GO:0072359	circulatory system development
1.37	3.27e-06	GO:0008219	cell death
1.20	3.94e-06	GO:0010468	regulation of gene expression
1.16	4.04e-06	GO:0019222	regulation of metabolic process
1.40	4.33e-06	GO:0012501	programmed cell death
1.36	5.96e-06	GO:0016265	death
1.34	8.21e-06	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.43	1.16e-05	GO:0010629	negative regulation of gene expression
1.71	1.25e-05	GO:0048011	nerve growth factor receptor signaling pathway
1.39	1.88e-05	GO:0006915	apoptosis
1.40	3.34e-05	GO:0010558	negative regulation of macromolecule biosynthetic process
1.34	3.57e-05	GO:0010605	negative regulation of macromolecule metabolic process
1.33	7.29e-05	GO:0050793	regulation of developmental process
1.40	8.50e-05	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
1.59	1.09e-04	GO:0001944	vasculature development
1.09	1.23e-04	GO:0008152	metabolic process
1.10	1.31e-04	GO:0044238	primary metabolic process
1.36	1.56e-04	GO:2000026	regulation of multicellular organismal development
1.49	1.57e-04	GO:0009968	negative regulation of signal transduction
1.60	1.61e-04	GO:0001568	blood vessel development
1.19	2.20e-04	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.43	2.31e-04	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
1.37	2.35e-04	GO:0009890	negative regulation of biosynthetic process
1.46	2.44e-04	GO:0010648	negative regulation of cell communication
1.37	2.67e-04	GO:0045595	regulation of cell differentiation
1.12	3.10e-04	GO:0043170	macromolecule metabolic process
1.45	3.62e-04	GO:0023057	negative regulation of signaling
1.23	3.63e-04	GO:0006996	organelle organization
1.29	3.72e-04	GO:0010646	regulation of cell communication
1.17	4.41e-04	GO:0051171	regulation of nitrogen compound metabolic process
1.30	5.32e-04	GO:0009892	negative regulation of metabolic process
1.19	5.70e-04	GO:0051252	regulation of RNA metabolic process
1.32	5.92e-04	GO:0040011	locomotion
1.36	5.96e-04	GO:0031327	negative regulation of cellular biosynthetic process
1.17	6.09e-04	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.58	6.73e-04	GO:0016567	protein ubiquitination
1.40	7.00e-04	GO:0045892	negative regulation of transcription, DNA-dependent
1.18	7.63e-04	GO:0010556	regulation of macromolecule biosynthetic process
1.43	9.81e-04	GO:0048646	anatomical structure formation involved in morphogenesis
1.41	1.05e-03	GO:0048585	negative regulation of response to stimulus
1.31	1.23e-03	GO:0051128	regulation of cellular component organization
1.39	1.27e-03	GO:0051253	negative regulation of RNA metabolic process
1.90	1.28e-03	GO:0010720	positive regulation of cell development
1.54	1.40e-03	GO:0032446	protein modification by small protein conjugation
1.14	1.54e-03	GO:0007165	signal transduction
1.30	1.59e-03	GO:0031324	negative regulation of cellular metabolic process
1.12	2.13e-03	GO:0051716	cellular response to stimulus
1.45	2.17e-03	GO:0000122	negative regulation of transcription from RNA polymerase II promoter
1.36	2.19e-03	GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.18	3.09e-03	GO:0006355	regulation of transcription, DNA-dependent
1.35	3.77e-03	GO:0051172	negative regulation of nitrogen compound metabolic process
