Motif ID: PDX1.p2

Z-value: 0.737


Transcription factors associated with PDX1.p2:

Gene SymbolEntrez IDGene Name
PDX1 3651 pancreatic and duodenal homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PDX1chr13_+_27392136-0.039.2e-01Click!


Activity profile for motif PDX1.p2.

activity profile for motif PDX1.p2


Sorted Z-values histogram for motif PDX1.p2

Sorted Z-values for motif PDX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PDX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_38185578 1.168 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr2_-_158008763 0.884 NM_004288
CYTIP
cytohesin 1 interacting protein
chr19_-_7672978 0.861 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr10_+_63478974 0.849 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr12_+_45896318 0.681 NM_138371
FAM113B
family with sequence similarity 113, member B
chr4_+_86615275 0.633 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr16_-_69114931 0.594 NM_001195139
NM_015386
COG4

component of oligomeric golgi complex 4

chr21_-_45173061 0.593 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr6_-_133076873 0.586 NM_004666
VNN1
vanin 1
chr1_+_40635058 0.546 NM_001198980
SMAP2
small ArfGAP2
chr12_+_45896511 0.531 FAM113B
family with sequence similarity 113, member B
chr3_+_101720753 0.527 TMEM45A
transmembrane protein 45A
chr15_-_38185865 0.482 NM_033503
BMF
Bcl2 modifying factor
chr16_+_69115227 0.464 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr16_+_69115225 0.458 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr16_+_69115189 0.434 NM_012426
SF3B3
splicing factor 3b, subunit 3, 130kDa
chr3_-_21767819 0.389 NM_024697
ZNF385D
zinc finger protein 385D
chr7_-_92615593 0.355 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr4_-_176970372 0.319 GPM6A
glycoprotein M6A
chr3_-_145049853 0.266 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr4_-_176970407 0.262 GPM6A
glycoprotein M6A
chr1_+_62835759 0.260 NM_014495
ANGPTL3
angiopoietin-like 3
chr6_-_31215089 0.243 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr5_+_147628567 0.242 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr13_-_40491491 0.227 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr19_-_55539769 0.227 NAPSB
napsin B aspartic peptidase pseudogene
chr7_+_129057152 0.226 NM_001040110
NRF1
nuclear respiratory factor 1
chr3_+_116824840 0.221 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr6_-_131333173 0.215 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr2_-_165768798 0.212 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr17_+_7900926 0.202


chr16_+_18986721 0.201 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr17_-_36418869 0.193 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr19_-_56229808 0.193 NM_019598
NM_145894
NM_145895
KLK12


kallikrein-related peptidase 12


chr3_+_35697432 0.191 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr3_-_121883647 0.190 HGD
homogentisate 1,2-dioxygenase
chr1_+_157246305 0.188 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr3_-_110155237 0.187 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr1_+_157441133 0.174 NM_002036
DARC
Duffy blood group, chemokine receptor
chr16_-_66075216 0.168 NM_001138
AGRP
agouti related protein homolog (mouse)
chr10_+_118177371 0.167 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chrX_-_131375217 0.165 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr2_+_17861266 0.155 NM_001105569
MSGN1
mesogenin 1
chr21_+_44844924 0.151 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr6_-_52060327 0.150 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr7_+_104468614 0.143 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr10_-_62002672 0.143 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr16_+_18986417 0.142 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr5_-_142795269 0.142 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr2_+_113452066 0.139 NM_019618
IL1F9
interleukin 1 family, member 9
chr15_-_42756377 0.139 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr18_-_45630154 0.137 MYO5B
myosin VB
chr16_+_29582480 0.136 SPN
sialophorin
chr7_+_156128431 0.132 NM_001184997
RNF32
ring finger protein 32
chr8_-_17624304 0.131 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr14_+_38653177 0.128 NM_001009182
NM_001009183
NM_003616
SIP1


survival of motor neuron protein interacting protein 1


chr1_+_78858675 0.127 NM_006820
IFI44L
interferon-induced protein 44-like
chr12_-_52306348 0.125 NM_001130060
NM_006856
ATF7

activating transcription factor 7

chr5_-_119768430 0.124


chr5_+_68703036 0.114 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr1_-_246869181 0.108 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr3_-_51884639 0.107 NM_001145059
IQCF5
IQ motif containing F5
chr16_+_18986459 0.105 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr8_+_32698892 0.105 NM_001159996
NRG1
neuregulin 1
chr19_-_14646626 0.103 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr11_+_55899675 0.103 NM_001005204
NM_001013356
OR8U1
OR8U8
olfactory receptor, family 8, subfamily U, member 1
olfactory receptor, family 8, subfamily U, member 8
chr9_-_139084833 0.100 NM_178448
C9orf140
chromosome 9 open reading frame 140
chr2_+_227900471 0.100 NM_020194
MFF
mitochondrial fission factor
chr11_-_116168316 0.096 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr6_-_123999640 0.096 NM_006073
TRDN
triadin
chrX_+_110252960 0.095 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr7_+_147918589 0.094 NM_145304
C7orf33
chromosome 7 open reading frame 33
chr18_+_29573152 0.093 ASXL3
additional sex combs like 3 (Drosophila)
chrX_-_48655978 0.090 PIM2
pim-2 oncogene
chr1_+_57093030 0.089 NM_000562
C8A
complement component 8, alpha polypeptide
chr5_-_134290789 0.086


