Motif ID: PRDM1.p3

Z-value: 2.948


Transcription factors associated with PRDM1.p3:

Gene SymbolEntrez IDGene Name
PRDM1 639 PR domain containing 1, with ZNF domain



Activity profile for motif PRDM1.p3.

activity profile for motif PRDM1.p3


Sorted Z-values histogram for motif PRDM1.p3

Sorted Z-values for motif PRDM1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_142777172 6.433 NM_000585
NM_172174
IL15

interleukin 15

chr5_-_142795269 6.089 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr16_+_55580910 5.825 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr17_+_6600080 5.754 XAF1
XIAP associated factor 1
chr11_-_104344473 5.486 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr1_-_111548440 5.025 DENND2D
DENN/MADD domain containing 2D
chr12_+_6431437 4.919 NM_018009
TAPBPL
TAP binding protein-like
chr17_+_6599879 4.756 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr22_-_28972683 4.531 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr11_+_32069183 4.185 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr5_+_131774478 4.087 NM_001013717
C5orf56
chromosome 5 open reading frame 56
chr1_+_160868932 4.083 DDR2
discoidin domain receptor tyrosine kinase 2
chr3_-_49826221 3.833 UBA7
ubiquitin-like modifier activating enzyme 7
chr9_-_16717887 3.813 BNC2
basonuclin 2
chr10_+_63478974 3.787 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr3_-_49826360 3.670 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr10_+_114125955 3.670 ACSL5
acyl-CoA synthetase long-chain family member 5
chr10_+_114125927 3.609 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_-_112682038 3.549 LAMA4
laminin, alpha 4
chr8_-_145132551 3.480 PARP10
poly (ADP-ribose) polymerase family, member 10
chr2_-_230792844 3.339 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr10_+_114126004 3.289 ACSL5
acyl-CoA synthetase long-chain family member 5
chr8_-_145132582 3.269 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr21_-_42219849 3.265 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr2_+_230900121 3.250 NM_138402
SP140L
SP140 nuclear body protein-like
chr11_-_85107569 3.104 NM_206929
SYTL2
synaptotagmin-like 2
chr1_+_160868822 3.061 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr16_+_49333513 3.029 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr4_+_14985272 2.896 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr3_-_115825742 2.863 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr6_-_112682401 2.861 LAMA4
laminin, alpha 4
chr6_+_32929902 2.835 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr8_-_79880095 2.807 NM_000880
IL7
interleukin 7
chr16_+_49333461 2.792 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr8_+_144711619 2.791 NM_024736
GSDMD
gasdermin D
chr6_-_112682459 2.599 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr6_-_32919751 2.585 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr2_+_230989177 2.560 SP100
SP100 nuclear antigen
chr11_+_5602782 2.523 NM_021616
TRIM34
tripartite motif containing 34
chr2_+_230989114 2.514 NM_001080391
NM_003113
SP100

SP100 nuclear antigen

chr6_+_37081387 2.480 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr21_+_25856311 2.354 MIR155HG
MIR155 host gene (non-protein coding)
chr2_-_189752575 2.340 NM_000393
COL5A2
collagen, type V, alpha 2
chr4_+_146623405 2.304 NM_001003688
SMAD1
SMAD family member 1
chr15_-_40537002 2.261 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr17_-_45626364 2.194


