Motif ID: TGIF1.p2

Z-value: 1.803


Transcription factors associated with TGIF1.p2:

Gene SymbolEntrez IDGene Name
TGIF1 7050 TGFB-induced factor homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TGIF1chr18_+_3402071-0.292.7e-01Click!


Activity profile for motif TGIF1.p2.

activity profile for motif TGIF1.p2


Sorted Z-values histogram for motif TGIF1.p2

Sorted Z-values for motif TGIF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TGIF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_27320983 2.801 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr2_-_179623030 2.516 NM_173648
CCDC141
coiled-coil domain containing 141
chr1_-_38185312 2.484 NM_005540
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr8_-_41641881 2.416 NM_001142445
NM_020478
NM_020480
ANK1


ankyrin 1, erythrocytic


chr6_-_33822659 2.335 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr8_+_67201684 2.255 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr2_+_223625105 2.231 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr1_-_38185307 2.188 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr1_-_38185291 1.984 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr15_-_68781662 1.984 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr2_+_33213111 1.916 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr1_-_38185254 1.889 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr15_-_46725087 1.817 NM_000138
FBN1
fibrillin 1
chr2_+_88148413 1.816 NM_198274
SMYD1
SET and MYND domain containing 1
chr10_-_73203202 1.762 NM_022153
C10orf54
chromosome 10 open reading frame 54
chr1_+_226462363 1.605 NM_001098623
NM_052843
OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

chr4_+_120167770 1.512 SYNPO2
synaptopodin 2
chr4_+_120168002 1.505 SYNPO2
synaptopodin 2
chr2_-_225519974 1.466 DOCK10
dedicator of cytokinesis 10
chr10_+_69539255 1.462 NM_032578
MYPN
myopalladin
chr18_+_13601664 1.400 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr4_+_120167950 1.365 SYNPO2
synaptopodin 2
chr20_+_8997791 1.362 PLCB4
phospholipase C, beta 4
chr8_-_72431274 1.352 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr9_-_14769530 1.338 NM_001177704
FREM1
FRAS1 related extracellular matrix 1
chr8_-_49996353 1.337 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr11_-_26700121 1.320 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr6_-_119137923 1.289 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr1_-_143750988 1.277 NM_001198832
PDE4DIP
phosphodiesterase 4D interacting protein
chr3_-_15814678 1.269 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr8_+_121892719 1.256


chr3_-_39209075 1.245 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr5_+_125786975 1.235 GRAMD3
GRAM domain containing 3
chr2_-_202271598 1.227 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr15_+_41597097 1.213 NM_002373
MAP1A
microtubule-associated protein 1A
chr17_+_65677255 1.202 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr1_+_78858675 1.155 NM_006820
IFI44L
interferon-induced protein 44-like
chr2_-_179380301 1.144 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr1_-_85816520 1.141 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr5_-_36337756 1.140 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr4_+_120167721 1.125 SYNPO2
synaptopodin 2
chr9_+_133154896 1.122 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr5_+_180190585 1.078 LOC729678
hypothetical LOC729678
chr9_+_18464138 1.074 ADAMTSL1
ADAMTS-like 1
chr9_-_8723893 1.069 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr7_+_101715110 1.058 NM_020979
SH2B2
SH2B adaptor protein 2
chr7_+_101715137 1.052 SH2B2
SH2B adaptor protein 2
chr4_+_3341521 1.043 NM_198227
RGS12
regulator of G-protein signaling 12
chr1_+_101474892 1.043 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr8_+_42671718 1.042 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr2_-_188021117 1.040 NM_005795
CALCRL
calcitonin receptor-like
chr9_+_18464090 1.038 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr4_+_113958652 1.029 NM_001127493
ANK2
ankyrin 2, neuronal
chr12_+_118100977 1.013 NM_014365
HSPB8
heat shock 22kDa protein 8
chr5_+_125786717 1.004 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr5_+_180190542 0.994


chr1_-_197173159 0.961 LOC100131234
familial acute myelogenous leukemia related factor
chr1_+_101475149 0.956 S1PR1
sphingosine-1-phosphate receptor 1
chr3_-_145049853 0.901 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr19_-_51856129 0.899 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chrX_-_21686079 0.889 NM_014332
SMPX
small muscle protein, X-linked
chrX_-_48818585 0.885 NM_007213
PRAF2
PRA1 domain family, member 2
chr11_+_111288686 0.872 HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr3_-_52694554 0.872 NM_018313
PBRM1
polybromo 1
chr13_-_32757835 0.859 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr11_+_111288669 0.854 NM_001541
HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr11_-_118799452 0.847 NM_006288
THY1
Thy-1 cell surface antigen
chr20_+_8997660 0.841 NM_001172646
PLCB4
phospholipase C, beta 4
chr2_+_238200922 0.834 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr7_-_94123308 0.812 SGCE
sarcoglycan, epsilon
chr10_-_49483002 0.812 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr17_+_56832255 0.802 TBX2
T-box 2
chr22_-_37480898 0.795 SUN2
Sad1 and UNC84 domain containing 2
chr5_+_90711887 0.795 LOC100129716
hypothetical LOC100129716
chr7_-_137337354 0.786 NM_194071
CREB3L2
cAMP responsive element binding protein 3-like 2
chr12_+_108921776 0.782 ANKRD13A
ankyrin repeat domain 13A
chr9_-_35802142 0.779 NM_001039592
NM_172312
SPAG8

