Motif ID: EN1,2.p2

Z-value: 3.042


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2



Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_50318801 5.959 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr3_+_188197029 4.606


chr10_-_98021144 4.355 NM_001114094
NM_013314
BLNK

B-cell linker

chr2_+_102401580 3.937 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr12_-_7172641 3.412 NM_031491
RBP5
retinol binding protein 5, cellular
chr2_-_158008763 3.353 NM_004288
CYTIP
cytohesin 1 interacting protein
chr1_+_173111306 3.313 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr4_-_40211324 3.099 RBM47
RNA binding motif protein 47
chr20_-_57015698 3.017 NM_001336
CTSZ
cathepsin Z
chr4_+_39874921 2.924 NM_004310
RHOH
ras homolog gene family, member H
chr15_-_32416336 2.886 NM_001042497
NM_133647
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr11_+_59979857 2.840 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr22_+_38627031 2.762 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr11_+_123600553 2.724 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr2_+_96355661 2.713 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr17_-_31441390 2.632 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chrX_+_65152004 2.520


chr20_-_45410033 2.459 ZMYND8
zinc finger, MYND-type containing 8
chr20_-_57015547 2.446 CTSZ
cathepsin Z
chr12_+_6424293 2.425 NM_001242
CD27
CD27 molecule
chrX_-_48212683 2.386 SLC38A5
solute carrier family 38, member 5
chr4_-_80466177 2.351 NM_032693
NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr17_-_40843530 2.291 ARHGAP27
Rho GTPase activating protein 27
chr6_+_32515596 2.291 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr14_+_87541220 2.123 NM_003608
GPR65
G protein-coupled receptor 65
chr3_+_99733432 2.107 NM_005290
GPR15
G protein-coupled receptor 15
chr12_+_91620749 2.073 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr6_-_33085290 2.062 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr11_-_47356650 2.061 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr22_+_38627129 2.031 GRAP2
GRB2-related adaptor protein 2
chr11_-_47356562 1.993 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr11_-_47356642 1.927 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr1_+_111217244 1.886 NM_000560
CD53
CD53 molecule
chr11_-_47356672 1.871 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr16_+_56567839 1.838 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr12_-_101396459 1.747 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr12_-_103846186 1.727 NM_032148
SLC41A2
solute carrier family 41, member 2
chr6_-_33085329 1.711 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr12_+_111829191 1.688 OAS1
2',5'-oligoadenylate synthetase 1, 40/46kDa
chr16_-_88358946 1.687 FANCA
Fanconi anemia, complementation group A
chr19_+_47073029 1.671 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chrX_-_7855400 1.616 NM_004650
PNPLA4
patatin-like phospholipase domain containing 4
chr12_+_55018925 1.609 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr11_+_22652957 1.600 GAS2
growth arrest-specific 2
chr1_+_159032551 1.593 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chrX_-_47374647 1.586 NM_002621
CFP
complement factor properdin
chr17_-_53764867 1.567


chr6_-_41811916 1.552 NM_001167827
TFEB
transcription factor EB
chr17_-_60439764 1.518 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr16_-_1761504 1.514 NME3
non-metastatic cells 3, protein expressed in
chr6_-_32121784 1.506 NM_032470
TNXB
tenascin XB
chr1_-_159306037 1.485 ARHGAP30
Rho GTPase activating protein 30
chr17_+_43165608 1.485 NM_013351
TBX21
T-box 21
chr11_-_47356479 1.436 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr3_-_113334657 1.435 NM_001190259
NM_001190260
NM_152785
GCET2


