Motif ID: TFEB.p2

Z-value: 2.501


Transcription factors associated with TFEB.p2:

Gene SymbolEntrez IDGene Name
TFEB 7942 transcription factor EB



Activity profile for motif TFEB.p2.

activity profile for motif TFEB.p2


Sorted Z-values histogram for motif TFEB.p2

Sorted Z-values for motif TFEB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFEB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_27162688 6.642 NM_006896
HOXA7
homeobox A7
chr5_+_34692124 6.034 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr5_+_34692239 4.999 RAI14
retinoic acid induced 14
chr5_+_34692352 4.893 NM_001145520
RAI14
retinoic acid induced 14
chr15_-_71712711 4.571 NM_001161363
NM_001161364
NM_012428
NM_017455
NPTN



neuroplastin



chr3_-_172109119 4.205 NM_020390
EIF5A2
eukaryotic translation initiation factor 5A2
chr3_-_172109075 3.742 EIF5A2
eukaryotic translation initiation factor 5A2
chr13_-_20533703 3.735 NM_014572
LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr13_+_112999462 3.593 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chr6_+_87921980 3.509 NM_015021
ZNF292
zinc finger protein 292
chr11_+_120399966 3.494 NM_001130047
NM_152715
TBCEL

tubulin folding cofactor E-like

chr13_-_109236897 3.460 NM_003749
IRS2
insulin receptor substrate 2
chr13_-_20533629 3.338 LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr12_+_52653176 3.204 NM_014212
HOXC11
homeobox C11
chr11_-_8849485 3.147 ST5
suppression of tumorigenicity 5
chr3_+_33293915 3.136 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr1_+_148521852 3.123 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr2_+_85834111 3.113 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr16_+_28893525 3.052 NM_001142448
NM_001142449
NM_001142450
NM_001142451
NM_032038
SPIN1
SPNS1




spindlin 1
spinster homolog 1 (Drosophila)




chr13_+_112999538 3.028 LAMP1
lysosomal-associated membrane protein 1
chr22_+_36928972 3.018 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr2_+_223625105 3.013 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr9_-_16860719 2.990 NM_017637
BNC2
basonuclin 2
chr15_-_38000379 2.947 NM_007223
GPR176
G protein-coupled receptor 176
chrX_-_34585287 2.917 NM_031442
TMEM47
transmembrane protein 47
chr15_-_71712605 2.910 NPTN
neuroplastin
chr1_-_152459667 2.899 C1orf43
chromosome 1 open reading frame 43
chrX_-_114703273 2.883


chr7_+_27102197 2.866


chr11_-_47427263 2.815 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr3_+_129927723 2.813 RAB7A
RAB7A, member RAS oncogene family
chr16_+_31132842 2.786 NM_001008274
TRIM72
tripartite motif containing 72
chr1_+_216585298 2.771 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr7_-_47588652 2.697 TNS3
tensin 3
chr13_-_35818603 2.682 NM_001142296
NM_015087
SPG20

spastic paraplegia 20 (Troyer syndrome)

chr1_-_151775221 2.669 NM_014624
S100A6
S100 calcium binding protein A6
chr11_+_101485946 2.660 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr1_-_68470585 2.657 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr3_+_129927726 2.636 RAB7A
RAB7A, member RAS oncogene family
chrX_+_100692071 2.615 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr2_-_183611470 2.604 NM_013436
NM_205842
NCKAP1

NCK-associated protein 1

chr11_+_119701047 2.567 NM_001198670
NM_001198671
NM_001198672
NM_001198673
NM_001198674
NM_001198675
NM_174926
TMEM136






transmembrane protein 136






chr1_-_152459506 2.555 C1orf43
chromosome 1 open reading frame 43
chr3_+_129927716 2.534 RAB7A
RAB7A, member RAS oncogene family
chr1_+_68070573 2.504


chr10_-_32257693 2.491 ARHGAP12
Rho GTPase activating protein 12
chr3_+_129927714 2.491 RAB7A
RAB7A, member RAS oncogene family
chr11_+_32993973 2.483 NM_001077242
DEPDC7
DEP domain containing 7
chr4_+_128773529 2.476 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr16_-_69277355 2.474 NM_138383
MTSS1L
metastasis suppressor 1-like
chr3_+_114948550 2.451 NM_001690
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr9_-_72218098 2.439 KLF9
Kruppel-like factor 9
chr7_+_27102508 2.435


