Motif ID: HMGA1,2.p2

Z-value: 0.958


Transcription factors associated with HMGA1,2.p2:

Gene SymbolEntrez IDGene Name
HMGA1 3159 high mobility group AT-hook 1
HMGA2 8091 high mobility group AT-hook 2



Activity profile for motif HMGA1,2.p2.

activity profile for motif HMGA1,2.p2


Sorted Z-values histogram for motif HMGA1,2.p2

Sorted Z-values for motif HMGA1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_5035967 2.098 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr10_+_118177371 1.848 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr3_+_123526700 1.842 NM_005213
CSTA
cystatin A (stefin A)
chr7_-_7724762 1.695 NM_002947
RPA3
replication protein A3, 14kDa
chr4_+_75449720 1.561 NM_001432
EREG
epiregulin
chr7_+_143043871 1.504 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr1_-_205272619 1.477 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr1_+_234624266 1.413 NM_145861
EDARADD
EDAR-associated death domain
chr1_+_239762179 1.374 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr10_+_4995597 1.303 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr1_+_99884018 1.295 NM_017734
PALMD
palmdelphin
chr4_+_170817787 1.264 CLCN3
chloride channel 3
chr3_-_152517204 1.215 NM_023915
GPR87
G protein-coupled receptor 87
chr1_-_143708467 1.210 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr12_+_18305740 1.208 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr10_+_4995453 1.201 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr3_-_17757402 1.191 NM_014744
TBC1D5
TBC1 domain family, member 5
chr5_-_58607673 1.189 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_-_139382672 1.181 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr4_+_75393053 1.159 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr6_-_43703024 1.149 GTPBP2
GTP binding protein 2
chr6_-_43703057 1.142 GTPBP2
GTP binding protein 2
chr7_-_112545840 1.097 LOC401397
hypothetical LOC401397
chr7_-_112545847 1.083 LOC401397
hypothetical LOC401397
chr7_-_16471817 1.060 NM_015464
SOSTDC1
sclerostin domain containing 1
chr8_+_26206648 1.011 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr4_+_159350850 0.979 NM_018342
TMEM144
transmembrane protein 144
chr10_+_4995685 0.977 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr6_+_147568795 0.945 STXBP5
syntaxin binding protein 5 (tomosyn)
chr7_-_20223467 0.887 NM_182762
MACC1
metastasis associated in colon cancer 1
chr10_+_89257569 0.887 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr20_+_19863716 0.885 RIN2
Ras and Rab interactor 2
chr1_-_159257567 0.848 F11R
F11 receptor
chr17_-_72151314 0.837 NM_018414
ST6GALNAC1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
chr2_+_102401580 0.829 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr6_+_126282078 0.817 NCOA7
nuclear receptor coactivator 7
chr14_+_38804226 0.813 NM_203354
CTAGE5
CTAGE family, member 5
chr11_-_33139449 0.806 NM_001033505
NM_001033506
NM_001326
CSTF3


cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa


chr12_+_14429499 0.803 ATF7IP
activating transcription factor 7 interacting protein
chr10_+_5976354 0.793 NM_032807
FBXO18
F-box protein, helicase, 18
chr9_+_74956601 0.790 ANXA1
annexin A1
chr4_+_140806536 0.788 MGST2
microsomal glutathione S-transferase 2
chr9_+_126460511 0.750


chr12_-_49708279 0.746 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr20_-_45410033 0.746 ZMYND8
zinc finger, MYND-type containing 8
chr2_+_169637255 0.741 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr16_+_54158084 0.739 NM_032330
CAPNS2
calpain, small subunit 2
chr11_-_107969554 0.736 NM_015065
EXPH5
exophilin 5
chr6_-_133161318 0.733 NM_052831
C6orf192
chromosome 6 open reading frame 192
chr2_-_170138558 0.729 NM_024622
FASTKD1
FAST kinase domains 1
chr7_-_104696678 0.726 NM_182691
SRPK2
SRSF protein kinase 2
chr22_+_38903825 0.720 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr2_+_113591940 0.711 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chrX_+_153644210 0.708 NM_001142463
NM_001363
DKC1

dyskeratosis congenita 1, dyskerin

chr9_+_74956614 0.703 ANXA1
annexin A1
chr7_+_123036312 0.702 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chrX_+_73080887 0.699 NCRNA00183
non-protein coding RNA 183
chr9_-_99740243 0.689 NM_197978
HEMGN
hemogen
chr1_+_86785346 0.689 NM_012128
CLCA4
chloride channel accessory 4
chr1_-_159604287 0.689 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chr22_-_41685827 0.683 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr1_-_158815895 0.683 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr1_+_196874867 0.669 PTPRC
protein tyrosine phosphatase, receptor type, C
chr10_+_47875229 0.666 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr4_-_40211324 0.662 RBM47
RNA binding motif protein 47
chr6_-_68655708 0.658


