ISMARA results for ENCODE cell lines, H3K9ac (Ernst 2011)

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
SNAI1..3.p2 8.443 SNAI2 (SLUGH1)
SNAI1 (SNA, SLUGH2, SNAH)
SNAI3 (SMUC, Zfp293)
RFX1..5_RFXANK_RFXAP.p2 7.405 RFX1 (EF-C)
RFXAP
RFX5
RFXANK (BLS, RFX-B, ANKRA1, F14150_1, MGC138628)
RFX4
RFX3
RFX2 (FLJ14226)
HNF4A_NR2F1,2.p2 7.381 NR2F1 (EAR-3, COUP-TFI, TCFCOUP1, SVP44)
NR2F2 (COUP-TFII, COUPTFB, SVP40)
HNF4A (NR2A1, HNF4)
HNF1A.p2 6.701 HNF1A (HNF1, LFB1)
PITX1..3.p2 6.424 PITX2 (IGDS, RS, Brx1, Otlx2, ARP1)
PITX3
PITX1 (PTX1, POTX)
FOS_FOS{B,L1}_JUN{B,D}.p2 5.821 FOS (c-fos, AP-1)
JUNB
FOSL1 (fra-1)
JUND (AP-1)
FOSB (G0S3, GOSB, GOS3, AP-1, MGC42291, DKFZp686C0818)
HIC1.p2 5.793 HIC1 (ZBTB29)
TEAD1.p2 5.596 TEAD1 (TEF-1)
TEAD2 (ETF, TEF4, TEF-4, TEAD-2)
TEAD3 (TEF5, TEAD5, TEF-5, DTEF-1, ETFR-1, TEAD-3)
TEAD4 (TEF3, RTEF1, TEF-3, EFTR-2, TEFR-1, TCF13L1, hRTEF-1B)
TFAP2{A,C}.p2 5.591 TFAP2C (AP2-GAMMA, ERF1, TFAP2G, hAP-2g)
TFAP2A (AP-2)
IRF1,2,7.p3 5.104 IRF1 (MAR, IRF-1)
IRF2 (IRF-2, DKFZp686F0244)
IRF7 (IRF7A, IRF-7H)
MZF1.p2 4.833 MZF1 (MZF1B, ZSCAN6, MZF-1, Zfp98)
RUNX1..3.p2 4.453 RUNX1 (PEBP2A2, AMLCR1)
RUNX3 (AML2, PEBP2A3)
RUNX2 (AML3, PEBP2A1, PEBP2aA1)
NFKB1_REL_RELA.p2 4.389 RELA (p65)
REL (I-Rel)
NFKB1 (KBF1, p105)
NFY{A,B,C}.p2 4.357 NFYC (CBF-C)
NFYB (CBF-A, HAP3)
NFYA (HAP2, CBF-B)
HBP1_HMGB_SSRP1_UBTF.p2 4.300 HMGB2
HMGB3 (HMG2A, MGC90319)
SSRP1 (FACT80)
UBTF (UBF, NOR-90)
HBP1
SPIB.p2 4.186 SPIB (SPI-B)
TCF4_dimer.p2 4.183 TCF4 (E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724)
EHF.p2 4.165 EHF
NRF1.p2 3.947 NRF1 (EWG, ALPHA-PAL)
MYOD1.p2 3.932 MYOD1 (PUM, MYOD, bHLHc1)
ELK1,4_GABP{A,B1}.p3 3.902 GABPA (E4TF1A, NFT2, NRF2, E4TF1-60, NRF2A)
GABPB1 (E4TF1-47, GABPB)
ELK4 (SAP1)
ELK1
ATF5_CREB3.p2 3.861 ATF5
CREB3 (LZIP, Luman)
GATA6.p2 3.835 GATA6
E2F1..5.p2 3.824 E2F4 (E2F-4)
E2F5
E2F2 (E2F-2)
E2F1 (RBP3)
E2F3
TFAP2B.p2 3.823 TFAP2B (AP2-B)
SPI1.p2 3.747 SPI1 (PU.1, SPI-A, OF, SFPI1, SPI-1)
ZEB1.p2 3.623 ZEB1 (BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a)
MTF1.p2 3.563 MTF1
KLF4.p3 3.507 KLF4 (EZF, GKLF)
ZNF143.p2 3.506 ZNF143 (SBF, pHZ-1, STAF)
TFCP2.p2 3.500 TFCP2 (CP2, LSF, LBP-1C, TFCP2C)
HOX{A6,A7,B6,B7}.p2 3.397 HOXB6