germinal center expressed transcript 2


chr20_+_61838479 1.428 LIME1
Lck interacting transmembrane adaptor 1
chr2_+_68445936 1.416 PLEK
pleckstrin
chr11_+_22652894 1.396 NM_005256
GAS2
growth arrest-specific 2
chr6_+_6533932 1.394 NM_004271
LY86
lymphocyte antigen 86
chr1_-_180822686 1.387 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr12_-_101115677 1.377 NM_002674
PMCH
pro-melanin-concentrating hormone
chr7_+_28418668 1.374 NM_182898
CREB5
cAMP responsive element binding protein 5
chr11_+_123639909 1.366 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr19_-_40925151 1.339 NM_024660
TMEM149
transmembrane protein 149
chr1_+_246635918 1.337 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr11_-_64403712 1.336 EHD1
EH-domain containing 1
chr11_+_123625632 1.327 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr11_-_116605761 1.326 PCSK7
proprotein convertase subtilisin/kexin type 7
chrX_+_128741578 1.323 SASH3
SAM and SH3 domain containing 3
chr1_-_240679380 1.302 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr1_+_152206969 1.287 NM_130898
CREB3L4
cAMP responsive element binding protein 3-like 4
chr14_+_99601498 1.271 NM_016337
EVL
Enah/Vasp-like
chr16_-_28425632 1.267 NM_145659
IL27
interleukin 27
chr3_-_184756101 1.247 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr2_+_68855436 1.226 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr16_+_28850760 1.203 NM_001178098
NM_001770
CD19

CD19 molecule

chr5_+_68703036 1.200 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr20_+_61838389 1.198 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr10_+_104169560 1.196 NM_024326
FBXL15
F-box and leucine-rich repeat protein 15
chr6_+_32713160 1.191 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr1_-_218329684 1.183 BPNT1
3'(2'), 5'-bisphosphate nucleotidase 1
chr1_+_154390939 1.176 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chrX_-_130792297 1.170 LOC286467
hypothetical LOC286467
chr2_-_65013070 1.164 LOC400958
hypothetical LOC400958
chr6_-_25834733 1.142 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chr3_-_122862391 1.140 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr10_-_104169458 1.120 PSD
pleckstrin and Sec7 domain containing
chr7_-_38355949 1.119


chr1_-_218329773 1.108 NM_006085
BPNT1
3'(2'), 5'-bisphosphate nucleotidase 1
chr1_+_144124547 1.106 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr19_-_44518465 1.103 GMFG
glia maturation factor, gamma
chrX_+_128741562 1.101 NM_018990
SASH3
SAM and SH3 domain containing 3
chr14_-_20340377 1.100 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr18_-_28247193 1.091


chr8_-_107023 1.066 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr7_+_106897737 1.065 NM_005295
GPR22
G protein-coupled receptor 22
chr1_+_111544469 1.061


chr1_-_114215768 1.054 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr16_-_49272617 1.054 SNX20
sorting nexin 20
chr1_+_43063817 1.048 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr9_-_97308687 1.042 PTCH1
patched 1
chrX_+_65300803 1.032 NM_001130860
NM_014799
HEPH

hephaestin

chr17_-_36594652 1.032 NM_033060
KRTAP4-1
keratin associated protein 4-1
chr5_+_132021763 1.027 NM_002188
IL13
interleukin 13
chr3_-_121884091 1.026 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr1_-_152185764 1.022 NM_014856
DENND4B
DENN/MADD domain containing 4B
chr17_-_53946899 1.021 MTMR4
myotubularin related protein 4
chr16_-_49272741 1.018 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr11_+_5367182 1.013 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr18_-_28247186 0.995


