Motif ID: POU1F1.p2

Z-value: 1.423


Transcription factors associated with POU1F1.p2:

Gene SymbolEntrez IDGene Name
POU1F1 5449 POU class 1 homeobox 1



Activity profile for motif POU1F1.p2.

activity profile for motif POU1F1.p2


Sorted Z-values histogram for motif POU1F1.p2

Sorted Z-values for motif POU1F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU1F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_105511615 1.610 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr5_-_78317444 1.549 NM_198709
ARSB
arylsulfatase B
chr3_+_152970904 1.518 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr13_+_45174446 1.472 NM_152719
SPERT
spermatid associated
chr2_-_88208650 1.461 NM_001443
FABP1
fatty acid binding protein 1, liver
chr5_-_78318112 1.439 NM_000046
ARSB
arylsulfatase B
chr8_-_17797127 1.363 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr6_+_167456230 1.345 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr21_+_41663853 1.237 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr12_-_101835183 1.215 PAH
phenylalanine hydroxylase
chr2_+_143351536 1.211 NM_001032998
NM_003937
KYNU

kynureninase

chr1_+_149877955 1.193 SNX27
sorting nexin family member 27
chr12_-_49076658 1.157 NM_001145475
FAM186A
family with sequence similarity 186, member A
chr11_+_59564323 1.115 NM_173801
PLAC1L
placenta-specific 1-like
chr13_-_45654292 1.080 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr3_+_123779122 1.079 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr5_-_41249270 1.073 NM_000065
C6
complement component 6
chr6_-_149847809 1.007 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr19_-_53081326 1.001 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr2_+_37282516 0.996 LOC100505876
hypothetical LOC100505876
chr6_-_33149244 0.995 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr4_-_110942783 0.986 NM_000204
CFI
complement factor I
chrX_-_30505804 0.959 NM_025159
CXorf21
chromosome X open reading frame 21
chr6_+_132000134 0.955 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr13_-_45654296 0.954 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr17_-_36418869 0.952 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr6_-_32742265 0.941 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr21_-_14840506 0.938 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr1_-_1701313 0.934 NM_001198994
NADK
NAD kinase
chr19_-_53444733 0.903 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr6_-_149847718 0.859 ZC3H12D
zinc finger CCCH-type containing 12D
chr4_+_74500748 0.858 ALB
albumin
chr6_-_26038817 0.822 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr19_+_47073029 0.803 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr13_-_45654327 0.803 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr3_-_122862447 0.788 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr1_-_167822248 0.787 F5
coagulation factor V (proaccelerin, labile factor)
chrX_-_2892288 0.783 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr16_-_28528149 0.767 NM_177530
NM_177534
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chrX_+_105823723 0.742 NM_024539
RNF128
ring finger protein 128
chr1_-_246869181 0.718 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr6_+_64344307 0.708 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr16_-_28528780 0.706 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr12_+_111829191 0.703 OAS1
2',5'-oligoadenylate synthetase 1, 40/46kDa
chr7_-_44985175 0.703 MYO1G
myosin IG
chr17_-_38385511 0.701 NM_025267
AARSD1
alanyl-tRNA synthetase domain containing 1
chr7_-_44985084 0.693 MYO1G
myosin IG
chr4_+_74520796 0.681 NM_001134
AFP
alpha-fetoprotein
chr1_+_84646621 0.670 NM_058248
DNASE2B
deoxyribonuclease II beta
chr7_-_44985202 0.664 NM_033054
MYO1G
myosin IG
chr4_+_74488910 0.660 ALB
albumin
chr4_+_74488947 0.652 ALB
albumin
chr12_-_101835026 0.651 PAH
phenylalanine hydroxylase
chr3_-_122862391 0.635 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr12_-_85756766 0.627 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr6_+_32515596 0.622 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr3_-_172227152 0.606 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr1_+_13903936 0.604 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr13_-_45577144 0.601 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr14_+_20595820 0.598 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr3_-_198784590 0.594 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr1_-_41399632 0.592 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr6_+_31647854 0.578 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr4_+_100714995 0.571 MTTP
microsomal triglyceride transfer protein
chr4_-_186934059 0.568 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr10_-_73953699 0.568 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chr1_+_178232379 0.555 CEP350
centrosomal protein 350kDa
chr9_-_122852356 0.552 NM_001735
C5
complement component 5
chr12_+_111829121 0.547 NM_001032409
NM_002534
NM_016816
OAS1


