Motif ID: RREB1.p2

Z-value: 2.147


Transcription factors associated with RREB1.p2:

Gene SymbolEntrez IDGene Name
RREB1 6239 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RREB1chr6_+_70527980.351.9e-01Click!


Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_96924582 5.562 NM_001172667
 FAM178B
family with sequence similarity 178, member B
chrX_+_151617900 4.337 NM_005363
NM_175868
 MAGEA6

melanoma antigen family A, 6

chrX_-_151688850 4.255 NM_005362
 MAGEA3
melanoma antigen family A, 3
chr1_-_30977931 3.703 LAPTM5
lysosomal protein transmembrane 5
chrX_-_151653756 2.973 NM_001166386
NM_001166387
NM_005367
 MAGEA12


melanoma antigen family A, 12


chr11_-_74740298 2.894 NM_004041
NM_020251
 ARRB1

arrestin, beta 1

chrX_+_151653874 2.740 NM_001102576
NM_153478
 CSAG1

chondrosarcoma associated gene 1

chrX_+_151633730 2.727 NM_005361
NM_175742
NM_175743
 MAGEA2


melanoma antigen family A, 2


chr7_-_100331417 2.414 NM_000665
NM_015831
 ACHE

acetylcholinesterase

chrX_-_152139267 2.347 NM_004988
 MAGEA1
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
chr17_-_44058612 2.319 NM_024017
 HOXB9
homeobox B9
chr14_+_28305922 2.311 NM_005249
 FOXG1
forkhead box G1
chrX_-_151672985 2.307 NM_005361
NM_175742
NM_175743
 MAGEA2


melanoma antigen family A, 2


chr4_-_109308893 2.204 NM_001130713
NM_001130714
NM_016269
 LEF1


lymphoid enhancer-binding factor 1


chr22_-_21231421 1.924 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
 PRAME




preferentially expressed antigen in melanoma




chr1_-_154318412 1.865 NM_001093725
 MEX3A
mex-3 homolog A (C. elegans)
chr20_-_22512893 1.856 FOXA2
forkhead box A2
chr20_-_55533544 1.856 NM_080618
 CTCFL
CCCTC-binding factor (zinc finger protein)-like
chr1_-_182273114 1.618 GLT25D2
glycosyltransferase 25 domain containing 2
chr12_+_54700955 1.612 NM_022465
 IKZF4
IKAROS family zinc finger 4 (Eos)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 87 entries
enrichment   p-value GO term description
1.92 4.25e-05 GO:0016569 covalent chromatin modification
1.90 1.24e-04 GO:0016570 histone modification
1.89 3.92e-11 GO:0016568 chromatin modification
1.67 1.33e-02 GO:0071375 cellular response to peptide hormone stimulus
1.62 1.51e-06 GO:0006325 chromatin organization
1.61 9.59e-03 GO:0061061 muscle structure development
1.58 4.64e-02 GO:0045596 negative regulation of cell differentiation
1.56 5.01e-07 GO:0051276 chromosome organization
1.52 1.77e-03 GO:0007268 synaptic transmission
1.52 4.25e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.51 6.35e-04 GO:0019226 transmission of nerve impulse
1.51 6.35e-04 GO:0035637 multicellular organismal signaling
1.51 1.84e-02 GO:0007420 brain development
1.48 4.03e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.48 4.93e-02 GO:0048598 embryonic morphogenesis
1.47 1.36e-03 GO:0051253 negative regulation of RNA metabolic process
1.47 1.83e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.47 2.88e-03 GO:0007417 central nervous system development
1.46 4.59e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.44 1.72e-03 GO:0010629 negative regulation of gene expression

Gene overrepresentation in compartment category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
3.71 4.08e-02 GO:0042627 chylomicron
3.54 3.04e-02 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
3.30 1.51e-02 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
3.13 3.33e-02 GO:0031519 PcG protein complex
2.54 9.38e-03 GO:0000118 histone deacetylase complex
2.04 2.89e-03 GO:0016585 chromatin remodeling complex
1.99 4.64e-02 GO:0042383 sarcolemma
1.36 1.13e-03 GO:0044451 nucleoplasm part
1.28 3.35e-04 GO:0005654 nucleoplasm
1.27 2.43e-06 GO:0031981 nuclear lumen
1.25 3.77e-06 GO:0044428 nuclear part
1.23 1.45e-05 GO:0043233 organelle lumen
1.22 3.34e-05 GO:0031974 membrane-enclosed lumen
1.22 8.29e-05 GO:0070013 intracellular organelle lumen
1.18 8.46e-05 GO:0043234 protein complex
1.18 1.66e-02 GO:0005829 cytosol
1.16 3.16e-09 GO:0005634 nucleus
1.14 3.92e-03 GO:0032991 macromolecular complex
1.10 9.36e-03 GO:0044422 organelle part
1.09 1.46e-05 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
3.15 1.28e-02 GO:0035064 methylated histone residue binding
2.17 4.57e-03 GO:0042393 histone binding
1.74 1.11e-03 GO:0010843 promoter binding
1.72 2.63e-03 GO:0003682 chromatin binding
1.69 2.66e-03 GO:0000975 regulatory region DNA binding
1.69 2.66e-03 GO:0001067 regulatory region nucleic acid binding
1.69 2.66e-03 GO:0044212 transcription regulatory region DNA binding
1.62 2.61e-04 GO:0016564 transcription repressor activity
1.56 4.26e-09 GO:0043565 sequence-specific DNA binding
1.43 2.64e-08 GO:0030528 transcription regulator activity
1.37 1.91e-05 GO:0001071 nucleic acid binding transcription factor activity
1.37 1.91e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.19 2.20e-03 GO:0003677 DNA binding
1.17 1.15e-15 GO:0005515 protein binding
1.16 1.42e-03 GO:0003676 nucleic acid binding
1.07 3.94e-08 GO:0005488 binding