Motif ID: NFIX.p2

Z-value: 2.565


Transcription factors associated with NFIX.p2:

Gene SymbolEntrez IDGene Name
NFIX 4784 nuclear factor I/X (CCAAT-binding transcription factor)



Activity profile for motif NFIX.p2.

activity profile for motif NFIX.p2


Sorted Z-values histogram for motif NFIX.p2

Sorted Z-values for motif NFIX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_150232900 4.392 S100A10
S100 calcium binding protein A10
chr1_-_150232927 4.330 S100A10
S100 calcium binding protein A10
chr1_-_150233337 4.299 NM_002966
S100A10
S100 calcium binding protein A10
chr14_+_51025604 3.653 NM_001042481
FRMD6
FERM domain containing 6
chr21_+_32706615 3.601 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr10_+_88718167 3.327 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr5_+_148941228 2.947 NM_001001669
ARHGEF37
Rho guanine nucleotide exchange factor (GEF) 37
chr9_-_21549696 2.792 LOC554202
hypothetical LOC554202
chr17_-_68100537 2.691 LOC100499467
hypothetical LOC100499467
chr9_-_25668230 2.653 TUSC1
tumor suppressor candidate 1
chr6_+_30959839 2.546 NM_001954
DDR1
discoidin domain receptor tyrosine kinase 1
chr22_+_44828338 2.409


chr4_+_146622154 2.351 NM_005900
SMAD1
SMAD family member 1
chr1_-_205272619 2.334 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr4_-_99798563 2.281 NM_005723
TSPAN5
tetraspanin 5
chr1_+_891739 2.263 NM_001160184
NM_032129
PLEKHN1

pleckstrin homology domain containing, family N member 1

chr21_-_43671355 2.249 NM_173354
SIK1
salt-inducible kinase 1
chr9_+_77695334 2.235 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr3_-_46710137 2.234 NM_001190707
NM_147129
ALS2CL

ALS2 C-terminal like

chr7_-_80386602 2.197 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr14_-_104507862 2.188 AHNAK2
AHNAK nucleoprotein 2
chr10_+_102782151 2.171 SFXN3
sideroflexin 3
chr19_+_45807909 2.105


chr2_+_241023703 2.103 NM_002081
GPC1
glypican 1
chr10_+_17312654 2.097 VIM
vimentin
chr1_+_20788027 2.070 NM_001785
CDA
cytidine deaminase
chr2_+_241023880 2.056


chr7_-_80386258 2.015 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr3_-_197103848 1.924 TNK2
tyrosine kinase, non-receptor, 2
chr15_-_29070909 1.891 NM_017762
MTMR10
myotubularin related protein 10
chr17_+_72795567 1.846 NM_001113492
SEPT9
septin 9
chr5_-_169340321 1.829 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr10_-_105982052 1.809 NM_025145
WDR96
WD repeat domain 96
chr3_-_41978464 1.795 NM_017886
ULK4
unc-51-like kinase 4 (C. elegans)
chr15_+_61123327 1.794 TPM1
tropomyosin 1 (alpha)
chr12_+_81604752 1.760 TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr20_+_17498507 1.693 NM_001011546
NM_006870
DSTN

destrin (actin depolymerizing factor)

chr1_+_63832067 1.688 NM_001172819
PGM1
phosphoglucomutase 1
chr3_+_191714533 1.672 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr4_-_177353707 1.656 NM_144644
SPATA4
spermatogenesis associated 4
chr5_+_178919298 1.653 NM_001040451
NM_001040452
RUFY1

RUN and FYVE domain containing 1

chr1_+_208569262 1.626 NM_001170580
HHAT
hedgehog acyltransferase
chr12_+_62523648 1.603


chr12_+_26239755 1.595 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr17_-_5428491 1.576 NM_001033053
NM_014922
NM_033004
NM_033006
NM_033007
NLRP1