chr3_+_129927668 2.418 NM_004637
RAB7A
RAB7A, member RAS oncogene family
chr3_+_51403760 2.412 NM_013286
RBM15B
RNA binding motif protein 15B
chr22_+_34107051 2.400 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr13_-_73605914 2.396 NM_007249
KLF12
Kruppel-like factor 12
chr22_+_34107087 2.395 HMOX1
heme oxygenase (decycling) 1
chr7_-_6278662 2.393 NM_004227
CYTH3
cytohesin 3
chr17_-_35510431 2.388 NM_021724
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr7_+_27191534 2.378 HOXA11-AS1
HOXA11 antisense RNA 1 (non-protein coding)
chr7_+_28415495 2.366 LOC401317
hypothetical LOC401317
chr17_+_17816851 2.315 NM_001130090
NM_001130091
NM_001130092
NM_031294
LRRC48



leucine rich repeat containing 48



chr7_-_47588160 2.312 TNS3
tensin 3
chr6_-_33822659 2.308 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr5_+_72957736 2.306 NM_001080479
NM_001177693
RGNEF

190 kDa guanine nucleotide exchange factor

chr1_-_197173159 2.278 LOC100131234
familial acute myelogenous leukemia related factor
chr7_+_17304707 2.278 NM_001621
AHR
aryl hydrocarbon receptor
chr17_-_35510074 2.272 NR1D1
nuclear receptor subfamily 1, group D, member 1
chr5_-_172687798 2.264 STC2
stanniocalcin 2
chr4_+_120167721 2.252 SYNPO2
synaptopodin 2
chrX_+_102749489 2.243 NM_001006933
NM_032926
TCEAL3

transcription elongation factor A (SII)-like 3

chr14_-_91642703 2.214 NM_001127696
NM_001127697
NM_001164774
NM_001164776
NM_001164777
NM_001164778
NM_001164779
NM_001164780
NM_001164781
NM_001164782
NM_004993
NM_030660
ATXN3











ataxin 3











chr7_-_27102049 2.213 NM_005522
NM_153620
HOXA1

homeobox A1

chr3_-_188946168 2.202 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr1_-_94475840 2.188 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr18_+_75967902 2.180 NM_014913
ADNP2
ADNP homeobox 2
chr2_-_196744546 2.176 NM_004226
STK17B
serine/threonine kinase 17b
chr1_-_31618405 2.163 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr7_-_27171648 2.126 HOXA9
homeobox A9
chr9_-_16860664 2.121 BNC2
basonuclin 2
chr7_-_47588266 2.111 TNS3
tensin 3
chr16_-_4837266 2.107 NM_032569
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr8_+_26296439 2.093 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr3_-_45858566 2.086 NM_020347
LZTFL1
leucine zipper transcription factor-like 1
chr7_+_4781784 2.077 NM_014855
KIAA0415
KIAA0415
chr17_-_44043361 2.072 NM_004502
HOXB7
homeobox B7
chr12_-_54409107 2.058 NM_001040034
NM_001780
CD63

CD63 molecule

chr7_-_27191287 2.049 NM_005523
HOXA11
homeobox A11
chr7_-_27171673 2.043 NM_152739
HOXA9
homeobox A9
chr2_+_187266899 2.031 NM_177454
FAM171B
family with sequence similarity 171, member B
chr7_-_27171600 2.028 HOXA9
homeobox A9
chr20_-_13567529 2.024 NM_017714
TASP1
taspase, threonine aspartase, 1
chr16_+_2510323 2.016 NM_001145815
NM_015944
AMDHD2

amidohydrolase domain containing 2

chr17_-_44026042 2.010 NM_002147
HOXB5
homeobox B5
chr11_+_119701214 2.009 TMEM136
transmembrane protein 136
chr9_-_122516399 2.008 NM_001080497
MEGF9
multiple EGF-like-domains 9
chrX_+_101862297 2.000 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr2_-_196744507 1.995 STK17B
serine/threonine kinase 17b
chr13_-_35818491 1.995 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr1_-_184916044 1.982 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr10_-_32257768 1.980 NM_018287
ARHGAP12
Rho GTPase activating protein 12
chr1_-_151775119 1.978 S100A6
S100 calcium binding protein A6
chr1_-_151775087 1.974 S100A6
S100 calcium binding protein A6
chr8_+_1759502 1.961 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr16_+_30952382 1.951 NM_004604
STX4
syntaxin 4
chr5_-_131160589 1.950 FNIP1
folliculin interacting protein 1
chr18_+_12397894 1.927 NM_001142405
NM_006553
SLMO1

slowmo homolog 1 (Drosophila)

chr16_-_57276108 1.921 NM_018231
SLC38A7
solute carrier family 38, member 7
chr5_-_72780107 1.910 NM_004472
FOXD1
forkhead box D1
chr12_+_52618815 1.894 NM_017410
HOXC13
homeobox C13
chr18_+_9126742 1.890 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr9_+_114953087 1.884 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr8_+_133856738 1.876 NM_016018
NM_032205
NM_198513
PHF20L1