sperm associated antigen 8

chr5_-_159730196 0.752 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr3_+_46423682 0.752 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr13_-_59223074 0.751


chr3_+_120495906 0.747 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr7_-_19123765 0.746 TWIST1
twist homolog 1 (Drosophila)
chr15_+_90738108 0.742 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr2_+_8739563 0.740 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr7_-_94123362 0.739 SGCE
sarcoglycan, epsilon
chr7_-_94123413 0.734 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr8_-_42184194 0.733 PLAT
plasminogen activator, tissue
chr7_+_94123556 0.732 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr4_+_78089968 0.728 SEPT11
septin 11
chr3_+_179736917 0.726 NM_181361
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr3_-_129024665 0.724 NM_001003794
MGLL
monoglyceride lipase
chr1_+_176330254 0.718 RASAL2
RAS protein activator like 2
chr12_+_51728999 0.718 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr7_+_119700924 0.717 NM_012281
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr12_+_108921616 0.716 NM_033121
ANKRD13A
ankyrin repeat domain 13A
chr6_-_109521969 0.712 NM_014454
SESN1
sestrin 1
chr5_+_43228083 0.706 NM_153361
MGC42105
serine/threonine-protein kinase NIM1
chr2_+_96566190 0.692 NM_212481
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr5_-_88235624 0.685 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr2_+_170074457 0.684 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr12_+_108921686 0.681 ANKRD13A
ankyrin repeat domain 13A
chr11_+_63730720 0.681 NM_031471
NM_178443
FERMT3

fermitin family member 3

chr7_-_5533621 0.667 ACTB
actin, beta
chr17_+_56831951 0.659 NM_005994
TBX2
T-box 2
chr1_-_16217025 0.657 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr11_-_77806413 0.648 GAB2
GRB2-associated binding protein 2
chr6_-_46401363 0.648 NM_005822
RCAN2
regulator of calcineurin 2
chr12_-_107551694 0.645 SELPLG
selectin P ligand
chr7_-_5534252 0.645 ACTB
actin, beta
chr15_+_87540238 0.641 ABHD2
abhydrolase domain containing 2
chr6_+_136214495 0.636 NM_018945
PDE7B
phosphodiesterase 7B
chr7_-_19123787 0.627 NM_000474
TWIST1
twist homolog 1 (Drosophila)
chr3_+_52694975 0.627 NM_014366
NM_206825
NM_206826
GNL3


guanine nucleotide binding protein-like 3 (nucleolar)


chr6_-_109522207 0.626 SESN1
sestrin 1
chr9_+_34980715 0.626 DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr6_+_32515596 0.624 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr3_+_46894239 0.608 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr9_-_16717887 0.607 BNC2
basonuclin 2
chr1_-_202595666 0.606 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr7_+_120378052 0.604 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chr14_+_23670514 0.604 NM_203402
FITM1
fat storage-inducing transmembrane protein 1
chr9_-_36266930 0.601 NM_001128227
NM_001190388
GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chr12_-_107551744 0.598 SELPLG
selectin P ligand
chr2_-_197883739 0.592 NM_001195144
NM_153697
ANKRD44

ankyrin repeat domain 44

chr8_+_134272463 0.591 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr3_+_186563529 0.587 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr18_+_64616296 0.587 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr13_+_47776026 0.586 RB1
retinoblastoma 1
chr2_+_66519949 0.585 MEIS1
Meis homeobox 1
chr10_+_94598204 0.583 NM_019053
EXOC6
exocyst complex component 6
chr9_-_71476917 0.579 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr7_+_94123612 0.579 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr12_+_51729239 0.579 TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr12_-_107551783 0.578 NM_003006
SELPLG
selectin P ligand
chr2_-_40593074 0.576 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr4_-_114901672 0.575 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr10_+_102662675 0.574 FAM178A
family with sequence similarity 178, member A
chr13_+_47775951 0.570 RB1
retinoblastoma 1
chr19_-_44518516 0.568 NM_004877
GMFG
glia maturation factor, gamma
chr4_+_159909658 0.566 FNIP2
folliculin interacting protein 2
chr10_+_90629880 0.565 NM_020799
STAMBPL1
STAM binding protein-like 1
chr17_+_30498948 0.564 NM_001033576
NM_173167
UNC45B

unc-45 homolog B (C. elegans)