1.33	4.09e-03	GO:0051254	positive regulation of RNA metabolic process
1.16	4.50e-03	GO:0031326	regulation of cellular biosynthetic process
1.49	4.71e-03	GO:0060284	regulation of cell development
1.13	4.99e-03	GO:0023052	signaling
1.27	5.06e-03	GO:0006793	phosphorus metabolic process
1.27	5.06e-03	GO:0006796	phosphate metabolic process
1.15	5.24e-03	GO:0009889	regulation of biosynthetic process
1.83	5.88e-03	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
1.47	6.48e-03	GO:0070647	protein modification by small protein conjugation or removal
1.24	6.92e-03	GO:0010604	positive regulation of macromolecule metabolic process
1.24	7.28e-03	GO:0031325	positive regulation of cellular metabolic process
1.28	7.52e-03	GO:0006351	transcription, DNA-dependent
1.34	7.58e-03	GO:0045893	positive regulation of transcription, DNA-dependent
1.53	1.31e-02	GO:0046578	regulation of Ras protein signal transduction
1.43	1.35e-02	GO:0051056	regulation of small GTPase mediated signal transduction
1.32	1.39e-02	GO:0010628	positive regulation of gene expression
1.55	1.64e-02	GO:0045786	negative regulation of cell cycle
1.22	1.72e-02	GO:0035556	intracellular signal transduction
1.36	1.73e-02	GO:0010942	positive regulation of cell death
1.25	1.86e-02	GO:0032268	regulation of cellular protein metabolic process
1.22	1.89e-02	GO:0051239	regulation of multicellular organismal process
1.88	1.96e-02	GO:0060828	regulation of canonical Wnt receptor signaling pathway
1.55	2.05e-02	GO:0048514	blood vessel morphogenesis
1.36	2.20e-02	GO:0043068	positive regulation of programmed cell death
1.22	2.25e-02	GO:0009893	positive regulation of metabolic process
1.36	2.28e-02	GO:0043065	positive regulation of apoptosis
1.37	2.33e-02	GO:0045944	positive regulation of transcription from RNA polymerase II promoter
1.70	2.49e-02	GO:0030111	regulation of Wnt receptor signaling pathway
1.52	2.54e-02	GO:0007507	heart development
1.74	2.70e-02	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.24	2.83e-02	GO:0010941	regulation of cell death
1.37	3.47e-02	GO:0051094	positive regulation of developmental process
2.24	3.48e-02	GO:0030509	BMP signaling pathway
1.43	3.67e-02	GO:0045597	positive regulation of cell differentiation
1.15	3.96e-02	GO:0044267	cellular protein metabolic process
1.34	4.02e-02	GO:0006935	chemotaxis
1.34	4.02e-02	GO:0042330	taxis
1.24	4.22e-02	GO:0042981	regulation of apoptosis
1.28	4.58e-02	GO:0051173	positive regulation of nitrogen compound metabolic process
1.24	4.75e-02	GO:0043067	regulation of programmed cell death
1.40	4.77e-02	GO:0048598	embryonic morphogenesis
1.91	4.83e-02	GO:0007173	epidermal growth factor receptor signaling pathway
1.29	5.00e-02	GO:0009790	embryo development

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.12	4.05e-36	GO:0005622	intracellular
1.12	4.21e-35	GO:0044424	intracellular part
1.13	1.04e-23	GO:0043226	organelle
1.13	2.05e-23	GO:0043229	intracellular organelle
1.14	9.31e-22	GO:0005737	cytoplasm
1.13	9.83e-21	GO:0043227	membrane-bounded organelle
1.13	1.72e-20	GO:0043231	intracellular membrane-bounded organelle
1.16	2.09e-15	GO:0044444	cytoplasmic part
1.16	1.26e-13	GO:0005634	nucleus
1.25	1.31e-08	GO:0005829	cytosol
1.92	1.31e-07	GO:0005912	adherens junction