2',5'-oligoadenylate synthetase 1, 40/46kDa


chr3_-_172227223 0.547 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr1_+_12046020 0.546 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr4_+_74488835 0.540 NM_000477
ALB
albumin
chr13_+_110653407 0.539 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr9_-_70780574 0.537


chr11_+_30209138 0.533 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr4_-_83566045 0.529


chr19_-_45141473 0.520 LOC440525
PRR13
proline rich 13 pseudogene
proline rich 13
chr1_+_165565006 0.519 POU2F1
POU class 2 homeobox 1
chr1_-_159546348 0.506 NM_000530
MPZ
myelin protein zero
chr22_-_25205376 0.504 NM_152841
HPS4
Hermansky-Pudlak syndrome 4
chr5_+_137701122 0.500 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr15_-_75259714 0.496 PEAK1
NKF3 kinase family member
chr1_+_246682699 0.495 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr17_+_3324096 0.493 NM_001128085
ASPA
aspartoacylase
chr8_-_42742729 0.486 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr6_-_76022565 0.481 TMEM30A
transmembrane protein 30A
chr3_-_147805715 0.480 PLSCR5
phospholipid scramblase family, member 5
chr2_-_230798687 0.478 NM_001185015
SP110
SP110 nuclear body protein
chr11_-_102250876 0.477 NM_002426
MMP12
matrix metallopeptidase 12 (macrophage elastase)
chr11_+_89507465 0.473 NM_005467
NAALAD2
N-acetylated alpha-linked acidic dipeptidase 2
chr18_-_38949481 0.468 NM_002930
RIT2
Ras-like without CAAX 2
chr8_-_17811750 0.468 FGL1
fibrinogen-like 1
chr2_+_68445936 0.466 PLEK
pleckstrin
chr15_-_32398220 0.458 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr2_+_102136833 0.451 NM_000877
IL1R1
interleukin 1 receptor, type I
chr16_+_68156497 0.438 NM_001113178
NM_006599
NM_138713
NM_138714
NM_173214
NFAT5




nuclear factor of activated T-cells 5, tonicity-responsive




chr5_+_68703036 0.437 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr3_+_123256902 0.435 NM_175862
CD86
CD86 molecule
chr3_+_188197029 0.433


chr6_-_109795925 0.432 CD164
CD164 molecule, sialomucin
chr3_+_82117978 0.426


chr17_+_7900926 0.417


chr1_-_158815895 0.414 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr6_-_48186868 0.411 C6orf138
chromosome 6 open reading frame 138
chr18_+_59726183 0.401 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr6_-_33028790 0.400 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr17_-_15463742 0.394 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr4_+_88076418 0.392


chr6_-_32665409 0.388 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chrX_-_39921525 0.384 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr19_-_42355172 0.381 NM_199126
ZNF585A
zinc finger protein 585A
chr3_-_113334657 0.379 NM_001190259
NM_001190260
NM_152785
GCET2


