Motif ID: NKX2-2,8.p2

Z-value: 1.498


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-8chr14_-_36121536-0.457.8e-02Click!
NKX2-2chr20_-_21442663-0.292.8e-01Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_40454188 4.983 ELF1
E74-like factor 1 (ets domain transcription factor)
chr3_-_15814678 2.547 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr3_-_122862391 2.403 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_-_122862447 2.272 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr2_+_102320148 2.218 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr12_-_101115677 2.123 NM_002674
PMCH
pro-melanin-concentrating hormone
chr13_-_40454360 1.879 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr21_-_14840506 1.831 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr12_-_9913199 1.750 CLEC2B
C-type lectin domain family 2, member B
chr2_-_144991556 1.673 ZEB2
zinc finger E-box binding homeobox 2
chr13_+_110653407 1.529 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr10_+_50177192 1.460 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr15_-_58477407 1.435 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr1_+_242281175 1.340 NM_205768
ZNF238
zinc finger protein 238
chr9_+_115303527 1.255 NM_130795
RGS3
regulator of G-protein signaling 3
chr9_+_122923864 1.226 CEP110
centrosomal protein 110kDa
chr5_+_40877053 1.216 NM_032587
CARD6
caspase recruitment domain family, member 6
chr11_+_65027721 1.174


chrX_+_134482212 1.133 NM_182540
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr4_-_24590867 1.102 NM_173463
CCDC149
coiled-coil domain containing 149
chr4_+_86918870 1.090 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chrX_-_154216929 1.054 NM_001289
CLIC2
chloride intracellular channel 2
chr2_+_170074457 1.040 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr5_+_162862808 1.040 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr1_+_239762179 1.031 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr1_+_242281199 1.029 ZNF238
zinc finger protein 238
chrX_+_11687655 1.014 NM_006800
MSL3
male-specific lethal 3 homolog (Drosophila)
chr10_+_97505398 1.012 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr21_-_35343065 0.995 RUNX1
runt-related transcription factor 1
chr1_-_41399632 0.994 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr14_-_99911409 0.991 WARS
tryptophanyl-tRNA synthetase
chr4_+_86918882 0.987 ARHGAP24
Rho GTPase activating protein 24
chr17_-_64462976 0.958 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr3_+_38010081 0.950 NM_015873
VILL
villin-like
chr3_-_71262426 0.945 FOXP1
forkhead box P1
chr1_+_160868822 0.927 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr3_-_71262405 0.888 FOXP1
forkhead box P1
chr14_-_99911528 0.881 WARS
tryptophanyl-tRNA synthetase
chr1_-_143708467 0.874 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr8_+_107807415 0.872 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr19_+_54530458 0.870 CD37
CD37 molecule
chr4_+_95595419 0.857 PDLIM5
PDZ and LIM domain 5
chr19_+_54530485 0.844 NM_001040031
NM_001774
CD37

CD37 molecule

chr9_-_113561613 0.839 NM_001080551
C9orf84
chromosome 9 open reading frame 84
chr10_+_94584449 0.833 NM_001013848
EXOC6
exocyst complex component 6
chr19_+_54530497 0.832 CD37
CD37 molecule
chr1_+_111818111 0.826 NM_174896
C1orf162
chromosome 1 open reading frame 162
chr13_-_98428244 0.813 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr7_-_92686773 0.804 NM_198151
HEPACAM2
HEPACAM family member 2
chr17_-_26665144 0.804 EVI2B
ecotropic viral integration site 2B
chr5_+_42792676 0.783 NM_001134848
CCDC152
coiled-coil domain containing 152
chr11_+_65023218 0.777


chr3_+_158637273 0.773 NM_002852
PTX3
pentraxin 3, long
chrX_-_100801472 0.769 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr19_+_54530512 0.765 CD37
CD37 molecule
chr1_-_20374273 0.763 NM_001105572
PLA2G2C
phospholipase A2, group IIC
chr12_-_69317441 0.757 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr14_-_72430545 0.756 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chr2_-_144994349 0.753 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chrX_+_47999740 0.734 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr1_-_180840016 0.734 NM_002928
RGS16
regulator of G-protein signaling 16
chr11_+_65023038 0.721 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr14_-_99911679 0.716 NM_004184
NM_213646
WARS

