Motif ID: E2F1..5.p2

Z-value: 3.824


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F2chr1_-_237298710.783.9e-04Click!
E2F3chr6_+_205100190.721.5e-03Click!
E2F5chr8_+_862871610.514.3e-02Click!
E2F1chr20_-_317378150.381.5e-01Click!
E2F4chr16_+_65783599-0.058.5e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_23729871 7.677 E2F2
E2F transcription factor 2
chr1_-_23730298 7.256 NM_004091
E2F2
E2F transcription factor 2
chr6_+_135544138 6.194 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr6_+_135544214 6.043 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr6_+_135544170 6.012 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr11_-_33847507 4.993 LMO2
LIM domain only 2 (rhombotin-like 1)
chr22_+_18485145 4.513 RANBP1
RAN binding protein 1
chr22_+_18485076 4.451 RANBP1
RAN binding protein 1
chr11_-_19219000 4.407 NM_024680
E2F8
E2F transcription factor 8
chr22_+_18485057 4.378 RANBP1
RAN binding protein 1
chr22_+_18485095 4.186 RANBP1
RAN binding protein 1
chr22_+_18485068 4.082 RANBP1
RAN binding protein 1
chr22_-_18484695 3.863 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr11_-_19219720 3.820 E2F8
E2F transcription factor 8
chr22_+_34126104 3.673 NM_006739
MCM5
minichromosome maintenance complex component 5
chr7_+_50314801 3.673 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr22_+_34126154 3.600 MCM5
minichromosome maintenance complex component 5
chr10_+_124885556 3.399 NM_001105574
HMX3
H6 family homeobox 3
chr20_-_35157744 3.394 RBL1
retinoblastoma-like 1 (p107)
chr11_-_33847834 3.269 LMO2
LIM domain only 2 (rhombotin-like 1)
chr22_+_18484810 3.262 NM_002882
RANBP1
RAN binding protein 1
chr20_-_35157815 3.260 NM_002895
NM_183404
RBL1

retinoblastoma-like 1 (p107)

chr1_+_3558958 3.230 NM_005427
TP73
tumor protein p73
chr9_-_122679387 3.177 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr11_-_33847937 3.153 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr22_-_18484744 3.152 NM_022727
NM_182984
TRMT2A

TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)

chr1_-_36008009 2.958 NM_001190481
NM_022111
CLSPN

claspin

chr11_-_33848013 2.864 LMO2
LIM domain only 2 (rhombotin-like 1)
chr10_+_62208256 2.765 CDK1
cyclin-dependent kinase 1
chr9_-_122679283 2.688 PHF19
PHD finger protein 19
chr22_+_34126294 2.685 MCM5
minichromosome maintenance complex component 5
chr20_-_31737731 2.633 E2F1
E2F transcription factor 1
chr6_-_52257500 2.620 NM_002388
MCM3
minichromosome maintenance complex component 3
chr12_-_75983329 2.573 NM_203394
E2F7
E2F transcription factor 7
chr6_-_52257475 2.539 MCM3
minichromosome maintenance complex component 3
chr6_-_52257431 2.522 MCM3
minichromosome maintenance complex component 3
chr22_-_37296012 2.501 NM_007068
DMC1
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
chr16_-_30010705 2.471 NM_004608
TBX6
T-box 6
chr6_+_27208763 2.466 NM_021064
HIST1H2AG
histone cluster 1, H2ag
chr2_-_136350404 2.465 MCM6
minichromosome maintenance complex component 6
chr2_+_74635019 2.452 NM_001381
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr7_-_99537362 2.450 NM_005916
MCM7
minichromosome maintenance complex component 7
chr6_+_31815703 2.399 NM_002441
NM_025259
NM_172165
NM_172166
MSH5-C6ORF26
MSH5



