Motif ID: NKX2-1,4.p2

Z-value: 0.959


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_36059084-0.401.2e-01Click!
NKX2-4chr20_-_21326046-0.253.4e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_11966464 2.667 NM_001192
 TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chrX_+_78087484 2.586 NM_014499
NM_198333
 P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr21_-_14840506 2.582 NM_022136
 SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr19_-_6621078 2.357 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chrX_-_154216929 1.877 NM_001289
 CLIC2
chloride intracellular channel 2
chr3_-_143230124 1.707 NM_001178141
NM_001178142
NM_006286
 TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr19_-_6621598 1.706 NM_003807
NM_172014
 TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr5_-_88155360 1.496 NM_001193348
NM_001193349
 MEF2C

myocyte enhancer factor 2C

chr1_+_159817752 1.389 NM_201563
 FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr1_-_143706196 1.287 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_+_159899528 1.203 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
 FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr2_+_161701711 1.158 NM_004180
NM_133484
 TANK

TRAF family member-associated NFKB activator

chr4_+_111053488 1.152 NM_001178130
NM_001178131
NM_001963
 EGF


epidermal growth factor


chr1_+_32489426 1.085 NM_005356
 LCK
lymphocyte-specific protein tyrosine kinase
chr10_-_11614279 1.010 NM_001080491
 USP6NL
USP6 N-terminal like
chr1_-_143706300 0.942 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
 PDE4DIP




phosphodiesterase 4D interacting protein




chr19_-_50688310 0.931 NM_206901
 RTN2
reticulon 2
chr1_-_143706265 0.914 PDE4DIP
phosphodiesterase 4D interacting protein
chrX_+_48427103 0.909 NM_000377
 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr10_-_104201234 0.897 NM_024886
 C10orf95
chromosome 10 open reading frame 95

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
3.73 5.06e-03 GO:0046649 lymphocyte activation
3.53 1.69e-03 GO:0045321 leukocyte activation
2.58 5.05e-03 GO:0001775 cell activation
1.38 2.91e-03 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
3.69 4.53e-02 GO:0031968 organelle outer membrane
1.37 1.00e-02 GO:0071944 cell periphery
1.31 9.30e-03 GO:0031224 intrinsic to membrane
1.30 1.68e-02 GO:0016021 integral to membrane

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
2.06 4.37e-03 GO:0004930 G-protein coupled receptor activity
1.61 3.63e-02 GO:0004872 receptor activity
1.55 3.07e-02 GO:0004871 signal transducer activity
1.55 3.07e-02 GO:0060089 molecular transducer activity