NLR family, pyrin domain containing 1




chr17_-_25112393 1.575 SSH2
slingshot homolog 2 (Drosophila)
chr1_-_206484258 1.573 NM_025179
PLXNA2
plexin A2
chr2_-_162883062 1.533 NM_022168
IFIH1
interferon induced with helicase C domain 1
chr12_+_81605032 1.512 NM_152588
TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr11_+_112690460 1.496 NM_017868
TTC12
tetratricopeptide repeat domain 12
chr16_+_65765256 1.476 NM_003946
NM_001185057
NOL3

nucleolar protein 3 (apoptosis repressor with CARD domain)

chr5_+_96024434 1.474 CAST
calpastatin
chr6_+_3696224 1.471


chr21_-_27139563 1.444 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr12_+_26239535 1.438 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr7_+_24579239 1.417 NM_016447
MPP6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr1_+_208568811 1.407 NM_001170587
NM_001170588
NM_018194
HHAT


hedgehog acyltransferase


chr12_+_54612055 1.380 NM_201444
NM_201445
NM_201554
DGKA


diacylglycerol kinase, alpha 80kDa


chr1_+_31658549 1.374 NM_178865
SERINC2
serine incorporator 2
chr8_-_41286088 1.371 NM_003012
SFRP1
secreted frizzled-related protein 1
chr22_+_29974368 1.368 LIMK2
LIM domain kinase 2
chr9_-_25668855 1.364 NM_001004125
TUSC1
tumor suppressor candidate 1
chr10_+_17311788 1.352 VIM
vimentin
chr10_+_17311962 1.343 VIM
vimentin
chr17_+_35587767 1.342 NM_016339
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr10_-_17311961 1.325


chr7_+_65307816 1.324 TPST1
tyrosylprotein sulfotransferase 1
chr8_-_33544184 1.311 NM_024787
RNF122
ring finger protein 122
chr9_+_70926205 1.303 TJP2
tight junction protein 2 (zona occludens 2)
chr1_+_31659246 1.292 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr14_-_99842519 1.257 NM_001039355
SLC25A29
solute carrier family 25, member 29
chr6_-_26125939 1.257 NM_005325
HIST1H1A
histone cluster 1, H1a
chr9_+_111850770 1.251 AKAP2
A kinase (PRKA) anchor protein 2
chr3_+_185762233 1.244 NM_004443
EPHB3
EPH receptor B3
chr10_+_124210980 1.232 NM_002775
HTRA1
HtrA serine peptidase 1
chr12_+_6179736 1.226 NM_001769
CD9
CD9 molecule
chr5_-_156935283 1.208


chr2_+_37425240 1.204 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr1_+_43769065 1.204 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr8_-_119192985 1.181 NM_000127
EXT1
exostosin 1
chr3_+_32408346 1.180 CMTM7
CKLF-like MARVEL transmembrane domain containing 7
chr9_+_70926009 1.175 NM_001170414
TJP2
tight junction protein 2 (zona occludens 2)
chr3_+_32408155 1.167 NM_138410
NM_181472
CMTM7

CKLF-like MARVEL transmembrane domain containing 7

chr16_+_3010311 1.164 NM_016639
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr9_+_111582317 1.157 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr6_+_53767251 1.150 LRRC1
leucine rich repeat containing 1
chr3_-_28365510 1.146 NM_001134432
NM_001134433
NM_022461
AZI2


5-azacytidine induced 2


chr4_-_83938920 1.146 NM_001037582
NM_024906
SCD5

stearoyl-CoA desaturase 5

chr22_+_38720881 1.128 NM_138435
FAM83F
family with sequence similarity 83, member F
chr9_+_111850698 1.127 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr10_+_73393998 1.125 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr1_-_23393808 1.106 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr20_-_42272709 1.076 C20orf111
chromosome 20 open reading frame 111
chr9_+_114953048 1.071 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr11_+_93501811 1.068 PANX1
pannexin 1
chr9_-_73573121 1.063 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr11_+_34599227 1.060 EHF
ets homologous factor
chr13_-_76358370 1.056 KCTD12
potassium channel tetramerisation domain containing 12
chr6_-_109437445 1.054 SESN1
sestrin 1
chr11_-_118286822 1.052 NM_182557
BCL9L
B-cell CLL/lymphoma 9-like
chr1_+_199975674 1.051 NAV1
neuron navigator 1
chr7_+_65307691 1.042 NM_003596
TPST1
tyrosylprotein sulfotransferase 1
chr9_+_123070191 1.038 NM_001127662
NM_001127663
NM_001127664
NM_001127665
NM_001127666
NM_001127667
NM_198252
GSN






