Motif ID: IRF1,2,7.p3

Z-value: 8.627


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7



Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_111900650 48.299 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr1_+_78858675 42.800 NM_006820
IFI44L
interferon-induced protein 44-like
chr10_+_91082218 23.107 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr17_-_37518213 21.831 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr21_+_41655786 20.367 NM_002463
LOC100131190
MX2
hypothetical protein LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr1_+_157246305 20.343 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr1_+_938709 17.053 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr7_+_150013716 16.372 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr3_+_188568861 15.789 NM_022147
RTP4
receptor (chemosensory) transporter protein 4
chr13_-_42464301 15.294 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr7_+_128367961 14.581 NM_001098627
IRF5
interferon regulatory factor 5
chr16_-_88358946 13.636 FANCA
Fanconi anemia, complementation group A
chr1_-_25164061 13.611 NM_001031680
RUNX3
runt-related transcription factor 3
chr6_-_27948065 13.337 NM_003533
HIST1H3I
histone cluster 1, H3i
chr11_-_605920 12.569 IRF7
interferon regulatory factor 7
chr4_+_142777172 12.528 NM_000585
NM_172174
IL15

interleukin 15

chr9_+_5500544 12.221 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr11_-_605998 11.945 NM_001572
NM_004029
IRF7

interferon regulatory factor 7

chr11_+_5602782 11.855 NM_021616
TRIM34
tripartite motif containing 34
chr7_+_134483305 11.837 NM_018295
TMEM140
transmembrane protein 140
chr10_+_91142301 11.731 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr19_-_7672978 11.647 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr7_+_73826244 11.178 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr4_+_89597257 11.091 NM_016323
HERC5
hect domain and RLD 5
chr22_-_34886727 11.007 NM_145640
APOL3
apolipoprotein L, 3
chr1_-_2486313 10.864 NM_003820
TNFRSF14
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr9_+_5440455 10.706 NM_014143
CD274
CD274 molecule
chr6_+_26548678 10.584 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr6_-_32920167 10.580 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr3_+_114733907 10.437 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr11_+_5667392 10.435 TRIM22
tripartite motif containing 22
chr6_+_6533932 10.379 NM_004271
LY86
lymphocyte antigen 86
chr11_+_1830763 9.924 NM_002339
LSP1
lymphocyte-specific protein 1
chr21_-_42219849 9.853 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr12_+_25096755 9.732 LRMP
lymphoid-restricted membrane protein
chr6_-_31432543 9.599 HLA-B
major histocompatibility complex, class I, B
chr5_+_131774478 9.501 NM_001013717
C5orf56
chromosome 5 open reading frame 56
chr1_+_78888064 9.395 NM_006417
IFI44
interferon-induced protein 44
chr6_-_32919751 9.347 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr4_-_169476391 9.326 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr22_-_16080265 9.293 CECR1
cat eye syndrome chromosome region, candidate 1
chr16_+_10878539 9.227 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr7_-_92615593 9.202 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr2_-_230792844 9.172 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr5_-_149772528 9.109


chr6_-_32929390 9.019 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr22_+_34374358 8.960 NM_030641
APOL6
apolipoprotein L, 6
chr6_-_32929570 8.916 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr16_-_11783908 8.781 NM_014153
ZC3H7A
zinc finger CCCH-type containing 7A
chr5_-_149772469 8.754 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr1_+_157067729 8.728 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr19_-_18058632 8.678 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr6_+_32929902 8.678 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr15_+_42790951 8.598 NM_004048
B2M
beta-2-microglobulin
chr3_+_123882355 8.597 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chr20_-_55628852 8.560 NM_001160417
NM_001160418
NM_001160419
NM_030776
ZBP1



Z-DNA binding protein 1



chr6_+_37081387 8.550 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr11_-_605649 8.545 NM_004031
IRF7
interferon regulatory factor 7
chr17_+_6600080 8.510 XAF1
XIAP associated factor 1
chr6_-_32929721 8.506 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_75851984 8.454


chr10_+_63478974 8.344 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr12_+_6431437 8.343 NM_018009
TAPBPL
TAP binding protein-like
chr19_-_55091942 8.264 NM_152899
IL4I1
interleukin 4 induced 1
chr21_+_41719847 8.214 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr6_+_31648071 8.038 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr15_+_86983038 7.922 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr17_+_6599879 7.858 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr11_-_60475558 7.818 NM_016582
SLC15A3
solute carrier family 15, member 3
chr17_+_38719371 7.656 NM_145041
TMEM106A
FLJ77644
transmembrane protein 106A
hypothetical LOC728772
chr1_-_9052170 7.641 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr5_-_149772563 7.641 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr1_-_9052207 7.529 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr6_-_30289092 7.527 NM_003449
TRIM26
tripartite motif containing 26
chr12_+_93066370 7.415 NM_005761
PLXNC1
plexin C1
chr10_+_91051685 7.364 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr1_-_89261021 7.286 NM_018284
GBP3
guanylate binding protein 3
chr15_-_42790805 7.275