MSH5-C6orf26 read-through transcript
mutS homolog 5 (E. coli)



chr17_-_43977273 2.329 NM_002145
HOXB2
homeobox B2
chr6_-_27208507 2.294 NM_021058
HIST1H2BJ
histone cluster 1, H2bj
chr6_+_20510019 2.250 NM_001949
E2F3
E2F transcription factor 3
chr6_-_26358811 2.241 NM_021018
HIST1H3F
histone cluster 1, H3f
chr20_-_31737815 2.196 NM_005225
E2F1
E2F transcription factor 1
chr10_+_62208094 2.187 NM_001170406
NM_001170407
NM_001786
NM_033379
CDK1



cyclin-dependent kinase 1



chr19_+_4860447 2.133 NM_001048201
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chrX_-_135677022 2.105 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr2_-_136350472 2.098 NM_005915
MCM6
minichromosome maintenance complex component 6
chr1_-_26105230 2.081 NM_203401
STMN1
stathmin 1
chrX_-_53465847 2.075 SMC1A
structural maintenance of chromosomes 1A
chr5_-_176671897 2.066 NM_001142935
NM_031300
MXD3

MAX dimerization protein 3

chr7_+_120378052 2.062 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chr19_-_60587414 2.062 NM_001190764
LOC388564
hypothetical protein LOC388564
chr6_+_27222839 2.041 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr2_+_10180145 2.036 NM_001165931
RRM2
ribonucleotide reductase M2
chr3_+_128799961 2.020 MCM2
minichromosome maintenance complex component 2
chr19_+_4861166 1.945 UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr2_+_10180304 1.930 NM_001034
RRM2
ribonucleotide reductase M2
chr7_+_99537065 1.887 NM_004722
AP4M1
adaptor-related protein complex 4, mu 1 subunit
chr6_-_27222556 1.881 NM_080593
HIST1H2BK
histone cluster 1, H2bk
chr1_-_226712140 1.851 NM_033445
HIST3H2A
histone cluster 3, H2a
chr1_+_226712430 1.841 NM_175055
HIST3H2BB
histone cluster 3, H2bb
chr17_+_27288152 1.834 NM_015355
SUZ12
suppressor of zeste 12 homolog (Drosophila)
chr17_-_44042924 1.803 HOXB7
homeobox B7
chr10_-_25281510 1.797 NM_020200
PRTFDC1
phosphoribosyl transferase domain containing 1
chr12_+_107047594 1.783 NM_014653
WSCD2
WSC domain containing 2
chr19_-_10540620 1.778 NM_001800
NM_079421
CDKN2D

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

chr1_-_28113540 1.774 RPA2
replication protein A2, 32kDa
chr7_-_158190193 1.728 NM_017760
NCAPG2
non-SMC condensin II complex, subunit G2
chr1_-_28113817 1.727 NM_002946
RPA2
replication protein A2, 32kDa
chr17_+_27288167 1.712 SUZ12
suppressor of zeste 12 homolog (Drosophila)
chr3_+_144321286 1.706 NM_004267
CHST2
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
chr7_-_106088565 1.690 NM_175884
FLJ36031
hypothetical protein FLJ36031
chr10_-_57791000 1.688 ZWINT
ZW10 interactor
chr3_-_140148671 1.684 NM_023067
FOXL2
forkhead box L2
chr4_+_129950222 1.681 NM_024900
NM_199320
PHF17

PHD finger protein 17

chr7_-_99536966 1.681 MCM7
minichromosome maintenance complex component 7
chr3_+_16901455 1.664 NM_001144382
PLCL2
phospholipase C-like 2
chr7_-_99536929 1.664 MCM7
minichromosome maintenance complex component 7
chr10_-_57791025 1.661 NM_001005413
NM_007057
NM_032997
ZWINT


ZW10 interactor


chr22_-_19685998 1.658 THAP7
THAP domain containing 7
chr16_+_87397686 1.644 NM_030928
CDT1
chromatin licensing and DNA replication factor 1
chr17_-_44043278 1.629 HOXB7
homeobox B7
chr1_-_47552238 1.627 NM_001048166
NM_003035
STIL

