Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 1.904


Transcription factors associated with AHR_ARNT_ARNT2.p2:

Gene SymbolEntrez IDGene Name
AHR 196 aryl hydrocarbon receptor
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ARNTchr1_-_149115771-0.381.5e-01Click!
AHRchr7_+_173047070.282.9e-01Click!
ARNT2chr15_+_78520634-0.146.0e-01Click!


Activity profile for motif AHR_ARNT_ARNT2.p2.

activity profile for motif AHR_ARNT_ARNT2.p2


Sorted Z-values histogram for motif AHR_ARNT_ARNT2.p2

Sorted Z-values for motif AHR_ARNT_ARNT2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT_ARNT2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_6298284 2.175 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr3_-_162305319 2.121 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr1_+_61320213 2.119 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr5_+_60663842 1.931 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr12_-_87498225 1.917 NM_000899
NM_003994
KITLG

KIT ligand

chr4_-_57671112 1.690 IGFBP7
insulin-like growth factor binding protein 7
chr4_-_57671307 1.681 IGFBP7
insulin-like growth factor binding protein 7
chr4_-_57671273 1.662 NM_001553
IGFBP7
insulin-like growth factor binding protein 7
chr9_-_25668230 1.584 TUSC1
tumor suppressor candidate 1
chr21_-_38954433 1.485 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr11_-_78829342 1.477 NM_001098816
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
chr16_+_81218142 1.462 CDH13
cadherin 13, H-cadherin (heart)
chr7_-_27149750 1.383 NM_019102
HOXA5
homeobox A5
chr16_-_86082818 1.309 NM_015144
ZCCHC14
zinc finger, CCHC domain containing 14
chr1_+_199519202 1.264 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr16_+_81218074 1.225 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr7_-_27136876 1.179 NM_002141
HOXA4
homeobox A4
chr12_-_74710741 1.166 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr6_-_10520592 1.144 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr21_-_35182842 1.128 NM_001001890
NM_001122607
RUNX1

runt-related transcription factor 1

chr21_-_35182873 1.100 RUNX1
runt-related transcription factor 1
chr3_-_65999548 1.075 NM_001033057
NM_004742
NM_015520
MAGI1


membrane associated guanylate kinase, WW and PDZ domain containing 1


chr19_-_61680510 1.074 NM_022103
ZNF667
zinc finger protein 667
chrX_-_128616594 1.072 NM_017413
APLN
apelin
chr1_+_85819004 0.994 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr6_+_21701942 0.985 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr3_-_31998241 0.959 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr18_+_19523526 0.958 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr6_-_10520264 0.950 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr9_-_83494198 0.932 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr2_+_219141546 0.930 RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr12_-_88269884 0.930 DUSP6
dual specificity phosphatase 6
chr7_+_113513828 0.925 FOXP2
forkhead box P2
chr16_-_85099941 0.920 LOC400550
hypothetical LOC400550
chr2_+_29191711 0.913 NM_024692
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr3_+_195336625 0.877 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr22_-_34754343 0.868 NM_001082578
NM_001082579
RBFOX2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr4_-_115120251 0.862 NM_024590
ARSJ
arylsulfatase family, member J
chr6_+_1336077 0.853


chr15_-_61461127 0.848 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr2_+_206255376 0.839 NM_003872
NM_018534
NM_201264
NM_201266
NM_201267
NM_201279
NRP2





neuropilin 2





chr18_-_21184824 0.837


chr15_-_69194854 0.835 NM_001102658
CT62
cancer/testis antigen 62
chr17_+_76988134 0.834 NM_001080519
BAHCC1
BAH domain and coiled-coil containing 1
chr13_-_32822759 0.823 STARD13
StAR-related lipid transfer (START) domain containing 13
chr4_-_122063118 0.822 NM_018699
PRDM5
PR domain containing 5
chr3_+_195336631 0.815 HES1
hairy and enhancer of split 1, (Drosophila)
chr17_-_8000362 0.805 PER1
period homolog 1 (Drosophila)
chr10_+_102782151 0.804 SFXN3
sideroflexin 3
chr3_-_31997738 0.804 OSBPL10
oxysterol binding protein-like 10
chr1_-_203557379 0.800 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr15_-_27901828 0.793 NM_003257
NM_175610
TJP1