HOXA7
HOXB7
HOXA6
TLX1..3_NFIC{dimer}.p2 3.179 TLX1
TLX3 (RNX)
EN1,2.p2 3.041 EN1
EN2
NHLH1,2.p2 3.041 NHLH1 (NSCL, NSCL1, bHLHa35)
NHLH2 (NSCL2, bHLHa34)
ESRRA.p2 2.986 ESRRA (ERR1, ERRalpha, NR3B1, ERRa)
MAFB.p2 2.957 MAFB
PAX5.p2 2.943 PAX5 (BSAP)
EP300.p2 2.932 EP300 (p300, KAT3B)
RXR{A,B,G}.p2 2.923 RXRA (NR2B1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
bHLH_family.p2 2.872 ARNTL (MOP3, JAP3, BMAL1, PASD3, bHLHe5)
MITF (WS2A, MI, bHLHe32)
MXI1 (MXD2, MAD2, MXI, bHLHc11)
TFE3 (TFEA, bHLHe33)
CLOCK (KIAA0334, KAT13D, bHLHe8)
OLIG2 (RACK17, OLIGO2, bHLHe19)
MXD4 (MAD4, MSTP149, MST149, bHLHc12)
HEY2 (bHLHb32)
HEY1 (HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31)
HEYL (bHLHb33)
MLXIPL (WS-bHLH, MIO, CHREBP, MONDOB)
HES6 (bHLHc23)
MXD3 (MAD3, bHLHc13)
ARNTL2 (BMAL2, MOP9, CLIF, PASD9, bHLHe6)
ID1 (dJ857M17.1.2, bHLHb24)
MNT (ROX, MXD6, MAD6, bHLHd3)
OLIG1 (BHLHB6, bHLHe21)
NPAS2 (MOP4, PASD4, bHLHe9)
MEF2{A,B,C,D}.p2 2.839 MEF2A (RSRFC4, RSRFC9)
MEF2C
MEF2D
MEF2BNB-MEF2B (MEF2B, LOC729991-MEF2B)
MEF2B (RSRFR2, FLJ32648)
ZNF423.p2 2.788 ZNF423 (KIAA0760, OAZ, Roaz, Ebfaz, Zfp104)
SRF.p3 2.759 SRF (MCM1)
YY1.p2 2.746 YY1 (NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S)
KLF12.p2 2.743 KLF12 (AP-2rep, HSPC122, AP2REP)
FEV.p2 2.732 FEV (PET-1, HSRNAFEV)
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2 2.722 ARNT (HIF-1beta, bHLHe2)
MAX (bHLHd4)
MYC (c-Myc, bHLHe39)
USF1 (UEF, MLTFI, bHLHb11)
BHLHB2 (DEC1, bHLHe40)
ARNT2 (KIAA0307, bHLHe1)
HAND1,2.p2 2.634 HAND1 (eHand, Thing1, Hxt, bHLHa27)
HAND2 (dHand, Thing2, Hed, bHLHa26)
NKX3-2.p2 2.620 NKX3-2 (NKX3B, NKX3.2)
PRRX1,2.p2 2.596 PRRX2 (PRX2, PMX2)
PRRX1 (PHOX1)
ESR1.p2 2.583 ESR1 (NR3A1, Era)
DBP.p2 2.579 DBP (DABP)
MAZ.p2 2.572 MAZ (ZF87, Pur-1, Zif87, ZNF801)
POU2F1..3.p2 2.568 POU2F2 (OCT2)
POU2F1 (OCT1)
POU2F3 (OCT11, PLA-1, Skn-1a, Epoc-1)
PATZ1.p2 2.568 PATZ1 (MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ)
NFATC1..3.p2 2.556 NFATC3 (NFAT4, NFATX)
NFATC2 (NF-ATP, NFATp, NFAT1)
NFATC1 (NF-ATC, NFATc, NFAT2)
FOXA2.p3 2.556 FOXA2
LMO2.p2 2.555 LMO2 (TTG2, RHOM2, RBTN2)
XBP1.p3 2.548 XBP1
LEF1_TCF7_TCF7L1,2.p2 2.540 TCF7 (TCF-1)
TCF7L2 (TCF-4)
LEF1 (TCF1ALPHA)