SCL/TAL1 interrupting locus

chr17_+_27288253 1.625 SUZ12
suppressor of zeste 12 homolog (Drosophila)
chr2_-_144991556 1.613 ZEB2
zinc finger E-box binding homeobox 2
chr16_+_28798735 1.610 ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr1_+_149309703 1.607 NM_144618
GABPB2
GA binding protein transcription factor, beta subunit 2
chr19_-_10166600 1.605 DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr17_-_44043361 1.587 NM_004502
HOXB7
homeobox B7
chr4_-_56197115 1.586 NM_006681
NMU
neuromedin U
chr15_+_39008822 1.582 NM_019074
DLL4
delta-like 4 (Drosophila)
chr19_+_4861339 1.578 NM_013282
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr7_-_99536852 1.551 MCM7
minichromosome maintenance complex component 7
chr7_+_88226617 1.546 NM_181646
ZNF804B
zinc finger protein 804B
chr2_+_74635354 1.545 DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr17_+_27288374 1.519


chr17_+_27288178 1.513 SUZ12
suppressor of zeste 12 homolog (Drosophila)
chr9_-_97119677 1.477 NM_000136
FANCC
Fanconi anemia, complementation group C
chr19_-_10166536 1.471 DNMT1
DNA (cytosine-5-)-methyltransferase 1
chrX_+_48440079 1.471 SUV39H1
suppressor of variegation 3-9 homolog 1 (Drosophila)
chr2_-_144991386 1.444 ZEB2
zinc finger E-box binding homeobox 2
chr11_+_817584 1.438 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr16_+_87397715 1.428 CDT1
chromatin licensing and DNA replication factor 1
chr3_-_44778099 1.413 NM_020696
KIAA1143
KIAA1143
chrX_+_48440068 1.382 NM_003173
SUV39H1
suppressor of variegation 3-9 homolog 1 (Drosophila)
chr3_+_140148765 1.378 NM_001040061
C3orf72
chromosome 3 open reading frame 72
chr13_-_78075683 1.378 NM_006237
POU4F1
POU class 4 homeobox 1
chr7_+_128861471 1.363 NM_001134336
NM_020704
FAM40B

family with sequence similarity 40, member B

chr1_-_26105477 1.362 NM_001145454
NM_005563
STMN1

stathmin 1

chr9_+_129962292 1.351 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr1_+_210275752 1.349 DTL
denticleless homolog (Drosophila)
chr3_+_44778284 1.348 KIF15
kinesin family member 15
chr6_-_153345786 1.345 NM_012177
FBXO5
F-box protein 5
chr7_-_148212336 1.333 NM_004456
NM_152998
EZH2

enhancer of zeste homolog 2 (Drosophila)

chr7_-_148212292 1.325 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr3_+_128799964 1.321 MCM2
minichromosome maintenance complex component 2
chr4_+_154485224 1.320 NM_032117
MND1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr4_-_105631915 1.316 NM_025212
CXXC4
CXXC finger protein 4
chr5_-_54558899 1.315 NM_001190787
LOC345643
hypothetical LOC345643
chrX_-_133758812 1.308 NM_001166599
NM_001166600
NM_001170757
FAM122B


family with sequence similarity 122B


chr7_-_148212312 1.300 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr3_+_128799902 1.300 NM_004526
MCM2
minichromosome maintenance complex component 2
chr7_-_148212230 1.293 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr8_+_55533047 1.289 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr15_+_39739933 1.287 MGA
MAX gene associated
chr13_+_33290254 1.276 RFC3
replication factor C (activator 1) 3, 38kDa
chr15_+_38550451 1.272 NM_130468
CHST14
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
chr19_+_34994701 1.268 NM_001238
CCNE1
cyclin E1
chrX_+_130985316 1.266 NM_001042452
MST4
serine/threonine protein kinase MST4
chrX_+_24621964 1.262 POLA1
polymerase (DNA directed), alpha 1, catalytic subunit
chr3_+_44778212 1.258 NM_020242
KIF15
kinesin family member 15
chr7_-_148212310 1.258 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr12_-_131773972 1.256 NM_006231
POLE
polymerase (DNA directed), epsilon
chr2_+_173927783 1.251 NM_031942
NM_145810
CDCA7

cell division cycle associated 7

chrX_+_130984912 1.239 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr19_-_10540328 1.231 CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr5_+_79986049 1.220 NM_002439
MSH3
mutS homolog 3 (E. coli)
chr19_-_10166645 1.217 NM_001130823
NM_001379
DNMT1