tight junction protein 1 (zona occludens 1)

chr7_+_113513726 0.791 FOXP2
forkhead box P2
chr7_-_27120015 0.777 HOXA3
homeobox A3
chr15_-_61460967 0.748 CA12
carbonic anhydrase XII
chr19_+_50663089 0.745 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr18_-_5533967 0.740 NM_012307
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr1_-_58815415 0.730 TACSTD2
tumor-associated calcium signal transducer 2
chr20_+_51022352 0.726 NM_173485
TSHZ2
teashirt zinc finger homeobox 2
chr7_-_131911768 0.718 PLXNA4
plexin A4
chr3_+_189354167 0.717 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chrX_+_17303798 0.711 NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr3_+_31998269 0.711 NM_001137674
ZNF860
zinc finger protein 860
chr1_+_219119623 0.709 HLX
H2.0-like homeobox
chr14_+_73073570 0.708 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr9_-_109290528 0.704 KLF4
Kruppel-like factor 4 (gut)
chr5_-_172688024 0.698 STC2
stanniocalcin 2
chr10_+_102782156 0.694 SFXN3
sideroflexin 3
chr3_+_30623376 0.693 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr2_+_219141761 0.689 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr5_-_172687798 0.682 STC2
stanniocalcin 2
chr10_+_124210980 0.677 NM_002775
HTRA1
HtrA serine peptidase 1
chr1_+_219119468 0.674 HLX
H2.0-like homeobox
chr20_+_51023159 0.663 TSHZ2
teashirt zinc finger homeobox 2
chr4_-_143987053 0.663 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr13_-_37341859 0.655 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr2_-_219141199 0.643 NM_020935
USP37
ubiquitin specific peptidase 37
chr16_+_22733307 0.640 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr9_-_112381593 0.632 NM_153366
SVEP1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr20_-_49818306 0.629 NM_006045
ATP9A
ATPase, class II, type 9A
chr5_-_16989290 0.627 MYO10
myosin X
chr4_-_103968104 0.626 NM_003340
NM_181886
NM_181888
NM_181889
UBE2D3



ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)



chr5_-_16989371 0.623 NM_012334
MYO10
myosin X
chr1_+_208472817 0.622 NM_019605
SERTAD4
SERTA domain containing 4
chr15_-_27901628 0.618 TJP1
tight junction protein 1 (zona occludens 1)
chr13_-_77391525 0.614


chr9_-_13269562 0.613 MPDZ
multiple PDZ domain protein
chr8_+_69026895 0.612 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr18_-_20231783 0.612 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr19_-_2378581 0.607 TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr7_+_113513600 0.606 FOXP2
forkhead box P2
chr3_-_71196696 0.604 FOXP1
forkhead box P1
chr9_-_109290107 0.599 KLF4
Kruppel-like factor 4 (gut)
chr20_-_10602429 0.597 NM_000214
JAG1
jagged 1
chr5_+_63497408 0.595 NM_001113561
NM_178532
RNF180

ring finger protein 180

chr1_+_199975674 0.592 NAV1
neuron navigator 1
chr3_-_191321367 0.589 LEPREL1
leprecan-like 1
chr5_+_151131709 0.588 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr18_+_45342398 0.583 NM_006033
LIPG
lipase, endothelial
chr3_-_129024665 0.582 NM_001003794
MGLL
monoglyceride lipase
chr18_-_20231709 0.582 OSBPL1A
oxysterol binding protein-like 1A
chr1_+_182622987 0.577 C1orf21
chromosome 1 open reading frame 21
chr20_-_49818268 0.576 ATP9A
ATPase, class II, type 9A
chr10_+_17311307 0.568 VIM
vimentin
chr17_-_60208083 0.566 LOC146880
hypothetical LOC146880
chr10_+_17311283 0.566 VIM
vimentin
chr10_+_17311282 0.565 VIM
vimentin
chr10_+_17311242 0.565 VIM
vimentin
chr4_+_81337663 0.560 NM_001099403
PRDM8
PR domain containing 8
chr7_-_131911808 0.559 NM_001105543
NM_020911
PLXNA4