gelsolin






chr12_+_106236281 1.031 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr19_+_34848166 1.019 NM_024310
PLEKHF1
pleckstrin homology domain containing, family F (with FYVE domain) member 1
chr4_+_186554958 1.015 ANKRD37
ankyrin repeat domain 37
chr1_+_199975563 1.013 NM_001167738
NAV1
neuron navigator 1
chr4_+_14614462 1.012 CPEB2
cytoplasmic polyadenylation element binding protein 2
chr5_-_156935317 1.010 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr9_+_123070276 0.996 GSN
gelsolin
chr15_+_61122957 0.994 TPM1
tropomyosin 1 (alpha)
chr12_+_74160779 0.987 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr6_+_86216020 0.986 NM_002526
NT5E
5'-nucleotidase, ecto (CD73)
chr15_-_58477407 0.972 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr4_+_166097548 0.972 NM_153027
C4orf39
chromosome 4 open reading frame 39
chr22_+_29974314 0.959 NM_001031801
NM_016733
LIMK2

LIM domain kinase 2

chr8_+_79740813 0.943 NM_016010
FAM164A
family with sequence similarity 164, member A
chr19_+_34848214 0.940 PLEKHF1
pleckstrin homology domain containing, family F (with FYVE domain) member 1
chr8_+_143778529 0.935 NM_001160354
NM_001160355
NM_017527
LY6K


lymphocyte antigen 6 complex, locus K


chr12_+_54611212 0.932 NM_001345
DGKA
diacylglycerol kinase, alpha 80kDa
chr21_-_27139143 0.926 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr1_-_6243621 0.924 NM_207370
GPR153
G protein-coupled receptor 153
chr2_-_105381855 0.920 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr20_-_42272837 0.919 NM_016470
C20orf111
chromosome 20 open reading frame 111
chr13_-_76358433 0.912 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr13_-_100866839 0.911 NALCN
sodium leak channel, non-selective
chr20_+_42273013 0.907 LOC100505783
hypothetical LOC100505783
chr4_+_186554886 0.901 ANKRD37
ankyrin repeat domain 37
chr9_-_112840801 0.900 LPAR1
lysophosphatidic acid receptor 1
chr10_-_101759630 0.896 NM_015221
DNMBP
dynamin binding protein
chr10_+_124211353 0.893 HTRA1
HtrA serine peptidase 1
chr1_+_148521852 0.890 NM_144697
C1orf51
chromosome 1 open reading frame 51
chrX_-_68301974 0.889 NM_001032396
NM_022368
NM_145119
PJA1


praja ring finger 1


chr2_-_40532651 0.883 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr3_-_28365284 0.879 AZI2
5-azacytidine induced 2
chr4_+_166097579 0.876 C4orf39
chromosome 4 open reading frame 39
chr6_-_109868400 0.876 PPIL6
peptidylprolyl isomerase (cyclophilin)-like 6
chr4_-_75938710 0.875 NM_001729
BTC
betacellulin
chr4_+_152549776 0.875 NM_001109977
FAM160A1
family with sequence similarity 160, member A1
chr10_-_123346148 0.874 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr1_-_72520735 0.873 NM_173808
NEGR1
neuronal growth regulator 1
chr4_+_186554831 0.872 NM_181726
ANKRD37
ankyrin repeat domain 37
chr9_+_123070234 0.870 GSN
gelsolin
chr5_+_135496437 0.853 SMAD5
SMAD family member 5
chr1_-_94779727 0.851 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr1_-_112083387 0.846 NM_019099
C1orf183
chromosome 1 open reading frame 183
chr1_+_24701886 0.844 NM_013441
RCAN3
RCAN family member 3
chr5_+_135496421 0.838 NM_001001419
NM_001001420
NM_005903
SMAD5