DNA (cytosine-5-)-methyltransferase 1

chr1_+_210275735 1.216 DTL
denticleless homolog (Drosophila)
chr9_-_98220360 1.209 ZNF367
zinc finger protein 367
chr5_-_79986104 1.205 DHFR
dihydrofolate reductase
chr1_-_203985701 1.199 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr2_+_177965734 1.189 AGPS
alkylglycerone phosphate synthase
chr8_+_69026895 1.188 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chrX_-_53466273 1.186 SMC1A
structural maintenance of chromosomes 1A
chr8_+_69027277 1.184 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_-_26105954 1.183 NM_203399
STMN1
stathmin 1
chr5_+_79986254 1.179 MSH3
mutS homolog 3 (E. coli)
chr1_-_203985896 1.179 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr5_+_79986227 1.175 MSH3
mutS homolog 3 (E. coli)
chr1_+_199259664 1.174


chr3_-_150286812 1.171 NM_003071
NM_139048
HLTF

helicase-like transcription factor

chr1_-_203985932 1.170


chr5_-_79986063 1.158 DHFR
dihydrofolate reductase
chr8_-_124477869 1.154 NM_014109
ATAD2
ATPase family, AAA domain containing 2
chr19_-_6453224 1.149 NM_006087
TUBB4
tubulin, beta 4
chr2_+_27293846 1.141 CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr2_+_27293737 1.136 NM_004341
CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr15_+_89061579 1.133 NM_000057
BLM
Bloom syndrome, RecQ helicase-like
chrX_+_24621984 1.133 NM_016937
POLA1
polymerase (DNA directed), alpha 1, catalytic subunit
chr5_+_79986222 1.130 MSH3
mutS homolog 3 (E. coli)
chr7_+_116380790 1.125 ST7
suppression of tumorigenicity 7
chr22_-_18484428 1.122 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr1_-_203985780 1.119 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr5_-_79986539 1.115 NM_000791
DHFR
dihydrofolate reductase
chr1_-_100370994 1.109 NM_194292
SASS6
spindle assembly 6 homolog (C. elegans)
chr6_-_27883662 1.106 NM_003519
HIST1H2BL
histone cluster 1, H2bl
chr13_+_113287048 1.101 NM_007111
TFDP1
transcription factor Dp-1
chr8_+_69027166 1.101 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr5_-_176671437 1.101 MXD3
MAX dimerization protein 3
chrX_+_152891184 1.097 NM_003492
TMEM187
transmembrane protein 187
chr15_+_62539831 1.097 ZNF609
zinc finger protein 609
chr9_+_125813849 1.093 LHX2
LIM homeobox 2
chr10_-_98470164 1.092 NM_152309
PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr17_+_26183074 1.091 NM_024857
ATAD5
ATPase family, AAA domain containing 5
chr8_-_27751207 1.090 NM_018492
PBK
PDZ binding kinase
chr12_-_131774061 1.090 POLE
polymerase (DNA directed), epsilon
chr1_+_210275541 1.089 NM_016448
DTL
denticleless homolog (Drosophila)
chr11_-_14869761 1.082 CYP2R1
cytochrome P450, family 2, subfamily R, polypeptide 1
chr19_-_46551607 1.077 TGFB1
transforming growth factor, beta 1
chr14_-_54727958 1.075 NM_001146015
NM_014750
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr15_+_30694982 1.074 NM_014783
NM_199357
ARHGAP11A