plexin A4

chr22_-_17891777 0.557 CLDN5
claudin 5
chr5_-_107034484 0.557 NM_001962
EFNA5
ephrin-A5
chr10_+_17311347 0.553 VIM
vimentin
chr7_+_28415495 0.552 LOC401317
hypothetical LOC401317
chr1_+_216586199 0.552 TGFB2
transforming growth factor, beta 2
chr19_+_12966970 0.552 NM_002501
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_-_223907283 0.549 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr10_+_114700775 0.547 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr15_+_96304942 0.533 ARRDC4
arrestin domain containing 4
chr19_-_2378530 0.533 TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr15_+_37660568 0.531 NM_003246
THBS1
thrombospondin 1
chr3_-_49424427 0.529 RHOA
ras homolog gene family, member A
chr11_-_44928803 0.528 NM_001076787
NM_006034
TP53I11

tumor protein p53 inducible protein 11

chr8_-_125809831 0.526 NM_014751
MTSS1
metastasis suppressor 1
chr11_+_102485293 0.526 NM_001080463
NM_001377
DYNC2H1

dynein, cytoplasmic 2, heavy chain 1

chr1_-_203916239 0.522 NM_033102
SLC45A3
solute carrier family 45, member 3
chr8_+_69027277 0.522 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr7_+_116099648 0.519 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr1_+_181258952 0.519 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr7_+_44110527 0.518 AEBP1
AE binding protein 1
chr3_-_49424413 0.516 RHOA
ras homolog gene family, member A
chr1_+_199975563 0.515 NM_001167738
NAV1
neuron navigator 1
chr16_+_30617962 0.513 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr1_+_181259317 0.513


chr3_-_45242072 0.511 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr5_+_42459568 0.507 NM_000163
GHR
growth hormone receptor
chr15_+_96304911 0.505 NM_183376
ARRDC4
arrestin domain containing 4
chr2_-_101291483 0.504 NM_173647
RNF149
ring finger protein 149
chr3_-_186353421 0.503 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chr8_+_1759502 0.500 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr8_+_102574012 0.498 GRHL2
grainyhead-like 2 (Drosophila)
chr17_+_19081267 0.497 NM_001102664
NM_014964
NM_148921
EPN2


epsin 2


chr12_-_41269679 0.496 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr4_-_103967784 0.496 NM_181887
NM_181891
UBE2D3

ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)

chr12_-_53099203 0.493 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr16_+_22732982 0.493 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr10_-_30065760 0.492 SVIL
supervillin
chr8_-_103737058 0.492 NM_005655
KLF10
Kruppel-like factor 10
chr1_+_32992131 0.490


chr6_+_3696224 0.489


chr2_+_219283751 0.488 NM_014640
TTLL4
tubulin tyrosine ligase-like family, member 4
chr8_+_69027166 0.480 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr17_+_58058783 0.475 MRC2
mannose receptor, C type 2
chr9_-_94472090 0.474 IPPK
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
chr13_-_39075200 0.469 LHFP
lipoma HMGIC fusion partner
chr17_-_35510074 0.467 NR1D1
nuclear receptor subfamily 1, group D, member 1
chr7_+_16652282 0.461 NM_001159767
NM_014038
BZW2

