Motif ID: EOMES.p2

Z-value: 1.083


Transcription factors associated with EOMES.p2:

Gene SymbolEntrez IDGene Name
EOMES 8320 eomesodermin

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EOMESchr3_-_277392010.381.5e-01Click!


Activity profile for motif EOMES.p2.

activity profile for motif EOMES.p2


Sorted Z-values histogram for motif EOMES.p2

Sorted Z-values for motif EOMES.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EOMES.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_105511615 2.737 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr2_+_171280046 2.218 NM_001003845
SP5
Sp5 transcription factor
chr2_-_74606819 2.007 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr2_+_171280944 1.984 SP5
Sp5 transcription factor
chr2_+_171280182 1.941


chr10_+_4995685 1.824 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr4_-_186969041 1.703 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr4_-_186969202 1.664 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr14_+_94148466 1.508 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr17_-_40858775 1.474 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr10_+_4995597 1.443 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr3_+_10832867 1.280 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr2_+_228386800 1.265 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr20_-_22513050 1.243 NM_021784
FOXA2
forkhead box A2
chr11_-_65070625 1.240 LTBP3
latent transforming growth factor beta binding protein 3
chr12_+_130004404 1.070 NM_198827
GPR133
G protein-coupled receptor 133
chr14_-_22516271 1.064 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr14_-_23107106 1.060 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr1_+_148496792 1.022 NM_012113
CA14
carbonic anhydrase XIV
chr10_+_114125955 0.971 ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_-_49434874 0.958 AMT
aminomethyltransferase
chr11_+_73037382 0.893 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr1_+_26609893 0.890 LIN28A
lin-28 homolog A (C. elegans)
chr17_+_53761293 0.889 LOC100506779
hypothetical LOC100506779
chr1_+_224477941 0.889 NM_031944
MIXL1
Mix1 homeobox-like 1 (Xenopus laevis)
chr14_-_23106779 0.884 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr7_+_50318801 0.883 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr1_+_42920946 0.859 YBX1
Y box binding protein 1
chr10_+_24537725 0.858 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr6_+_167456230 0.835 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr7_-_150283794 0.833 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr1_+_144149794 0.831 NM_006472
TXNIP
thioredoxin interacting protein
chr16_+_11966464 0.829 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr3_-_49701085 0.822 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr20_+_32926452 0.818 ACSS2
acyl-CoA synthetase short-chain family member 2
chr11_+_60858611 0.817 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr14_-_23106372 0.810 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr1_+_42920755 0.795 YBX1
Y box binding protein 1
chrX_-_135783496 0.794


