Motif ID: SOX2.p2

Z-value: 1.120


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2



Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_139654807 2.559 NM_153235
TXLNB
taxilin beta
chr3_-_150533948 2.270 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr7_-_27186400 2.076 NM_153715
HOXA10
homeobox A10
chr4_-_101658094 1.618 NM_001159694
NM_016242
EMCN

endomucin

chr6_+_130381408 1.405 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr1_-_171441234 1.382 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr4_+_146623405 1.349 NM_001003688
SMAD1
SMAD family member 1
chr4_+_86918882 1.312 ARHGAP24
Rho GTPase activating protein 24
chr1_+_66570363 1.279 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr2_-_37752272 1.278 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr1_-_197173159 1.270 LOC100131234
familial acute myelogenous leukemia related factor
chr12_-_6103945 1.214 NM_000552
VWF
von Willebrand factor
chr7_-_27180398 1.212 NM_018951
HOXA10
homeobox A10
chr2_-_188021117 1.206 NM_005795
CALCRL
calcitonin receptor-like
chr13_-_98428244 1.205 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr7_+_102340579 1.130 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr6_+_12398514 1.107 NM_001168319
NM_001955
EDN1

endothelin 1

chr7_+_27190688 1.089


chrX_+_15428820 1.071 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr21_-_38792173 1.069 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr1_-_95165089 1.069 NM_001839
CNN3
calponin 3, acidic
chr17_-_18890963 1.066 NM_006613
GRAP
GRB2-related adaptor protein
chr6_+_114285209 1.050 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr9_+_18464138 1.050 ADAMTSL1
ADAMTS-like 1
chr9_+_18464090 1.047 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr12_-_101115677 1.042 NM_002674
PMCH
pro-melanin-concentrating hormone
chr7_-_27190882 1.028 HOXA11
homeobox A11
chr6_+_153060722 1.023 NM_025107
MYCT1
myc target 1
chr13_-_73606362 1.021 KLF12
Kruppel-like factor 12
chr16_-_71639670 1.000 NM_006885
ZFHX3
zinc finger homeobox 3
chrX_+_86659370 0.992 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr1_-_95165037 0.977 CNN3
calponin 3, acidic
chr5_+_15553736 0.976 FBXL7
F-box and leucine-rich repeat protein 7
chr9_-_35640852 0.973 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr5_+_15553288 0.956 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr11_+_5667494 0.934 NM_006074
TRIM22
tripartite motif containing 22
chr5_-_100266769 0.925 NM_175052
NM_005668
ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chr5_-_111119846 0.924 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr7_-_27171673 0.908 NM_152739
HOXA9
homeobox A9
chr3_-_116272911 0.908 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr5_+_15553539 0.887 FBXL7
F-box and leucine-rich repeat protein 7
chr8_-_124622434 0.887 NM_058229
FBXO32
F-box protein 32
chr10_+_22765996 0.885 LOC100289455
hypothetical LOC100289455
chr10_+_70517863 0.867 SRGN
serglycin
chr12_-_68369322 0.843 NM_152439
BEST3
bestrophin 3
chr9_-_116190038 0.842 AKNA
AT-hook transcription factor
chr6_-_56824371 0.837 DST
dystonin
chr10_+_70517823 0.835 NM_002727
SRGN
serglycin
chr13_-_98757634 0.833 NM_004951
GPR183
G protein-coupled receptor 183
chr15_-_80125403 0.831 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr15_-_80125514 0.820 MEX3B
mex-3 homolog B (C. elegans)
chr5_-_88155360 0.815 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr17_-_59818033 0.814 PECAM1
platelet/endothelial cell adhesion molecule
chr7_+_93388951 0.798 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr11_+_129496792 0.795 APLP2
amyloid beta (A4) precursor-like protein 2
chr13_-_32658215 0.795 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr1_-_85816520 0.782 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr2_+_108637698 0.772 NM_001193485
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_-_198248828 0.771 NM_144629
RFTN2
raftlin family member 2
chr9_+_89302574 0.771 NM_004938
DAPK1
death-associated protein kinase 1
chr18_+_13601664 0.764 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr15_-_68781662 0.755 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr13_+_110653407 0.754 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr3_+_148593911 0.754


