Motif ID: MSX1,2.p2

Z-value: 1.904


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MSX1chr4_+_49122720.591.6e-02Click!
MSX2chr5_+_174084137-0.514.1e-02Click!


Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_7785360 5.126 ITIH2
inter-alpha (globulin) inhibitor H2
chr9_-_115880372 4.776 AMBP
alpha-1-microglobulin/bikunin precursor
chr3_-_150422474 4.681 NM_000096
CP
ceruloplasmin (ferroxidase)
chr2_-_180135559 4.570 NM_001113398
ZNF385B
zinc finger protein 385B
chr10_+_7785331 4.439 ITIH2
inter-alpha (globulin) inhibitor H2
chr9_-_126309510 3.600 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr21_-_36774257 3.400 NM_001146079
NM_144492
CLDN14

claudin 14

chr7_-_96471544 3.306 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chrX_+_115481774 3.290 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr9_-_115880281 3.287 AMBP
alpha-1-microglobulin/bikunin precursor
chr12_+_70119785 3.192 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr10_-_74384569 3.145 PLA2G12B
phospholipase A2, group XIIB
chr9_-_115880425 3.109 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_-_74384485 2.933 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr14_-_64479198 2.929 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr1_-_149245503 2.639 NM_001163259
NM_001163260
NM_001040217
FAM63A


family with sequence similarity 63, member A


chr2_-_192420168 2.584 NM_004657
SDPR
serum deprivation response
chr10_+_7785347 2.431 ITIH2
inter-alpha (globulin) inhibitor H2
chr16_-_11918019 2.317 NM_001130007
GSPT1
G1 to S phase transition 1
chr3_+_129690735 2.245


chr3_-_150578148 2.239 TM4SF1
transmembrane 4 L six family member 1
chrX_+_115481848 2.090 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr10_+_7785290 2.064 ITIH2
inter-alpha (globulin) inhibitor H2
chr3_+_52803823 2.002 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr16_-_29817841 1.958 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr5_+_59819761 1.952 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr3_-_150578207 1.822 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr12_+_108038774 1.745 ACACB
acetyl-CoA carboxylase beta
chr1_-_108032645 1.729 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr1_+_200246370 1.708 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr9_-_115880366 1.652 AMBP
alpha-1-microglobulin/bikunin precursor
chr14_-_93324518 1.645 NM_178013
PRIMA1
proline rich membrane anchor 1
chr10_-_44794146 1.641 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr8_-_145613034 1.587 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr8_-_145613058 1.553 NM_130849
SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr2_-_237987553 1.520 COL6A3
collagen, type VI, alpha 3
chr2_-_237987554 1.502 COL6A3
collagen, type VI, alpha 3
chr2_-_237987545 1.472 COL6A3
collagen, type VI, alpha 3
chr2_-_192419896 1.471 SDPR
serum deprivation response
chr6_-_48186868 1.458 C6orf138
chromosome 6 open reading frame 138
chr17_-_61655915 1.447 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr2_-_104834344 1.437 LOC100506421
hypothetical LOC100506421
chr2_-_237987579 1.423 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr4_-_186970366 1.398 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr2_-_237987509 1.334 COL6A3
collagen, type VI, alpha 3
chr4_-_159311959 1.324 FAM198B
family with sequence similarity 198, member B
chr4_+_89115862 1.252 SPP1
secreted phosphoprotein 1
chr2_-_77602843 1.239 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr3_-_121884091 1.222 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr5_-_148738980 1.197 NM_014443
IL17B
interleukin 17B
chr6_+_64289585 1.180 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr6_+_16237264 1.135 NM_013262
MYLIP
myosin regulatory light chain interacting protein
chr3_-_150578023 1.115 TM4SF1
transmembrane 4 L six family member 1
chr12_+_56114724 1.110 NM_005538
INHBC
inhibin, beta C
chr4_+_90252990 1.095 NM_145715
TIGD2
tigger transposable element derived 2
chr3_-_121883647 1.085 HGD
homogentisate 1,2-dioxygenase
chr2_+_138438277 1.037 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr4_+_89115825 1.031 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr5_-_90645974 1.017 LOC100505994
hypothetical LOC100505994
chr12_+_49605010 1.009 METTL7A
methyltransferase like 7A
chr20_-_48686832 0.972 NM_080829
FAM65C
family with sequence similarity 65, member C
chr19_-_40696393 0.970 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr16_-_74056083 0.966 NM_145254
TMEM170A
transmembrane protein 170A
chr4_+_89115892 0.965 SPP1
secreted phosphoprotein 1
chr7_+_111850367 0.965 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr7_+_116238309 0.964 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr10_+_7785235 0.953 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr3_+_25445071 0.941 RARB
retinoic acid receptor, beta
chr3_-_150578103 0.940 TM4SF1
transmembrane 4 L six family member 1
chr12_+_52105131 0.938 AMHR2
anti-Mullerian hormone receptor, type II
chr13_-_45577144 0.918 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr12_-_69837831 0.901 TSPAN8
tetraspanin 8
chr8_-_38127489 0.870 NM_000349
STAR
steroidogenic acute regulatory protein
chr10_+_685887 0.865 C10orf108
chromosome 10 open reading frame 108
chrX_-_15530112 0.847 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr2_-_165133239 0.823 GRB14
growth factor receptor-bound protein 14
chr3_+_9919295 0.819 NM_153483
IL17RE
interleukin 17 receptor E
chrX_-_24600661 0.819 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr6_+_127940011 0.793 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr2_+_162908828 0.781 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr22_+_33792125 0.762 NM_001008494
ISX
intestine-specific homeobox
chr19_-_17236522 0.761 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr16_+_55042936 0.751 OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr3_+_25444753 0.750 NM_016152
RARB
retinoic acid receptor, beta
chr16_+_55042924 0.741 NM_018233
OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr20_+_71230 0.730 NM_030931
DEFB126
defensin, beta 126
chr2_+_233633348 0.725 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr9_-_115880494 0.725 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_71096830 0.720 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr6_-_24491498 0.715 NM_001195610
DCDC2
doublecortin domain containing 2
chr21_+_44729875 0.704


