Motif ID: NKX2-1,4.p2

Z-value: 0.959


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_36059084-0.401.2e-01Click!
NKX2-4chr20_-_21326046-0.253.4e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_11966464 2.667 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chrX_+_78087484 2.586 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr21_-_14840506 2.582 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr19_-_6621078 2.357 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chrX_-_154216929 1.877 NM_001289
CLIC2
chloride intracellular channel 2
chr3_-_143230124 1.707 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr19_-_6621598 1.706 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr5_-_88155360 1.496 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr1_+_159817752 1.389 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr1_-_143706196 1.287 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_+_159899528 1.203 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr2_+_161701711 1.158 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr4_+_111053488 1.152 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr1_+_32489426 1.085 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr10_-_11614279 1.010 NM_001080491
USP6NL
USP6 N-terminal like
chr1_-_143706300 0.942 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr19_-_50688310 0.931 NM_206901
RTN2
reticulon 2
chr1_-_143706265 0.914 PDE4DIP
phosphodiesterase 4D interacting protein
chrX_+_48427103 0.909 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr10_-_104201234 0.897 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr19_-_60458915 0.884 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr19_-_51979838 0.864 NM_001145145
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr2_-_100125402 0.863 NM_002285
AFF3
AF4/FMR2 family, member 3
chr11_+_59979857 0.853 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr1_+_180836050 0.848


chr11_-_16380967 0.715 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr16_+_56567839 0.712 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr10_-_32707549 0.695 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr15_-_81271859 0.693 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr4_-_68793928 0.662 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr1_-_158948176 0.652 NM_001778
CD48
CD48 molecule
chr12_-_51887266 0.651 NM_000889
ITGB7
integrin, beta 7
chr7_+_50318801 0.648 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr3_-_120761092 0.601 NM_005191
CD80
CD80 molecule
chr12_-_119733062 0.590 SPPL3
signal peptide peptidase 3
chr7_+_129634935 0.579 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr2_+_143603368 0.550 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr10_+_70650064 0.546 NM_025130
HKDC1
hexokinase domain containing 1
chr6_-_32268267 0.533 GPSM3
G-protein signaling modulator 3
chr17_-_5078773 0.521 NM_207103
C17orf87
chromosome 17 open reading frame 87
chr12_-_101115677 0.517 NM_002674
PMCH
pro-melanin-concentrating hormone
chr21_+_37714470 0.516 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr18_+_70317548 0.510 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr6_-_119137923 0.505 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr3_+_190831909 0.496 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr2_+_143603439 0.487 ARHGAP15
Rho GTPase activating protein 15
chr5_-_88004891 0.486 LOC645323
hypothetical LOC645323
chrX_-_100920493 0.471 GK
glycerol kinase
chr1_-_158815850 0.466 CD84
CD84 molecule
chr19_-_45132372 0.448 NM_003890
FCGBP
Fc fragment of IgG binding protein
chr1_-_178100204 0.447