TCF7L1
ETS1,2.p2 2.503 ETS2
ETS1 (FLJ10768, ETS-1)
EBF1.p2 2.453 EBF1 (OLF1)
SP1.p2 2.445 SP1
GFI1B.p2 2.430 GFI1B
GATA1..3.p2 2.392 GATA1 (ERYF1, NFE1)
GATA2 (NFE1B)
GATA3 (HDR)
TFDP1.p2 2.376 TFDP1 (Dp-1, DRTF1, DP1)
ZNF384.p2 2.343 ZNF384 (CAGH1A, CIZ, NMP4, NP)
MYB.p2 2.318 MYB (c-myb)
FOX{D1,D2}.p2 2.312 FOXD2 (FREAC9)
FOXD1 (FREAC4)
HLF.p2 2.304 HLF (MGC33822)
DMAP1_NCOR{1,2}_SMARC.p2 2.276 SMARCA1 (SNF2LB, NURF140, ISWI, SWI)
SMARCC2 (BAF170, Rsc8, CRACC2)
SMARCA5 (hSNF2H, hISWI, ISWI)
NCOR1 (N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216)
NCOR2 (SMRT, SMRTE, TRAC-1, CTG26, TNRC14)
DMAP1 (DNMAP1, FLJ11543, KIAA1425, DNMTAP1, EAF2, SWC4)
PRDM1.p3 2.270 PRDM1 (PRDI-BF1)
ATF6.p2 2.262 ATF6 (ATF6A)
TFEB.p2 2.249 TFEB
ELF1,2,4.p2 2.226 ELF2 (EU32, NERF, NERF-2, NERF-1A, NERF-1B)
ELF1
ELF4 (MEF, ELFR)
CTCF.p2 2.199 CTCF
ZNF238.p2 2.197 ZNF238 (C2H2-171, TAZ-1, RP58, ZBTB18)
RREB1.p2 2.147 RREB1 (HNT)
TBP.p2 2.104 TBP (TFIID)
GFI1.p2 2.093 GFI1
ONECUT1,2.p2 2.085 ONECUT2 (OC-2)
ONECUT1 (HNF-6)
CRX.p2 2.085 CRX (CRD, LCA7, OTX3)
MYFfamily.p2 2.072 MYOD1 (PUM, MYOD, bHLHc1)
MYF6 (MRF4, bHLHc4)
MYF5 (bHLHc2)
MYOG (bHLHc3)
NFE2L1.p2 2.070 NFE2L1 (NRF1, LCR-F1, FLJ00380, TCF11)
SOX{8,9,10}.p2 2.062 SOX9 (SRA1)
SOX8
SOX10 (DOM, WS4, WS2E)
NR5A1,2.p2 2.018 NR5A1 (FTZ1, SF-1, ELP, AD4BP)
NR5A2 (FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2)
HMGA1,2.p2 1.976 HMGA1
HMGA2 (BABL, LIPO)
GTF2I.p2 1.955 GTF2I (TFII-I, BAP-135, SPIN, BTKAP1, DIWS, IB291)
NR1H4.p2 1.955 NR1H4 (FXR, RIP14, HRR1, HRR-1)
JUN.p2 1.954 JUN (c-Jun, AP-1)
JUND (AP-1)
JUNB
SOX2.p2 1.905 SOX2
AHR_ARNT_ARNT2.p2 1.904 ARNT (HIF-1beta, bHLHe2)
AHR
ARNT2 (KIAA0307, bHLHe1)
MSX1,2.p2 1.904 MSX1 (HYD1, OFC5)
MSX2 (CRS2, FPP, HOX8, MSH, PFM)
GTF2A1,2.p2 1.885 GTF2A1 (TFIIA)
GTF2A2 (TFIIA, HsT18745)
BPTF.p2 1.865 BPTF (FAC1, NURF301)
NFE2L2.p2 1.842 NFE2L2 (NRF2)
NFIX.p2 1.838 NFIX (NF1A)
TGIF1.p2 1.803 TGIF1
ZFP161.p2 1.792 ZFP161 (ZNF478, ZBTB14)
FOX{I1,J2}.p2 1.766 FOXI1 (FREAC6)
FOXJ2 (FHX)
ZBTB6.p2 1.746 ZBTB6 (ZID)
CEBPA,B_DDIT3.p2 1.728 DDIT3 (CHOP10, GADD153, CHOP)
CEBPA (C/EBP-alpha)
CEBPB (LAP, CRP2, NFIL6, IL6DBP)
FOXQ1.p2 1.713 FOXQ1 (HFH1)
ZBTB16.p2 1.690 ZBTB16 (PLZF)