chr4_-_155753332 0.691 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr3_+_25444837 0.689 NM_000965
RARB
retinoic acid receptor, beta
chr1_-_229071957 0.686 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr5_-_42847716 0.671 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr3_+_9919511 0.665 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr17_-_36113502 0.662 NM_019016
KRT24
keratin 24
chr16_-_67943157 0.656 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr4_+_89115923 0.654 SPP1
secreted phosphoprotein 1
chr1_+_200246312 0.654 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr12_-_15757114 0.641 EPS8
epidermal growth factor receptor pathway substrate 8
chr7_+_94377145 0.639 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chrX_+_128966844 0.636 NM_021946
BCORL1
BCL6 corepressor-like 1
chr17_+_38306339 0.632 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr9_+_130942029 0.612 PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr5_-_22248630 0.585 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr5_+_176726918 0.582 RGS14
regulator of G-protein signaling 14
chrX_+_99726445 0.573 NM_022144
TNMD
tenomodulin
chr1_-_188713324 0.559 NM_199051
FAM5C
family with sequence similarity 5, member C
chr11_+_101488380 0.557 NM_001195045
YAP1
Yes-associated protein 1
chr19_-_14030970 0.554 NM_001145028
PALM3
paralemmin 3
chr16_-_55042614 0.542 NM_007006
NUDT21
nudix (nucleoside diphosphate linked moiety X)-type motif 21
chr13_+_51496679 0.535 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr11_-_85074848 0.504 NM_152723
CCDC89
coiled-coil domain containing 89
chr9_+_133295353 0.496


chr20_+_2224612 0.495 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr1_-_145163520 0.493 FMO5
flavin containing monooxygenase 5
chr15_-_41381744 0.491 NM_052955
TGM7
transglutaminase 7
chr4_-_39199527 0.490 UGDH
UDP-glucose 6-dehydrogenase
chr9_-_96395828 0.479 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr14_+_20595820 0.477 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr2_-_162638174 0.465 DPP4
dipeptidyl-peptidase 4
chr11_-_114593838 0.462 CADM1
cell adhesion molecule 1
chr6_-_123999640 0.461 NM_006073
TRDN
triadin
chr6_-_26038817 0.461 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr20_+_31613800 0.461 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr5_-_59819642 0.459 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr16_+_80626402 0.456 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_+_80626459 0.454 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_-_21197072 0.453 CRYM
crystallin, mu
chr21_+_39117064 0.453 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr12_-_6354818 0.434 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr1_+_54132447 0.430 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr4_+_155703581 0.423 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr2_-_68952006 0.416 NM_014482
BMP10
bone morphogenetic protein 10
chr12_+_7039453 0.412


chr16_+_80626456 0.411 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr11_-_40272239 0.405 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr3_-_101316038 0.395 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr14_-_23653965 0.394 NRL
neural retina leucine zipper
chr17_+_4795128 0.386 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr6_+_132901119 0.386 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr5_+_73145098 0.384 RGNEF
190 kDa guanine nucleotide exchange factor
chr1_+_150029798 0.368