chr11_+_71387572 2.148 NM_001039659
NM_001039660
NM_173042
IL18BP


interleukin 18 binding protein


chr21_-_34820916 2.137 NM_203418
RCAN1
regulator of calcineurin 1
chr10_+_91082218 2.121 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr22_-_34886727 2.120 NM_145640
APOL3
apolipoprotein L, 3
chr5_+_96237923 2.103 ERAP2
endoplasmic reticulum aminopeptidase 2
chr11_+_63060848 2.094 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr3_+_120495906 2.079 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr1_-_2486313 2.032 NM_003820
TNFRSF14
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr13_+_107719977 2.016 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr6_-_112682573 2.015 LAMA4
laminin, alpha 4
chr13_+_107720206 2.014 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr14_+_23675233 1.898 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr7_+_134483305 1.836 NM_018295
TMEM140
transmembrane protein 140
chr19_+_40931285 1.813 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr14_+_23675206 1.808 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr1_-_8406288 1.796 NM_001042682
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr2_+_230989150 1.775 SP100
SP100 nuclear antigen
chr7_-_92301147 1.758 NM_001259
CDK6
cyclin-dependent kinase 6
chr3_+_8518508 1.754 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr17_+_3326045 1.726 NM_000049
ASPA
aspartoacylase
chr10_+_91051685 1.687 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr4_+_37569093 1.636 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr11_+_71388310 1.631 NM_001145057
IL18BP
interleukin 18 binding protein
chr1_-_142536082 1.591


chr19_-_18058632 1.557 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr5_+_49998528 1.552 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr13_+_107720475 1.531 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr11_+_71388619 1.520 NM_001145055
IL18BP
interleukin 18 binding protein
chr16_-_71650034 1.509 NM_001164766
ZFHX3
zinc finger homeobox 3
chr1_+_32438788 1.492 NM_024296
CCDC28B
coiled-coil domain containing 28B
chr11_-_786175 1.488 NM_024698
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr3_+_8518539 1.470 LMCD1
LIM and cysteine-rich domains 1
chr6_+_32919873 1.408


chr3_-_8518327 1.391 LOC100288428
hypothetical LOC100288428
chr1_-_152847256 1.380 ADAR
adenosine deaminase, RNA-specific
chr14_+_23982017 1.362


chr14_-_68329407 1.335 NM_004926
ZFP36L1
zinc finger protein 36, C3H type-like 1
chr15_-_78050515 1.316 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr12_+_25096472 1.310 NM_006152
LRMP
lymphoid-restricted membrane protein
chr3_-_11598829 1.309 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr3_+_51952326 1.283 PARP3
poly (ADP-ribose) polymerase family, member 3
chr17_+_75851984 1.231


chr2_-_19421852 1.230 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr6_+_167445284 1.229 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr17_-_78000890 1.206 NM_001193655
C17orf62
chromosome 17 open reading frame 62
chr11_+_58668827 1.201 NM_022074
NM_198847
FAM111A

family with sequence similarity 111, member A

chr3_+_51951314 1.197 NM_001003931
NM_005485
PARP3

poly (ADP-ribose) polymerase family, member 3

chr10_-_13789628 1.185 FRMD4A
FERM domain containing 4A
chr21_+_42807052 1.174 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr19_-_52427698 1.129 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr6_+_126282078 1.125 NCOA7
nuclear receptor coactivator 7
chr1_-_146398501 1.124 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr19_+_54669283 1.123 NM_001459
FLT3LG
fms-related tyrosine kinase 3 ligand
chr11_-_4371463 1.084 NM_003141
TRIM21
tripartite motif containing 21
chr11_-_85108030 1.083 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr17_+_38412267 1.056 NM_005533
IFI35
interferon-induced protein 35
chr14_-_23685629 1.042 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr1_-_143232464 0.997


chr19_-_23370066 0.985 NM_003430
ZNF91
zinc finger protein 91
chr11_-_5662762 0.970 NM_033034
NM_033092
NM_033093
TRIM5


