Motif ID: SREBF1,2.p2

Z-value: 1.131


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SREBF1chr17_-_17681013-0.591.7e-02Click!
SREBF2chr22_+_405592140.097.5e-01Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_47604930 2.773 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr22_+_34107087 2.535 HMOX1
heme oxygenase (decycling) 1
chr13_+_112999538 2.518 LAMP1
lysosomal-associated membrane protein 1
chr9_-_37566248 2.347 NM_012166
FBXO10
F-box protein 10
chr13_+_112999590 2.251 LAMP1
lysosomal-associated membrane protein 1
chr13_+_112999462 2.207 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chr10_-_14090459 2.102 FRMD4A
FERM domain containing 4A
chr19_+_54149941 2.077 BAX
BCL2-associated X protein
chr19_+_54149963 2.070 BAX
BCL2-associated X protein
chr19_+_54149843 1.987 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr12_+_52733927 1.876 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr13_-_31900218 1.779 NM_001079691
NM_052818
N4BP2L1

NEDD4 binding protein 2-like 1

chr14_-_93512818 1.761 ASB2
ankyrin repeat and SOCS box containing 2
chr22_+_34107051 1.711 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr13_-_32757835 1.698 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr7_-_29995809 1.622 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr11_+_9642226 1.560 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr11_+_9642200 1.520 NM_015055
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr13_+_48582389 1.520 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr10_-_98021144 1.475 NM_001114094
NM_013314
BLNK

B-cell linker

chr11_+_9642182 1.447 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr10_+_106018915 1.440 GSTO2
glutathione S-transferase omega 2
chr11_+_9642229 1.432 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr12_-_57600564 1.416 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr9_-_21984329 1.403 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr19_+_55614006 1.401 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr13_-_49057629 1.394 RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr9_-_21984414 1.386 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr9_-_21984379 1.382 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr8_+_75066117 1.380 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr1_-_197173159 1.367 LOC100131234
familial acute myelogenous leukemia related factor
chr16_+_639278 1.360 NM_145294
WDR90
WD repeat domain 90
chr18_+_54958095 1.354 NM_033280
SEC11C
SEC11 homolog C (S. cerevisiae)
chr20_-_4743768 1.353 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr13_-_49057707 1.346 NM_018191
RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr3_-_126414252 1.344 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr12_-_57600336 1.329 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr18_+_54682261 1.305 ZNF532
zinc finger protein 532
chr19_-_15436333 1.283 NM_022904
RASAL3
RAS protein activator like 3
chr3_-_113763449 1.278 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr19_-_52710129 1.255 NM_003827
NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr3_-_113763454 1.248 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr12_+_56284867 1.240 NM_178502
DTX3
deltex homolog 3 (Drosophila)
chrX_+_128741578 1.228 SASH3
SAM and SH3 domain containing 3
chr11_-_60475558 1.223 NM_016582
SLC15A3
solute carrier family 15, member 3
chr3_-_49370755 1.217 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr1_+_148521852 1.214 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr3_+_44878380 1.184 NM_144638
TMEM42
transmembrane protein 42
chr7_-_27162688 1.181 NM_006896
HOXA7
homeobox A7
chr3_-_49370682 1.181 GPX1
glutathione peroxidase 1
chr11_+_120828275 1.175 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr3_-_113763425 1.172 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chrX_+_128741562 1.160 NM_018990
SASH3
SAM and SH3 domain containing 3
chr16_+_28893525 1.154 NM_001142448
NM_001142449
NM_001142450
NM_001142451
NM_032038
SPIN1
SPNS1




spindlin 1
spinster homolog 1 (Drosophila)




chrX_+_102749489 1.151 NM_001006933
NM_032926
TCEAL3

transcription elongation factor A (SII)-like 3

chr16_+_55580910 1.137 NM_032206
NLRC5
NLR family, CARD domain containing 5
chrX_-_114703273 1.101


chr12_+_54396118 1.096 BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr5_-_150517499 1.092 ANXA6
annexin A6
chr3_-_113763217 1.091 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr17_-_41018291 1.084