chr1_-_148854503 0.989


chr12_-_51585004 0.988 NM_002273
KRT8
keratin 8
chr6_-_30188845 0.987 NM_007028
TRIM31
tripartite motif containing 31
chr1_+_157526127 0.972 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr15_+_42815851 0.964 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr14_+_59782222 0.960 NM_177952
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr14_+_77939845 0.959 NM_004796
NRXN3
neurexin 3
chr16_+_49288550 0.952 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr1_+_210275735 0.949 DTL
denticleless homolog (Drosophila)
chr13_+_110637173 0.948 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr19_-_44518516 0.945 NM_004877
GMFG
glia maturation factor, gamma
chr10_+_70152216 0.944 CCAR1
cell division cycle and apoptosis regulator 1
chr6_-_76022565 0.943 TMEM30A
transmembrane protein 30A
chr1_+_210275752 0.941 DTL
denticleless homolog (Drosophila)
chr17_-_36209672 0.939 NM_181535
KRT28
keratin 28
chr3_-_122862447 0.937 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr19_-_19487237 0.920 NM_032037
TSSK6
testis-specific serine kinase 6
chr14_+_99601517 0.898 EVL
Enah/Vasp-like
chr11_-_123918759 0.889 NM_001005195
OR8B12
olfactory receptor, family 8, subfamily B, member 12
chr1_+_25471470 0.883 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr6_+_14032655 0.880 NM_001165034
RNF182
ring finger protein 182
chr1_-_24067347 0.880 NM_000147
FUCA1
fucosidase, alpha-L- 1, tissue
chr2_+_191009265 0.876 MFSD6
major facilitator superfamily domain containing 6
chrX_+_134803450 0.872 NM_018666
SAGE1
sarcoma antigen 1
chr15_+_89248423 0.872 NM_006122
MAN2A2
mannosidase, alpha, class 2A, member 2
chrX_+_9391314 0.867 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr6_-_137536412 0.864 NM_052962
NM_181309
NM_181310
IL22RA2


interleukin 22 receptor, alpha 2


chr15_-_78050515 0.861 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr1_-_153098811 0.860 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr16_+_557011 0.836 NM_176677
NHLRC4
PIGQ
NHL repeat containing 4
phosphatidylinositol glycan anchor biosynthesis, class Q
chr14_-_20340830 0.835 NM_002933
NM_198234
NM_198235
RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr1_-_159306369 0.827 NM_001025598
NM_181720
ARHGAP30

Rho GTPase activating protein 30

chr9_-_70780574 0.825


chr16_+_29581783 0.820 NM_001030288
SPN
sialophorin
chr1_-_159306327 0.809 ARHGAP30
Rho GTPase activating protein 30
chr8_-_66863841 0.807 NM_002603
PDE7A
phosphodiesterase 7A
chr12_-_9777126 0.804 NM_172004
CLECL1
C-type lectin-like 1
chr1_-_210275402 0.802 NM_015434
INTS7
integrator complex subunit 7
chr7_-_25234582 0.797 NM_022150
NPVF
neuropeptide VF precursor
chr8_+_144802972 0.795 NM_014789
ZNF623
zinc finger protein 623
chr6_+_106653429 0.789 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr14_-_52689782 0.787 NM_001160147
NM_001160148
NM_030637
DDHD1


DDHD domain containing 1


chr19_-_59309719 0.780 TFPT
TCF3 (E2A) fusion partner (in childhood Leukemia)
chr2_+_183290912 0.780 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr6_+_41411505 0.778 NM_004828
NCR2
natural cytotoxicity triggering receptor 2
chr12_-_56159895 0.776 NM_032496
ARHGAP9
Rho GTPase activating protein 9
chr5_+_180190585 0.767 LOC729678
hypothetical LOC729678
chr14_-_22658078 0.764 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr21_+_44597911 0.763 NM_003307
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr2_-_171725150 0.759 TLK1
tousled-like kinase 1
chr1_-_226357552 0.759 NM_024319
C1orf35
chromosome 1 open reading frame 35
chr10_+_5976354 0.757 NM_032807
FBXO18
F-box protein, helicase, 18
chr1_+_210275541 0.757 NM_016448
DTL
denticleless homolog (Drosophila)
chr12_+_111829121 0.754 NM_001032409
NM_002534
NM_016816
OAS1