chr12_+_25096472 7.201 NM_006152
LRMP
lymphoid-restricted membrane protein
chr11_-_63087430 7.105 NM_017878
HRASLS2
HRAS-like suppressor 2
chr4_+_37569093 7.067 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr16_+_55580910 7.050 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr3_-_173723754 6.817 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr10_+_97505398 6.717 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr7_-_149960218 6.691 GIMAP6
GTPase, IMAP family member 6
chr3_-_49826221 6.663 UBA7
ubiquitin-like modifier activating enzyme 7
chr1_-_89303478 6.655 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible, 67kDa
chr9_+_139758336 6.579 EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr16_-_49272617 6.435 SNX20
sorting nexin 20
chr11_-_104274606 6.429 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr3_-_49826360 6.377 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr10_-_6059460 6.197 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr12_+_111829121 6.186 NM_001032409
NM_002534
NM_016816
OAS1


2',5'-oligoadenylate synthetase 1, 40/46kDa


chr22_+_34374421 6.103 APOL6
apolipoprotein L, 6
chr1_-_159306369 6.100 NM_001025598
NM_181720
ARHGAP30

Rho GTPase activating protein 30

chr11_-_57091656 6.099 NM_004223
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr17_-_30783631 6.062 NM_018042
SLFN12
schlafen family member 12
chr9_-_21375258 5.986 NM_000605
IFNA2
interferon, alpha 2
chr16_-_49272741 5.974 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr8_-_145132551 5.935 PARP10
poly (ADP-ribose) polymerase family, member 10
chr12_+_12115668 5.848 NM_030766
NM_138722
BCL2L14

BCL2-like 14 (apoptosis facilitator)

chr17_-_74244539 5.831


chr2_-_37237530 5.791 EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr1_+_159334774 5.775 NM_001007255
NM_152366
KLHDC9

kelch domain containing 9

chr2_+_230900121 5.770 NM_138402
SP140L
SP140 nuclear body protein-like
chr20_-_24986501 5.756 ACSS1
acyl-CoA synthetase short-chain family member 1
chr20_+_44180355 5.742 CD40
CD40 molecule, TNF receptor superfamily member 5
chr19_-_52427698 5.683 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr11_-_4371463 5.644 NM_003141
TRIM21
tripartite motif containing 21
chr17_-_44642934 5.641 NM_001198754
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr8_-_145132582 5.625 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr11_+_71388310 5.598 NM_001145057
IL18BP
interleukin 18 binding protein
chr6_+_37509028 5.540 FTSJD2
FtsJ methyltransferase domain containing 2
chr3_+_161189322 5.519 NM_000882
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr7_-_76667045 5.516 NM_006682
FGL2
fibrinogen-like 2
chr5_+_96237923 5.510 ERAP2
endoplasmic reticulum aminopeptidase 2
chr2_+_33554824 5.465 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr6_-_138231006 5.454


chr7_+_154351087 5.439 LOC100132707
hypothetical LOC100132707
chr1_-_159306327 5.423 ARHGAP30
Rho GTPase activating protein 30
chr16_+_29739256 5.415 MVP
major vault protein
chr2_+_33555182 5.399 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr5_-_95184121 5.393 GLRX
glutaredoxin (thioltransferase)
chr9_-_32516164 5.390 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_+_126282078 5.375 NCOA7
nuclear receptor coactivator 7
chr2_-_162883062 5.298 NM_022168
IFIH1
interferon induced with helicase C domain 1
chr1_-_152847301 5.274 NM_001111
NM_015840
NM_015841
ADAR


adenosine deaminase, RNA-specific


chr1_-_149586341 5.218 NM_000449
NM_001025603
RFX5

regulatory factor X, 5 (influences HLA class II expression)

chr17_+_44643067 5.211 ABI3
ABI family, member 3
chr21_+_41714311 5.185 NM_001144925
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr19_+_18145578 5.167 NM_006332
IFI30
interferon, gamma-inducible protein 30
chr16_-_66528152 5.162 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr2_-_151854379 5.119 NMI
N-myc (and STAT) interactor
chr1_-_152847105 5.085 ADAR
adenosine deaminase, RNA-specific
chr2_-_37237651 5.065 NM_001135651
NM_002759
EIF2AK2