SMAD family member 5


chr9_-_83493415 0.834 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr11_+_27019084 0.833 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr9_+_5440455 0.828 NM_014143
CD274
CD274 molecule
chr13_-_100866706 0.815 NM_052867
NALCN
sodium leak channel, non-selective
chr11_+_93501791 0.813 PANX1
pannexin 1
chr15_+_81275383 0.812 WHAMM
WAS protein homolog associated with actin, golgi membranes and microtubules
chr3_-_162305319 0.811 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr2_+_241023908 0.807 GPC1
glypican 1
chr3_+_132228383 0.803 NM_001146003
NM_024800
NM_145910
NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr2_-_127694123 0.790 CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr6_+_86216457 0.788 NT5E
5'-nucleotidase, ecto (CD73)
chr6_+_109868580 0.784 NM_003080
SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr15_-_68971665 0.782 NM_020147
THAP10
THAP domain containing 10
chr8_-_7200278 0.772 FAM66B
family with sequence similarity 66, member B
chr14_+_58174489 0.763 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr11_+_122258600 0.760 NM_024806
NM_199124
C11orf63

chromosome 11 open reading frame 63

chr4_+_77446700 0.759 NM_003943
STBD1
starch binding domain 1
chr6_+_109868736 0.756 SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr8_-_54918325 0.755 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr4_-_76774594 0.748 NM_003948
CDKL2
cyclin-dependent kinase-like 2 (CDC2-related kinase)
chr19_-_19599973 0.744 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr15_-_76890626 0.743 NM_014272
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr10_-_15170779 0.742 NM_001039844
ACBD7
acyl-CoA binding domain containing 7
chr11_-_110888273 0.740 NM_017589
BTG4
B-cell translocation gene 4
chr15_+_38849450 0.734 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr11_+_93501708 0.728 NM_015368
PANX1
pannexin 1
chrX_-_101658297 0.726 NM_021992
TMSB15A
TMSB15B
thymosin beta 15a
thymosin beta 15B
chr5_+_34692239 0.720 RAI14
retinoic acid induced 14
chr6_+_109437599 0.717


chr1_-_151855413 0.712 NM_020672
S100A14
S100 calcium binding protein A14
chr10_+_134972902 0.712


chr6_-_109869066 0.709 NM_001111298
NM_173672
PPIL6

peptidylprolyl isomerase (cyclophilin)-like 6

chr8_-_54918099 0.694 NM_213620
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr5_+_34692352 0.693 NM_001145520
RAI14
retinoic acid induced 14
chr9_-_32516164 0.690 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr4_+_47713532 0.680 NM_207330
NIPAL1
NIPA-like domain containing 1
chr12_+_32151351 0.680 NM_001003398
NM_001714
BICD1

bicaudal D homolog 1 (Drosophila)

chr9_+_114953087 0.680 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr16_-_1600654 0.678 IFT140
intraflagellar transport 140 homolog (Chlamydomonas)
chr4_+_120167264 0.669 SYNPO2
synaptopodin 2
chr8_-_54918369 0.666 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr13_-_41433118 0.666 NM_001009814
NM_015058
KIAA0564

KIAA0564

chr4_+_89597257 0.665 NM_016323
HERC5
hect domain and RLD 5
chr1_+_67923331 0.662 NM_001924
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr5_+_141468498 0.655 NM_030571
NDFIP1
Nedd4 family interacting protein 1
chr14_+_104785898 0.654 NM_033271
BTBD6
BTB (POZ) domain containing 6
chr12_+_732992 0.647 WNK1
WNK lysine deficient protein kinase 1
chr16_-_22293097 0.644 NM_001802
CDR2
cerebellar degeneration-related protein 2, 62kDa
chr4_-_143987053 0.644 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr9_+_115382760 0.641 NM_021106
RGS3
regulator of G-protein signaling 3
chr17_+_21128625 0.639 MAP2K3
mitogen-activated protein kinase kinase 3
chr4_+_75699652 0.635 NM_001657
AREG
amphiregulin

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.14 5.19e-04 GO:0005737 cytoplasm
1.16 1.02e-02 GO:0044444 cytoplasmic part
1.08 2.83e-02 GO:0044424 intracellular part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.73 6.62e-03 GO:0008092 cytoskeletal protein binding