chr10_+_74540215 0.657 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr7_+_116447499 0.652 ST7
suppression of tumorigenicity 7
chr6_+_47774247 0.644 NM_153838
GPR115
G protein-coupled receptor 115
chr4_+_100957003 0.643 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr1_-_158815850 0.641 CD84
CD84 molecule
chr2_-_188127294 0.641 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr13_+_96672541 0.638 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr1_+_45789111 0.631 AKR1A1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr17_-_53847937 0.628 RNF43
ring finger protein 43
chr3_+_138132006 0.627 NM_001190796
NCK1
NCK adaptor protein 1
chrX_-_78509662 0.618 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr4_-_74704964 0.606 NM_177532
NM_201431
RASSF6

Ras association (RalGDS/AF-6) domain family member 6

chr8_+_107807415 0.605 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr1_-_108032645 0.601 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr15_-_74091817 0.599 NM_138573
NRG4
neuregulin 4
chr14_-_19867372 0.598 NM_182852
NM_182851
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr2_-_61098867 0.592 NM_144709
PUS10
pseudouridylate synthase 10
chr10_-_5436781 0.591 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr3_-_95230143 0.589 NM_001001850
STX19
syntaxin 19
chr7_-_122985060 0.584 NM_005000
NDUFA5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa
chr1_+_233597350 0.580 NM_001079515
NM_003193
TBCE

tubulin folding cofactor E

chr5_+_40877053 0.579 NM_032587
CARD6
caspase recruitment domain family, member 6
chr7_+_116447527 0.579 ST7
suppression of tumorigenicity 7
chr19_+_10258642 0.576 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr1_-_26058434 0.570 NM_024037
C1orf135
chromosome 1 open reading frame 135
chr12_-_15706340 0.562 EPS8
epidermal growth factor receptor pathway substrate 8
chr1_+_196874839 0.561 PTPRC
protein tyrosine phosphatase, receptor type, C
chr19_-_53450953 0.561 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr2_-_188127430 0.559 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr3_+_138159396 0.554 NM_144717
IL20RB
interleukin 20 receptor beta
chr1_-_149004852 0.553 CTSS
cathepsin S
chr13_+_96672705 0.549 MBNL2
muscleblind-like 2 (Drosophila)
chr9_+_74956494 0.545 NM_000700
ANXA1
annexin A1
chr1_+_207668787 0.545 NM_001104548
LOC642587
NPC-A-5
chr10_+_70517823 0.544 NM_002727
SRGN
serglycin
chr8_-_38324809 0.543 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr1_-_149004879 0.533 CTSS
cathepsin S
chr12_+_25096755 0.532 LRMP
lymphoid-restricted membrane protein
chr1_-_149004916 0.532 NM_004079
CTSS
cathepsin S
chr1_+_185064654 0.532 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr4_-_153820535 0.526 NM_152680
TMEM154
transmembrane protein 154
chr9_-_111253484 0.526 NM_001145369
NM_001145370
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr3_-_42818221 0.525


chr1_+_234625338 0.522 NM_080738
EDARADD
EDAR-associated death domain
chr9_-_69729984 0.519 NM_001024916
NM_201453
CBWD5
CBWD3
COBW domain containing 5
COBW domain containing 3
chr10_-_105835609 0.517 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr3_-_150993299 0.515 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr10_+_70517863 0.514 SRGN
serglycin
chr2_+_157822355 0.513 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr7_-_43735571 0.511 NM_018224
C7orf44
chromosome 7 open reading frame 44
chr1_+_196874759 0.502 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr18_+_54039779 0.501 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr11_+_65023556 0.498


chr19_+_60109319 0.496 NM_001145457
NM_001145458
NM_004829
NCR1


natural cytotoxicity triggering receptor 1


chr11_-_5110383 0.491 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chr18_+_54039818 0.490 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr13_-_40454188 0.484 ELF1
E74-like factor 1 (ets domain transcription factor)
chr11_+_7574992 0.480 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr11_-_5130174 0.477 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr1_-_207892420 0.476 NM_000228
LAMB3
laminin, beta 3
chr10_-_62002672 0.475 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr5_+_147562531 0.474 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr2_+_102320148 0.467 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr16_+_10430225 0.466 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chrX_+_80343958 0.463 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr3_+_142175329 0.461 SLC25A36
solute carrier family 25, member 36
chr3_-_15814678 0.458 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr11_+_57285809 0.454 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001331
CTNND1












catenin (cadherin-associated protein), delta 1












chr13_+_48582389 0.450 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr12_-_8110268 0.445 C3AR1
complement component 3a receptor 1
chr4_-_74307637 0.439 ANKRD17
ankyrin repeat domain 17
chr12_+_52696908 0.439 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr5_+_102493155 0.434 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr17_+_36228869 0.434 NM_001195387
NM_145274
NM_001195386
TMEM99