chr11_+_120828058 1.076 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr3_+_113763561 1.073 NM_017945
SLC35A5
solute carrier family 35, member A5
chr22_+_40724674 1.066 NM_152613
WBP2NL
WBP2 N-terminal like
chr9_+_6747919 1.031 KDM4C
lysine (K)-specific demethylase 4C
chr1_-_152797707 1.026 NM_017582
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr5_-_150517454 1.025 ANXA6
annexin A6
chr17_-_7078446 1.016 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr12_-_44949046 1.011 SLC38A1
solute carrier family 38, member 1
chr1_-_24386324 1.005 NM_170743
NM_173064
NM_173065
IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr3_+_113763601 1.000 SLC35A5
solute carrier family 35, member A5
chr1_-_152797760 0.983 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr6_+_139391511 0.977 NM_021243
C6orf115
chromosome 6 open reading frame 115
chr14_-_67353046 0.970 NM_015346
ZFYVE26
zinc finger, FYVE domain containing 26
chr14_+_44501083 0.969 NM_015091
FAM179B
family with sequence similarity 179, member B
chr12_+_54396099 0.955 BLOC1S1-RDH5
BLOC1S1
BLOC1S1-RDH5 read-through transcript
biogenesis of lysosomal organelles complex-1, subunit 1
chr19_-_52709975 0.954 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr17_-_3407780 0.948 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr7_+_17304707 0.947 NM_001621
AHR
aryl hydrocarbon receptor
chr11_+_59979857 0.946 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr10_+_51497716 0.941 FAM21A
family with sequence similarity 21, member A
chr12_+_64869181 0.939 NM_001142523
NM_007199
IRAK3

interleukin-1 receptor-associated kinase 3

chr2_+_241174803 0.937 NM_023083
NM_023085
CAPN10

calpain 10

chr7_+_27102508 0.935


chr19_+_10625896 0.932 NM_001137673
NM_004516
NM_012218
NM_017620
NM_153464
ILF3




interleukin enhancer binding factor 3, 90kDa




chr2_+_219751207 0.918 FAM134A
family with sequence similarity 134, member A
chr17_-_33043514 0.917 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chrX_+_55760774 0.916 NM_006064
NM_016656
RRAGB

Ras-related GTP binding B

chr8_+_109525050 0.915 TTC35
tetratricopeptide repeat domain 35
chr4_+_91267706 0.912 NM_001145065
FAM190A
family with sequence similarity 190, member A
chr1_-_152797767 0.899 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr1_+_234372454 0.888 NM_003272
GPR137B
G protein-coupled receptor 137B
chr2_+_219751192 0.887 FAM134A
family with sequence similarity 134, member A
chr19_-_52710089 0.886 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr8_+_109525010 0.879 NM_014673
TTC35
tetratricopeptide repeat domain 35
chr12_+_102982365 0.875 NM_013320
HCFC2
host cell factor C2
chr7_-_29996429 0.868 NM_001145514
SCRN1
secernin 1
chr16_-_66827449 0.865 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr15_+_86983038 0.860 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr7_+_27102197 0.859


chr12_-_44948976 0.859 SLC38A1
solute carrier family 38, member 1
chr9_-_133574928 0.858 NM_198679
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr2_-_196744546 0.850 NM_004226
STK17B
serine/threonine kinase 17b
chr1_+_111544469 0.849


chr3_-_123995216 0.849 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr14_-_93512647 0.842 ASB2
ankyrin repeat and SOCS box containing 2
chr7_-_27102049 0.834 NM_005522
NM_153620
HOXA1

homeobox A1

chr3_+_114733907 0.831 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr14_-_91642641 0.829 ATXN3
ATXN8
ataxin 3
ataxin 8
chr2_+_143603439 0.827 ARHGAP15
Rho GTPase activating protein 15
chr14_-_91642703 0.825 NM_001127696
NM_001127697
NM_001164774
NM_001164776
NM_001164777
NM_001164778
NM_001164779
NM_001164780
NM_001164781
NM_001164782
NM_004993
NM_030660
ATXN3











ataxin 3











chr3_-_113763049 0.823 NM_022488
ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr2_+_219751230 0.819 FAM134A
family with sequence similarity 134, member A
chr8_+_26296439 0.818 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr12_+_54396086 0.816 NM_001487
BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr11_-_85457469 0.812 PICALM
phosphatidylinositol binding clathrin assembly protein
chr2_-_219750975 0.811 C2orf24
chromosome 2 open reading frame 24
chr14_-_80757018 0.811 NM_015859
GTF2A1
general transcription factor IIA, 1, 19/37kDa
chr2_-_196744507 0.811 STK17B
serine/threonine kinase 17b
chr6_+_139391570 0.807 C6orf115
chromosome 6 open reading frame 115
chr6_-_84994032 0.804 NM_014895
KIAA1009
KIAA1009
chr12_+_64869271 0.803 IRAK3
interleukin-1 receptor-associated kinase 3
chr11_+_7491789 0.800 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr2_+_219751145 0.800 NM_024293
FAM134A
family with sequence similarity 134, member A
chr11_+_7491576 0.794 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_-_7078399 0.789 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr1_-_152797820 0.787 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr1_-_42694263 0.779 ZMYND12
zinc finger, MYND-type containing 12
chrX_+_101267315 0.775 NM_080390
TCEAL2
transcription elongation factor A (SII)-like 2
chr17_+_75851984 0.768