chr3_-_129023850 0.560 NM_007283
MGLL
monoglyceride lipase
chr1_+_149309703 0.559 NM_144618
GABPB2
GA binding protein transcription factor, beta subunit 2
chr12_+_63958689 0.555 NM_001031679
NM_001193460
NM_198080
MSRB3


methionine sulfoxide reductase B3


chr5_+_149867866 0.552 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr11_-_77806500 0.548 NM_080491
GAB2
GRB2-associated binding protein 2
chr21_+_33844793 0.532 SON
SON DNA binding protein
chr9_-_33437527 0.531 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr13_-_22905822 0.524 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr3_+_35697432 0.513 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr14_+_99220349 0.513 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr6_+_41128917 0.512 NM_006789
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr4_-_114901789 0.511 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr11_+_120478584 0.507 NM_005422
TECTA
tectorin alpha
chr3_-_56784634 0.507 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr7_-_80386258 0.503 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr18_+_52469559 0.501 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr7_+_94123672 0.498 PEG10
paternally expressed 10
chr11_-_85115105 0.494 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr14_-_72430545 0.494 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chr7_+_33911636 0.493 NM_133468
BMPER
BMP binding endothelial regulator
chr9_+_126094067 0.493 NM_001166170
NM_001166171
NEK6

NIMA (never in mitosis gene a)-related kinase 6

chr9_-_129580732 0.483 NM_170600
SH2D3C
SH2 domain containing 3C
chr11_-_110755112 0.483 POU2AF1
POU class 2 associating factor 1
chr1_-_171442937 0.482 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr6_-_56824672 0.480 DST
dystonin
chr3_+_45042754 0.477 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr2_-_119322228 0.475 NM_001426
EN1
engrailed homeobox 1
chr22_-_17891777 0.474 CLDN5
claudin 5
chr11_-_127897271 0.472 NM_001162422
NM_005238
ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

chr1_-_199348316 0.462 NM_000069
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr6_-_41781655 0.458 TFEB
transcription factor EB
chr9_+_34980266 0.457 NM_001135005
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr2_+_33514896 0.455 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr5_+_149845503 0.455 NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr10_+_102662315 0.454 NM_001136123
NM_018121
FAM178A

family with sequence similarity 178, member A

chr3_-_130807865 0.452 NM_015103
PLXND1
plexin D1
chr13_+_113577228 0.452 NM_001143946
GAS6
growth arrest-specific 6
chr3_+_101381002 0.452


chr3_-_197103848 0.450 TNK2
tyrosine kinase, non-receptor, 2
chr11_-_76058542 0.449 NM_005512
LRRC32
leucine rich repeat containing 32
chr8_-_93099040 0.446 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_-_112301123 0.442 NM_002037
FYN
FYN oncogene related to SRC, FGR, YES
chr9_-_35640852 0.440 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr10_+_124210980 0.439 NM_002775
HTRA1
HtrA serine peptidase 1
chr9_+_101623957 0.434 NM_006981
NM_173199
NR4A3

nuclear receptor subfamily 4, group A, member 3

chr5_-_64813459 0.433 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr1_-_153098811 0.433 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr2_+_114916368 0.427 NM_020868
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr4_+_187227302 0.424 NM_003265
TLR3
toll-like receptor 3
chr16_+_55373241 0.424 NUP93
nucleoporin 93kDa
chr6_-_130224108 0.423 NM_001010876
C6orf191
chromosome 6 open reading frame 191
chr8_+_38363150 0.421 NM_144652
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr12_+_108921343 0.420 ANKRD13A
ankyrin repeat domain 13A
chrX_-_19727775 0.420 SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_51208499 0.420 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr9_-_133605037 0.419 RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr11_+_6368213 0.418 NM_000543
NM_001007593
SMPD1

sphingomyelin phosphodiesterase 1, acid lysosomal

chr11_+_124539814 0.417 PKNOX2
PBX/knotted 1 homeobox 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.15 6.59e-03 GO:0065007 biological regulation
1.26 7.72e-03 GO:0023052 signaling
1.17 8.17e-03 GO:0050794 regulation of cellular process
1.27 1.31e-02 GO:0007165 signal transduction
1.15 1.78e-02 GO:0050789 regulation of biological process
1.77 1.89e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.23 2.00e-02 GO:0051716 cellular response to stimulus
2.29 4.52e-02 GO:0003012 muscle system process
1.93 4.53e-02 GO:0015672 monovalent inorganic cation transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.26 1.13e-04 GO:0071944 cell periphery
1.26 1.28e-04 GO:0005886 plasma membrane
1.41 3.51e-03 GO:0005856 cytoskeleton
1.32 7.44e-03 GO:0044459 plasma membrane part
2.61 8.05e-03 GO:0030016 myofibril
2.68 1.79e-02 GO:0030017 sarcomere
2.46 2.13e-02 GO:0043292 contractile fiber
2.44 4.86e-02 GO:0044449 contractile fiber part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 3.43e-02 GO:0005515 protein binding