chr3_+_190831909 0.750 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr1_-_85703198 0.747 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr2_+_108637916 0.738 LIMS1
LIMS3
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 3
chr17_-_59817456 0.734 PECAM1
platelet/endothelial cell adhesion molecule
chr3_+_182900081 0.729 SOX2OT
SOX2 overlapping transcript (non-protein coding)
chr17_-_59817722 0.727 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr13_-_32678142 0.724 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr3_-_192531018 0.721 NM_198152
UTS2D
urotensin 2 domain containing
chr2_-_56266408 0.709 LOC100129434
hypothetical LOC100129434
chr17_-_59817654 0.705 PECAM1
platelet/endothelial cell adhesion molecule
chr13_-_73605914 0.705 NM_007249
KLF12
Kruppel-like factor 12
chr9_+_115303527 0.705 NM_130795
RGS3
regulator of G-protein signaling 3
chr6_-_56816403 0.701 DST
dystonin
chr10_+_80672842 0.701 ZMIZ1
zinc finger, MIZ-type containing 1
chr9_+_89302239 0.697 DAPK1
death-associated protein kinase 1
chr17_-_59817575 0.697 PECAM1
platelet/endothelial cell adhesion molecule
chr17_+_18971506 0.688 NM_001129778
GRAPL
GRB2-related adaptor protein-like
chr1_+_84540921 0.672 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr2_-_110665188 0.669 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr17_-_30783631 0.667 NM_018042
SLFN12
schlafen family member 12
chr12_-_31635089 0.660 NM_144973
DENND5B
DENN/MADD domain containing 5B
chr2_+_110013297 0.659 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr4_+_37655385 0.659 TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr5_+_98132898 0.652 NM_001012761
RGMB
RGM domain family, member B
chr2_-_207739815 0.644 KLF7
Kruppel-like factor 7 (ubiquitous)
chr15_+_37330176 0.642 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr7_+_20337249 0.642 NM_002214
ITGB8
integrin, beta 8
chr1_+_242281199 0.640 ZNF238
zinc finger protein 238
chr6_+_21701942 0.640 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr2_-_37752731 0.639 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr8_-_29262240 0.639 NM_057158
DUSP4
dual specificity phosphatase 4
chr7_-_47588266 0.638 TNS3
tensin 3
chr6_-_56824672 0.637 DST
dystonin
chr5_+_15553768 0.606 FBXL7
F-box and leucine-rich repeat protein 7
chr7_+_134114912 0.603 CALD1
caldesmon 1
chr9_+_27099138 0.598 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr17_-_46479127 0.598 SPAG9
sperm associated antigen 9
chr5_-_156935283 0.597


chr14_-_88953059 0.595 NM_005197
FOXN3
forkhead box N3
chr7_-_11838260 0.594 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr8_-_33544184 0.592 NM_024787
RNF122
ring finger protein 122
chr3_-_115826481 0.588 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr7_+_134114957 0.573 CALD1
caldesmon 1
chr4_+_146622154 0.571 NM_005900
SMAD1
SMAD family member 1
chrX_+_10084984 0.569 NM_001830
CLCN4
chloride channel 4
chr2_-_128138435 0.568 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr3_-_150858274 0.563 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr3_-_11660395 0.562 NM_001128219
VGLL4
vestigial like 4 (Drosophila)
chr21_-_27261276 0.562 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr5_-_156935317 0.561 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr5_+_95093267 0.561


chr7_-_47588160 0.557 TNS3
tensin 3
chr10_-_14686243 0.557 FAM107B
family with sequence similarity 107, member B
chr4_-_7991992 0.548 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr7_+_139175420 0.547 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr16_+_64958025 0.544 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr3_-_58538110 0.543 FAM107A
family with sequence similarity 107, member A
chr3_+_174598937 0.543 NM_014932
NLGN1
neuroligin 1
chr3_-_58538530 0.540 NM_001076778
NM_007177
FAM107A

