Motif ID: NKX3-1.p2

Z-value: 1.110


Transcription factors associated with NKX3-1.p2:

Gene SymbolEntrez IDGene Name
NKX3-1 4824 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-1chr8_-_23596346-0.048.8e-01Click!


Activity profile for motif NKX3-1.p2.

activity profile for motif NKX3-1.p2


Sorted Z-values histogram for motif NKX3-1.p2

Sorted Z-values for motif NKX3-1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_132000134 3.876 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr17_-_61655915 1.752 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr17_-_18890963 1.428 NM_006613
GRAP
GRB2-related adaptor protein
chr4_+_74520796 1.319 NM_001134
AFP
alpha-fetoprotein
chr12_+_130004404 1.126 NM_198827
GPR133
G protein-coupled receptor 133
chr19_-_56612653 1.101 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr4_+_74488947 1.065 ALB
albumin
chr6_+_30238961 1.051 NM_033229
TRIM15
tripartite motif containing 15
chr14_-_22516271 1.043 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr2_+_228064531 0.985 AGFG1
ArfGAP with FG repeats 1
chr15_+_57691382 0.981 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr5_+_156628929 0.966 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr4_+_74491272 0.965 ALB
albumin
chr3_-_198784590 0.956 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr14_+_38772870 0.913 NM_054024
MIA2
melanoma inhibitory activity 2
chr14_+_87541220 0.899 NM_003608
GPR65
G protein-coupled receptor 65
chr17_-_53847937 0.888 RNF43
ring finger protein 43
chr6_+_32003180 0.850 NM_000063
NM_001145903
C2

complement component 2

chr2_-_32344192 0.849 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr1_+_205329206 0.821 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr17_-_16197433 0.819 NM_181716
CENPV
centromere protein V
chr14_+_66901237 0.818 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr2_+_37282516 0.817 LOC100505876
hypothetical LOC100505876
chr17_+_50698169 0.795 HLF
hepatic leukemia factor
chr1_+_57093030 0.781 NM_000562
C8A
complement component 8, alpha polypeptide
chr22_+_38652555 0.761 GRAP2
GRB2-related adaptor protein 2
chr12_-_101835510 0.748 NM_000277
PAH
phenylalanine hydroxylase
chr4_-_186969041 0.746 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr10_-_74384485 0.737 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr6_+_153060722 0.732 NM_025107
MYCT1
myc target 1
chr12_-_120725210 0.731 LOC338799
hypothetical LOC338799
chr3_-_42892195 0.725 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr4_+_74493918 0.703 ALB
albumin
chr13_+_23042722 0.694 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr5_+_43645018 0.691 NNT
nicotinamide nucleotide transhydrogenase
chr15_+_57691272 0.689 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr3_+_152970904 0.685 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr3_+_173043832 0.684 NM_001164436
TMEM212
transmembrane protein 212
chr4_+_39084936 0.671 KLB
klotho beta
chrX_+_105823723 0.663 NM_024539
RNF128
ring finger protein 128
chr2_-_165259334 0.660 COBLL1
COBL-like 1
chr8_+_40130143 0.655 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr12_+_91620749 0.647 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr4_+_74488835 0.643 NM_000477
ALB
albumin
chr9_+_89302574 0.635 NM_004938
DAPK1
death-associated protein kinase 1
chr8_-_17797127 0.618 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr10_-_11614279 0.603 NM_001080491
USP6NL
USP6 N-terminal like
chr18_+_70318001 0.592 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr18_-_50776276 0.583 NM_001143829
CCDC68
coiled-coil domain containing 68
chr20_+_30160952 0.573 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr11_+_89507465 0.570 NM_005467
NAALAD2
N-acetylated alpha-linked acidic dipeptidase 2
chr6_+_64344307 0.562 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chrX_-_130792297 0.559 LOC286467
hypothetical LOC286467
chr9_-_103237851 0.552 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr6_+_32003380 0.548 C2
complement component 2
chr5_-_78317444 0.543 NM_198709
ARSB
arylsulfatase B
chr17_-_16197549 0.527 CENPV
centromere protein V
chr9_+_89302239 0.525 DAPK1
death-associated protein kinase 1
chr10_-_73953699 0.524 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chr10_-_69267774 0.524 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr17_+_35097851 0.524 NM_001005862
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr20_+_30161173 0.512 TM9SF4
transmembrane 9 superfamily protein member 4
chr6_-_32268615 0.503 GPSM3
G-protein signaling modulator 3
chr3_-_121883647 0.502 HGD
homogentisate 1,2-dioxygenase
chr5_-_179040580 0.499 NM_001164444
CBY3
chibby homolog 3 (Drosophila)
chrX_+_99726445 0.498 NM_022144
TNMD
tenomodulin
chr4_+_89115862 0.498 SPP1
secreted phosphoprotein 1
chr19_-_56549853 0.495 NM_001014763
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr17_-_64752550 0.480 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr12_+_25096472 0.476 NM_006152
LRMP
lymphoid-restricted membrane protein
chr2_+_183290912 0.474 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr7_+_94377145 0.471 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr14_-_22515725 0.471 JUB
jub, ajuba homolog (Xenopus laevis)
chr1_-_229627412 0.468 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr6_+_27885692 0.468 NM_003536
HIST1H3H
histone cluster 1, H3h
chr17_-_36113502 0.455 NM_019016
KRT24
keratin 24
chr18_+_27210737 0.454 NM_001134453
NM_177986
DSG4

desmoglein 4

chr5_+_140709907 0.451 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr20_-_52120710 0.450 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr17_+_58440629 0.447 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr4_-_69852090 0.445 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr1_+_165565006 0.444 POU2F1
POU class 2 homeobox 1
chr4_+_17125885 0.443 NM_001079827
CLRN2
clarin 2
chr17_+_71975224 0.442 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr3_-_152403636 0.441 NM_013308
GPR171
G protein-coupled receptor 171
chr6_+_153113624 0.440 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr6_-_33016561 0.440 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr14_+_94148466 0.432 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr6_-_28294642 0.428 LOC222699
transducer of ERBB2, 2 pseudogene
chr4_+_74488910 0.425 ALB
albumin
chr1_-_158815850 0.423 CD84
CD84 molecule
chr14_+_31868229 0.422 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr20_-_34707971 0.419 NM_032214
NM_175077
SLA2