PHD finger protein 20-like 1


chr12_+_54396099 1.867 BLOC1S1-RDH5
BLOC1S1
BLOC1S1-RDH5 read-through transcript
biogenesis of lysosomal organelles complex-1, subunit 1
chr20_+_43953606 1.863 CTSA
cathepsin A
chr19_+_45546369 1.855 PLD3
phospholipase D family, member 3
chr14_-_91642641 1.855 ATXN3
ATXN8
ataxin 3
ataxin 8
chr3_-_11736946 1.835 NM_014667
VGLL4
vestigial like 4 (Drosophila)
chr12_+_120840829 1.832 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr13_-_35818396 1.825 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr17_-_44043278 1.825 HOXB7
homeobox B7
chr19_+_10625896 1.819 NM_001137673
NM_004516
NM_012218
NM_017620
NM_153464
ILF3




interleukin enhancer binding factor 3, 90kDa




chr12_+_54396086 1.815 NM_001487
BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr1_+_201364050 1.814 ADORA1
adenosine A1 receptor
chr3_+_160002605 1.809 MFSD1
major facilitator superfamily domain containing 1
chr5_+_52812165 1.808 FST
follistatin
chr3_-_188945921 1.781 BCL6
B-cell CLL/lymphoma 6
chrX_-_106846924 1.780 NM_004089
TSC22D3
TSC22 domain family, member 3
chr12_-_54409059 1.772 CD63
CD63 molecule
chr13_-_49597776 1.768 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr7_-_27149750 1.767 NM_019102
HOXA5
homeobox A5
chr8_+_98857190 1.767 LAPTM4B
lysosomal protein transmembrane 4 beta
chr19_-_10625449 1.762 LOC147727
hypothetical LOC147727
chr1_+_11788827 1.760 CLCN6
chloride channel 6
chrX_+_102518064 1.759 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr5_-_131160614 1.759 NM_001008738
NM_133372
FNIP1

folliculin interacting protein 1

chr13_-_95094920 1.757 NM_014934
NM_198968
DZIP1

DAZ interacting protein 1

chr2_-_183610992 1.754 NCKAP1
NCK-associated protein 1
chr16_+_30952350 1.753 STX4
syntaxin 4
chr17_+_75689955 1.744 GAA
glucosidase, alpha; acid
chr12_-_54409015 1.738 CD63
CD63 molecule
chr4_-_77354011 1.730 NM_005506
SCARB2
scavenger receptor class B, member 2
chr6_-_80713589 1.727 NM_022726
ELOVL4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chrX_+_49573952 1.724 NM_001127898
NM_001127899
CLCN5

chloride channel 5

chr13_-_49057629 1.701 RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr1_+_66772393 1.680 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr8_+_133856793 1.669 PHF20L1
PHD finger protein 20-like 1
chr17_-_43977273 1.667 NM_002145
HOXB2
homeobox B2
chr1_-_152459697 1.658 NM_001098616
NM_015449
NM_138740
C1orf43


chromosome 1 open reading frame 43


chr7_+_97748959 1.653 BRI3
brain protein I3
chr17_-_44022595 1.651 HOXB3
homeobox B3
chr18_+_54682261 1.647 ZNF532
zinc finger protein 532
chr9_+_114953048 1.644 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr17_-_17816425 1.639 NM_001033551
NM_001082968
TOM1L2

target of myb1-like 2 (chicken)

chr12_+_54396118 1.635 BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr3_+_134239860 1.635 NM_001136469
NM_023943
TMEM108

transmembrane protein 108

chr17_-_33043514 1.632 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr4_+_120167770 1.594 SYNPO2
synaptopodin 2
chr1_-_203557379 1.586 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr12_+_52665196 1.580 NM_017409
HOXC10
homeobox C10
chr11_-_85457736 1.579 PICALM
phosphatidylinositol binding clathrin assembly protein
chr1_-_33669190 1.573 PHC2
polyhomeotic homolog 2 (Drosophila)
chr7_-_139744725 1.569 NM_032295
NM_207113
SLC37A3

solute carrier family 37 (glycerol-3-phosphate transporter), member 3

chr3_+_160002571 1.563 MFSD1
major facilitator superfamily domain containing 1
chr4_-_77353972 1.563 SCARB2
scavenger receptor class B, member 2
chr20_+_43953372 1.561 CTSA
cathepsin A
chr7_+_4781803 1.557 KIAA0415
KIAA0415
chr20_-_43953036 1.557 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chr12_-_54409067 1.553 CD63
CD63 molecule
chr9_-_37566248 1.549 NM_012166
FBXO10
F-box protein 10
chr3_-_4483939 1.543 SUMF1
sulfatase modifying factor 1
chr1_-_94475504 1.530 ARHGAP29
Rho GTPase activating protein 29
chr6_-_84994032 1.527 NM_014895
KIAA1009
KIAA1009
chr5_-_131160608 1.520 FNIP1
folliculin interacting protein 1
chr2_-_227372574 1.515 IRS1
insulin receptor substrate 1
chrX_+_102498035 1.512 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr11_+_113815317 1.511 NM_015523
REXO2
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
chr5_+_52812236 1.511 NM_006350
NM_013409
FST