germinal center expressed transcript 2


chr7_+_137411717 0.377 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr21_-_42659671 0.377 NM_003225
TFF1
trefoil factor 1
chr12_+_9925354 0.376 NM_001190765
KLRF2
killer cell lectin-like receptor subfamily F, member 2
chr6_-_41276901 0.375 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr15_+_64481270 0.372 MAP2K1
mitogen-activated protein kinase kinase 1
chr4_+_141484046 0.371 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr3_-_186752952 0.371 NM_139248
LIPH
lipase, member H
chr12_-_9777126 0.369 NM_172004
CLECL1
C-type lectin-like 1
chr16_+_11966464 0.367 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr2_-_242205556 0.361 NM_001164356
THAP4
THAP domain containing 4
chr2_+_11600238 0.357 GREB1
growth regulation by estrogen in breast cancer 1
chr17_-_36232366 0.355 NM_000421
KRT10
keratin 10
chr4_+_69716298 0.354 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chrX_+_14813333 0.351 NM_001177475
MOSPD2
motile sperm domain containing 2
chr14_-_72523404 0.348 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chrX_-_19727828 0.344 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr2_-_6924092 0.340 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr12_+_91341865 0.340 NM_001025233
CLLU1
chronic lymphocytic leukemia up-regulated 1
chrX_-_131375217 0.338 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr10_+_97505398 0.336 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr7_-_36991189 0.336 NM_001039459
ELMO1
engulfment and cell motility 1
chr4_-_70115037 0.334 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr1_+_205344200 0.334 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr6_-_22405708 0.331 NM_000948
PRL
prolactin
chr6_+_32713160 0.331 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr3_-_27473248 0.329 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr13_+_23742846 0.329 SPATA13
spermatogenesis associated 13
chr4_-_77547481 0.326 NM_001042784
CCDC158
coiled-coil domain containing 158
chr10_+_91488704 0.325 KIF20B
kinesin family member 20B
chr4_-_83566246 0.325 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr2_+_24660849 0.325 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr12_+_94200306 0.324 VEZT
vezatin, adherens junctions transmembrane protein
chr22_+_42908102 0.323 NM_022141
PARVG
parvin, gamma
chr11_-_4346191 0.322 NM_001005161
OR52B4
olfactory receptor, family 52, subfamily B, member 4
chr14_+_38772870 0.322 NM_054024
MIA2
melanoma inhibitory activity 2
chr12_-_11041740 0.321 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr6_-_66473790 0.319 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr5_+_156628929 0.318 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr9_+_101717278 0.318 STX17
syntaxin 17
chr3_+_28258027 0.318 NM_182523
CMC1
COX assembly mitochondrial protein homolog (S. cerevisiae)
chr7_+_37689903 0.317


chr15_-_43457916 0.316 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr10_+_101532544 0.315 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr3_+_109504021 0.312 NM_007072
HHLA2
HERV-H LTR-associating 2
chr2_+_216682251 0.306 NM_021141
XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr3_-_139960874 0.301 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr18_-_3001944 0.299 NM_014646
LPIN2
lipin 2
chr5_-_149772469 0.298 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr11_-_58032153 0.297 NM_001005218
OR5B21
olfactory receptor, family 5, subfamily B, member 21
chrX_-_130250880 0.297 IGSF1
immunoglobulin superfamily, member 1
chr13_-_40454360 0.297 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr3_+_120799411 0.297 NM_015900
PLA1A
phospholipase A1 member A
chr17_+_24394043 0.296 NM_016518
PIPOX
pipecolic acid oxidase
chr17_-_59817456 0.295 PECAM1
platelet/endothelial cell adhesion molecule
chr15_-_53349775 0.292 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr5_-_37220702 0.291 C5orf42
chromosome 5 open reading frame 42
chr11_+_55319607 0.290 NM_001004735
OR5D14
olfactory receptor, family 5, subfamily D, member 14
chr2_+_165804157 0.289 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr5_+_40945244 0.288 C7
complement component 7
chr2_+_68445821 0.287 NM_002664
PLEK
pleckstrin
chr5_+_40945315 0.287 NM_000587
C7
complement component 7
chr10_-_82039158 0.286 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr4_-_104217618 0.286 NM_178833
NHEDC2
Na+/H+ exchanger domain containing 2
chr13_-_98708549 0.282 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr1_+_190811479 0.280 NM_002922
RGS1
regulator of G-protein signaling 1
chr3_-_195553297 0.279 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr1_-_158815850 0.279 CD84
CD84 molecule
chr1_-_20318578 0.278 NM_012400
PLA2G2D
phospholipase A2, group IID
chr6_+_131936057 0.275 NM_000045
ARG1
arginase, liver
chr20_+_5935897 0.275 NM_001127458
CRLS1
cardiolipin synthase 1
chr12_-_54150188 0.273 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr4_+_74505710 0.273