tryptophanyl-tRNA synthetase

chr11_+_93916653 0.702 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr13_-_45654327 0.687 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_-_48902692 0.685 NM_001113547
LIMA1
LIM domain and actin binding 1
chrX_-_19727775 0.681 SH3KBP1
SH3-domain kinase binding protein 1
chr3_+_133798770 0.675 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr5_-_88155360 0.674 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr1_+_84382575 0.672 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_-_102194938 0.667 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr19_+_54530546 0.656 CD37
CD37 molecule
chr17_-_35975227 0.655 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr3_-_33675484 0.652 CLASP2
cytoplasmic linker associated protein 2
chr5_-_98290117 0.647 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr1_+_196874839 0.643 PTPRC
protein tyrosine phosphatase, receptor type, C
chr9_-_41944687 0.638 MGC21881
hypothetical locus MGC21881
chr3_+_188197029 0.636


chr1_-_197173159 0.633 LOC100131234
familial acute myelogenous leukemia related factor
chr7_+_104468614 0.632 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr4_-_177427252 0.631 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr11_-_72111027 0.623 NM_001135190
NM_015242
ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

chr3_-_153541468 0.621 NM_001123228
TMEM14E
transmembrane protein 14E
chr7_+_113853790 0.620 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr2_+_33514896 0.618 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_+_196874759 0.613 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr8_-_133841988 0.611 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr9_+_66293049 0.606 MGC21881
hypothetical locus MGC21881
chr5_+_140772691 0.606 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr1_+_61642287 0.605 NFIA
nuclear factor I/A
chr1_+_196874867 0.605 PTPRC
protein tyrosine phosphatase, receptor type, C
chrX_-_19727828 0.600 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr5_-_43550891 0.595 NM_198566
C5orf34
chromosome 5 open reading frame 34
chr12_+_25096755 0.559 LRMP
lymphoid-restricted membrane protein
chr13_-_48873735 0.559 NM_030925
CAB39L
calcium binding protein 39-like
chr11_-_26700121 0.557 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr17_-_26665194 0.541 EVI2B
ecotropic viral integration site 2B
chr7_-_13992351 0.540 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr1_+_169747788 0.532 PRRC2C
proline-rich coiled-coil 2C
chr1_-_205161821 0.531 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr12_-_120725210 0.531 LOC338799
hypothetical LOC338799
chr7_-_87180499 0.530 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr3_-_113701073 0.527 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chr4_-_38534802 0.526 NM_006068
TLR6
toll-like receptor 6
chr17_-_26665213 0.526 EVI2B
ecotropic viral integration site 2B
chr14_-_60022487 0.525 NM_174978
C14orf39
chromosome 14 open reading frame 39
chr17_-_26665220 0.524 NM_006495
EVI2B
ecotropic viral integration site 2B
chrX_-_39921525 0.523 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr1_-_158759606 0.522 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr9_+_27099138 0.520 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr10_+_5478521 0.514 NM_005863
NET1
neuroepithelial cell transforming 1
chr17_+_35425139 0.512 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr2_-_63518589 0.506 NM_001042692
WDPCP
WD repeat containing planar cell polarity effector
chr1_+_149299504 0.504 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr10_-_64698831 0.493 NM_004241
JMJD1C
jumonji domain containing 1C
chr4_-_74307637 0.490 ANKRD17
ankyrin repeat domain 17
chr1_-_35143570 0.488 NM_001080418
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chr1_+_190394214 0.488 NM_130782
RGS18
regulator of G-protein signaling 18
chr1_+_234625338 0.488 NM_080738
EDARADD
EDAR-associated death domain
chr12_+_115455579 0.487 NCRNA00173
non-protein coding RNA 173
chr9_+_102380156 0.484 NM_001018116
MURC
muscle-related coiled-coil protein
chr4_-_71751205 0.483 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr1_-_156923111 0.482 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr17_+_72827654 0.480 SEPT9
septin 9
chr11_+_65023556 0.471


chr1_+_23994914 0.469


chr9_+_263025 0.467 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr7_+_838663 0.466 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr2_+_102401580 0.460 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr8_+_124264054 0.457 FAM83A
family with sequence similarity 83, member A
chr6_-_29081015 0.454 NM_001010877
ZNF311
zinc finger protein 311
chr1_+_144198658 0.453 LIX1L
Lix1 homolog (mouse)-like
chr1_-_67039518 0.449 NM_005478
INSL5
insulin-like 5
chr17_-_31281843 0.448 NM_001034836
NM_001163120
NM_001163121
NM_145654
RDM1