family with sequence similarity 107, member A

chr1_+_198975227 0.538 NM_203459
CAMSAP1L1
calmodulin regulated spectrin-associated protein 1-like 1
chr16_+_64958060 0.536 CDH5
cadherin 5, type 2 (vascular endothelium)
chr2_-_207738858 0.531 NM_003709
KLF7
Kruppel-like factor 7 (ubiquitous)
chr6_+_89847019 0.531 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr2_+_33213111 0.531 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr10_-_88707299 0.530 NM_024756
MMRN2
multimerin 2
chrX_+_100692071 0.529 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr4_-_140696740 0.526 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr4_+_86918870 0.521 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr9_+_4480193 0.520 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr8_-_6407882 0.518 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr16_+_64958086 0.517 CDH5
cadherin 5, type 2 (vascular endothelium)
chr5_-_71838875 0.517 NM_152625
ZNF366
zinc finger protein 366
chr11_+_113436438 0.514 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr1_+_242283129 0.514 NM_006352
ZNF238
zinc finger protein 238
chr1_+_43539239 0.513 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr19_+_13767207 0.511 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr8_-_108579270 0.509 NM_001146
ANGPT1
angiopoietin 1
chr5_-_111120929 0.502 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr6_+_89847183 0.502 PNRC1
proline-rich nuclear receptor coactivator 1
chr3_+_25444837 0.501 NM_000965
RARB
retinoic acid receptor, beta
chr15_-_81667773 0.501 HDGFRP3
hepatoma-derived growth factor, related protein 3
chr6_+_44295219 0.501 NM_001078174
NM_004955
SLC29A1

solute carrier family 29 (nucleoside transporters), member 1

chr15_-_81667169 0.498 NM_016073
HDGFRP3
hepatoma-derived growth factor, related protein 3
chr1_-_26105954 0.498 NM_203399
STMN1
stathmin 1
chr1_-_224993498 0.495 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr10_+_104525877 0.493 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr1_+_66570683 0.489 PDE4B
phosphodiesterase 4B, cAMP-specific
chr3_-_115825742 0.488 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr5_+_76418545 0.487 LOC728723
hypothetical LOC728723
chr3_+_25444753 0.486 NM_016152
RARB
retinoic acid receptor, beta
chr4_+_3264509 0.486 RGS12
regulator of G-protein signaling 12
chr1_-_32574185 0.485 NM_023009
MARCKSL1
MARCKS-like 1
chr12_-_41164052 0.482 NM_001144882
NM_001144883
PRICKLE1

prickle homolog 1 (Drosophila)

chr1_-_223907283 0.481 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr5_-_111120817 0.474 NM_004772
C5orf13
chromosome 5 open reading frame 13
chrX_+_12904207 0.474 TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chrX_-_128616594 0.474 NM_017413
APLN
apelin
chr6_+_116939500 0.473 NM_153711
FAM26E
family with sequence similarity 26, member E
chr12_-_41164010 0.472 PRICKLE1
prickle homolog 1 (Drosophila)
chrX_+_28515479 0.470 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr11_+_111313067 0.470 NM_001037954
DIXDC1
DIX domain containing 1
chr19_-_14121728 0.467 LPHN1
latrophilin 1
chr15_+_22751162 0.465 NM_003097
NM_022804
NM_005678
SNRPN
SNURF

small nuclear ribonucleoprotein polypeptide N
SNRPN upstream reading frame

chr15_-_80123935 0.464 MEX3B
mex-3 homolog B (C. elegans)
chr12_-_10142779 0.464 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr13_-_20533703 0.461 NM_014572
LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr12_-_47869134 0.459 TUBA1A
tubulin, alpha 1a
chr9_+_115382990 0.458 RGS3
regulator of G-protein signaling 3
chr11_+_111313227 0.456 DIXDC1
DIX domain containing 1
chr14_+_76298693 0.453 VASH1
vasohibin 1
chr10_-_14686413 0.453 FAM107B
family with sequence similarity 107, member B
chr9_+_36026900 0.452 NM_021111
RECK
reversion-inducing-cysteine-rich protein with kazal motifs
chr13_-_22905822 0.450 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr8_+_67201684 0.449 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr15_-_93671314 0.448 LOC400456
hypothetical LOC400456
chr3_+_29297806 0.447 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr11_+_128068982 0.445 NM_002017
FLI1
Friend leukemia virus integration 1
chr5_-_111120764 0.441 C5orf13
chromosome 5 open reading frame 13
chr17_-_26672757 0.440 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr5_-_111782637 0.440 NM_022140
EPB41L4A
erythrocyte membrane protein band 4.1 like 4A
chr7_-_47588652 0.439 TNS3
tensin 3
chr5_-_95184221 0.438 NM_001118890
NM_002064
GLRX

glutaredoxin (thioltransferase)

