Motif ID: PDX1.p2

Z-value: 0.893


Transcription factors associated with PDX1.p2:

Gene SymbolEntrez IDGene Name
PDX1 3651 pancreatic and duodenal homeobox 1



Activity profile for motif PDX1.p2.

activity profile for motif PDX1.p2


Sorted Z-values histogram for motif PDX1.p2

Sorted Z-values for motif PDX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PDX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_63478974 1.896 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr2_-_158008763 1.535 NM_004288
CYTIP
cytohesin 1 interacting protein
chr19_-_7672978 1.516 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr15_-_38185578 1.416 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr1_+_157246305 0.945 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr11_+_22652957 0.895 GAS2
growth arrest-specific 2
chr16_-_69114931 0.768 NM_001195139
NM_015386
COG4

component of oligomeric golgi complex 4

chr11_+_22652894 0.709 NM_005256
GAS2
growth arrest-specific 2
chr15_-_38185865 0.655 NM_033503
BMF
Bcl2 modifying factor
chr16_+_69115225 0.643 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr16_+_69115227 0.616 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr16_+_69115189 0.580 NM_012426
SF3B3
splicing factor 3b, subunit 3, 130kDa
chr1_+_40635058 0.579 NM_001198980
SMAP2
small ArfGAP2
chr16_-_66075216 0.469 NM_001138
AGRP
agouti related protein homolog (mouse)
chr21_-_45173061 0.451 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr19_-_55539769 0.422 NAPSB
napsin B aspartic peptidase pseudogene
chr19_-_57100052 0.408 NM_023074
ZNF649
zinc finger protein 649
chr15_-_42756377 0.401 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr10_+_118177371 0.388 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr1_-_20122638 0.387 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr16_+_18986417 0.385 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr7_-_92615593 0.378 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr2_+_17861266 0.377 NM_001105569
MSGN1
mesogenin 1
chr2_+_113452066 0.372 NM_019618
IL1F9
interleukin 1 family, member 9
chr13_-_40491491 0.372 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr3_+_101720753 0.364 TMEM45A
transmembrane protein 45A
chr3_-_145049853 0.341 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr16_+_18986721 0.334 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr12_+_45896318 0.327 NM_138371
FAM113B
family with sequence similarity 113, member B
chr16_+_18986459 0.307 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr17_+_7900926 0.277


chr14_+_38653177 0.273 NM_001009182
NM_001009183
NM_003616
SIP1


survival of motor neuron protein interacting protein 1


chr12_-_56159631 0.267 NM_001080157
ARHGAP9
Rho GTPase activating protein 9
chr12_+_45896511 0.265 FAM113B
family with sequence similarity 113, member B
chr6_+_167624792 0.251 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr3_-_121883647 0.244 HGD
homogentisate 1,2-dioxygenase
chr6_-_26151863 0.239 NM_021062
HIST1H2BB
histone cluster 1, H2bb
chr3_-_110155237 0.237 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr1_-_246869181 0.228 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr17_-_36890877 0.226 NM_002280
KRT35
keratin 35
chr18_-_45630154 0.225 MYO5B
myosin VB
chr5_-_142795269 0.214 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr17_-_7023378 0.213 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr1_+_78858675 0.213 NM_006820
IFI44L
interferon-induced protein 44-like
chr5_+_68703036 0.196 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr1_+_62835759 0.193 NM_014495
ANGPTL3
angiopoietin-like 3
chr10_+_116687904 0.191 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chrX_-_131375217 0.186 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr4_+_109033868 0.183 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr14_+_20580224 0.166 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr17_-_36418869 0.165 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr3_-_139315011 0.152 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr12_-_52306348 0.152 NM_001130060
NM_006856
ATF7