2',5'-oligoadenylate synthetase 1, 40/46kDa


chr17_+_44643067 0.754 ABI3
ABI family, member 3
chr9_+_95886558 0.753 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr12_+_6925997 0.750 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr4_-_38710376 0.749 NM_024943
TMEM156
transmembrane protein 156
chr11_-_55661769 0.747 NM_001004064
OR8J3
olfactory receptor, family 8, subfamily J, member 3
chr13_-_45654296 0.739 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_-_123999640 0.732 NM_006073
TRDN
triadin
chr16_-_79811475 0.721 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr1_-_47468029 0.720 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr4_+_71235259 0.716 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr3_-_25658829 0.714 TOP2B
topoisomerase (DNA) II beta 180kDa
chr13_+_52114565 0.707 HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr1_+_160618143 0.705 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr6_-_159386007 0.704 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr4_-_116254381 0.701 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr6_+_14225836 0.696 NM_001040280
NM_004233
CD83

CD83 molecule

chr13_-_45654292 0.693 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_+_35373632 0.685 DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr15_+_89246780 0.684 MAN2A2
mannosidase, alpha, class 2A, member 2
chr2_-_142605010 0.678 LRP1B
low density lipoprotein receptor-related protein 1B
chrX_-_70390666 0.675 ZMYM3
zinc finger, MYM-type 3
chr22_+_33792125 0.672 NM_001008494
ISX
intestine-specific homeobox
chr12_+_6926014 0.670 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr3_+_52788976 0.669 NM_001166435
NM_001166436
ITIH1

inter-alpha (globulin) inhibitor H1

chr7_+_106293112 0.669 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr14_-_23107106 0.664 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr13_-_45654327 0.652 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr3_+_120375053 0.641 NM_006952
UPK1B
uroplakin 1B
chr11_+_303852 0.640 NM_003641
IFITM1
interferon induced transmembrane protein 1 (9-27)
chr20_-_34807882 0.638 NM_022477
NM_032013
NDRG3

NDRG family member 3

chr17_-_44642934 0.638 NM_001198754
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr6_-_30760413 0.638 KIAA1949
KIAA1949
chr5_-_135729062 0.637 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr7_-_100077072 0.636 NM_003227
TFR2
transferrin receptor 2
chrX_-_70390704 0.632 NM_201599
ZMYM3
zinc finger, MYM-type 3
chr11_-_123685871 0.631 NM_001002917
OR8D1
olfactory receptor, family 8, subfamily D, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.58 2.01e-32 GO:0007606 sensory perception of chemical stimulus
3.73 9.82e-32 GO:0007608 sensory perception of smell
2.61 4.37e-25 GO:0007600 sensory perception
1.99 3.45e-17 GO:0050877 neurological system process
1.85 1.01e-16 GO:0003008 system process
1.32 5.52e-13 GO:0050896 response to stimulus
1.29 6.13e-08 GO:0032501 multicellular organismal process
1.86 3.40e-06 GO:0006955 immune response
1.71 3.02e-04 GO:0006952 defense response
1.51 2.89e-03 GO:0002376 immune system process
1.97 5.05e-03 GO:0045087 innate immune response
3.18 1.14e-02 GO:0006959 humoral immune response
2.53 1.49e-02 GO:0002252 immune effector process
3.25 2.60e-02 GO:0002449 lymphocyte mediated immunity

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.41 7.72e-14 GO:0071944 cell periphery
1.42 9.04e-14 GO:0005886 plasma membrane
1.26 1.18e-07 GO:0031224 intrinsic to membrane
1.25 5.97e-07 GO:0016021 integral to membrane
1.20 1.18e-05 GO:0044425 membrane part
1.14 1.15e-03 GO:0016020 membrane
1.33 4.51e-03 GO:0005576 extracellular region
2.16 4.00e-02 GO:0005882 intermediate filament

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.87 1.10e-33 GO:0004984 olfactory receptor activity
2.62 4.79e-27 GO:0004930 G-protein coupled receptor activity
2.11 2.20e-21 GO:0004888 transmembrane receptor activity
1.77 6.07e-19 GO:0004871 signal transducer activity
1.77 6.07e-19 GO:0060089 molecular transducer activity
1.85 9.02e-18 GO:0004872 receptor activity