Motif ID: FOXL1.p2

Z-value: 1.570


Transcription factors associated with FOXL1.p2:

Gene SymbolEntrez IDGene Name
FOXL1 2300 forkhead box L1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXL1chr16_+_851696150.332.2e-01Click!


Activity profile for motif FOXL1.p2.

activity profile for motif FOXL1.p2


Sorted Z-values histogram for motif FOXL1.p2

Sorted Z-values for motif FOXL1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXL1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_33139349 3.649 NM_004006
DMD
dystrophin
chr4_+_169654742 3.195 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr1_+_194887630 2.332 NM_000186
NM_001014975
CFH

complement factor H

chr5_-_88155360 1.853 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr12_+_79625538 1.833 NM_002469
MYF6
myogenic factor 6 (herculin)
chrX_-_77801480 1.814 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr2_+_189547323 1.652 NM_000090
COL3A1
collagen, type III, alpha 1
chr2_+_151922350 1.522 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr7_+_93862137 1.484 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr5_+_140772691 1.396 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr5_-_111119846 1.376 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr1_+_160868932 1.350 DDR2
discoidin domain receptor tyrosine kinase 2
chr4_-_138673078 1.309 NM_019035
PCDH18
protocadherin 18
chr1_+_160868822 1.272 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr4_-_71751205 1.239 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr12_-_101115677 1.216 NM_002674
PMCH
pro-melanin-concentrating hormone
chr12_+_130004404 1.189 NM_198827
GPR133
G protein-coupled receptor 133
chr2_+_170074457 1.183 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr2_+_24660849 1.163 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr9_-_94338072 1.150 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr1_+_242281199 1.150 ZNF238
zinc finger protein 238
chr15_+_47502666 1.138 NM_002009
FGF7
fibroblast growth factor 7
chr9_+_102380156 1.128 NM_001018116
MURC
muscle-related coiled-coil protein
chr6_+_136214495 1.125 NM_018945
PDE7B
phosphodiesterase 7B
chr2_+_143603368 1.102 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr14_+_87541220 1.097 NM_003608
GPR65
G protein-coupled receptor 65
chr19_+_55614006 1.055 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr2_-_63518589 1.046 NM_001042692
WDPCP
WD repeat containing planar cell polarity effector
chr7_-_112515068 0.999 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr3_-_25658829 0.963 TOP2B
topoisomerase (DNA) II beta 180kDa
chr10_+_69539255 0.956 NM_032578
MYPN
myopalladin
chr5_-_83052606 0.949 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr1_-_199613406 0.946 TNNT2
troponin T type 2 (cardiac)
chr3_+_190831909 0.941 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr1_-_199613427 0.940 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr4_-_71751070 0.934 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr10_-_75080784 0.932 NM_024875
SYNPO2L
synaptopodin 2-like
chr10_+_89257569 0.920 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr15_+_55298908 0.914 NM_207040
TCF12
transcription factor 12
chr5_+_140719773 0.908 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr7_-_112515035 0.906 GPR85
G protein-coupled receptor 85
chr16_+_31132842 0.901 NM_001008274
TRIM72
tripartite motif containing 72
chr5_+_53787187 0.891 NM_006308
HSPB3
heat shock 27kDa protein 3
chr2_-_105421661 0.891 NM_201557
FHL2
four and a half LIM domains 2
chr4_+_113958652 0.880 NM_001127493
ANK2
ankyrin 2, neuronal
chr8_+_107807415 0.876 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr9_-_74757735 0.859 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr1_+_190811479 0.855 NM_002922
RGS1
regulator of G-protein signaling 1
chr10_+_94584449 0.853 NM_001013848
EXOC6
exocyst complex component 6
chr7_+_110518297 0.844 NM_001099658
NM_001099660
NM_018334
LRRN3


