Motif ID: E2F1..5.p2

Z-value: 3.824


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F2chr1_-_237298710.783.9e-04Click!
E2F3chr6_+_205100190.721.5e-03Click!
E2F5chr8_+_862871610.514.3e-02Click!
E2F1chr20_-_317378150.381.5e-01Click!
E2F4chr16_+_65783599-0.058.5e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_23729871 7.677 E2F2
E2F transcription factor 2
chr1_-_23730298 7.256 NM_004091
 E2F2
E2F transcription factor 2
chr6_+_135544138 6.194 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
 MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr6_+_135544214 6.043 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr6_+_135544170 6.012 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr11_-_33847507 4.993 LMO2
LIM domain only 2 (rhombotin-like 1)
chr22_+_18485145 4.513 RANBP1
RAN binding protein 1
chr22_+_18485076 4.451 RANBP1
RAN binding protein 1
chr11_-_19219000 4.407 NM_024680
 E2F8
E2F transcription factor 8
chr22_+_18485057 4.378 RANBP1
RAN binding protein 1
chr22_+_18485095 4.186 RANBP1
RAN binding protein 1
chr22_+_18485068 4.082 RANBP1
RAN binding protein 1
chr22_-_18484695 3.863 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr11_-_19219720 3.820 E2F8
E2F transcription factor 8
chr22_+_34126104 3.673 NM_006739
 MCM5
minichromosome maintenance complex component 5
chr7_+_50314801 3.673 NM_006060
 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr22_+_34126154 3.600 MCM5
minichromosome maintenance complex component 5
chr10_+_124885556 3.399 NM_001105574
 HMX3
H6 family homeobox 3
chr20_-_35157744 3.394 RBL1
retinoblastoma-like 1 (p107)
chr11_-_33847834 3.269 LMO2
LIM domain only 2 (rhombotin-like 1)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 150 entries
enrichment   p-value GO term description
9.61 1.34e-02 GO:0007064 mitotic sister chromatid cohesion
8.54 3.76e-02 GO:0002566 somatic diversification of immune receptors via somatic mutation
8.54 3.76e-02 GO:0016446 somatic hypermutation of immunoglobulin genes
8.33 4.07e-07 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
7.83 2.85e-05 GO:0007062 sister chromatid cohesion
7.32 4.94e-08 GO:0006271 DNA strand elongation involved in DNA replication
7.05 1.30e-04 GO:2000104 negative regulation of DNA-dependent DNA replication
6.99 3.56e-05 GO:0006270 DNA-dependent DNA replication initiation
6.83 2.03e-07 GO:0022616 DNA strand elongation
6.68 6.92e-05 GO:0090329 regulation of DNA-dependent DNA replication
6.07 1.14e-02 GO:0032201 telomere maintenance via semi-conservative replication
5.87 1.44e-03 GO:0031055 chromatin remodeling at centromere
5.77 1.93e-02 GO:0000722 telomere maintenance via recombination
5.24 4.95e-02 GO:0006336 DNA replication-independent nucleosome assembly
5.24 4.95e-02 GO:0034080 CenH3-containing nucleosome assembly at centromere
5.24 4.95e-02 GO:0034724 DNA replication-independent nucleosome organization
5.12 1.78e-10 GO:0006261 DNA-dependent DNA replication
5.12 2.65e-03 GO:0007131 reciprocal meiotic recombination
5.12 2.15e-02 GO:0043486 histone exchange
5.06 1.45e-04 GO:0008156 negative regulation of DNA replication

Gene overrepresentation in compartment category:

Showing 1 to 20 of 51 entries
enrichment   p-value GO term description
11.21 5.43e-05 GO:0042555 MCM complex
9.96 2.28e-04 GO:0005721 centromeric heterochromatin
6.41 1.10e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
6.41 1.54e-02 GO:0001673 male germ cell nucleus
6.03 7.23e-03 GO:0030894 replisome
6.03 7.23e-03 GO:0043601 nuclear replisome
5.61 4.46e-02 GO:0043073 germ cell nucleus
5.24 8.50e-03 GO:0043596 nuclear replication fork
5.19 1.63e-05 GO:0005657 replication fork
4.66 3.53e-05 GO:0000792 heterochromatin
4.34 1.49e-06 GO:0000786 nucleosome
4.09 1.64e-09 GO:0032993 protein-DNA complex
3.57 8.50e-18 GO:0000785 chromatin
3.32 2.30e-10 GO:0044454 nuclear chromosome part
3.28 3.31e-04 GO:0000790 nuclear chromatin
3.21 4.94e-27 GO:0044427 chromosomal part
3.20 1.82e-32 GO:0005694 chromosome
3.17 1.24e-11 GO:0000228 nuclear chromosome
2.96 4.29e-06 GO:0000775 chromosome, centromeric region
2.75 1.14e-04 GO:0000793 condensed chromosome

Gene overrepresentation in function category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
6.41 2.20e-02 GO:0030983 mismatched DNA binding
4.27 1.61e-05 GO:0003697 single-stranded DNA binding
4.27 2.03e-04 GO:0003684 damaged DNA binding
3.80 1.30e-04 GO:0008094 DNA-dependent ATPase activity
2.60 1.97e-05 GO:0003682 chromatin binding
2.56 4.60e-05 GO:0043566 structure-specific DNA binding
2.47 7.92e-03 GO:0003690 double-stranded DNA binding
1.71 1.40e-19 GO:0003677 DNA binding
1.66 1.26e-04 GO:0003723 RNA binding
1.65 4.57e-26 GO:0003676 nucleic acid binding
1.55 6.15e-04 GO:0030528 transcription regulator activity
1.55 7.13e-04 GO:0001071 nucleic acid binding transcription factor activity
1.55 7.13e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.36 9.00e-05 GO:0000166 nucleotide binding
1.35 3.17e-02 GO:0032559 adenyl ribonucleotide binding
1.34 4.18e-02 GO:0030554 adenyl nucleotide binding
1.26 1.64e-13 GO:0005515 protein binding
1.13 2.72e-12 GO:0005488 binding