activating transcription factor 7

chr20_+_43423990 0.138 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr16_+_29582480 0.130 SPN
sialophorin
chr18_+_54039779 0.118 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr8_-_81155564 0.115 NM_001025252
TPD52
tumor protein D52
chr18_+_54039730 0.113 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_-_121964373 0.111 CLASP1
cytoplasmic linker associated protein 1
chr2_+_227900471 0.101 NM_020194
MFF
mitochondrial fission factor
chr12_-_119938667 0.101 NM_022895
C12orf43
chromosome 12 open reading frame 43
chr12_-_101835510 0.099 NM_000277
PAH
phenylalanine hydroxylase
chr1_+_57093030 0.097 NM_000562
C8A
complement component 8, alpha polypeptide
chr7_+_129057152 0.093 NM_001040110
NRF1
nuclear respiratory factor 1
chr3_+_44992733 0.092 NM_015004
EXOSC7
exosome component 7
chr1_-_31251315 0.090 PUM1
pumilio homolog 1 (Drosophila)
chr4_+_74500748 0.089 ALB
albumin
chr9_+_137553104 0.088 NM_002297
LCN1
lipocalin 1 (tear prealbumin)
chr3_-_152517204 0.084 NM_023915
GPR87
G protein-coupled receptor 87
chr12_-_119938593 0.082 C12orf43
chromosome 12 open reading frame 43
chr10_-_62002672 0.079 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr4_+_95595419 0.077 PDLIM5
PDZ and LIM domain 5
chr2_+_169465995 0.073 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr18_-_49944986 0.072 MBD2
methyl-CpG binding domain protein 2
chr2_+_169634330 0.071 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_+_28637247 0.071 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr4_-_155753249 0.068 FGG
fibrinogen gamma chain
chr17_-_39499527 0.067 LSM12
LSM12 homolog (S. cerevisiae)
chr17_+_73511843 0.066 NM_001142640
NM_018996
TNRC6C

trinucleotide repeat containing 6C

chr11_-_116168316 0.064 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr1_-_202402043 0.060 NM_000537
REN
renin
chr2_+_24660849 0.057 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr21_+_44844924 0.055 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr5_+_68702617 0.053 NM_133340
NM_133341
RAD17

RAD17 homolog (S. pombe)

chr9_-_139084833 0.052 NM_178448
C9orf140
chromosome 9 open reading frame 140
chr8_-_17624304 0.052 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr3_+_52786642 0.051 NM_002215
ITIH1
inter-alpha (globulin) inhibitor H1
chr6_-_41362370 0.050 NM_018643
TREM1
triggering receptor expressed on myeloid cells 1
chrX_+_37524250 0.049 CYBB
cytochrome b-245, beta polypeptide
chr14_+_57964462 0.048 NM_014749
KIAA0586
KIAA0586
chrX_-_62697473 0.048 LOC92249
hypothetical LOC92249
chr8_-_17624009 0.047 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr16_-_21078262 0.047 NM_017539
DNAH3
dynein, axonemal, heavy chain 3
chr13_-_93929719 0.047 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr17_+_7423662 0.046 CD68
CD68 molecule
chr4_+_71492581 0.046 NM_016519
AMBN
ameloblastin (enamel matrix protein)
chr18_+_29573152 0.046 ASXL3
additional sex combs like 3 (Drosophila)
chr9_+_140226457 0.045 NM_001145249
FAM157B
family with sequence similarity 157, member B
chr3_-_44992604 0.042 NM_001135179
NM_016598
ZDHHC3

zinc finger, DHHC-type containing 3

chr18_+_54039818 0.039 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr17_+_35372751 0.037 NM_178171
GSDMA
gasdermin A
chr4_+_187424111 0.037 NM_000128
F11
coagulation factor XI
chr21_-_30631882 0.035 NM_001077711
KRTAP27-1
keratin associated protein 27-1
chr3_+_116824840 0.035 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr4_-_39199527 0.034 UGDH
UDP-glucose 6-dehydrogenase
chr1_+_151456683 0.032 NM_001195571
PRR9
proline rich 9
chr2_+_105799354 0.027 NCK2
NCK adaptor protein 2
chr18_+_19286784 0.027 NM_003831
RIOK3
RIO kinase 3 (yeast)
chr18_-_28247193 0.027