chr1_+_42920635 0.790 NM_004559
YBX1
Y box binding protein 1
chr10_+_24538094 0.778 KIAA1217
KIAA1217
chr6_-_130578110 0.776 NM_152552
SAMD3
sterile alpha motif domain containing 3
chr15_-_50270856 0.775 NM_016194
GNB5
guanine nucleotide binding protein (G protein), beta 5
chr7_-_16471817 0.772 NM_015464
SOSTDC1
sclerostin domain containing 1
chr16_+_56259657 0.756 NM_170776
GPR97
G protein-coupled receptor 97
chr17_-_36346240 0.745 KRT23
keratin 23 (histone deacetylase inducible)
chrX_+_57329834 0.743 NM_174912
FAAH2
fatty acid amide hydrolase 2
chr2_+_176680251 0.737 NM_021192
HOXD11
homeobox D11
chr1_+_42920718 0.737 YBX1
Y box binding protein 1
chr12_-_23995109 0.728 SOX5
SRY (sex determining region Y)-box 5
chr1_+_42920685 0.719 YBX1
Y box binding protein 1
chr20_+_35406497 0.715 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr1_+_26609819 0.713 NM_024674
LIN28A
lin-28 homolog A (C. elegans)
chr12_-_23995220 0.711 SOX5
SRY (sex determining region Y)-box 5
chr3_+_47004457 0.696 NBEAL2
neurobeachin-like 2
chr1_+_42920692 0.694 YBX1
Y box binding protein 1
chr16_-_51139214 0.691 NM_001146188
TOX3
TOX high mobility group box family member 3
chr1_+_42920683 0.688 YBX1
Y box binding protein 1
chr18_+_53863865 0.673 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chrX_+_70360184 0.659 GJB1
gap junction protein, beta 1, 32kDa
chr1_+_151867483 0.659 NM_006271
S100A1
S100 calcium binding protein A1
chr3_-_140879463 0.646 NM_178177
NMNAT3
nicotinamide nucleotide adenylyltransferase 3
chr9_+_34642125 0.646 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chr10_+_114125927 0.643 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr11_+_46358909 0.629 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr11_+_20000938 0.605 NAV2
neuron navigator 2
chr6_+_34867794 0.595 UHRF1BP1
UHRF1 binding protein 1
chr1_-_51198383 0.594 FAF1
Fas (TNFRSF6) associated factor 1
chr2_-_25328452 0.593 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr7_+_113853790 0.591 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr5_+_147754467 0.581 FBXO38
F-box protein 38
chr1_-_151867338 0.576 NM_005979
S100A13
S100 calcium binding protein A13
chr4_+_109763119 0.576 RPL34
ribosomal protein L34
chr11_-_5227611 0.575 NM_000559
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr12_+_56435042 0.564 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr12_+_97513644 0.559 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr16_-_18845223 0.549 NM_015092
SMG1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chrX_+_152608159 0.549 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr17_-_53761119 0.543 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr21_+_39745649 0.543 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr2_-_61098867 0.536 NM_144709
PUS10
pseudouridylate synthase 10
chr10_+_114126004 0.534 ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_-_42818221 0.534


chr1_-_51198052 0.528 FAF1
Fas (TNFRSF6) associated factor 1
chr2_-_61551350 0.524 NM_014709
USP34
ubiquitin specific peptidase 34
chr5_+_61750467 0.519 NM_001134779
IPO11
importin 11
chr19_-_45947667 0.518 NM_198476
C19orf54
chromosome 19 open reading frame 54
chr1_-_159459814 0.518 APOA2
apolipoprotein A-II
chrX_-_106033202 0.516 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr1_-_167822248 0.515 F5
coagulation factor V (proaccelerin, labile factor)
chr17_+_38247493 0.514 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr11_+_20001130 0.512 NM_001111019
NAV2
neuron navigator 2
chr20_+_42463350 0.508 HNF4A
hepatocyte nuclear factor 4, alpha
chr1_-_51198417 0.508 FAF1
Fas (TNFRSF6) associated factor 1
chr5_-_138746840 0.508 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr1_-_199259133 0.508 KIF21B
kinesin family member 21B
chr13_+_51496679 0.506 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr5_-_138746917 0.505 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr12_+_54760211 0.505 ERBB3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr12_+_73219826 0.504


chr18_+_30812205 0.502 NM_001143827
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr5_+_133478252 0.499 NM_003202
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr10_+_114125003 0.480 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr12_-_1791146 0.467 CACNA2D4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr2_+_218954995 0.466 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr6_+_131936057 0.462 NM_000045
ARG1
arginase, liver
chr1_-_155053124 0.455 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr12_-_7172641 0.454 NM_031491
RBP5
retinol binding protein 5, cellular
chr17_+_22823151 0.453 NM_014238
KSR1
kinase suppressor of ras 1
chr20_+_42463279 0.453 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr7_-_20793028 0.452 NM_182700
NM_198956
SP8