FOXO1,3,4.p2 1.687 FOXO1 (FKH1)
FOXO4 (AFX1)
FOXO3 (AF6q21, FOXO2)
ZIC1..3.p2 1.685 ZIC1 (ZIC, ZNF201)
ZIC2 (HPE5)
ZIC3 (HTX, ZNF203)
IKZF2.p2 1.667 IKZF2 (Helios)
POU5F1.p2 1.660 POU5F1 (OCT3, Oct4, MGC22487)
MYBL2.p2 1.645 MYBL2 (BMYB, B-MYB)
ZNF148.p2 1.627 ZNF148 (BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52)
TFAP4.p2 1.626 TFAP4 (AP-4)
EVI1.p2 1.604 EVI1 (MDS1-EVI1, PRDM3)
NANOG{mouse}.p2 1.577 NANOG (FLJ12581, FLJ40451)
FOXL1.p2 1.570 FOXL1 (FREAC7, FKH6)
PAX4.p2 1.568 PAX4
IKZF1.p2 1.534 IKZF1 (hIk-1, LyF-1, Hs.54452, IKAROS)
FOXN1.p2 1.530 FOXN1 (FKHL20)
RXRA_VDR{dimer}.p2 1.524 VDR (NR1I1)
SRY.p2 1.519 SRY (TDF)
ATF4.p2 1.516 ATF4 (TAXREB67, CREB-2)
PBX1.p2 1.502 PBX1
NKX2-2,8.p2 1.498 NKX2-2 (NKX2.2)
NKX2-8 (NKX2.8, Nkx2-9)
HIF1A.p2 1.480 HIF1A (MOP1, HIF-1alpha, PASD8, HIF1)
POU3F1..4.p2 1.479 POU3F1 (OCT6, SCIP)
POU3F3 (BRN1, OTF8)
POU3F2 (POUF3, BRN2, OCT7)
POU3F4 (BRN4, OTF9)
STAT5{A,B}.p2 1.458 STAT5B
STAT5A (MGF)
HOX{A4,D4}.p2 1.455 HOXA4
HOXD4
TBX4,5.p2 1.412 TBX5
TBX4
RBPJ.p2 1.394 RBPJ (SUH, IGKJRB, RBPJK, KBF2, RBP-J, CBF1)
STAT2,4,6.p2 1.391 STAT2 (STAT113)
STAT4
STAT6 (D12S1644, IL-4-STAT)
GLI1..3.p2 1.381 GLI1
GLI2 (THP2, HPE9, THP1)
GLI3 (PAP-A, PAPA, PAPA1, PAPB, ACLS, PPDIV)
FOX{F1,F2,J1}.p2 1.381 FOXF2 (FREAC2)
FOXJ1 (HFH-4, HFH4)
FOXF1 (FREAC1)
ATF2.p2 1.368 ATF2 (TREB7, CRE-BP1, HB16)
HOX{A5,B5}.p2 1.356 HOXB5
HOXA5
CREB1.p2 1.348 CREB1
HES1.p2 1.316 HES1 (FLJ20408, HES-1, Hes1, bHLHb39)
SOX17.p2 1.314 SOX17
SMAD1..7,9.p2 1.282 SMAD5 (Dwfc, JV5-1)
SMAD1 (MADR1, JV4-1)
SMAD3 (JV15-2, HsT17436)
SMAD4 (DPC4)
SMAD2 (MADR2, JV18-1)
SMAD6 (HsT17432)
SMAD7
SMAD9
EGR1..3.p2 1.260 EGR3 (PILOT)
EGR1 (TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225)
EGR2
TLX2.p2 1.244 TLX2 (Enx, Tlx2, NCX)
FOX{C1,C2}.p2 1.240 FOXC1 (FREAC3, ARA, IGDA, IHG1)
FOXC2 (MFH-1)
EWSR1-FLI1.p2 1.238 FLI1 (EWSR2, SIC-1)
EWSR1 (EWS, K984G1.4)
SOX5.p2 1.231 SOX5 (L-SOX5, MGC35153)
FOXP3.p2 1.221 FOXP3 (JM2, XPID, AIID, PIDX, DIETER, SCURFIN)
POU5F1_SOX2{dimer}.p2 1.215 POU5F1 (OCT3, Oct4, MGC22487)
SOX2
POU6F1.p2 1.210 POU6F1 (BRN5, MPOU, TCFB1)
NFE2.p2 1.200 NFE2 (NF-E2)
POU1F1.p2 1.181 POU1F1 (GHF-1)
HSF1,2.p2 1.167 HSF1 (HSTF1)
HSF2
CDC5L.p2 1.132 CDC5L (PCDC5RP, hCDC5, CEF1)