follistatin

chr14_-_54025414 1.502 GMFB
glia maturation factor, beta
chr3_+_134239906 1.499 TMEM108
transmembrane protein 108
chr16_-_65742323 1.493 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr1_+_109221271 1.489 GPSM2
G-protein signaling modulator 2
chr5_-_131160541 1.484 FNIP1
folliculin interacting protein 1
chr4_-_77353929 1.483 SCARB2
scavenger receptor class B, member 2
chr4_+_159909626 1.481 NM_020840
FNIP2
folliculin interacting protein 2
chr14_-_80757327 1.477 NM_201595
GTF2A1
general transcription factor IIA, 1, 19/37kDa
chr2_+_238060602 1.467 NM_001042467
NM_024101
MLPH

melanophilin

chr6_+_123152044 1.465 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr10_-_14090459 1.458 FRMD4A
FERM domain containing 4A
chr4_-_152901542 1.455 NM_004564
PET112L
PET112-like (yeast)
chr3_+_160002582 1.452 MFSD1
major facilitator superfamily domain containing 1
chr13_+_112999590 1.447 LAMP1
lysosomal-associated membrane protein 1
chr4_+_56414565 1.446 NM_001024924
NM_018261
NM_178237
EXOC1


exocyst complex component 1


chr3_+_4996141 1.445 BHLHE40
basic helix-loop-helix family, member e40
chr14_-_54025464 1.442 NM_004124
GMFB
glia maturation factor, beta
chr3_-_57653634 1.432 NM_152678
FAM116A
family with sequence similarity 116, member A
chr12_+_104025686 1.429


chr5_-_172130766 1.418 NM_004417
DUSP1
dual specificity phosphatase 1
chr7_-_13997389 1.409 NM_001163149
ETV1
ets variant 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
7.14 1.19e-03 GO:0015682 ferric iron transport
7.14 1.19e-03 GO:0033572 transferrin transport
1.73 3.61e-03 GO:0008104 protein localization
1.61 1.26e-02 GO:0033036 macromolecule localization
4.43 2.43e-02 GO:0048704 embryonic skeletal system morphogenesis
1.74 2.61e-02 GO:0015031 protein transport
1.59 3.00e-02 GO:0051641 cellular localization
3.80 3.10e-02 GO:0048706 embryonic skeletal system development
1.77 3.17e-02 GO:0046907 intracellular transport
1.71 4.53e-02 GO:0045184 establishment of protein localization
1.95 4.80e-02 GO:0034613 cellular protein localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.19 1.04e-09 GO:0005773 vacuole
1.15 1.18e-06 GO:0044424 intracellular part
1.21 1.31e-06 GO:0043227 membrane-bounded organelle
1.21 1.68e-06 GO:0043231 intracellular membrane-bounded organelle
2.94 2.21e-06 GO:0000323 lytic vacuole
2.94 2.21e-06 GO:0005764 lysosome
1.18 2.51e-06 GO:0043226 organelle
1.18 4.35e-06 GO:0043229 intracellular organelle
1.14 8.17e-06 GO:0005622 intracellular
3.41 2.53e-05 GO:0044437 vacuolar part
3.43 4.19e-05 GO:0005774 vacuolar membrane
2.19 3.28e-04 GO:0005768 endosome
1.24 1.79e-03 GO:0044422 organelle part
3.35 2.12e-03 GO:0005765 lysosomal membrane
1.24 2.80e-03 GO:0044446 intracellular organelle part
1.17 3.01e-03 GO:0005737 cytoplasm
2.98 4.23e-03 GO:0005769 early endosome
2.42 5.12e-03 GO:0010008 endosome membrane
1.21 5.79e-03 GO:0044444 cytoplasmic part
2.40 5.95e-03 GO:0044440 endosomal part
7.50 7.16e-03 GO:0033176 proton-transporting V-type ATPase complex
3.11 1.03e-02 GO:0005770 late endosome
4.02 1.17e-02 GO:0031902 late endosome membrane
1.22 1.24e-02 GO:0005634 nucleus
1.40 1.61e-02 GO:0044428 nuclear part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 5.81e-03 GO:0005515 protein binding
5.71 2.33e-02 GO:0019829 cation-transporting ATPase activity
1.72 4.93e-02 GO:0043565 sequence-specific DNA binding