chr18_-_21186107 0.438 NM_015461
ZNF521
zinc finger protein 521
chr5_+_72148173 0.437 NM_002270
TNPO1
transportin 1
chr4_-_54119102 0.436 LNX1
ligand of numb-protein X 1
chrX_-_50573759 0.436 NM_020717
SHROOM4
shroom family member 4
chr8_-_18710575 0.434 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr9_-_4289574 0.433 GLIS3
GLIS family zinc finger 3
chr4_-_54119159 0.429 NM_032622
LNX1
ligand of numb-protein X 1
chr12_-_47869067 0.428 NM_006009
TUBA1A
tubulin, alpha 1a
chr1_-_79244948 0.426 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr3_-_194118627 0.425 NM_178496
MB21D2
Mab-21 domain containing 2
chr7_-_27171648 0.423 HOXA9
homeobox A9
chr12_+_48443588 0.422 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr1_-_153107084 0.421


chr3_-_194118321 0.420 MB21D2
Mab-21 domain containing 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.28 9.02e-08 GO:0007275 multicellular organismal development
1.27 9.18e-08 GO:0032502 developmental process
1.32 1.38e-07 GO:0048731 system development
1.21 4.50e-07 GO:0032501 multicellular organismal process
1.29 5.22e-07 GO:0048856 anatomical structure development
1.16 2.48e-06 GO:0050794 regulation of cellular process
1.42 4.81e-06 GO:0007399 nervous system development
1.96 3.71e-05 GO:0030029 actin filament-based process
1.14 8.82e-05 GO:0050789 regulation of biological process
1.55 2.04e-04 GO:2000026 regulation of multicellular organismal development
1.12 4.74e-04 GO:0065007 biological regulation
1.95 4.75e-04 GO:0030036 actin cytoskeleton organization
1.21 1.89e-03 GO:0007165 signal transduction
1.34 2.27e-03 GO:0009653 anatomical structure morphogenesis
1.20 2.78e-03 GO:0023052 signaling
1.55 3.45e-03 GO:0000902 cell morphogenesis
1.43 5.40e-03 GO:0050793 regulation of developmental process
1.27 6.62e-03 GO:0048869 cellular developmental process
1.27 7.23e-03 GO:0030154 cell differentiation
1.59 7.74e-03 GO:0000904 cell morphogenesis involved in differentiation
1.13 8.40e-03 GO:0050896 response to stimulus
1.60 9.11e-03 GO:0072358 cardiovascular system development
1.60 9.11e-03 GO:0072359 circulatory system development
1.63 9.98e-03 GO:0007409 axonogenesis
1.49 2.01e-02 GO:0030030 cell projection organization
1.56 2.24e-02 GO:0007010 cytoskeleton organization
1.59 2.61e-02 GO:0048812 neuron projection morphogenesis
1.68 2.62e-02 GO:0007411 axon guidance
1.55 2.70e-02 GO:0031175 neuron projection development
1.27 2.79e-02 GO:0007166 cell surface receptor linked signaling pathway
1.48 2.87e-02 GO:0032989 cellular component morphogenesis
1.40 3.03e-02 GO:0022008 neurogenesis
1.58 4.22e-02 GO:0048667 cell morphogenesis involved in neuron differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.21 9.29e-05 GO:0005912 adherens junction
2.43 1.40e-04 GO:0030055 cell-substrate junction
2.50 1.46e-04 GO:0005925 focal adhesion
2.38 5.22e-04 GO:0005924 cell-substrate adherens junction
2.04 7.97e-04 GO:0070161 anchoring junction
3.40 3.62e-03 GO:0042641 actomyosin
1.70 4.87e-03 GO:0015629 actin cytoskeleton
1.13 5.85e-03 GO:0005634 nucleus
3.48 1.12e-02 GO:0001725 stress fiber
3.24 2.76e-02 GO:0032432 actin filament bundle
1.14 2.81e-02 GO:0071944 cell periphery
1.14 2.91e-02 GO:0005886 plasma membrane
2.23 3.40e-02 GO:0030027 lamellipodium
1.80 3.91e-02 GO:0031252 cell leading edge
1.42 4.43e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.82 6.35e-05 GO:0003779 actin binding
2.31 1.14e-03 GO:0017124 SH3 domain binding
1.52 4.83e-03 GO:0008092 cytoskeletal protein binding
1.35 1.40e-02 GO:0030528 transcription regulator activity
2.37 1.73e-02 GO:0031625 ubiquitin protein ligase binding
2.75 2.63e-02 GO:0005070 SH3/SH2 adaptor activity