basic leucine zipper and W2 domains 2

chr8_+_102573837 0.459 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr15_+_81907176 0.459 SH3GL3
SH3-domain GRB2-like 3
chr8_+_69027143 0.454 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr11_-_2907169 0.452 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr9_-_109291866 0.451 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr3_+_157875063 0.451 TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr4_-_140696740 0.451 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr12_+_64504835 0.448 HMGA2
high mobility group AT-hook 2
chr3_-_49424397 0.446 RHOA
ras homolog gene family, member A
chr1_-_203916160 0.443 SLC45A3
solute carrier family 45, member 3
chr15_-_73719546 0.443 NM_018285
IMP3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr3_-_189354510 0.442 LOC339929
hypothetical LOC339929
chr11_-_86061003 0.441 NM_006680
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chrX_+_149282097 0.441 NM_001177465
MAMLD1
mastermind-like domain containing 1
chr10_+_124211353 0.440 HTRA1
HtrA serine peptidase 1
chr1_+_64709063 0.440 NM_020925
CACHD1
cache domain containing 1
chr20_+_13924263 0.437 MACROD2
MACRO domain containing 2
chr7_-_84654106 0.435 SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr11_+_66827563 0.434 SSH3
slingshot homolog 3 (Drosophila)
chr1_+_1437400 0.434 ATAD3A
ATAD3B
ATPase family, AAA domain containing 3A
ATPase family, AAA domain containing 3B
chr1_+_199975271 0.433 NAV1
neuron navigator 1
chr19_-_63301418 0.433 NM_001145543
NM_001145544
NM_023926
ZSCAN18