chr14_+_63752424 0.446 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr17_+_63338500 0.443 BPTF
bromodomain PHD finger transcription factor
chrX_+_48427137 0.440 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr17_-_53761119 0.438 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr19_+_45797413 0.429 LTBP4
latent transforming growth factor beta binding protein 4
chr2_-_242205556 0.428 NM_001164356
THAP4
THAP domain containing 4
chr1_-_158815895 0.413 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr13_-_98757634 0.411 NM_004951
GPR183
G protein-coupled receptor 183
chr7_-_107230867 0.403 NM_000111
SLC26A3
solute carrier family 26, member 3
chr2_+_102744921 0.402 NM_144632
TMEM182
transmembrane protein 182
chr3_-_17757402 0.395 NM_014744
TBC1D5
TBC1 domain family, member 5
chr20_+_56455866 0.392 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr12_+_111900650 0.383 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr12_+_25096755 0.381 LRMP
lymphoid-restricted membrane protein
chr14_+_75058518 0.381 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr1_-_41398126 0.381 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr3_+_46386636 0.377 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr12_+_54700955 0.376 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr8_+_77928372 0.372 ZFHX4
zinc finger homeobox 4
chr9_+_114671635 0.364 SNX30
sorting nexin family member 30
chr1_-_158883666 0.361 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr5_+_140166842 0.360 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr12_-_51887318 0.351 ITGB7
integrin, beta 7
chr4_-_176970372 0.351 GPM6A
glycoprotein M6A
chr17_-_64462976 0.350 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr6_+_35373632 0.349 DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr4_-_176970407 0.347 GPM6A
glycoprotein M6A
chr1_+_196874867 0.344 PTPRC
protein tyrosine phosphatase, receptor type, C
chr13_+_110637173 0.344 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr11_+_22646229 0.342 NM_177553
GAS2
growth arrest-specific 2
chr2_+_161980865 0.341 NM_006593
TBR1
T-box, brain, 1
chr4_+_90252990 0.332 NM_145715
TIGD2
tigger transposable element derived 2
chr12_-_53064565 0.327 ZNF385A
zinc finger protein 385A
chr7_-_7724762 0.327 NM_002947
RPA3
replication protein A3, 14kDa
chr7_-_16471817 0.322 NM_015464
SOSTDC1
sclerostin domain containing 1
chr12_+_15590552 0.316 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr10_-_49152918 0.312 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr2_+_102401580 0.307 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr11_+_118463906 0.304 NM_001024382
HMBS
hydroxymethylbilane synthase
chr6_-_11887265 0.304 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr13_+_45174446 0.304 NM_152719
SPERT
spermatid associated
chrX_-_72351381 0.300 NAP1L2
nucleosome assembly protein 1-like 2
chr6_-_149847809 0.296 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr1_+_196874759 0.294 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr2_+_33554824 0.294 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr8_+_124264054 0.290 FAM83A
family with sequence similarity 83, member A
chr4_-_123761615 0.289 NM_021803
IL21
interleukin 21
chr1_-_26266571 0.288 NM_032588
TRIM63
tripartite motif containing 63
chr17_+_20048890 0.287 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr9_-_99740243 0.286 NM_197978
HEMGN
hemogen
chrX_+_48529905 0.282 NM_002049
GATA1
GATA binding protein 1 (globin transcription factor 1)
chr17_-_10393664 0.281 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr1_-_89364273 0.280 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr10_-_76538859 0.276 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr2_-_175170674 0.273 WIPF1
WAS/WASL interacting protein family, member 1
chr14_-_94669547 0.273 NM_001195573
DICER1
dicer 1, ribonuclease type III
chrX_-_72351392 0.272 NM_021963
NAP1L2
nucleosome assembly protein 1-like 2
chr19_-_53950458 0.272 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr15_-_53349775 0.271 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr6_-_149847718 0.271 ZC3H12D
zinc finger CCCH-type containing 12D
chr12_+_54132264 0.266 NM_054105
OR6C2
olfactory receptor, family 6, subfamily C, member 2
chr11_+_118259684 0.264 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr8_+_124263932 0.263 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr17_-_26665144 0.263 EVI2B
ecotropic viral integration site 2B
chr2_+_178893216 0.257 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr12_-_110410730 0.245 ATXN2
ataxin 2
chr5_-_142795269 0.240 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr9_-_5958367 0.237


chr3_-_180460372 0.236 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr7_+_143457083 0.234 NM_001001659
OR2A14
olfactory receptor, family 2, subfamily A, member 14
chr8_-_82536312 0.234 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr2_-_88946767 0.234


chr10_+_86121526 0.233 FAM190B
family with sequence similarity 190, member B
chrX_-_137649180 0.232 NM_033642
FGF13
fibroblast growth factor 13
chr17_-_26665213 0.229 EVI2B
ecotropic viral integration site 2B
chr17_-_26665220 0.227 NM_006495
EVI2B
ecotropic viral integration site 2B
chr12_-_52980914 0.227 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr10_+_114125003 0.224 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_61642287 0.223 NFIA
nuclear factor I/A
chr1_+_172683834 0.222 NM_005684
GPR52
G protein-coupled receptor 52
chr8_+_9990471 0.222 NM_001135671
MSRA
methionine sulfoxide reductase A
chr12_-_54392328 0.222 NM_001144997
ITGA7
integrin, alpha 7
chr12_+_117067214 0.218 PEBP1
phosphatidylethanolamine binding protein 1
chr12_+_130004404 0.217 NM_198827
GPR133
G protein-coupled receptor 133
chr17_+_65009986 0.217 MAP2K6
mitogen-activated protein kinase kinase 6
chr1_-_246503738 0.215 NM_001004695
OR2T33
olfactory receptor, family 2, subfamily T, member 33
chrX_+_70682204 0.214 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr11_+_62195710 0.213 C11orf83
chromosome 11 open reading frame 83
chr10_-_69125932 0.212 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr1_+_144124547 0.209 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr3_-_57209319 0.209 NM_003865
HESX1
HESX homeobox 1
chr10_-_108448990 0.208 SORCS1
sortilin-related VPS10 domain containing receptor 1
chr12_-_53064723 0.208 NM_015481
ZNF385A
zinc finger protein 385A
chr19_+_16691786 0.207 NM_001007525
NWD1
NACHT and WD repeat domain containing 1
chr1_+_151498802 0.206 NM_000427
LOR
loricrin
chr14_+_75058591 0.205 BATF
basic leucine zipper transcription factor, ATF-like
chr16_+_29982941 0.202 ALDOA
aldolase A, fructose-bisphosphate
chr11_+_63775567 0.195 NM_000932
NM_001184883
PLCB3