chr8_+_32698892 0.026 NM_001159996
NRG1
neuregulin 1
chr16_+_56286212 0.026 NM_032269
CCDC135
coiled-coil domain containing 135
chrX_+_48572226 0.026 NM_181532
ERAS
ES cell expressed Ras
chr12_-_54150188 0.023 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr17_-_36113502 0.022 NM_019016
KRT24
keratin 24
chr21_-_30460841 0.022 NM_012131
CLDN17
claudin 17
chr17_-_1359745 0.021 INPP5K
inositol polyphosphate-5-phosphatase K
chr14_-_46882144 0.021 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr17_-_36725470 0.020 NM_031964
KRTAP17-1
keratin associated protein 17-1
chr4_+_187424336 0.020 F11
coagulation factor XI
chr11_-_55684368 0.019 NM_001004058
OR8K5
olfactory receptor, family 8, subfamily K, member 5
chr17_-_36444626 0.018 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr7_+_156128431 0.017 NM_001184997
RNF32
ring finger protein 32
chr9_+_96561750 0.017 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr17_-_1195096 0.017 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr3_+_185253528 0.016 NM_130770
HTR3C
5-hydroxytryptamine (serotonin) receptor 3, family member C
chr11_+_6823458 0.016 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr17_-_39499463 0.016 LSM12
LSM12 homolog (S. cerevisiae)
chr17_-_26665213 0.016 EVI2B
ecotropic viral integration site 2B
chr1_+_84540921 0.015 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr17_-_9635325 0.015 NM_001105571
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chrX_-_48655978 0.015 PIM2
pim-2 oncogene
chr17_-_26665220 0.015 NM_006495
EVI2B
ecotropic viral integration site 2B
chr3_+_35658852 0.014 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr2_-_46988449 0.013 MCFD2
multiple coagulation factor deficiency 2
chr12_+_31691360 0.013 NM_001135864
METTL20
methyltransferase like 20
chrX_+_77041612 0.013 NM_001866
COX7B
cytochrome c oxidase subunit VIIb
chr10_+_126620681 0.012 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr4_+_53975597 0.012 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr11_-_57883117 0.012 NM_001005489
OR5B17
olfactory receptor, family 5, subfamily B, member 17
chr11_-_70971556 0.012 NM_001005405
KRTAP5-11
keratin associated protein 5-11
chrX_+_118592568 0.011 UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chrX_-_10605726 0.010 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr7_+_116182676 0.010


chr12_+_79362256 0.009 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr17_-_36403910 0.009 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr11_+_5367182 0.009 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr8_+_92330691 0.008 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr12_+_4700012 0.008 NM_017417
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr4_+_89115825 0.007 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr19_-_14646626 0.005 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr8_-_7331313 0.005 NM_152251
NM_001040704
DEFB106A
DEFB106B
defensin, beta 106A
defensin, beta 106B
chr1_-_150463292 0.004 NM_001009931
HRNR
hornerin
chrX_+_118592879 0.004 UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr5_-_180099663 0.003 NM_001001657
OR2Y1
olfactory receptor, family 2, subfamily Y, member 1
chr8_-_20084892 0.003 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr3_+_49522871 0.003 DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr17_+_7423685 0.002 CD68
CD68 molecule
chr12_-_10853940 0.002 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr2_+_38746742 0.001 GALM
galactose mutarotase (aldose 1-epimerase)
chr2_-_199922047 0.001 SATB2
SATB homeobox 2
chr5_+_147628567 0.000 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr11_-_66201894 0.000 RBM4B
RNA binding motif protein 4B

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.31 1.69e-03 GO:0045111 intermediate filament cytoskeleton
6.48 4.31e-03 GO:0005882 intermediate filament

Nothing significant found in function category.