Rho GTPase activating protein 11A

chr16_-_2970390 1.074 PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
chr4_+_134292630 1.073 PCDH10
protocadherin 10
chr7_-_44854222 1.073 NM_012412
NM_138635
NM_201436
NM_201516
NM_201517
H2AFV




H2A histone family, member V




chr19_+_50601306 1.073 NM_012099
CD3EAP
CD3e molecule, epsilon associated protein
chr1_-_203985752 1.065 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr17_+_35697656 1.059 CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr1_-_203985963 1.059 NM_022731
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr3_-_48204332 1.057 CDC25A
cell division cycle 25 homolog A (S. pombe)
chr11_+_65414677 1.043 CCDC85B
coiled-coil domain containing 85B
chr17_-_16197433 1.042 NM_181716
CENPV
centromere protein V
chr8_+_69027143 1.041 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr15_+_39739864 1.041 NM_001080541
NM_001164273
MGA

MAX gene associated

chr6_+_84799969 1.040 NM_138409
MRAP2
melanocortin 2 receptor accessory protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.65 4.87e-35 GO:0007049 cell cycle
2.99 8.13e-32 GO:0022403 cell cycle phase
2.79 2.92e-31 GO:0022402 cell cycle process
1.90 7.08e-27 GO:0090304 nucleic acid metabolic process
2.84 1.53e-24 GO:0051276 chromosome organization
1.74 1.55e-24 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.89 2.79e-24 GO:0006259 DNA metabolic process
2.90 2.94e-24 GO:0000278 mitotic cell cycle
1.48 3.37e-19 GO:0044260 cellular macromolecule metabolic process
1.59 1.07e-18 GO:0034641 cellular nitrogen compound metabolic process
3.34 5.09e-18 GO:0051325 interphase
3.35 7.30e-18 GO:0051329 interphase of mitotic cell cycle
1.56 1.70e-17 GO:0006807 nitrogen compound metabolic process
1.87 2.86e-17 GO:0006996 organelle organization
2.88 2.87e-17 GO:0000279 M phase
4.05 3.26e-17 GO:0006260 DNA replication
4.79 1.35e-14 GO:0065004 protein-DNA complex assembly
2.56 1.54e-14 GO:0006974 response to DNA damage stimulus
4.65 1.84e-14 GO:0071824 protein-DNA complex subunit organization
4.97 2.13e-14 GO:0031497 chromatin assembly
2.94 2.56e-14 GO:0010564 regulation of cell cycle process
2.95 3.17e-14 GO:0006281 DNA repair
2.37 5.94e-14 GO:0051726 regulation of cell cycle
4.30 8.02e-14 GO:0006323 DNA packaging
3.96 2.66e-13 GO:0071103 DNA conformation change
4.60 1.09e-12 GO:0034728 nucleosome organization
4.82 1.27e-12 GO:0006334 nucleosome assembly
1.35 1.85e-12 GO:0043170 macromolecule metabolic process
2.52 2.01e-12 GO:0006325 chromatin organization
3.96 2.45e-12 GO:0000082 G1/S transition of mitotic cell cycle
1.55 2.73e-12 GO:0071842 cellular component organization at cellular level
1.53 2.91e-12 GO:0071841 cellular component organization or biogenesis at cellular level
3.26 6.32e-12 GO:0071156 regulation of cell cycle arrest
3.93 7.58e-12 GO:0006333 chromatin assembly or disassembly
1.29 8.48e-12 GO:0044237 cellular metabolic process
3.27 2.02e-11 GO:0000075 cell cycle checkpoint
1.44 3.38e-11 GO:0016043 cellular component organization
1.43 9.36e-11 GO:0071840 cellular component organization or biogenesis
2.84 9.57e-11 GO:0000280 nuclear division
2.84 9.57e-11 GO:0007067 mitosis
5.12 1.78e-10 GO:0006261 DNA-dependent DNA replication