Sp8 transcription factor

chr3_+_152970904 0.449 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr2_+_218992053 0.449 NM_007127
VIL1
villin 1
chr2_-_61551403 0.443 USP34
ubiquitin specific peptidase 34
chr17_-_36232366 0.443 NM_000421
KRT10
keratin 10
chr19_+_10242763 0.441 ICAM1
intercellular adhesion molecule 1
chr3_-_197549588 0.436 TM4SF19
transmembrane 4 L six family member 19
chr1_-_44255583 0.434 NM_006934
NM_201649
SLC6A9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr12_+_119418294 0.429 DYNLL1
dynein, light chain, LC8-type 1
chr20_+_42463419 0.429 HNF4A
hepatocyte nuclear factor 4, alpha
chr7_-_96471544 0.425 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr1_-_16843764 0.423 CROCCP2
ciliary rootlet coiled-coil, rootletin pseudogene 2
chr2_+_27573206 0.420 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr19_+_60283571 0.415 NM_017729
EPS8L1
EPS8-like 1
chr11_-_124311512 0.415 NM_152722
HEPACAM
hepatic and glial cell adhesion molecule
chr2_+_152900076 0.408 FMNL2
formin-like 2
chr20_+_42463387 0.407 HNF4A
hepatocyte nuclear factor 4, alpha
chrX_+_38545636 0.404 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr12_+_27740694 0.403 NM_001029874
REP15
RAB15 effector protein
chr1_-_23998515 0.403 NM_001127621
GALE
UDP-galactose-4-epimerase
chr17_+_43082302 0.402 KPNB1
karyopherin (importin) beta 1
chr10_-_123346148 0.400 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr6_+_124166767 0.399 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr11_-_118405288 0.397 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr1_+_156991133 0.397 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chr16_-_87244896 0.390 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr11_-_111255354 0.389 NM_138378
ALG9
FDXACB1
asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog (S. cerevisiae)
ferredoxin-fold anticodon binding domain containing 1
chr1_-_16006779 0.388 NM_001089591
UQCRHL
ubiquinol-cytochrome c reductase hinge protein-like
chr10_+_7785235 0.387 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chrX_+_23595579 0.385 PRDX4
peroxiredoxin 4
chrX_-_15783015 0.384 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr12_+_119418215 0.383 NM_001037495
NM_003746
DYNLL1

dynein, light chain, LC8-type 1

chr1_-_16843744 0.380 CROCCP2
ciliary rootlet coiled-coil, rootletin pseudogene 2
chr2_+_62787534 0.379 NM_001142614
EHBP1
EH domain binding protein 1
chr1_+_93072947 0.379 RPL5
ribosomal protein L5
chr12_-_51173238 0.374 NM_005554
KRT6A
keratin 6A
chr2_+_154436670 0.373 NM_052917
GALNT13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr16_+_70646008 0.369 NM_001126102
NM_005143
HP

haptoglobin

chrX_+_38545597 0.369 NM_001098790
NM_001098791
MID1IP1

MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))

chr12_-_7935010 0.366 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr16_+_67697622 0.365 NM_138612
HAS3
hyaluronan synthase 3
chr1_+_42920729 0.360 YBX1
Y box binding protein 1
chr1_+_559129 0.359


chr2_+_169021039 0.359 NM_203463
LASS6
LAG1 homolog, ceramide synthase 6
chr4_-_68793928 0.358 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr3_+_143797895 0.356 NM_001145319
PLS1
plastin 1
chr17_-_44226595 0.354 NM_173623
TTLL6
tubulin tyrosine ligase-like family, member 6
chr1_+_32489426 0.352 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr1_-_51198328 0.352 FAF1
Fas (TNFRSF6) associated factor 1
chr1_-_167822334 0.352 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr1_+_17719405 0.352 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr1_-_51198506 0.351 NM_007051
FAF1
Fas (TNFRSF6) associated factor 1
chr17_+_38014883 0.349 NM_001070
TUBG1
tubulin, gamma 1
chr8_+_86345274 0.346


