Motif ID: ZIC1..3.p2

Z-value: 1.685


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZIC1chr3_+_1486105160.523.9e-02Click!
ZIC2chr13_+_99432258-0.495.1e-02Click!
ZIC3chrX_+_1364763530.467.6e-02Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_85169615 4.596 NM_005250
 FOXL1
forkhead box L1
chr3_+_160964574 4.360 SCHIP1
schwannomin interacting protein 1
chr3_-_73756668 4.081 NM_015009
 PDZRN3
PDZ domain containing ring finger 3
chr15_+_37660568 3.467 NM_003246
 THBS1
thrombospondin 1
chr4_+_72271218 3.167 NM_001098484
NM_001134742
 SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr3_+_64645819 2.893 LOC100507098
hypothetical LOC100507098
chr9_-_112840064 2.441 NM_001401
NM_057159
 LPAR1

lysophosphatidic acid receptor 1

chr21_-_27139143 2.308 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr10_+_52421120 2.306 PRKG1
protein kinase, cGMP-dependent, type I
chr16_+_85158357 2.285 NM_005251
 FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr21_-_27139563 2.195 NM_006988
 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr11_+_19691397 2.147 NM_145117
NM_182964
 NAV2

neuron navigator 2

chr9_+_111850698 2.139 NM_001004065
NM_001198656
 AKAP2

A kinase (PRKA) anchor protein 2

chr9_+_108665168 2.133 NM_021224
 ZNF462
zinc finger protein 462
chr20_+_19903778 2.129 RIN2
Ras and Rab interactor 2
chr7_-_27191287 2.034 NM_005523
 HOXA11
homeobox A11
chr14_+_100362236 2.005 MEG3
maternally expressed 3 (non-protein coding)
chr3_+_155321826 1.970 NM_015595
 ARHGEF26
Rho guanine nucleotide exchange factor (GEF) 26
chr14_+_100362204 1.898 MEG3
maternally expressed 3 (non-protein coding)
chr16_+_54070302 1.891 NM_004530
 MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 80 entries
enrichment   p-value GO term description
7.42 4.85e-02 GO:0042693 muscle cell fate commitment
2.59 4.00e-02 GO:0030336 negative regulation of cell migration
2.59 4.00e-02 GO:2000146 negative regulation of cell motility
2.34 5.12e-03 GO:0042692 muscle cell differentiation
2.18 4.84e-02 GO:0034329 cell junction assembly
2.15 2.10e-02 GO:0043062 extracellular structure organization
2.15 2.81e-02 GO:0034330 cell junction organization
2.01 3.08e-04 GO:0061061 muscle structure development
2.00 5.42e-05 GO:0001501 skeletal system development
1.94 1.09e-03 GO:0001944 vasculature development
1.91 4.57e-02 GO:0048514 blood vessel morphogenesis
1.86 2.28e-02 GO:0030334 regulation of cell migration
1.85 4.37e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.84 2.49e-02 GO:0001568 blood vessel development
1.84 3.29e-02 GO:2000145 regulation of cell motility
1.80 1.27e-02 GO:0060284 regulation of cell development
1.80 2.80e-02 GO:0051270 regulation of cellular component movement
1.75 4.38e-04 GO:0072358 cardiovascular system development
1.75 4.38e-04 GO:0072359 circulatory system development
1.63 3.45e-02 GO:0051094 positive regulation of developmental process

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
2.54 7.49e-04 GO:0005925 focal adhesion
2.41 2.23e-03 GO:0005924 cell-substrate adherens junction
2.38 3.89e-05 GO:0005912 adherens junction
2.32 5.01e-03 GO:0030055 cell-substrate junction
2.31 3.61e-05 GO:0070161 anchoring junction
1.61 2.09e-04 GO:0030054 cell junction
1.61 1.53e-02 GO:0045202 synapse
1.49 2.97e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.48 1.85e-03 GO:0031410 cytoplasmic vesicle
1.46 7.25e-03 GO:0031988 membrane-bounded vesicle
1.45 5.76e-03 GO:0031982 vesicle
1.31 7.34e-03 GO:0005856 cytoskeleton
1.24 1.62e-02 GO:0044459 plasma membrane part
1.10 3.47e-03 GO:0005737 cytoplasm
1.09 4.80e-07 GO:0005622 intracellular
1.09 4.20e-05 GO:0044424 intracellular part
1.08 3.51e-02 GO:0043229 intracellular organelle
1.04 4.52e-02 GO:0044464 cell part
1.04 4.66e-02 GO:0005623 cell

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
4.95 3.96e-02 GO:0005248 voltage-gated sodium channel activity
1.47 1.75e-02 GO:0043565 sequence-specific DNA binding
1.44 9.73e-04 GO:0001071 nucleic acid binding transcription factor activity
1.44 9.73e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.43 1.92e-03 GO:0030528 transcription regulator activity
1.16 1.65e-06 GO:0005515 protein binding
1.08 1.25e-04 GO:0005488 binding