chr8_-_81246215 0.761 NM_001025253
NM_005079
TPD52

tumor protein D52

chr17_+_3486753 0.755 CTNS
cystinosis, nephropathic
chr15_-_70455355 0.745 NM_000520
HEXA
hexosaminidase A (alpha polypeptide)
chr12_+_120840829 0.742 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr10_+_51497660 0.728 NM_001005751
FAM21C
FAM21A
family with sequence similarity 21, member C
family with sequence similarity 21, member A
chr11_+_120399966 0.726 NM_001130047
NM_152715
TBCEL

tubulin folding cofactor E-like

chr13_-_73605914 0.721 NM_007249
KLF12
Kruppel-like factor 12
chr8_+_98725505 0.716 NM_178812
MTDH
metadherin
chrX_+_72699834 0.710 CHIC1
cysteine-rich hydrophobic domain 1
chr10_-_90332927 0.707 NM_001031709
NM_018363
RNLS

renalase, FAD-dependent amine oxidase

chr7_+_101861007 0.707 ORAI2
ORAI calcium release-activated calcium modulator 2
chr12_+_64869296 0.702 IRAK3
interleukin-1 receptor-associated kinase 3
chr15_-_70455153 0.696 HEXA
hexosaminidase A (alpha polypeptide)
chr19_+_7493436 0.687 NM_020533
MCOLN1
mucolipin 1
chr12_-_119826073 0.681 SPPL3
signal peptide peptidase 3
chr16_-_4528380 0.680 NM_001199054
C16orf5
chromosome 16 open reading frame 5
chr5_-_150517528 0.678 NM_001155
ANXA6
annexin A6
chr3_+_49002774 0.677 P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr3_-_11736946 0.674 NM_014667
VGLL4
vestigial like 4 (Drosophila)
chr14_+_19993181 0.673 APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr4_-_47160403 0.671 NM_017845
COMMD8
COMM domain containing 8
chr2_+_227898163 0.671 MFF
mitochondrial fission factor
chr19_+_10625987 0.664 ILF3
interleukin enhancer binding factor 3, 90kDa
chr8_+_98725604 0.664 MTDH
metadherin
chrX_+_102727068 0.657 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr8_+_67507271 0.657 NM_144650
ADHFE1
alcohol dehydrogenase, iron containing, 1
chr8_+_123863075 0.651 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr1_-_184916044 0.651 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr22_+_23153529 0.651 NM_000675
ADORA2A
adenosine A2a receptor
chr17_+_39778016 0.646 NM_002087
GRN
granulin
chr16_+_68353662 0.644 WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr14_+_23700261 0.644 NM_006084
IRF9
interferon regulatory factor 9
chr17_-_7078304 0.643 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr11_+_66915997 0.641 NM_004584
RAD9A
RAD9 homolog A (S. pombe)
chr3_+_133619193 0.638 NM_015268
DNAJC13
DnaJ (Hsp40) homolog, subfamily C, member 13
chr8_+_98725670 0.636 MTDH
metadherin
chr4_-_47160476 0.623 COMMD8
COMM domain containing 8
chr14_-_64040072 0.615 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr19_-_42098919 0.612 NM_001037232
ZNF829
zinc finger protein 829
chr17_-_71487038 0.608 ACOX1
acyl-CoA oxidase 1, palmitoyl
chr17_+_6856521 0.606 NM_001004333
RNASEK-C17ORF49
RNASEK
RNASEK-C17orf49 read-through transcript
ribonuclease, RNase K
chr17_+_63713171 0.601


chr21_+_25856311 0.596 MIR155HG
MIR155 host gene (non-protein coding)
chr19_+_1018536 0.595 HMHA1
histocompatibility (minor) HA-1
chr12_-_9913199 0.595 CLEC2B
C-type lectin domain family 2, member B
chr19_-_10625449 0.595 LOC147727
hypothetical LOC147727
chr8_-_54918325 0.592 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr10_-_105442868 0.591 SH3PXD2A
SH3 and PX domains 2A
chr14_+_44622916 0.591 NM_017922
PRPF39
PRP39 pre-mRNA processing factor 39 homolog (S. cerevisiae)
chr17_+_39778153 0.589 GRN
granulin
chr7_+_101860958 0.589 NM_001126340
NM_032831
ORAI2