zinc finger and SCAN domain containing 18


chr13_-_39075304 0.432 LHFP
lipoma HMGIC fusion partner
chr1_+_61319976 0.431 NM_001145512
NFIA
nuclear factor I/A
chr19_-_63301386 0.426 ZSCAN18
zinc finger and SCAN domain containing 18
chr7_-_93357881 0.424 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chrX_-_18282698 0.423 NM_006089
SCML2
sex comb on midleg-like 2 (Drosophila)
chr5_+_151131707 0.421 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr12_-_24606616 0.421 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr3_+_195888701 0.420 FAM43A
family with sequence similarity 43, member A
chr3_-_49424380 0.419 RHOA
ras homolog gene family, member A
chr17_+_52026058 0.419 NM_005450
NOG
noggin
chr11_-_87548199 0.417 NM_022337
RAB38
RAB38, member RAS oncogene family
chr20_-_10602139 0.416 JAG1
jagged 1
chr5_+_151131704 0.416 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr2_-_160972606 0.414 RBMS1
RNA binding motif, single stranded interacting protein 1
chr10_-_35970363 0.413 NM_031866
FZD8
frizzled homolog 8 (Drosophila)
chr20_+_13924014 0.411 NM_080676
MACROD2
MACRO domain containing 2
chr15_+_78775008 0.411 FAM108C1
family with sequence similarity 108, member C1
chr7_-_5429702 0.409 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr2_+_10101081 0.408 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr3_+_157874898 0.408 NM_015508
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr3_-_49424361 0.407 RHOA
ras homolog gene family, member A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 5.59e-16 GO:0050794 regulation of cellular process
1.21 1.61e-13 GO:0050789 regulation of biological process
1.19 1.70e-12 GO:0065007 biological regulation
1.30 3.64e-12 GO:0044260 cellular macromolecule metabolic process
1.12 7.99e-12 GO:0009987 cellular process
1.22 3.15e-11 GO:0044237 cellular metabolic process
1.31 2.16e-09 GO:0031323 regulation of cellular metabolic process
1.31 8.36e-09 GO:0060255 regulation of macromolecule metabolic process
1.35 1.47e-08 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.18 4.15e-08 GO:0008152 metabolic process
1.29 4.33e-08 GO:0080090 regulation of primary metabolic process
1.27 4.53e-08 GO:0019222 regulation of metabolic process
1.19 8.07e-08 GO:0044238 primary metabolic process
1.23 1.37e-07 GO:0043170 macromolecule metabolic process
1.44 3.31e-07 GO:0023051 regulation of signaling
1.33 3.32e-07 GO:0048518 positive regulation of biological process
1.41 4.00e-07 GO:0010467 gene expression
1.26 5.75e-07 GO:0032502 developmental process
1.70 7.72e-07 GO:0045595 regulation of cell differentiation
1.29 8.85e-07 GO:0034641 cellular nitrogen compound metabolic process
1.46 9.13e-07 GO:0007399 nervous system development
1.68 1.92e-06 GO:0019220 regulation of phosphate metabolic process
1.68 1.92e-06 GO:0051174 regulation of phosphorus metabolic process
1.26 2.14e-06 GO:0023052 signaling
1.27 3.98e-06 GO:0007275 multicellular organismal development
1.44 5.49e-06 GO:0009966 regulation of signal transduction
1.27 5.59e-06 GO:0006807 nitrogen compound metabolic process
1.57 6.21e-06 GO:0050793 regulation of developmental process
1.30 6.24e-06 GO:0048731 system development
1.39 6.85e-06 GO:0016070 RNA metabolic process
1.66 7.05e-06 GO:0042325 regulation of phosphorylation
1.32 7.62e-06 GO:0048522 positive regulation of cellular process
1.27 8.46e-06 GO:0048856 anatomical structure development
1.34 8.98e-06 GO:0048523 negative regulation of cellular process
1.51 9.29e-06 GO:0051246 regulation of protein metabolic process
1.46 1.34e-05 GO:0009893 positive regulation of metabolic process
1.52 1.44e-05 GO:0032268 regulation of cellular protein metabolic process
1.65 3.90e-05 GO:0001932 regulation of protein phosphorylation
2.61 4.26e-05 GO:0006469 negative regulation of protein kinase activity
1.31 5.20e-05 GO:0048519 negative regulation of biological process
2.42 6.42e-05 GO:0006184 GTP catabolic process
1.29 8.29e-05 GO:0044267 cellular protein metabolic process
1.24 9.41e-05 GO:0007165 signal transduction
1.45 1.06e-04 GO:0031325 positive regulation of cellular metabolic process
1.77 1.07e-04 GO:0023057 negative regulation of signaling
1.74 1.18e-04 GO:0045859 regulation of protein kinase activity
4.43 1.39e-04 GO:0010717 regulation of epithelial to mesenchymal transition
1.49 1.98e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.47 2.06e-04 GO:0033673 negative regulation of kinase activity
2.30 2.08e-04 GO:0046039 GTP metabolic process
1.86 2.47e-04 GO:0045597 positive regulation of cell differentiation
1.38 2.58e-04 GO:0009653 anatomical structure morphogenesis
1.30 2.85e-04 GO:0090304 nucleic acid metabolic process
1.55 2.94e-04 GO:2000026 regulation of multicellular organismal development
1.46 3.05e-04 GO:0010646 regulation of cell communication
1.32 3.70e-04 GO:0030154 cell differentiation
1.51 4.30e-04 GO:0009891 positive regulation of biosynthetic process
1.31 4.59e-04 GO:0048869 cellular developmental process
1.50 4.68e-04 GO:0006351 transcription, DNA-dependent
1.69 4.81e-04 GO:0043549 regulation of kinase activity
1.43 4.83e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.72 4.93e-04 GO:0010648 negative regulation of cell communication
1.26 7.73e-04 GO:0009889 regulation of biosynthetic process
1.71 7.85e-04 GO:0051094 positive regulation of developmental process
2.01 8.48e-04 GO:0009261 ribonucleotide catabolic process
1.74 8.95e-04 GO:0009968 negative regulation of signal transduction
1.87 8.99e-04 GO:0009144 purine nucleoside triphosphate metabolic process
1.84 9.22e-04 GO:0001501 skeletal system development
1.88 1.06e-03 GO:0001944 vasculature development
2.34 1.09e-03 GO:0051348 negative regulation of transferase activity
1.85 1.09e-03 GO:0009141 nucleoside triphosphate metabolic process
1.51 1.18e-03 GO:0031399 regulation of protein modification process
1.34 1.27e-03 GO:0009059 macromolecule biosynthetic process