leucine rich repeat neuronal 3


chr10_-_69095362 0.843 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr5_-_169657312 0.841 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr10_-_31328426 0.835 NM_001143769
ZNF438
zinc finger protein 438
chr10_-_14090459 0.835 FRMD4A
FERM domain containing 4A
chrX_-_11194015 0.834 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr2_-_179623030 0.831 NM_173648
CCDC141
coiled-coil domain containing 141
chr4_-_177427252 0.828 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr6_-_131333173 0.826 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr13_+_23042722 0.816 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr2_+_143603439 0.815 ARHGAP15
Rho GTPase activating protein 15
chr12_+_79362256 0.813 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr13_-_98757634 0.812 NM_004951
GPR183
G protein-coupled receptor 183
chr5_-_169657395 0.812 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr13_+_48923688 0.808 NM_001160308
SETDB2
SET domain, bifurcated 2
chr15_-_78050515 0.802 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr1_+_32438788 0.796 NM_024296
CCDC28B
coiled-coil domain containing 28B
chr12_+_9713472 0.774 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr5_-_169657192 0.770 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr17_-_64752550 0.753 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr1_+_242281175 0.750 NM_205768
ZNF238
zinc finger protein 238
chr11_-_13474101 0.742 NM_000315
PTH
parathyroid hormone
chr11_-_47356479 0.741 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr7_-_112514990 0.741 GPR85
G protein-coupled receptor 85
chr14_+_20319049 0.734 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr12_+_25096472 0.731 NM_006152
LRMP
lymphoid-restricted membrane protein
chr4_+_86968069 0.725 ARHGAP24
Rho GTPase activating protein 24
chr4_+_120276386 0.718 NM_016599
MYOZ2
myozenin 2
chr7_+_18502342 0.716 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr5_-_169657360 0.715 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr10_+_35524835 0.712 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr16_+_14187965 0.687 MKL2
MKL/myocardin-like 2
chr17_-_10362583 0.682 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr1_-_191422346 0.673 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr11_-_47356650 0.671 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr13_+_110653407 0.671 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr3_-_87408301 0.661 NM_000306
NM_001122757
POU1F1

POU class 1 homeobox 1

chr6_-_139654807 0.657 NM_153235
TXLNB
taxilin beta
chr3_-_13032130 0.650


chr11_-_47356642 0.649 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr8_+_75066117 0.647 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr13_+_45174446 0.646 NM_152719
SPERT
spermatid associated
chr8_+_17866373 0.644 PCM1
pericentriolar material 1
chr6_-_32665409 0.641 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr1_+_103898844 0.638 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr2_-_224175293 0.633 SCG2
secretogranin II
chr10_-_45350804 0.627 NM_001002266
MARCH8
membrane-associated ring finger (C3HC4) 8
chr3_-_12916547 0.625 IQSEC1
IQ motif and Sec7 domain 1
chr4_-_44348414 0.618 NM_182592
YIPF7
Yip1 domain family, member 7
chr7_+_143263191 0.617 NM_001004685
OR2F2
olfactory receptor, family 2, subfamily F, member 2
chr11_-_47356562 0.616 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr1_-_154727014 0.616 MEF2D
myocyte enhancer factor 2D
chr17_-_34603577 0.609 CACNB1
calcium channel, voltage-dependent, beta 1 subunit
chr18_+_70318001 0.609 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr1_+_165565006 0.607 POU2F1
POU class 2 homeobox 1
chr1_+_13903936 0.601 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr11_+_65023038 0.581 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr9_-_99740243 0.578 NM_197978
HEMGN
hemogen
chr19_+_40322231 0.577 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr11_-_47356672 0.577 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr18_-_65766068 0.576 CD226
CD226 molecule
chr3_-_17757402 0.574 NM_014744
TBC1D5
TBC1 domain family, member 5
chr1_-_246869181 0.573 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr10_+_50177192 0.573 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr5_+_156628929 0.570 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr7_-_81237162 0.569 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr4_-_138673014 0.569 PCDH18
protocadherin 18
chr11_+_65023218 0.560