transmembrane protein 99


chr1_-_47468029 0.429 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr6_+_20642665 0.429 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr4_+_159351092 0.429 TMEM144
transmembrane protein 144
chr2_-_113310796 0.427 NM_000576
IL1B
interleukin 1, beta
chrX_-_107569256 0.424 NM_001847
COL4A6
collagen, type IV, alpha 6
chr2_+_183651756 0.423 DUSP19
dual specificity phosphatase 19
chr16_-_21221872 0.420 NM_001014444
NM_001888
CRYM

crystallin, mu

chr19_-_12858956 0.420 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr16_+_20682812 0.418 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr17_-_27252746 0.418 UTP6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr11_+_65023218 0.418


chr6_-_42293564 0.417 MRPS10
mitochondrial ribosomal protein S10
chr19_-_4289750 0.417 NM_001013841
NM_017720
STAP2

signal transducing adaptor family member 2

chr12_-_9913724 0.416 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr20_-_43316597 0.415 NM_003064
SLPI
secretory leukocyte peptidase inhibitor
chr7_+_77307382 0.414 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr6_+_30796064 0.414 TUBB
tubulin, beta
chr1_+_78243181 0.413 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr22_-_34564611 0.412 RPL41P5
ribosomal protein L41 pseudogene 5
chr4_-_83566802 0.411 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chrX_-_15198093 0.411 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr12_-_8110196 0.410 NM_004054
C3AR1
complement component 3a receptor 1
chr9_-_69729918 0.407 CBWD5
COBW domain containing 5
chr2_+_169367345 0.405 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr3_-_120761092 0.403 NM_005191
CD80
CD80 molecule
chr17_-_53849888 0.402 RNF43
ring finger protein 43
chr5_-_16561936 0.401 NM_019000
FAM134B
family with sequence similarity 134, member B
chr18_-_59480082 0.401 NM_006919
SERPINB3
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 3
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr1_+_24518501 0.397 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr19_+_61624 0.397 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr17_-_64752550 0.397 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr6_-_143813481 0.396 NM_182503
ADAT2
adenosine deaminase, tRNA-specific 2, TAD2 homolog (S. cerevisiae)
chr7_+_141084591 0.396 NM_003143
SSBP1
single-stranded DNA binding protein 1
chr4_+_22608252 0.395


chr19_+_49455872 0.394 NM_181756
ZNF233
zinc finger protein 233
chr1_-_160648429 0.394 NM_053282
SH2D1B
SH2 domain containing 1B
chr9_-_95255694 0.391 NM_198841
FAM120AOS
family with sequence similarity 120A opposite strand
chr16_+_56567839 0.383 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr6_-_52060327 0.381 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr17_-_31231421 0.376 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr18_+_27281729 0.376 NM_001944
DSG3
desmoglein 3
chrX_-_70243362 0.372 NM_001025265
CXorf65
chromosome X open reading frame 65
chrX_+_38545636 0.372 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr1_+_86662356 0.371 NM_006536
CLCA2
chloride channel accessory 2
chr9_+_99807257 0.371


chr17_-_27693246 0.371 NM_022344
C17orf75
chromosome 17 open reading frame 75
chr2_-_65447267 0.371 SPRED2
sprouty-related, EVH1 domain containing 2
chr9_-_168913 0.370 NM_001145355
NM_001145356
NM_018491
CBWD2
CBWD1


COBW domain containing 2
COBW domain containing 1


chr19_+_45973139 0.369 NM_006533
MIA
melanoma inhibitory activity
chr6_-_42293581 0.369 NM_018141
MRPS10
mitochondrial ribosomal protein S10
chr1_+_65492679 0.369 LOC645195
DNAJC6
hypothetical LOC645195
DnaJ (Hsp40) homolog, subfamily C, member 6
chr16_+_33168191 0.367 NM_001099687
TP53TG3B
TP53 target 3B
chr5_-_39238818 0.367 FYB
FYN binding protein
chr20_+_57027703 0.367 NM_030773
TUBB1
tubulin, beta 1
chr7_-_13992351 0.365 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr14_-_19871267 0.365 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr17_-_59437782 0.364 NM_000873
ICAM2
intercellular adhesion molecule 2
chrX_+_153644300 0.364 DKC1
dyskeratosis congenita 1, dyskerin
chr9_-_14388981 0.356 NM_001190738
NFIB
nuclear factor I/B
chr6_-_42293575 0.356 MRPS10
mitochondrial ribosomal protein S10

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.72 1.13e-04 GO:0007606 sensory perception of chemical stimulus
1.76 1.22e-04 GO:0007608 sensory perception of smell

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.79 2.85e-05 GO:0004984 olfactory receptor activity
2.39 1.46e-02 GO:0008135 translation factor activity, nucleic acid binding