RAD52 motif 1



chr8_-_17599438 0.440 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr1_-_41398126 0.438 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr7_-_13997574 0.433 NM_001163148
ETV1
ets variant 1
chr1_-_103269356 0.427 COL11A1
collagen, type XI, alpha 1
chr18_-_65766068 0.423 CD226
CD226 molecule
chr1_+_165564904 0.423 NM_001198783
POU2F1
POU class 2 homeobox 1
chr1_-_115060956 0.418 NM_002524
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr2_-_183095308 0.416 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr7_+_23686268 0.411 NM_001127364
NM_001127365
NM_199136
C7orf46


chromosome 7 open reading frame 46


chr6_-_47030492 0.410 NM_015234
GPR116
G protein-coupled receptor 116
chr4_-_145046109 0.406 NM_002102
NM_198682
GYPE

glycophorin E (MNS blood group)

chr22_+_38627031 0.406 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr3_+_25444837 0.406 NM_000965
RARB
retinoic acid receptor, beta
chr21_+_29322100 0.405 USP16
ubiquitin specific peptidase 16
chr17_+_72827227 0.405 SEPT9
septin 9
chr12_-_47869067 0.404 NM_006009
TUBA1A
tubulin, alpha 1a
chr1_-_224993498 0.402 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr3_+_25444753 0.402 NM_016152
RARB
retinoic acid receptor, beta
chr1_+_103840900 0.400 RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr1_+_45251007 0.398 UROD
uroporphyrinogen decarboxylase
chr12_-_47869134 0.398 TUBA1A
tubulin, alpha 1a
chr6_+_30799130 0.397 TUBB
tubulin, beta
chr7_-_111216180 0.396 DOCK4
dedicator of cytokinesis 4
chr22_+_38627129 0.394 GRAP2
GRB2-related adaptor protein 2
chr7_-_107667728 0.393 NM_001037132
NRCAM
neuronal cell adhesion molecule
chrX_-_70248022 0.390 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr5_+_54491702 0.388 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr7_+_149696263 0.388 REPIN1
replication initiator 1
chr2_+_173394560 0.388 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr1_+_149299307 0.385 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr7_-_92693716 0.381 NM_001039372
HEPACAM2
HEPACAM family member 2
chr10_-_50066386 0.379 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr19_+_46121963 0.377 CYP2B7P1
cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1
chr2_+_143603368 0.373 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr5_-_169340321 0.372 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr5_+_159781454 0.367 PTTG1
pituitary tumor-transforming 1
chr12_-_91346054 0.366 NM_001025232
CLLU1OS
chronic lymphocytic leukemia up-regulated 1 opposite strand
chr8_+_144522389 0.364 NM_052924
RHPN1
rhophilin, Rho GTPase binding protein 1
chr5_-_150501393 0.361 NM_001193544
ANXA6
annexin A6
chr12_+_25096472 0.359 NM_006152
LRMP
lymphoid-restricted membrane protein
chr15_-_91078307 0.357 FAM174B
family with sequence similarity 174, member B
chr12_-_88573949 0.356 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr4_+_134292630 0.354 PCDH10
protocadherin 10
chrX_+_122923279 0.352 STAG2
stromal antigen 2
chr1_-_180622083 0.352 GLUL
glutamate-ammonia ligase
chr4_-_71751070 0.351 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr8_+_17866373 0.350 PCM1
pericentriolar material 1
chr1_-_115060857 0.350 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chrX_+_142794838 0.349 NM_001012989
UBE2NL
ubiquitin-conjugating enzyme E2N-like
chr1_-_177378801 0.349 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr1_+_149299490 0.348 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_53253204 0.347 SCP2
sterol carrier protein 2
chr1_-_74971679 0.345 NM_001130042
NM_001130043
NM_001134759
NM_001889
CRYZ



crystallin, zeta (quinone reductase)



chr1_-_200396328 0.344 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr7_+_115650240 0.344 NM_152829
TES
testis derived transcript (3 LIM domains)
chr12_+_4700012 0.343 NM_017417
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr1_+_165565006 0.342 POU2F1
POU class 2 homeobox 1
chr19_+_43847049 0.339


chr10_-_61570665 0.338 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr18_-_29273979 0.338 NM_001105528
C18orf34
chromosome 18 open reading frame 34
chr5_-_96544694 0.336 RIOK2
RIO kinase 2 (yeast)
chr3_-_39209075 0.336 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr11_-_128217550 0.329 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr5_+_71538456 0.327 MAP1B
microtubule-associated protein 1B
chr1_-_26266571 0.325 NM_032588
TRIM63
tripartite motif containing 63
chr10_+_70152216 0.324 CCAR1
cell division cycle and apoptosis regulator 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.34 9.86e-03 GO:0007165 signal transduction
1.17 4.45e-02 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.37 2.26e-02 GO:0044459 plasma membrane part

Nothing significant found in function category.