chr4_+_77575276 0.080 NM_020859
SHROOM3
shroom family member 3
chr4_+_95595419 0.080 PDLIM5
PDZ and LIM domain 5
chr2_+_169629544 0.080 NM_005771
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_-_230717850 0.080 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr18_-_49944986 0.078 MBD2
methyl-CpG binding domain protein 2
chr17_+_32807040 0.078 NM_173625
C17orf78
chromosome 17 open reading frame 78
chr11_+_22652894 0.074 NM_005256
GAS2
growth arrest-specific 2
chr12_-_56159631 0.073 NM_001080157
ARHGAP9
Rho GTPase activating protein 9
chr10_+_70650064 0.073 NM_025130
HKDC1
hexokinase domain containing 1
chr1_+_184532027 0.072 NM_001127708
NM_001127709
NM_001127710
NM_005807
PRG4



proteoglycan 4



chr14_-_80934523 0.070 NM_033104
STON2
stonin 2
chr9_+_140226457 0.069 NM_001145249
FAM157B
family with sequence similarity 157, member B
chr14_+_20580224 0.069 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr20_+_43423990 0.069 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr6_+_72979234 0.068 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chrX_+_77041612 0.068 NM_001866
COX7B
cytochrome c oxidase subunit VIIb
chr2_+_24660849 0.068 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr21_-_44824907 0.067 NM_198694
KRTAP10-5
keratin associated protein 10-5
chr3_-_152517204 0.066 NM_023915
GPR87
G protein-coupled receptor 87
chr3_+_44992733 0.066 NM_015004
EXOSC7
exosome component 7
chr5_+_140698537 0.065 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr1_-_202402043 0.064 NM_000537
REN
renin
chr2_-_121964373 0.063 CLASP1
cytoplasmic linker associated protein 1
chr3_-_47909001 0.063 MAP4
microtubule-associated protein 4
chr3_+_46594079 0.062 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr12_-_102968044 0.062 NM_031302
GLT8D2
glycosyltransferase 8 domain containing 2
chr6_+_147566559 0.062 STXBP5
syntaxin binding protein 5 (tomosyn)
chr12_+_10351683 0.061 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr2_-_199922047 0.060 SATB2
SATB homeobox 2
chr3_+_35658852 0.059 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr1_-_31251315 0.059 PUM1
pumilio homolog 1 (Drosophila)
chr5_+_68702617 0.059 NM_133340
NM_133341
RAD17

RAD17 homolog (S. pombe)

chr11_+_22652957 0.057 GAS2
growth arrest-specific 2
chr7_+_128099581 0.057 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr3_-_139315011 0.056 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr1_+_43508251 0.053 NM_144626
TMEM125
transmembrane protein 125
chr6_-_41362370 0.053 NM_018643
TREM1
triggering receptor expressed on myeloid cells 1
chr6_+_144654565 0.050 NM_007124
UTRN
utrophin
chr14_+_57964462 0.050 NM_014749
KIAA0586
KIAA0586
chr6_-_29563657 0.049 NM_052967
MAS1L
MAS1 oncogene-like
chr4_+_109033868 0.049 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr11_-_57883117 0.049 NM_001005489
OR5B17
olfactory receptor, family 5, subfamily B, member 17
chr12_-_101835510 0.048 NM_000277
PAH
phenylalanine hydroxylase
chr17_-_36403910 0.048 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr4_-_176970895 0.048 GPM6A
glycoprotein M6A
chr11_+_123639909 0.047 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr1_+_157676135 0.046 NM_012351
OR10J1
olfactory receptor, family 10, subfamily J, member 1
chr6_-_46933901 0.045 GPR116
G protein-coupled receptor 116
chr12_+_79362256 0.045 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr19_-_57100052 0.044 NM_023074
ZNF649
zinc finger protein 649
chr16_-_70339666 0.043 AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chr11_+_6823458 0.042 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr8_+_76614757 0.042 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr10_-_108448990 0.041 SORCS1
sortilin-related VPS10 domain containing receptor 1
chr11_-_55661769 0.039 NM_001004064
OR8J3
olfactory receptor, family 8, subfamily J, member 3
chr11_-_66201894 0.037 RBM4B
RNA binding motif protein 4B
chr4_-_140280031 0.036 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr3_+_99350859 0.036 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr4_+_74500748 0.035 ALB
albumin
chr3_-_44992604 0.034 NM_001135179
NM_016598
ZDHHC3