ORAI calcium release-activated calcium modulator 2

chr9_-_139128777 0.585 DPP7
dipeptidyl-peptidase 7
chr17_+_6856676 0.585 RNASEK-C17ORF49
RNASEK
RNASEK-C17orf49 read-through transcript
ribonuclease, RNase K
chr6_-_152664906 0.583 SYNE1
spectrin repeat containing, nuclear envelope 1
chr16_+_80370426 0.581 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr17_+_71487080 0.575 C17orf106
chromosome 17 open reading frame 106
chr8_-_54918389 0.573 NM_015941
NM_213619
ATP6V1H

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

chr3_-_121550767 0.572 NM_001099678
LRRC58
leucine rich repeat containing 58
chr10_+_23768203 0.571 NM_001145373
OTUD1
OTU domain containing 1
chrX_-_100801472 0.571 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr16_-_66072477 0.566 NM_004691
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr15_-_71712711 0.564 NM_001161363
NM_001161364
NM_012428
NM_017455
NPTN



neuroplastin



chr10_-_105427898 0.564 SH3PXD2A
SH3 and PX domains 2A
chr6_-_80713589 0.560 NM_022726
ELOVL4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr12_+_14409875 0.560 NM_018179
ATF7IP
activating transcription factor 7 interacting protein
chr17_+_73638430 0.553 NM_152468
TMC8
transmembrane channel-like 8
chr17_+_7152417 0.553 NM_001143762
EIF5A
eukaryotic translation initiation factor 5A
chr4_+_113958652 0.546 NM_001127493
ANK2
ankyrin 2, neuronal
chr14_-_92869124 0.545 NM_001002860
NM_018167
BTBD7

BTB (POZ) domain containing 7

chr8_-_82186832 0.544 NM_018440
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.34 2.23e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
5.22 8.16e-03 GO:0015682 ferric iron transport
5.22 8.16e-03 GO:0033572 transferrin transport
1.10 1.03e-02 GO:0009987 cellular process
1.28 1.30e-02 GO:0006807 nitrogen compound metabolic process
1.18 1.36e-02 GO:0044237 cellular metabolic process
1.28 2.87e-02 GO:0034641 cellular nitrogen compound metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.14 1.86e-09 GO:0005622 intracellular
1.30 4.10e-09 GO:0044446 intracellular organelle part
1.29 5.40e-09 GO:0044422 organelle part
1.14 9.84e-09 GO:0044424 intracellular part
1.19 5.14e-08 GO:0043227 membrane-bounded organelle
1.18 8.76e-08 GO:0043231 intracellular membrane-bounded organelle
1.19 8.95e-08 GO:0005737 cytoplasm
1.16 3.12e-07 GO:0043226 organelle
1.25 4.50e-07 GO:0044444 cytoplasmic part
1.16 6.39e-07 GO:0043229 intracellular organelle
1.62 2.99e-06 GO:0005654 nucleoplasm
1.44 5.25e-06 GO:0031974 membrane-enclosed lumen
1.44 7.16e-06 GO:0070013 intracellular organelle lumen
1.43 8.89e-06 GO:0043233 organelle lumen
1.42 4.08e-05 GO:0044428 nuclear part
1.47 4.91e-05 GO:0031981 nuclear lumen
1.73 2.85e-04 GO:0044451 nucleoplasm part
2.08 1.12e-03 GO:0005773 vacuole
1.37 2.23e-03 GO:0005829 cytosol
1.19 2.33e-03 GO:0005634 nucleus
2.47 7.00e-03 GO:0005774 vacuolar membrane
1.25 8.45e-03 GO:0032991 macromolecular complex
3.56 1.02e-02 GO:0016605 PML body
5.70 1.46e-02 GO:0033176 proton-transporting V-type ATPase complex
2.36 1.59e-02 GO:0044437 vacuolar part
1.05 1.84e-02 GO:0044464 cell part
1.05 1.88e-02 GO:0005623 cell
1.96 3.75e-02 GO:0000323 lytic vacuole
1.96 3.75e-02 GO:0005764 lysosome
1.25 3.81e-02 GO:0043234 protein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 8.57e-05 GO:0005515 protein binding
1.09 1.60e-03 GO:0005488 binding
6.33 8.21e-03 GO:0046961 proton-transporting ATPase activity, rotational mechanism
2.63 2.51e-02 GO:0015631 tubulin binding
1.83 2.80e-02 GO:0003712 transcription cofactor activity
1.83 3.00e-02 GO:0000988 protein binding transcription factor activity
1.83 3.00e-02 GO:0000989 transcription factor binding transcription factor activity