eukaryotic translation initiation factor 2-alpha kinase 2

chr16_-_66528235 5.059 NM_002801
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr22_+_37747063 5.054 NM_152426
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr2_-_6923215 5.043 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr11_-_60880799 5.012 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr4_-_40212670 5.007 NM_019027
RBM47
RNA binding motif protein 47
chr17_+_69974361 4.999 CD300A
CD300a molecule
chr22_+_25155220 4.979 NM_020437
ASPHD2
aspartate beta-hydroxylase domain containing 2
chr10_+_115429622 4.961 CASP7
caspase 7, apoptosis-related cysteine peptidase
chr2_-_191587127 4.931 STAT1
signal transducer and activator of transcription 1, 91kDa
chr6_+_32713160 4.926 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr15_+_73278285 4.925 C15orf39
chromosome 15 open reading frame 39
chr8_+_79740813 4.917 NM_016010
FAM164A
family with sequence similarity 164, member A
chr19_+_18145619 4.908 IFI30
interferon, gamma-inducible protein 30
chr2_-_191587169 4.887 NM_007315
NM_139266
STAT1

signal transducer and activator of transcription 1, 91kDa

chr6_+_30018287 4.827 NM_002116
HLA-A
major histocompatibility complex, class I, A
chr12_-_48902692 4.804 NM_001113547
LIMA1
LIM domain and actin binding 1
chr6_+_37508830 4.799 NM_015050
FTSJD2
FtsJ methyltransferase domain containing 2
chr5_-_95184221 4.798 NM_001118890
NM_002064
GLRX

glutaredoxin (thioltransferase)

chr22_+_17012841 4.791 USP18
ubiquitin specific peptidase 18
chr1_-_9052253 4.753 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr2_-_191587153 4.731 STAT1
signal transducer and activator of transcription 1, 91kDa
chr2_-_191587128 4.679 STAT1
signal transducer and activator of transcription 1, 91kDa
chr19_+_17495109 4.624 NM_001098524
NM_173544
FAM129C

family with sequence similarity 129, member C

chr2_-_242449662 4.622 NM_005018
PDCD1
programmed cell death 1
chr1_-_152847256 4.593 ADAR
adenosine deaminase, RNA-specific
chr16_+_29739215 4.509 NM_005115
NM_017458
MVP

major vault protein

chr17_-_41018291 4.486


chr2_+_230989150 4.456 SP100
SP100 nuclear antigen
chr16_-_73292188 4.442 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr19_+_10057972 4.425 C19orf66
chromosome 19 open reading frame 66
chr11_-_104421240 4.319 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr11_+_71387572 4.312 NM_001039659
NM_001039660
NM_173042
IL18BP


interleukin 18 binding protein


chr19_-_17377383 4.310 NM_004335
BST2
bone marrow stromal cell antigen 2
chr10_+_22765996 4.281 LOC100289455
hypothetical LOC100289455
chr20_+_44180296 4.249 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr18_+_59726183 4.229 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr4_-_38460983 4.226 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr12_+_9713472 4.192 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr21_+_42807052 4.189 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr10_+_91077581 4.186 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr19_+_10058023 4.136 C19orf66
chromosome 19 open reading frame 66
chr2_+_68445821 4.082 NM_002664
PLEK
pleckstrin
chr11_+_63060848 4.045 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr22_+_37802955 4.022 NM_021822
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr13_+_48968097 3.965 PHF11
PHD finger protein 11
chr14_+_90650466 3.964 C14orf159
chromosome 14 open reading frame 159
chr18_-_6404900 3.947 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr22_+_37823174 3.936 NM_001166002
NM_001166003
NM_001166004
NM_181773
APOBEC3H



apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H



chr22_+_38627031 3.928 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr4_-_157094443 3.899 NM_001334
CTSO
cathepsin O
chr7_-_76883642 3.898 NM_017439
PION
pigeon homolog (Drosophila)
chr19_+_17377502 3.870 LOC100507535
hypothetical LOC100507535
chr12_+_4628521 3.850 NM_005002
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr10_+_115429415 3.793 NM_001227
NM_033338
NM_033339
CASP7


caspase 7, apoptosis-related cysteine peptidase


chr2_-_88946767 3.788


chr12_+_38905053 3.779 NM_198578
LRRK2
leucine-rich repeat kinase 2
chr14_+_90650720 3.764 NM_001102367
C14orf159
chromosome 14 open reading frame 159
chr7_-_92585253 3.755 NM_001193307
NM_017654
SAMD9

sterile alpha motif domain containing 9

chr10_+_82290554 3.718 NM_001145719
SH2D4B
SH2 domain containing 4B
chr11_+_303852 3.679 NM_003641
IFITM1
interferon induced transmembrane protein 1 (9-27)
chr6_+_32919873 3.674


chr18_+_19848749 3.657 TTC39C
tetratricopeptide repeat domain 39C
chr19_-_46504831 3.621


chr11_+_32069183 3.614 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr19_+_10057757 3.612 NM_018381
C19orf66
chromosome 19 open reading frame 66