1.81 1.32e-03 GO:0009259 ribonucleotide metabolic process
1.88 1.33e-03 GO:0071900 regulation of protein serine/threonine kinase activity
1.64 1.43e-03 GO:0051338 regulation of transferase activity
1.99 1.48e-03 GO:0009154 purine ribonucleotide catabolic process
1.85 1.49e-03 GO:0009199 ribonucleoside triphosphate metabolic process
1.25 1.54e-03 GO:0031326 regulation of cellular biosynthetic process
1.90 1.68e-03 GO:0001568 blood vessel development
1.52 1.70e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.82 1.73e-03 GO:0060284 regulation of cell development
1.99 1.85e-03 GO:0009203 ribonucleoside triphosphate catabolic process
1.99 1.85e-03 GO:0009207 purine ribonucleoside triphosphate catabolic process
1.48 1.97e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.98 2.18e-03 GO:0009146 purine nucleoside triphosphate catabolic process
1.38 2.41e-03 GO:0051239 regulation of multicellular organismal process
1.72 2.41e-03 GO:0006163 purine nucleotide metabolic process
1.44 2.57e-03 GO:0032774 RNA biosynthetic process
2.29 2.59e-03 GO:0048705 skeletal system morphogenesis
1.83 2.82e-03 GO:0009205 purine ribonucleoside triphosphate metabolic process
1.33 3.08e-03 GO:0034645 cellular macromolecule biosynthetic process
1.96 3.52e-03 GO:0009143 nucleoside triphosphate catabolic process
1.63 3.65e-03 GO:0000904 cell morphogenesis involved in differentiation
1.91 3.86e-03 GO:0006195 purine nucleotide catabolic process
2.29 3.95e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.49 4.59e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25 4.83e-03 GO:0010468 regulation of gene expression
2.27 4.89e-03 GO:0022604 regulation of cell morphogenesis
1.21 5.28e-03 GO:0016043 cellular component organization
1.48 5.36e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.53 5.76e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.77 6.11e-03 GO:0009150 purine ribonucleotide metabolic process
1.24 6.18e-03 GO:0071842 cellular component organization at cellular level
1.24 6.81e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.20 6.82e-03 GO:0071840 cellular component organization or biogenesis
1.24 7.24e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25 7.27e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.55 7.38e-03 GO:0000902 cell morphogenesis
2.29 7.40e-03 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.94 7.55e-03 GO:0048514 blood vessel morphogenesis
1.44 8.27e-03 GO:0022008 neurogenesis
1.84 8.98e-03 GO:0009166 nucleotide catabolic process
1.86 9.25e-03 GO:0072523 purine-containing compound catabolic process
1.59 9.94e-03 GO:0048585 negative regulation of response to stimulus
1.52 1.10e-02 GO:0006396 RNA processing
1.44 1.17e-02 GO:0048699 generation of neurons
1.79 1.22e-02 GO:0051270 regulation of cellular component movement
1.29 1.24e-02 GO:0048513 organ development
1.23 1.43e-02 GO:0051171 regulation of nitrogen compound metabolic process
2.86 1.49e-02 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
6.78 1.53e-02 GO:0010719 negative regulation of epithelial to mesenchymal transition
1.49 1.81e-02 GO:0009890 negative regulation of biosynthetic process
1.51 1.84e-02 GO:0045893 positive regulation of transcription, DNA-dependent
2.81 2.05e-02 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
1.62 2.17e-02 GO:0007268 synaptic transmission
1.58 2.21e-02 GO:0019226 transmission of nerve impulse
1.58 2.21e-02 GO:0035637 multicellular organismal signaling
1.24 2.27e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.28 2.29e-02 GO:0048583 regulation of response to stimulus
1.28 2.35e-02 GO:0006464 protein modification process
1.40 2.36e-02 GO:0032879 regulation of localization
1.49 2.37e-02 GO:0051254 positive regulation of RNA metabolic process
1.62 2.41e-02 GO:0072521 purine-containing compound metabolic process
1.41 2.43e-02 GO:0048468 cell development
3.42 2.71e-02 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
1.56 2.84e-02 GO:0007417 central nervous system development
1.48 2.93e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.77 3.06e-02 GO:0061061 muscle structure development
1.90 3.41e-02 GO:0043405 regulation of MAP kinase activity
1.24 3.44e-02 GO:0051252 regulation of RNA metabolic process
1.17 3.47e-02 GO:0051716 cellular response to stimulus
1.97 3.60e-02 GO:0030900 forebrain development
1.47 3.81e-02 GO:0010628 positive regulation of gene expression
1.31 3.91e-02 GO:0065009 regulation of molecular function
2.10 4.40e-02 GO:0060537 muscle tissue development
1.35 4.43e-02 GO:0050790 regulation of catalytic activity
1.74 4.54e-02 GO:0040012 regulation of locomotion
2.55 4.85e-02 GO:0010563 negative regulation of phosphorus metabolic process
2.55 4.85e-02 GO:0045936 negative regulation of phosphate metabolic process
1.60 4.90e-02 GO:0008285 negative regulation of cell proliferation
1.54 4.96e-02 GO:0006753 nucleoside phosphate metabolic process
1.54 4.96e-02 GO:0009117 nucleotide metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.14 1.78e-18 GO:0005622 intracellular
1.13 1.53e-14 GO:0044424 intracellular part
1.23 2.55e-11 GO:0005634 nucleus
1.15 1.23e-10 GO:0043231 intracellular membrane-bounded organelle
1.15 1.82e-10 GO:0043227 membrane-bounded organelle
1.16 4.87e-10 GO:0005737 cytoplasm
1.13 2.83e-09 GO:0043229 intracellular organelle
1.13 3.95e-09 GO:0043226 organelle
1.30 2.54e-05 GO:0070013 intracellular organelle lumen
1.05 3.12e-05 GO:0044464 cell part
1.05 3.27e-05 GO:0005623 cell
1.29 5.32e-05 GO:0043233 organelle lumen
1.29 5.42e-05 GO:0031974 membrane-enclosed lumen
1.32 1.04e-04 GO:0031981 nuclear lumen
1.28 2.09e-04 GO:0044428 nuclear part
1.37 2.73e-04 GO:0005654 nucleoplasm
1.13 2.82e-03 GO:0044444 cytoplasmic part
1.13 8.06e-03 GO:0044446 intracellular organelle part
1.43 1.04e-02 GO:0044451 nucleoplasm part
1.13 1.52e-02 GO:0044422 organelle part
1.23 2.47e-02 GO:0005829 cytosol