chr5_-_149772528 0.272


chr16_-_46823682 0.271 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr5_-_59819642 0.271 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr14_+_31868229 0.269 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr5_+_40945374 0.268 C7
complement component 7
chr7_+_29486010 0.268 NM_001039936
CHN2
chimerin (chimaerin) 2
chr20_+_56903595 0.267 GNAS
GNAS complex locus
chr11_+_71387572 0.266 NM_001039659
NM_001039660
NM_173042
IL18BP


interleukin 18 binding protein


chr3_-_49826221 0.266 UBA7
ubiquitin-like modifier activating enzyme 7
chr6_+_53043729 0.266 NM_012347
FBXO9
F-box protein 9
chr5_-_146441184 0.264 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr11_+_59027624 0.264 NM_001004706
OR4D11
olfactory receptor, family 4, subfamily D, member 11
chr3_+_12367993 0.262 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr13_+_96726415 0.261 MBNL2
muscleblind-like 2 (Drosophila)
chr16_-_3567354 0.261 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr11_-_35235325 0.259 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.50 3.74e-18 GO:0007606 sensory perception of chemical stimulus
3.48 8.54e-16 GO:0007608 sensory perception of smell
2.28 2.18e-08 GO:0006955 immune response
2.21 2.21e-08 GO:0007600 sensory perception
1.30 5.11e-07 GO:0050896 response to stimulus
2.12 7.57e-07 GO:0006952 defense response
1.82 4.91e-06 GO:0002376 immune system process
1.76 1.12e-05 GO:0050877 neurological system process
2.44 1.58e-05 GO:0050776 regulation of immune response
1.65 1.89e-05 GO:0003008 system process
2.42 3.19e-04 GO:0045087 innate immune response
9.86 7.27e-04 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
2.75 1.78e-03 GO:0002253 activation of immune response
2.47 3.40e-03 GO:0050778 positive regulation of immune response
3.59 3.54e-03 GO:0002768 immune response-regulating cell surface receptor signaling pathway
3.53 8.78e-03 GO:0002429 immune response-activating cell surface receptor signaling pathway
2.75 1.63e-02 GO:0002764 immune response-regulating signaling pathway
2.05 2.03e-02 GO:0002684 positive regulation of immune system process
1.23 2.06e-02 GO:0032501 multicellular organismal process
2.70 3.56e-02 GO:0002757 immune response-activating signal transduction
2.62 3.72e-02 GO:0019221 cytokine-mediated signaling pathway
1.79 3.81e-02 GO:0002682 regulation of immune system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.43 3.98e-09 GO:0071944 cell periphery
1.43 6.82e-09 GO:0005886 plasma membrane
11.97 1.61e-05 GO:0042613 MHC class II protein complex
1.28 2.33e-05 GO:0031224 intrinsic to membrane
1.28 2.35e-05 GO:0016021 integral to membrane
1.24 6.04e-05 GO:0044425 membrane part
1.43 2.17e-03 GO:0005576 extracellular region
5.89 3.39e-03 GO:0042611 MHC protein complex
1.16 3.71e-03 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.59 7.52e-17 GO:0004984 olfactory receptor activity
2.14 9.39e-14 GO:0004888 transmembrane receptor activity
2.45 2.52e-13 GO:0004930 G-protein coupled receptor activity
1.84 1.71e-10 GO:0004872 receptor activity
1.64 6.75e-08 GO:0004871 signal transducer activity
1.64 6.75e-08 GO:0060089 molecular transducer activity
4.71 3.71e-02 GO:0003823 antigen binding