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
10.71 1.49e-24 GO:0034340 response to type I interferon
10.56 1.66e-23 GO:0060337 type I interferon-mediated signaling pathway
10.56 1.66e-23 GO:0071357 cellular response to type I interferon
5.50 4.94e-21 GO:0019221 cytokine-mediated signaling pathway
5.16 1.76e-20 GO:0071345 cellular response to cytokine stimulus
2.91 1.69e-19 GO:0006955 immune response
4.14 8.35e-18 GO:0034097 response to cytokine stimulus
3.67 1.28e-16 GO:0045087 innate immune response
2.29 2.21e-16 GO:0002376 immune system process
5.28 8.69e-16 GO:0009615 response to virus
2.46 1.25e-12 GO:0006952 defense response
2.87 2.66e-09 GO:0051707 response to other organism
2.57 3.24e-08 GO:0009607 response to biotic stimulus
2.32 1.41e-07 GO:0071310 cellular response to organic substance
2.08 1.52e-07 GO:0051704 multi-organism process
5.21 5.38e-07 GO:0034341 response to interferon-gamma
5.55 1.20e-06 GO:0071346 cellular response to interferon-gamma
8.60 1.38e-06 GO:0060338 regulation of type I interferon-mediated signaling pathway
1.56 1.93e-06 GO:0006950 response to stress
2.76 4.41e-06 GO:0031347 regulation of defense response
2.13 5.21e-06 GO:0002682 regulation of immune system process
5.44 1.33e-05 GO:0060333 interferon-gamma-mediated signaling pathway
12.21 8.65e-05 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
5.12 9.56e-05 GO:0001959 regulation of cytokine-mediated signaling pathway
2.31 1.16e-04 GO:0050776 regulation of immune response
5.04 1.22e-04 GO:0060759 regulation of response to cytokine stimulus
2.19 1.87e-04 GO:0080134 regulation of response to stress
1.25 2.49e-04 GO:0050896 response to stimulus
1.83 2.78e-04 GO:0070887 cellular response to chemical stimulus
8.93 4.26e-04 GO:0048002 antigen processing and presentation of peptide antigen
2.63 5.13e-04 GO:0001817 regulation of cytokine production
2.99 6.48e-04 GO:0050867 positive regulation of cell activation
3.36 1.09e-03 GO:0001819 positive regulation of cytokine production
2.60 2.22e-03 GO:0050865 regulation of cell activation
4.02 3.38e-03 GO:0043900 regulation of multi-organism process
2.69 3.75e-03 GO:0051249 regulation of lymphocyte activation
3.57 4.67e-03 GO:0050670 regulation of lymphocyte proliferation
2.90 5.05e-03 GO:0051251 positive regulation of lymphocyte activation
3.54 5.42e-03 GO:0032944 regulation of mononuclear cell proliferation
2.82 5.45e-03 GO:0002696 positive regulation of leukocyte activation
3.11 7.08e-03 GO:0050870 positive regulation of T cell activation
1.60 8.05e-03 GO:0010033 response to organic substance
3.44 8.37e-03 GO:0070663 regulation of leukocyte proliferation
2.53 8.65e-03 GO:0002694 regulation of leukocyte activation
2.82 8.65e-03 GO:0045088 regulation of innate immune response
3.69 1.09e-02 GO:0030330 DNA damage response, signal transduction by p53 class mediator
2.19 1.29e-02 GO:0044419 interspecies interaction between organisms
14.17 1.30e-02 GO:0019883 antigen processing and presentation of endogenous antigen
1.32 1.34e-02 GO:0007165 signal transduction
2.22 1.75e-02 GO:0044257 cellular protein catabolic process
2.75 2.07e-02 GO:0050863 regulation of T cell activation
8.17 2.11e-02 GO:0050691 regulation of defense response to virus by host
5.95 2.30e-02 GO:0032480 negative regulation of type I interferon production
1.27 2.45e-02 GO:0051716 cellular response to stimulus
3.63 2.65e-02 GO:2000045 regulation of G1/S transition of mitotic cell cycle
4.33 3.05e-02 GO:0019882 antigen processing and presentation
2.84 3.11e-02 GO:0002697 regulation of immune effector process
2.13 3.15e-02 GO:0030163 protein catabolic process
2.00 4.15e-02 GO:0002684 positive regulation of immune system process
4.55 4.23e-02 GO:0032479 regulation of type I interferon production
4.18 4.48e-02 GO:0002819 regulation of adaptive immune response
1.90 4.68e-02 GO:0044265 cellular macromolecule catabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.95 1.08e-02 GO:0005839 proteasome core complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.68 2.96e-03 GO:0005126 cytokine receptor binding
5.76 6.80e-03 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
6.62 2.31e-02 GO:0004298 threonine-type endopeptidase activity
6.62 2.31e-02 GO:0070003 threonine-type peptidase activity