zinc finger, DHHC-type containing 3

chr6_-_55848317 0.034 NM_021073
BMP5
bone morphogenetic protein 5
chr22_-_23665312 0.034 NM_001001663
TMEM211
transmembrane protein 211
chr13_-_93929719 0.033 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chrX_-_62697473 0.032 LOC92249
hypothetical LOC92249
chr12_+_74071145 0.031 NM_152436
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr1_+_28637247 0.031 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr17_-_36559579 0.030 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr10_+_86174665 0.029 FAM190B
family with sequence similarity 190, member B
chr11_-_55684368 0.028 NM_001004058
OR8K5
olfactory receptor, family 8, subfamily K, member 5
chr5_+_179934143 0.028 CNOT6
CCR4-NOT transcription complex, subunit 6
chrX_+_118592568 0.027 UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chrX_+_118592879 0.027 UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chrX_+_37524250 0.026 CYBB
cytochrome b-245, beta polypeptide
chr6_+_158653679 0.026 NM_001007466
NM_020245
TULP4

tubby like protein 4

chrX_+_48572226 0.025 NM_181532
ERAS
ES cell expressed Ras
chr3_-_124822113 0.025 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr22_-_16070778 0.025 NM_017424
CECR1
cat eye syndrome chromosome region, candidate 1
chr12_-_54150188 0.025 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr12_+_31691360 0.024 NM_001135864
METTL20
methyltransferase like 20
chr17_-_1359745 0.024 INPP5K
inositol polyphosphate-5-phosphatase K
chr6_-_26151863 0.024 NM_021062
HIST1H2BB
histone cluster 1, H2bb
chr11_+_61732715 0.024 NM_002407
SCGB2A1
secretoglobin, family 2A, member 1
chr17_-_36725470 0.023 NM_031964
KRTAP17-1
keratin associated protein 17-1
chr12_+_74071116 0.022 GLIPR1L2
GLI pathogenesis-related 1 like 2
chr17_-_7023378 0.022 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr17_-_36444626 0.021 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr12_+_21417068 0.021 NM_000415
IAPP
islet amyloid polypeptide
chr4_+_169250281 0.020 NM_007193
ANXA10
annexin A10
chr2_-_27215781 0.019 NM_178553
C2orf53
chromosome 2 open reading frame 53
chr6_+_167624792 0.019 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr1_-_150463292 0.018 NM_001009931
HRNR
hornerin
chr8_-_81155564 0.018 NM_001025252
TPD52
tumor protein D52
chr7_+_150376537 0.017 NM_004769
NM_020321
NM_020322
ACCN3


amiloride-sensitive cation channel 3


chr21_-_30666417 0.017 NM_181621
KRTAP13-2
keratin associated protein 13-2
chr2_+_169634330 0.017 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr10_+_80942362 0.015 NM_001099692
EIF5AL1
eukaryotic translation initiation factor 5A-like 1
chr4_-_155753249 0.015 FGG
fibrinogen gamma chain
chr18_+_59374372 0.015 NM_080474
SERPINB12
serpin peptidase inhibitor, clade B (ovalbumin), member 12
chr21_-_30781537 0.015 NM_181608
KRTAP19-2
keratin associated protein 19-2
chr17_+_18566060 0.015 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr19_+_41872141 0.013 NM_152603
ZNF567
zinc finger protein 567
chr1_-_150328153 0.013 NM_001008536
TCHHL1
trichohyalin-like 1
chr2_+_38746742 0.013 GALM
galactose mutarotase (aldose 1-epimerase)
chr7_+_142459538 0.012 NM_001001667
OR6V1
olfactory receptor, family 6, subfamily V, member 1
chrX_-_10605726 0.012 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chrX_-_131923092 0.012 NM_001077188
NM_147175
HS6ST2

heparan sulfate 6-O-sulfotransferase 2

chr6_-_55848346 0.011 BMP5
bone morphogenetic protein 5
chr14_-_57133361 0.010 NM_001080455
SLC35F4
solute carrier family 35, member F4
chr11_-_5178505 0.009 NM_001004760
OR51V1
olfactory receptor, family 51, subfamily V, member 1
chr8_+_92330691 0.009 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr7_+_116182676 0.008


chr16_+_56286212 0.008 NM_032269
CCDC135
coiled-coil domain containing 135
chr1_-_159867781 0.007 NM_000570
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr3_+_199363633 0.007 NM_001145248
FAM157A
family with sequence similarity 157, member A
chr17_-_9635325 0.005 NM_001105571
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr14_-_46882144 0.004 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr21_-_30631882 0.004 NM_001077711
KRTAP27-1
keratin associated protein 27-1
chr17_-_1195096 0.003 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr17_-_36409632 0.001 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr3_+_149930656 0.001 NM_032049
AGTR1
angiotensin II receptor, type 1
chr12_-_52305900 0.000 ATF7
activating transcription factor 7

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
35.92 3.77e-02 GO:0006570 tyrosine metabolic process
3.59 4.43e-02 GO:0007608 sensory perception of smell

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
7.10 6.52e-05 GO:0005882 intermediate filament
6.15 2.73e-04 GO:0045111 intermediate filament cytoskeleton
9.43 1.35e-03 GO:0045095 keratin filament
2.36 2.23e-02 GO:0044430 cytoskeletal part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.74 5.95e-03 GO:0004930 G-protein coupled receptor activity
3.76 6.55e-03 GO:0004984 olfactory receptor activity