tripartite motif containing 5


chr1_-_152847301 0.961 NM_001111
NM_015840
NM_015841
ADAR


adenosine deaminase, RNA-specific


chr14_-_23981493 0.933 NM_020195
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr14_-_68332942 0.928 NM_207442
C14orf181
chromosome 14 open reading frame 181
chr3_+_69998064 0.925 NM_198177
MITF
microphthalmia-associated transcription factor
chr3_-_189354510 0.922 LOC339929
hypothetical LOC339929
chr20_+_56904042 0.920 GNAS
GNAS complex locus
chr22_+_37802955 0.903 NM_021822
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr11_-_104411065 0.899 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr11_+_93501791 0.877 PANX1
pannexin 1
chr7_+_128367961 0.868 NM_001098627
IRF5
interferon regulatory factor 5
chr3_+_189354167 0.864 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr7_-_86686754 0.856 NM_024315
C7orf23
chromosome 7 open reading frame 23
chr6_+_30018287 0.856 NM_002116
HLA-A
major histocompatibility complex, class I, A
chr9_+_108665168 0.845 NM_021224
ZNF462
zinc finger protein 462
chr9_+_136673464 0.818 NM_000093
COL5A1
collagen, type V, alpha 1
chrX_+_102770303 0.816 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chr2_-_191587128 0.798 STAT1
signal transducer and activator of transcription 1, 91kDa
chr19_+_54669629 0.791 FLT3LG
fms-related tyrosine kinase 3 ligand
chr11_+_93501811 0.789 PANX1
pannexin 1
chr11_-_58099884 0.782 NM_004811
LPXN
leupaxin
chr1_-_142535878 0.781 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr1_-_219982016 0.777 DUSP10
dual specificity phosphatase 10
chr1_-_242073094 0.758 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr6_-_32920167 0.748 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr15_+_68971835 0.741 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr11_-_85015961 0.737 NM_001142699
DLG2
discs, large homolog 2 (Drosophila)
chr22_+_37747063 0.728 NM_152426
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr4_-_153523113 0.712 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr1_-_219982049 0.674 DUSP10
dual specificity phosphatase 10
chr6_-_25044156 0.672 FAM65B
family with sequence similarity 65, member B
chr4_-_185632610 0.670 NM_002199
IRF2
interferon regulatory factor 2
chr22_+_37766554 0.665 NM_001006666
NM_145298
APOBEC3F

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F

chr11_+_93501708 0.628 NM_015368
PANX1
pannexin 1
chr1_+_149638633 0.615 NM_002796
PSMB4
proteasome (prosome, macropain) subunit, beta type, 4
chr1_+_158063102 0.612 NM_020125
SLAMF8
SLAM family member 8
chr8_+_97575052 0.607 NM_002998
SDC2
syndecan 2
chr5_+_96237399 0.601 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr8_+_143805595 0.600 NM_016647
C8orf55
chromosome 8 open reading frame 55
chr1_-_143232526 0.597 FAM91A2
family with sequence similarity 91, member A2
chr1_-_7998265 0.594 ERRFI1
ERBB receptor feedback inhibitor 1
chr17_-_5078773 0.584 NM_207103
C17orf87
chromosome 17 open reading frame 87
chr1_-_197173159 0.567 LOC100131234
familial acute myelogenous leukemia related factor
chr12_+_100795480 0.563 DRAM1
DNA-damage regulated autophagy modulator 1
chr9_+_96806235 0.563 C9orf3
chromosome 9 open reading frame 3
chr1_+_220884257 0.548 MIA3
melanoma inhibitory activity family, member 3
chr20_+_56903595 0.547 GNAS
GNAS complex locus
chr8_+_97575071 0.541 SDC2
syndecan 2
chr1_-_219982081 0.534 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr4_-_48477021 0.528 FRYL
FRY-like
chr2_+_230798687 0.518 NM_001005176
NM_007237
SP140

SP140 nuclear body protein

chrX_+_102770547 0.512 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr12_+_100795213 0.500 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr1_-_146543016 0.497


chr4_+_187227302 0.496 NM_003265
TLR3
toll-like receptor 3
chr4_-_48477038 0.486 NM_015030
FRYL
FRY-like
chr9_+_111582317 0.484 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr8_-_143805371 0.480 LOC100288181
hypothetical LOC100288181
chr15_+_65245546 0.470 NM_001145104
SMAD3
SMAD family member 3
chr8_+_97575196 0.460 SDC2
syndecan 2
chr2_+_3605611 0.460 RPS7
ribosomal protein S7
chr8_-_42184350 0.457 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr2_-_202216451 0.452 NM_001044385
ALS2CR4
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4
chr12_+_120055013 0.447 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr12_-_47605478 0.447 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr8_-_41641881 0.446 NM_001142445
NM_020478
NM_020480
ANK1