1.14 1.88e-10 GO:0009987 cellular process
2.76 3.73e-10 GO:0000087 M phase of mitotic cell cycle
2.75 4.40e-10 GO:0048285 organelle fission
4.08 4.52e-10 GO:0051320 S phase
1.26 7.55e-10 GO:0044238 primary metabolic process
4.03 1.42e-09 GO:0000084 S phase of mitotic cell cycle
2.52 2.39e-09 GO:0034622 cellular macromolecular complex assembly
3.61 3.13e-09 GO:0006310 DNA recombination
1.61 1.75e-08 GO:0034645 cellular macromolecule biosynthetic process
1.91 2.16e-08 GO:0033554 cellular response to stress
7.32 4.94e-08 GO:0006271 DNA strand elongation involved in DNA replication
1.59 5.03e-08 GO:0009059 macromolecule biosynthetic process
1.58 6.63e-08 GO:0016070 RNA metabolic process
1.97 8.71e-08 GO:0065003 macromolecular complex assembly
1.21 8.78e-08 GO:0008152 metabolic process
6.83 2.03e-07 GO:0022616 DNA strand elongation
2.15 2.46e-07 GO:0034621 cellular macromolecular complex subunit organization
8.33 4.07e-07 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
2.07 6.13e-07 GO:0016071 mRNA metabolic process
1.36 7.54e-07 GO:0060255 regulation of macromolecule metabolic process
1.68 7.68e-07 GO:0044085 cellular component biogenesis
1.34 1.15e-06 GO:0031323 regulation of cellular metabolic process
1.34 1.90e-06 GO:0080090 regulation of primary metabolic process
1.70 1.99e-06 GO:0022607 cellular component assembly
2.31 2.13e-06 GO:0051301 cell division
1.80 2.15e-06 GO:0043933 macromolecular complex subunit organization
1.43 2.73e-06 GO:0044249 cellular biosynthetic process
3.41 6.12e-06 GO:0007126 meiosis
3.41 6.12e-06 GO:0051327 M phase of meiotic cell cycle
1.38 7.27e-06 GO:0051171 regulation of nitrogen compound metabolic process
3.38 7.71e-06 GO:0051321 meiotic cell cycle
4.77 7.80e-06 GO:0051053 negative regulation of DNA metabolic process
3.45 8.61e-06 GO:0007059 chromosome segregation
1.38 1.42e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.38 1.42e-05 GO:0031326 regulation of cellular biosynthetic process
1.81 1.45e-05 GO:0071844 cellular component assembly at cellular level
1.39 1.57e-05 GO:0009058 biosynthetic process
1.40 1.95e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.29 2.33e-05 GO:0019222 regulation of metabolic process
1.47 2.45e-05 GO:0010467 gene expression
1.37 2.64e-05 GO:0009889 regulation of biosynthetic process
7.83 2.85e-05 GO:0007062 sister chromatid cohesion
3.78 3.27e-05 GO:0000216 M/G1 transition of mitotic cell cycle
6.99 3.56e-05 GO:0006270 DNA-dependent DNA replication initiation
1.88 3.64e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.38 5.24e-05 GO:0010556 regulation of macromolecule biosynthetic process
2.15 5.75e-05 GO:0016568 chromatin modification
2.11 6.17e-05 GO:0006397 mRNA processing
1.86 6.43e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
6.68 6.92e-05 GO:0090329 regulation of DNA-dependent DNA replication
7.05 1.30e-04 GO:2000104 negative regulation of DNA-dependent DNA replication
5.06 1.45e-04 GO:0008156 negative regulation of DNA replication
1.39 1.55e-04 GO:0051252 regulation of RNA metabolic process
1.36 1.95e-04 GO:0010468 regulation of gene expression
1.66 2.42e-04 GO:0010605 negative regulation of macromolecule metabolic process