SREBF1,2.p2 1.131 SREBF1 (SREBP1, bHLHd1)
SREBF2 (SREBP2, bHLHd2)
NKX2-3_NKX2-5.p2 1.123 NKX2-5 (CSX1, NKX2.5, NKX4-1)
NKX2-3 (NKX2.3, CSX3, NKX4-3)
TP53.p2 1.118 TP53 (p53, LFS1)
NKX3-1.p2 1.110 NKX3-1 (NKX3.1, BAPX2)
HOXA9_MEIS1.p2 1.092 MEIS1
HOXA9
AIRE.p2 1.088 AIRE (PGA1, APS1)
HMX1.p2 1.085 HMX1 (H6, NKX5-3)
EOMES.p2 1.083 EOMES (TBR2)
FOXD3.p2 1.074 FOXD3 (Genesis, HFH2)
RXRG_dimer.p3 1.071 NR1H2 (NER, NER-I, RIP15, LXR-b)
RXRA (NR2B1)
PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
PPARA (hPPAR, NR1C1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
NANOG.p2 1.063 NANOG (FLJ12581, FLJ40451)
SPZ1.p2 1.047 SPZ1 (NYD-TSP1, FLJ25709)
BACH2.p2 1.044 BACH2
PAX2.p2 1.041 PAX2
REST.p3 0.993 REST (NRSF, XBR)
T.p2 0.986 T
NKX2-1,4.p2 0.959 NKX2-1 (TTF-1)
NKX2-4 (NKX2.4)
CUX2.p2 0.919 CUX2 (KIAA0293, CDP2)
TAL1_TCF{3,4,12}.p2 0.890 TCF3 (E2A, ITF1, MGC129647, MGC129648, bHLHb21)
TCF4 (SEF2-1B, ITF2, bHLHb19)
TAL1 (SCL, bHLHa17)
TCF12 (HEB, HTF4, HsT17266, bHLHb20)
NKX6-1,2.p2 0.882 NKX6-1 (Nkx6.1)
NKX6-2 (NKX6B, GTX, NKX6.1)
ADNP_IRX_SIX_ZHX.p2 0.877 SIX5
ZHX1
IRX4
ADNP (KIAA0784, ADNP1)
ZHX3 (KIAA0395)
ZHX2 (KIAA0854)
IRX5 (IRX-2a)
SIX2
ALX1.p2 0.877 ALX1
CDX1,2,4.p2 0.854 CDX1
CDX2
CDX4
STAT1,3.p3 0.830 STAT1 (STAT91, ISGF-3)
STAT3 (APRF)
PPARG.p2 0.823 PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
FOSL2.p2 0.817 FOSL2 (FRA2, FLJ23306)
LHX3,4.p2 0.779 LHX3
LHX4 (Gsh4)
ARID5B.p2 0.766 ARID5B (FLJ21150, MRF2)
NR3C1.p2 0.741 NR3C1 (GR)
PDX1.p2 0.737 PDX1 (IDX-1, STF-1, PDX-1, MODY4)
GZF1.p2 0.667 GZF1 (dJ322G13.2, ZBTB23)
VSX1,2.p2 0.661 VSX2 (RET1)
VSX1 (PPD)
AR.p2 0.622 AR (AIS, NR3C4, SMAX1, HUMARA)
RORA.p2 0.573 RORA (RZRA, ROR1, ROR2, ROR3, NR1F1)
NFIL3.p2 0.427 NFIL3 (E4BP4, NFIL3A, NF-IL3A)
PAX6.p2 0.417 PAX6 (D11S812E, AN, WAGR)
NR6A1.p2 0.371 NR6A1 (GCNF1, RTR)
PAX8.p2 0.218 PAX8
PAX3,7.p2 0.213 PAX7 (Hup1)
PAX3 (HUP2)

All samples sorted alphabetically


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Project name:

Sample name Condition Replicate/Batch
Rep1_GM12878
Rep1_HepG2
Rep1_HMEC
Rep1_HSMM
Rep1_Huvec
Rep1_K562
Rep1_NHEK
Rep1_NHLF
Rep2_GM12878
Rep2_HepG2
Rep2_HMEC
Rep2_HSMM
Rep2_Huvec
Rep2_K562
Rep2_NHEK
Rep2_NHLF