chr10_+_96512447 0.556 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr12_-_90097384 0.556 NM_133503
DCN
decorin
chr6_-_116553918 0.554 NM_000493
COL10A1
collagen, type X, alpha 1
chr8_+_50147455 0.550 NM_001007176
C8orf22
chromosome 8 open reading frame 22
chrX_-_135691168 0.547 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chrX_+_37524190 0.544 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr1_+_78243181 0.543 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr1_-_153107084 0.538


chr10_-_69125932 0.535 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr20_+_56455866 0.533 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr19_+_39402167 0.532 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr3_-_143230124 0.532 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr3_-_150422474 0.530 NM_000096
CP
ceruloplasmin (ferroxidase)
chr8_-_62764839 0.528 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr2_-_99412694 0.525 REV1
REV1 homolog (S. cerevisiae)
chr6_-_76259976 0.524 NM_015687
FILIP1
filamin A interacting protein 1
chr3_-_48573556 0.519 PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr15_-_40537002 0.519 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr19_-_43608641 0.517 NM_001146202
NM_001146203
NM_001146204
NM_001146205
NM_001146206
NM_001146207
NM_170604
RASGRP4






RAS guanyl releasing protein 4






chr17_+_58440629 0.512 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr17_+_25292748 0.512 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chrX_+_77889861 0.508 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr1_-_158815895 0.506 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr15_-_75135496 0.505 TSPAN3
tetraspanin 3
chr22_-_14829803 0.503 NM_001005239
OR11H1
olfactory receptor, family 11, subfamily H, member 1
chr3_+_162697289 0.498 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr17_-_10393664 0.496 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr13_-_45654327 0.495 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr9_-_13240313 0.494 NM_003829
MPDZ
multiple PDZ domain protein
chr7_-_135263737 0.492 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr1_+_50344550 0.491 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr7_+_90176647 0.488 NM_012395
CDK14
cyclin-dependent kinase 14
chr1_-_27113018 0.484 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr1_-_93030538 0.481 NM_005665
EVI5
ecotropic viral integration site 5
chr9_+_263025 0.480 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chrX_-_138114846 0.479 NM_001139498
NM_001139500
NM_001139501
FGF13


fibroblast growth factor 13


chr16_+_7322751 0.478 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr14_-_22354851 0.478 NM_001126105
NM_003982
SLC7A7

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

chr1_-_85816520 0.478 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr22_+_27779877 0.473 ZNRF3
zinc and ring finger 3
chr12_-_52281050 0.471 NM_001130059
ATF7
activating transcription factor 7
chr4_+_155703581 0.469 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr1_+_40635058 0.468 NM_001198980
SMAP2
small ArfGAP2
chr4_+_157044296 0.465 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr5_+_42792676 0.464 NM_001134848
CCDC152
coiled-coil domain containing 152
chr4_+_71713324 0.464 NM_031889
ENAM
enamelin
chr1_+_62835759 0.463 NM_014495
ANGPTL3
angiopoietin-like 3
chr2_+_88148413 0.463 NM_198274
SMYD1
SET and MYND domain containing 1
chr9_+_112470871 0.463 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr1_+_149395728 0.462 NM_024575
TNFAIP8L2
tumor necrosis factor, alpha-induced protein 8-like 2
chr5_-_142795269 0.462 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr12_-_90029672 0.460 NM_002345
LUM
lumican
chrX_+_37524250 0.460 CYBB
cytochrome b-245, beta polypeptide
chr17_-_15463742 0.458 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr7_+_106897737 0.458 NM_005295
GPR22
G protein-coupled receptor 22
chr1_-_27604656 0.454 WASF2
WAS protein family, member 2
chr7_-_92615593 0.452 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr3_+_46423682 0.451 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr3_+_120799411 0.446 NM_015900
PLA1A
phospholipase A1 member A
chr15_-_42756377 0.442 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr8_+_70567634 0.440 SULF1
sulfatase 1
chr10_-_92670764 0.440 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr3_-_116272911 0.438 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_196874759 0.437 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr18_+_70317802 0.435 NM_001168499
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr8_-_82557956 0.434 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr2_-_200033445 0.432 SATB2
SATB homeobox 2
chr2_-_198248828 0.432 NM_144629
RFTN2
raftlin family member 2
chr1_-_201321711 0.430 MYOG
myogenin (myogenic factor 4)
chr1_-_205161821 0.430 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr2_-_190635566 0.428 NM_005259
MSTN
myostatin
chr2_-_99284070 0.427 NM_174898
LYG1
lysozyme G-like 1
chr1_-_177106702 0.426 NM_004673
ANGPTL1
angiopoietin-like 1
chrX_-_21686079 0.422 NM_014332
SMPX
small muscle protein, X-linked
chr4_+_37569093 0.422 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr14_-_94669547 0.418 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr1_+_158603480 0.415 NM_005598
NHLH1
nescient helix loop helix 1
chr4_+_70831387 0.415 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr2_-_180319013 0.410 NM_001113397
ZNF385B
zinc finger protein 385B
chr7_-_135063461 0.407 NM_012450
SLC13A4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr18_-_39111243 0.407 NM_020783
SYT4
synaptotagmin IV
chr7_-_107230867 0.406 NM_000111
SLC26A3
solute carrier family 26, member 3
chr13_+_75092570 0.405 NM_005358
LMO7
LIM domain 7