4.12 2.87e-04 GO:0007127 meiosis I
4.56 2.96e-04 GO:0000819 sister chromatid segregation
1.62 3.56e-04 GO:0009892 negative regulation of metabolic process
1.38 4.05e-04 GO:0006355 regulation of transcription, DNA-dependent
1.78 4.07e-04 GO:0006396 RNA processing
2.17 5.14e-04 GO:0008380 RNA splicing
4.58 6.89e-04 GO:0000070 mitotic sister chromatid segregation
2.47 7.55e-04 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.47 7.55e-04 GO:0000398 nuclear mRNA splicing, via spliceosome
3.51 1.09e-03 GO:0006338 chromatin remodeling
5.87 1.44e-03 GO:0031055 chromatin remodeling at centromere
2.40 1.48e-03 GO:0000375 RNA splicing, via transesterification reactions
1.76 1.55e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
4.90 1.74e-03 GO:0000080 G1 phase of mitotic cell cycle
5.12 2.65e-03 GO:0007131 reciprocal meiotic recombination
1.60 2.71e-03 GO:0031324 negative regulation of cellular metabolic process
1.69 3.48e-03 GO:0031327 negative regulation of cellular biosynthetic process
2.83 3.49e-03 GO:0031570 DNA integrity checkpoint
2.55 3.64e-03 GO:0000226 microtubule cytoskeleton organization
1.70 4.70e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.15 5.09e-03 GO:0050794 regulation of cellular process
2.60 5.24e-03 GO:0051052 regulation of DNA metabolic process
4.50 5.36e-03 GO:0051318 G1 phase
1.35 5.51e-03 GO:0048523 negative regulation of cellular process
1.32 6.92e-03 GO:0048519 negative regulation of biological process
1.66 7.96e-03 GO:0009890 negative regulation of biosynthetic process
2.71 8.06e-03 GO:0050657 nucleic acid transport
2.71 8.06e-03 GO:0050658 RNA transport
2.71 8.06e-03 GO:0051236 establishment of RNA localization
5.03 9.30e-03 GO:0043044 ATP-dependent chromatin remodeling
3.29 1.10e-02 GO:0006302 double-strand break repair
6.07 1.14e-02 GO:0032201 telomere maintenance via semi-conservative replication
1.53 1.33e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
9.61 1.34e-02 GO:0007064 mitotic sister chromatid cohesion
2.07 1.41e-02 GO:0007346 regulation of mitotic cell cycle
2.63 1.51e-02 GO:0006403 RNA localization
1.14 1.62e-02 GO:0050789 regulation of biological process
2.73 1.80e-02 GO:0051028 mRNA transport
5.77 1.93e-02 GO:0000722 telomere maintenance via recombination
3.04 2.13e-02 GO:0006275 regulation of DNA replication
5.12 2.15e-02 GO:0043486 histone exchange
1.88 2.79e-02 GO:0007420 brain development
4.93 3.25e-02 GO:0006312 mitotic recombination
3.66 3.44e-02 GO:0007051 spindle organization
3.66 3.44e-02 GO:0032200 telomere organization
8.54 3.76e-02 GO:0002566 somatic diversification of immune receptors via somatic mutation
8.54 3.76e-02 GO:0016446 somatic hypermutation of immunoglobulin genes
4.40 4.18e-02 GO:0000724 double-strand break repair via homologous recombination
4.40 4.18e-02 GO:0000725 recombinational repair
2.43 4.23e-02 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
1.53 4.47e-02 GO:0006351 transcription, DNA-dependent
5.24 4.95e-02 GO:0006336 DNA replication-independent nucleosome assembly
5.24 4.95e-02 GO:0034080 CenH3-containing nucleosome assembly at centromere
5.24 4.95e-02 GO:0034724 DNA replication-independent nucleosome organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.60 7.67e-47 GO:0005634 nucleus