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.21 6.64e-15 GO:0005515 protein binding
1.12 2.60e-14 GO:0005488 binding
1.40 2.63e-10 GO:0000166 nucleotide binding
1.46 5.62e-05 GO:0030528 transcription regulator activity
1.33 5.62e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.32 1.08e-04 GO:0017076 purine nucleotide binding
1.31 1.90e-04 GO:0032553 ribonucleotide binding
1.31 1.90e-04 GO:0032555 purine ribonucleotide binding
1.76 2.59e-04 GO:0005525 GTP binding
1.98 6.39e-04 GO:0003924 GTPase activity
1.21 7.61e-04 GO:0003676 nucleic acid binding
1.70 9.60e-04 GO:0019001 guanyl nucleotide binding
1.70 9.60e-04 GO:0032561 guanyl ribonucleotide binding
1.41 1.64e-03 GO:0001071 nucleic acid binding transcription factor activity
1.41 1.64e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.48 3.45e-03 GO:0043565 sequence-specific DNA binding
1.43 7.31e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.42 8.11e-03 GO:0003723 RNA binding
1.42 9.02e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
1.43 9.34e-03 GO:0016462 pyrophosphatase activity
1.43 1.37e-02 GO:0017111 nucleoside-triphosphatase activity
3.58 3.21e-02 GO:0019003 GDP binding