chrX_+_70359780 0.344 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr19_+_41419165 0.344 ZNF146
zinc finger protein 146
chr17_+_43082273 0.344 NM_002265
KPNB1
karyopherin (importin) beta 1
chrX_-_154216929 0.341 NM_001289
CLIC2
chloride intracellular channel 2
chr1_+_158317967 0.340 NM_004983
KCNJ9
potassium inwardly-rectifying channel, subfamily J, member 9
chr16_+_70654625 0.339 NM_020995
HPR
haptoglobin-related protein
chr3_-_197549640 0.338 NM_138461
TM4SF19
transmembrane 4 L six family member 19
chr20_+_43943254 0.335 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr3_-_186752952 0.335 NM_139248
LIPH
lipase, member H
chr6_+_30402599 0.334 NM_021253
TRIM39
tripartite motif containing 39
chr20_-_54013418 0.333 NM_080617
CBLN4
cerebellin 4 precursor
chr8_-_42353719 0.333 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr20_+_55338221 0.330 NM_012444
NM_198265
SPO11

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

chr21_+_42697058 0.330 NM_001001895
NM_018961
UBASH3A

ubiquitin associated and SH3 domain containing A

chr9_+_109131814 0.328 RAD23B
RAD23 homolog B (S. cerevisiae)
chr9_+_114289178 0.326 KIAA1958
KIAA1958
chr17_-_77462506 0.320 NM_001184917
NM_002861
PCYT2

phosphate cytidylyltransferase 2, ethanolamine

chr12_+_55148567 0.320 NM_207344
SPRYD4
SPRY domain containing 4
chr18_-_3209846 0.320 MYOM1
myomesin 1, 185kDa
chr5_+_176446425 0.320 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr6_+_131190237 0.319 NM_001195597
LOC285733
hypothetical LOC285733
chr5_-_78318112 0.319 NM_000046
ARSB
arylsulfatase B
chr16_-_79811475 0.317 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr14_+_20537253 0.316 NM_014579
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr19_+_8180179 0.316 NM_024552
LASS4
LAG1 homolog, ceramide synthase 4
chr18_-_46977103 0.316 MEX3C
mex-3 homolog C (C. elegans)
chr1_-_12599934 0.316 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr2_-_169455167 0.313 NM_020675
SPC25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr1_-_26505653 0.312 NM_001077262
NM_183008
UBXN11

UBX domain protein 11

chr1_+_42920889 0.311 YBX1
Y box binding protein 1
chr1_-_243092581 0.309 HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr7_-_99365178 0.306 NM_181538
GJC3
gap junction protein, gamma 3, 30.2kDa
chr20_+_2465252 0.303 NM_080751
TMC2
transmembrane channel-like 2
chr20_-_2589476 0.302 IDH3B
isocitrate dehydrogenase 3 (NAD+) beta
chr12_+_54000611 0.300 NM_001005182
OR6C1
olfactory receptor, family 6, subfamily C, member 1
chr5_+_154072654 0.300 NM_015315
LARP1
La ribonucleoprotein domain family, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.22 1.85e-03 GO:0032501 multicellular organismal process
1.26 5.48e-03 GO:0023052 signaling
5.56 1.16e-02 GO:0045840 positive regulation of mitosis
5.56 1.16e-02 GO:0051785 positive regulation of nuclear division
1.55 1.38e-02 GO:0007154 cell communication

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.85 6.75e-03 GO:0015267 channel activity
1.84 7.26e-03 GO:0022803 passive transmembrane transporter activity
5.21 1.54e-02 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
1.79 2.49e-02 GO:0022838 substrate-specific channel activity
1.47 2.85e-02 GO:0022892 substrate-specific transporter activity
1.43 3.01e-02 GO:0005215 transporter activity
1.51 3.03e-02 GO:0022891 substrate-specific transmembrane transporter activity
1.89 3.70e-02 GO:0022836 gated channel activity
1.48 4.25e-02 GO:0022857 transmembrane transporter activity