1.31 2.88e-40 GO:0043226 organelle
1.31 5.91e-40 GO:0043229 intracellular organelle
2.05 5.26e-38 GO:0044428 nuclear part
1.34 1.46e-37 GO:0043227 membrane-bounded organelle
1.34 1.89e-37 GO:0043231 intracellular membrane-bounded organelle
2.09 1.77e-33 GO:0031981 nuclear lumen
1.23 3.55e-33 GO:0044424 intracellular part
3.20 1.82e-32 GO:0005694 chromosome
1.21 1.68e-31 GO:0005622 intracellular
1.48 1.18e-30 GO:0044446 intracellular organelle part
1.92 1.23e-30 GO:0070013 intracellular organelle lumen
1.89 9.74e-30 GO:0043233 organelle lumen
1.88 1.63e-29 GO:0031974 membrane-enclosed lumen
1.47 2.61e-29 GO:0044422 organelle part
2.20 1.42e-27 GO:0005654 nucleoplasm
3.21 4.94e-27 GO:0044427 chromosomal part
3.57 8.50e-18 GO:0000785 chromatin
1.59 3.92e-17 GO:0043228 non-membrane-bounded organelle
1.59 3.92e-17 GO:0043232 intracellular non-membrane-bounded organelle
1.47 7.60e-15 GO:0032991 macromolecular complex
3.17 1.24e-11 GO:0000228 nuclear chromosome
3.32 2.30e-10 GO:0044454 nuclear chromosome part
2.01 5.03e-10 GO:0044451 nucleoplasm part
4.09 1.64e-09 GO:0032993 protein-DNA complex
4.34 1.49e-06 GO:0000786 nucleosome
1.35 1.73e-06 GO:0043234 protein complex
2.56 1.91e-06 GO:0016604 nuclear body
1.05 2.95e-06 GO:0044464 cell part
1.05 3.06e-06 GO:0005623 cell
2.96 4.29e-06 GO:0000775 chromosome, centromeric region
5.19 1.63e-05 GO:0005657 replication fork
4.66 3.53e-05 GO:0000792 heterochromatin
11.21 5.43e-05 GO:0042555 MCM complex
2.75 1.14e-04 GO:0000793 condensed chromosome
1.83 1.84e-04 GO:0030529 ribonucleoprotein complex
9.96 2.28e-04 GO:0005721 centromeric heterochromatin
3.28 3.31e-04 GO:0000790 nuclear chromatin
2.41 4.96e-04 GO:0005819 spindle
1.67 7.35e-04 GO:0015630 microtubule cytoskeleton
6.41 1.10e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.95 1.31e-03 GO:0005815 microtubule organizing center
2.15 2.93e-03 GO:0005813 centrosome
1.71 5.39e-03 GO:0005730 nucleolus
6.03 7.23e-03 GO:0030894 replisome
6.03 7.23e-03 GO:0043601 nuclear replisome
5.24 8.50e-03 GO:0043596 nuclear replication fork
6.41 1.54e-02 GO:0001673 male germ cell nucleus
1.54 2.03e-02 GO:0031967 organelle envelope
1.53 2.20e-02 GO:0031975 envelope
5.61 4.46e-02 GO:0043073 germ cell nucleus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.65 4.57e-26 GO:0003676 nucleic acid binding
1.71 1.40e-19 GO:0003677 DNA binding
1.26 1.64e-13 GO:0005515 protein binding
1.13 2.72e-12 GO:0005488 binding
4.27 1.61e-05 GO:0003697 single-stranded DNA binding
2.60 1.97e-05 GO:0003682 chromatin binding
2.56 4.60e-05 GO:0043566 structure-specific DNA binding
1.36 9.00e-05 GO:0000166 nucleotide binding
1.66 1.26e-04 GO:0003723 RNA binding
3.80 1.30e-04 GO:0008094 DNA-dependent ATPase activity
4.27 2.03e-04 GO:0003684 damaged DNA binding
1.55 6.15e-04 GO:0030528 transcription regulator activity
1.55 7.13e-04 GO:0001071 nucleic acid binding transcription factor activity
1.55 7.13e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
2.47 7.92e-03 GO:0003690 double-stranded DNA binding
6.41 2.20e-02 GO:0030983 mismatched DNA binding
1.35 3.17e-02 GO:0032559 adenyl ribonucleotide binding
1.34 4.18e-02 GO:0030554 adenyl nucleotide binding