1.03	1.05e-06	GO:0044464	cell part
1.03	1.14e-06	GO:0005623	cell
1.78	6.80e-06	GO:0070161	anchoring junction
1.70	4.08e-05	GO:0031252	cell leading edge
1.20	2.75e-04	GO:0031981	nuclear lumen
1.85	3.48e-04	GO:0030055	cell-substrate junction
1.10	3.94e-04	GO:0044446	intracellular organelle part
1.10	6.27e-04	GO:0044422	organelle part
1.86	6.72e-04	GO:0005925	focal adhesion
1.17	7.47e-04	GO:0044428	nuclear part
1.26	1.18e-03	GO:0005794	Golgi apparatus
1.20	1.30e-03	GO:0012505	endomembrane system
1.81	1.56e-03	GO:0005924	cell-substrate adherens junction
1.20	1.60e-03	GO:0005856	cytoskeleton
1.21	3.86e-03	GO:0005654	nucleoplasm
1.30	8.52e-03	GO:0030054	cell junction
1.28	9.48e-03	GO:0015630	microtubule cytoskeleton
1.26	1.85e-02	GO:0031410	cytoplasmic vesicle
1.25	1.93e-02	GO:0031982	vesicle
1.79	2.05e-02	GO:0030027	lamellipodium
1.14	2.29e-02	GO:0043233	organelle lumen
1.14	2.37e-02	GO:0070013	intracellular organelle lumen
1.26	2.69e-02	GO:0031988	membrane-bounded vesicle
1.25	3.99e-02	GO:0016023	cytoplasmic membrane-bounded vesicle
1.12	4.65e-02	GO:0043234	protein complex

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.08	1.40e-15	GO:0005488	binding
1.14	3.31e-14	GO:0005515	protein binding
1.68	8.79e-06	GO:0004842	ubiquitin-protein ligase activity
1.31	1.25e-05	GO:0030528	transcription regulator activity
1.42	2.05e-05	GO:0008092	cytoskeletal protein binding
1.31	2.38e-05	GO:0001071	nucleic acid binding transcription factor activity
1.31	2.38e-05	GO:0003700	sequence-specific DNA binding transcription factor activity
1.44	4.77e-05	GO:0060589	nucleoside-triphosphatase regulator activity
1.61	1.36e-04	GO:0019787	small conjugating protein ligase activity
2.43	1.56e-04	GO:0046332	SMAD binding
1.43	1.58e-04	GO:0030695	GTPase regulator activity
1.43	1.85e-04	GO:0019904	protein domain specific binding
1.53	1.94e-04	GO:0016879	ligase activity, forming carbon-nitrogen bonds
1.49	2.16e-04	GO:0042578	phosphoric ester hydrolase activity
1.55	2.44e-04	GO:0016881	acid-amino acid ligase activity
1.10	3.06e-04	GO:0003824	catalytic activity
1.49	4.25e-04	GO:0003779	actin binding
1.56	4.72e-04	GO:0016791	phosphatase activity
3.77	6.24e-04	GO:0070411	I-SMAD binding
1.51	7.16e-04	GO:0005083	small GTPase regulator activity
1.17	7.75e-04	GO:0003677	DNA binding
1.12	1.22e-03	GO:0046872	metal ion binding
1.48	1.26e-03	GO:0016564	transcription repressor activity
1.47	1.47e-03	GO:0016563	transcription activator activity
1.12	1.97e-03	GO:0043169	cation binding
1.12	2.18e-03	GO:0043167	ion binding
1.77	3.00e-03	GO:0051020	GTPase binding
1.29	3.85e-03	GO:0019899	enzyme binding
1.46	5.37e-03	GO:0008134	transcription factor binding
1.36	9.37e-03	GO:0016874	ligase activity
1.82	9.86e-03	GO:0017016	Ras GTPase binding
1.53	1.39e-02	GO:0000975	regulatory region DNA binding
1.53	1.39e-02	GO:0001067	regulatory region nucleic acid binding
1.53	1.39e-02	GO:0044212	transcription regulatory region DNA binding
1.75	1.79e-02	GO:0031267	small GTPase binding
1.73	3.18e-02	GO:0005057	receptor signaling protein activity
1.51	3.36e-02	GO:0010843	promoter binding
1.56	4.24e-02	GO:0004721	phosphoprotein phosphatase activity
1.56	4.24e-02	GO:0005085	guanyl-nucleotide exchange factor activity