phospholipase C, beta 3 (phosphatidylinositol-specific)

chrX_-_48101044 0.191 NM_021014
NM_175711
SSX3

synovial sarcoma, X breakpoint 3

chr1_+_38033666 0.189 NM_152496
MANEAL
mannosidase, endo-alpha-like
chr17_-_3407780 0.189 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr8_-_7207899 0.188 NM_001164457
ZNF705G
zinc finger protein 705G
chr6_+_31782618 0.186 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chrX_-_72351348 0.186 NAP1L2
nucleosome assembly protein 1-like 2
chr1_-_43168247 0.185 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr12_-_7739591 0.183 NM_020634
GDF3
growth differentiation factor 3
chr5_-_147996769 0.182 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr13_-_74799898 0.181 TBC1D4
TBC1 domain family, member 4
chr1_-_42574116 0.180 NM_001198850
FOXJ3
forkhead box J3
chrX_-_110542040 0.179 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chrX_+_41468351 0.178 NM_080817
GPR82
G protein-coupled receptor 82
chr3_+_68136056 0.178 NM_213609
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr19_-_60360768 0.177 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr1_-_160648429 0.176 NM_053282
SH2D1B
SH2 domain containing 1B
chr14_-_20694023 0.175 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr1_-_9052207 0.175 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr10_-_6144119 0.175 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr3_+_188397967 0.173 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chr1_-_156937065 0.172 NM_001005279
OR6K2
olfactory receptor, family 6, subfamily K, member 2
chr1_-_76170563 0.170 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chr4_-_77547481 0.167 NM_001042784
CCDC158
coiled-coil domain containing 158
chr2_-_157890400 0.167 NM_020711
ERMN
ermin, ERM-like protein
chr3_-_180467483 0.166 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr9_+_130485754 0.165 NM_001122821
SET
SET nuclear oncogene
chr1_-_240679380 0.165 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr1_+_154120170 0.165 SYT11
synaptotagmin XI
chr6_-_152681171 0.164 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chrX_-_48655978 0.163 PIM2
pim-2 oncogene
chr14_+_55148488 0.163 KTN1
kinectin 1 (kinesin receptor)
chr17_-_39630951 0.162 NM_001098833
NM_020218
ATXN7L3

ataxin 7-like 3

chr8_-_110726921 0.161 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr6_-_11219932 0.161 NM_207582
ERVFRDE1
HERV-FRD provirus ancestral Env polyprotein
chr5_-_156468614 0.159 NM_032782
HAVCR2
hepatitis A virus cellular receptor 2
chr12_-_48246488 0.157 NM_001012300
MCRS1
microspherule protein 1
chr11_-_5212168 0.155 NM_000519
HBD
hemoglobin, delta
chr18_-_59137488 0.153 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chr10_-_75005421 0.153 NM_152586
USP54
ubiquitin specific peptidase 54
chr1_+_149299530 0.152 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr6_+_155579788 0.152 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr4_-_185963859 0.151 ACSL1
acyl-CoA synthetase long-chain family member 1
chr1_-_100416358 0.149 NM_144620
LRRC39
leucine rich repeat containing 39
chr8_-_6901661 0.149 NM_021010
DEFA5
defensin, alpha 5, Paneth cell-specific
chr2_-_37397669 0.149 NM_005813
PRKD3
protein kinase D3
chr7_+_38984133 0.149 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr11_-_31789168 0.149 PAX6
paired box 6
chr21_-_35343065 0.148 RUNX1
runt-related transcription factor 1
chr2_+_38009405 0.148 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr17_-_74244539 0.148


chr11_-_57643491 0.147 NM_001005211
OR9I1
olfactory receptor, family 9, subfamily I, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.53 1.69e-03 GO:0045321 leukocyte activation
1.38 2.91e-03 GO:0032501 multicellular organismal process
2.58 5.05e-03 GO:0001775 cell activation
3.73 5.06e-03 GO:0046649 lymphocyte activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.31 9.30e-03 GO:0031224 intrinsic to membrane
1.37 1.00e-02 GO:0071944 cell periphery
1.30 1.68e-02 GO:0016021 integral to membrane
3.69 4.53e-02 GO:0031968 organelle outer membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.06 4.37e-03 GO:0004930 G-protein coupled receptor activity
1.55 3.07e-02 GO:0004871 signal transducer activity
1.55 3.07e-02 GO:0060089 molecular transducer activity
1.61 3.63e-02 GO:0004872 receptor activity