chr12_-_89922888 0.360 NM_004950
EPYC
epiphycan
chr6_-_55848346 0.356 BMP5
bone morphogenetic protein 5
chr10_+_114123828 0.348 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr10_-_50269912 0.332 NM_001080520
DRGX
dorsal root ganglia homeobox
chr2_+_228064531 0.330 AGFG1
ArfGAP with FG repeats 1
chr5_+_140509803 0.324 NM_018939
PCDHB6
protocadherin beta 6
chr8_-_110689396 0.321 SYBU
syntabulin (syntaxin-interacting)
chr14_-_104330982 0.320 NM_005163
AKT1
v-akt murine thymoma viral oncogene homolog 1
chr5_-_160211623 0.317 NM_025153
ATP10B
ATPase, class V, type 10B
chr2_-_51112743 0.315 NRXN1
neurexin 1
chr6_-_31938572 0.313 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr6_+_16237300 0.312 MYLIP
myosin regulatory light chain interacting protein
chr16_-_74055998 0.309 TMEM170A
transmembrane protein 170A
chr6_-_31215089 0.307 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr12_-_110410730 0.306 ATXN2
ataxin 2
chr12_-_9252227 0.302 NM_002864
PZP
pregnancy-zone protein
chr11_+_130745580 0.299 NM_001048209
NTM
neurotrimin
chr16_+_64958025 0.297 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr2_+_234209838 0.297 NM_019075
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr6_-_31789824 0.291


chr5_+_139856688 0.291 ANKHD1
ankyrin repeat and KH domain containing 1
chr17_+_67628763 0.290 SOX9
SRY (sex determining region Y)-box 9
chr17_+_67628749 0.290 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr17_-_19592178 0.288 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr1_+_22852268 0.287 NM_000491
C1QB
complement component 1, q subcomponent, B chain
chr11_-_104344473 0.283 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr6_-_46155937 0.282 NM_001114086
CLIC5
chloride intracellular channel 5
chr1_+_31823097 0.278 TINAGL1
tubulointerstitial nephritis antigen-like 1
chrX_+_153310171 0.275 NM_001183
ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr7_-_99555399 0.273 NM_001190415
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr9_+_134843918 0.272 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chrX_-_76824726 0.272 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr16_+_64958060 0.269 CDH5
cadherin 5, type 2 (vascular endothelium)
chr1_+_110361634 0.264 AHCYL1
adenosylhomocysteinase-like 1
chr12_-_89922875 0.264 EPYC
epiphycan
chrX_+_28515479 0.263 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chrX_-_110542040 0.258 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr18_+_3584056 0.257 FLJ35776
hypothetical LOC649446
chr20_+_23293020 0.256 NM_022482
GZF1
GDNF-inducible zinc finger protein 1
chr20_-_34707971 0.252 NM_032214
NM_175077
SLA2

Src-like-adaptor 2

chr9_+_133295297 0.250 NM_013318
PRRC2B
proline-rich coiled-coil 2B
chr17_+_39213328 0.246 NM_001136483
C17orf105
chromosome 17 open reading frame 105
chr14_-_23752875 0.242 NM_014169
CHMP4A
chromatin modifying protein 4A
chr20_-_29360048 0.241 NM_001037731
DEFB116
defensin, beta 116
chr10_+_124020810 0.241 NM_144587
BTBD16
BTB (POZ) domain containing 16
chr14_-_106282128 0.240 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_+_137464931 0.240 NM_001080427
THSD7B
thrombospondin, type I, domain containing 7B
chr12_-_6354650 0.238 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr17_-_15109315 0.236 NM_000304
PMP22
peripheral myelin protein 22
chr6_-_150109324 0.232 NM_198887
NUP43
nucleoporin 43kDa
chr21_-_31995972 0.232 SCAF4
SR-related CTD-associated factor 4
chr20_-_5879036 0.227 NM_015939
TRMT6
tRNA methyltransferase 6 homolog (S. cerevisiae)
chr4_-_176970372 0.226 GPM6A
glycoprotein M6A
chr6_-_154719560 0.226 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr13_+_57103789 0.223 NM_001040429
PCDH17
protocadherin 17
chr9_-_21472311 0.220 NM_176891
IFNE
interferon, epsilon

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.44 4.41e-03 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.37 1.04e-03 GO:0005626 insoluble fraction
1.48 2.20e-03 GO:0071944 cell periphery
2.30 3.75e-03 GO:0005624 membrane fraction
2.08 3.94e-03 GO:0000267 cell fraction
1.43 1.82e-02 GO:0005886 plasma membrane
1.65 2.92e-02 GO:0005576 extracellular region
24.32 4.20e-02 GO:0005577 fibrinogen complex

Nothing significant found in function category.