ankyrin 1, erythrocytic


chr8_-_23596346 0.442 NM_006167
NKX3-1
NK3 homeobox 1
chr16_-_66528152 0.435 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr8_+_97575244 0.431 SDC2
syndecan 2
chr11_+_64946848 0.429


chr12_-_55791202 0.424 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr14_+_23771464 0.413 NM_001002000
NM_001002001
GMPR2

guanosine monophosphate reductase 2

chr6_+_26070957 0.412 NM_006355
TRIM38
tripartite motif containing 38
chr11_+_64946820 0.410 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr9_-_8723893 0.408 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr22_-_30018329 0.406 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr10_+_69539255 0.404 NM_032578
MYPN
myopalladin
chr2_-_230798687 0.404 NM_001185015
SP110
SP110 nuclear body protein
chr3_-_113495763 0.399 NM_183061
SLC9A10
solute carrier family 9, member 10
chr5_-_37220702 0.397 C5orf42
chromosome 5 open reading frame 42
chr12_-_56159895 0.389 NM_032496
ARHGAP9
Rho GTPase activating protein 9
chr1_-_143232275 0.372 LOC728855
hypothetical LOC728855
chr7_+_134114957 0.369 CALD1
caldesmon 1
chrX_-_62921937 0.357 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr10_-_27569269 0.347 NM_145698
ACBD5
acyl-CoA binding domain containing 5
chr7_-_132371208 0.338 EEF1G
eukaryotic translation elongation factor 1 gamma
chr8_+_134272463 0.318 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr7_+_134114701 0.316 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr12_-_55791388 0.316 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr10_+_122600843 0.314 WDR11
WD repeat domain 11
chr1_-_143232344 0.312 LOC728855
hypothetical LOC728855
chr13_-_109600709 0.311 COL4A1
collagen, type IV, alpha 1
chr13_+_30207690 0.308 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr8_-_23768242 0.296 NM_003155
STC1
stanniocalcin 1
chr7_-_158304062 0.295 ESYT2
extended synaptotagmin-like protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
12.91 7.34e-07 GO:0060337 type I interferon-mediated signaling pathway
12.91 7.34e-07 GO:0071357 cellular response to type I interferon
12.71 8.78e-07 GO:0034340 response to type I interferon
3.38 1.46e-06 GO:0006955 immune response
5.71 2.32e-05 GO:0071345 cellular response to cytokine stimulus
2.59 2.41e-05 GO:0002376 immune system process
5.94 3.87e-05 GO:0019221 cytokine-mediated signaling pathway
4.21 6.86e-05 GO:0045087 innate immune response
6.15 2.15e-04 GO:0009615 response to virus
2.75 1.27e-03 GO:0006952 defense response
4.12 2.00e-03 GO:0034097 response to cytokine stimulus
2.61 2.24e-03 GO:0051704 multi-organism process
2.75 1.82e-02 GO:0071310 cellular response to organic substance
3.26 2.13e-02 GO:0051707 response to other organism
2.65 2.18e-02 GO:0002682 regulation of immune system process
1.76 2.20e-02 GO:0048522 positive regulation of cellular process
2.40 2.34e-02 GO:0010605 negative regulation of macromolecule metabolic process
6.77 2.49e-02 GO:0030330 DNA damage response, signal transduction by p53 class mediator
2.45 3.38e-02 GO:0006508 proteolysis
1.74 3.85e-02 GO:0006950 response to stress

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
8.09 3.80e-03 GO:0000502 proteasome complex
14.56 2.24e-02 GO:0005839 proteasome core complex

Nothing significant found in function category.