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.10 1.88e-18 GO:0007608 sensory perception of smell
2.90 2.57e-17 GO:0007606 sensory perception of chemical stimulus
1.41 2.74e-15 GO:0032501 multicellular organismal process
1.82 2.00e-14 GO:0003008 system process
2.09 6.26e-11 GO:0007600 sensory perception
1.78 1.06e-09 GO:0050877 neurological system process
1.24 3.67e-06 GO:0050896 response to stimulus
2.88 6.93e-06 GO:0007517 muscle organ development
2.31 5.52e-04 GO:0061061 muscle structure development
2.87 1.41e-03 GO:0007156 homophilic cell adhesion
3.60 1.41e-02 GO:0007519 skeletal muscle tissue development
3.38 3.36e-02 GO:0060538 skeletal muscle organ development
1.62 3.50e-02 GO:0006955 immune response
2.59 3.77e-02 GO:0060537 muscle tissue development
5.45 4.23e-02 GO:0071248 cellular response to metal ion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.46 1.62e-15 GO:0071944 cell periphery
1.45 6.39e-15 GO:0005886 plasma membrane
1.49 6.24e-07 GO:0005576 extracellular region
3.12 5.31e-05 GO:0030016 myofibril
1.61 8.47e-05 GO:0044421 extracellular region part
3.08 1.19e-04 GO:0044449 contractile fiber part
2.95 1.80e-04 GO:0043292 contractile fiber
2.84 6.25e-03 GO:0030017 sarcomere
1.92 1.28e-02 GO:0005578 proteinaceous extracellular matrix
1.95 1.36e-02 GO:0015629 actin cytoskeleton
1.15 1.59e-02 GO:0044425 membrane part
1.81 1.90e-02 GO:0031012 extracellular matrix
1.54 2.10e-02 GO:0005615 extracellular space
1.16 4.79e-02 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.21 5.88e-20 GO:0004984 olfactory receptor activity
2.28 1.59e-16 GO:0004930 G-protein coupled receptor activity
1.89 3.70e-13 GO:0004888 transmembrane receptor activity
1.69 6.80e-11 GO:0004872 receptor activity
1.58 6.79e-10 GO:0004871 signal transducer activity
1.58 6.79e-10 GO:0060089 molecular transducer activity
2.07 9.17e-04 GO:0003779 actin binding
3.89 2.02e-02 GO:0008307 structural constituent of muscle