Src-like-adaptor 2

chr4_+_89115892 0.418 SPP1
secreted phosphoprotein 1
chr3_-_57209319 0.415 NM_003865
HESX1
HESX homeobox 1
chr3_-_195553297 0.413 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr14_-_24115268 0.408 NM_001911
CTSG
cathepsin G
chr6_+_28425666 0.402 NM_024493
ZKSCAN3
zinc finger with KRAB and SCAN domains 3
chr4_+_1872150 0.397 NM_133334
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr4_+_89115923 0.397 SPP1
secreted phosphoprotein 1
chr6_-_138862271 0.396 NM_001144060
NHSL1
NHS-like 1
chr7_+_141457977 0.395 LOC93432
maltase-glucoamylase-like pseudogene
chr4_-_10295412 0.389 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr7_+_99654806 0.389 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr6_-_49712483 0.387 NM_000324
RHAG
Rh-associated glycoprotein
chr1_-_205012348 0.387 NM_000572
IL10
interleukin 10
chr4_+_89115825 0.386 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr4_-_140280031 0.381 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr22_+_29696662 0.381


chr10_+_101078784 0.371 NM_020348
CNNM1
cyclin M1
chr21_+_39117064 0.371 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr9_+_4829763 0.369 RCL1
RNA terminal phosphate cyclase-like 1
chr2_-_39310176 0.369 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr6_-_138862273 0.368


chr14_+_22859236 0.367 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr7_-_143213296 0.365 FAM115A
family with sequence similarity 115, member A
chr4_-_68793928 0.363 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr12_-_15757114 0.362 EPS8
epidermal growth factor receptor pathway substrate 8
chr3_-_120761092 0.352 NM_005191
CD80
CD80 molecule
chr2_+_42649105 0.348 NM_020744
MTA3
metastasis associated 1 family, member 3
chr2_-_21106291 0.347 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_246869181 0.346 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr10_-_7722747 0.345 ITIH5
inter-alpha (globulin) inhibitor H5
chr6_+_105511615 0.345 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr16_+_80626331 0.344 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr13_+_51496679 0.343 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr16_+_80626459 0.342 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr4_-_38710376 0.339 NM_024943
TMEM156
transmembrane protein 156
chr2_-_99412694 0.338 REV1
REV1 homolog (S. cerevisiae)
chr4_-_176970407 0.335 GPM6A
glycoprotein M6A
chr7_+_119700924 0.334 NM_012281
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr8_-_82557956 0.334 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr1_+_103898844 0.328 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr5_+_92944680 0.327 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chrX_+_57329834 0.326 NM_174912
FAAH2
fatty acid amide hydrolase 2
chr9_-_13240313 0.326 NM_003829
MPDZ
multiple PDZ domain protein
chr21_-_42659671 0.326 NM_003225
TFF1
trefoil factor 1
chr2_+_102744921 0.325 NM_144632
TMEM182
transmembrane protein 182
chr11_-_100505667 0.323 NM_000926
PGR
progesterone receptor
chr16_+_2195424 0.322 NM_022372
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr6_-_152681171 0.321 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr6_+_144654565 0.320 NM_007124
UTRN
utrophin
chrX_-_30505804 0.319 NM_025159
CXorf21
chromosome X open reading frame 21
chr16_+_82540172 0.316 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr11_+_89624017 0.315


chr3_-_150569574 0.315 TM4SF1
transmembrane 4 L six family member 1
chrX_-_2892288 0.312 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chrX_-_76824726 0.310 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr14_-_24148658 0.310 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr3_-_184756101 0.309 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr17_-_16816113 0.306 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr4_+_71418886 0.304 NM_212557
AMTN
amelotin
chr10_+_7785360 0.298 ITIH2
inter-alpha (globulin) inhibitor H2
chr2_+_173394560 0.298 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr1_-_158815895 0.296 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr19_+_63508569 0.296 LOC100506584
hypothetical protein LOC100506584
chr15_+_97990705 0.295 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr9_+_130056513 0.295


chr2_-_207291364 0.294 NM_001093730
DYTN
dystrotelin
chr17_-_39500512 0.293 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr20_+_60191455 0.292 NM_015666
GTPBP5
GTP binding protein 5 (putative)
chr1_+_66230977 0.285 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr6_+_167445284 0.282 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr3_-_168853982 0.281 NM_178824
WDR49
WD repeat domain 49
chr9_+_106496480 0.280 NM_001004484
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr7_+_104468614 0.279 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr1_+_246682699 0.278 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr16_+_80626402 0.275 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr8_-_37576515 0.272 LOC157860
hypothetical protein LOC157860
chr1_+_158975662 0.270 NM_021181
SLAMF7
SLAM family member 7
chr4_+_74498042 0.270 ALB
albumin
chr3_-_42892636 0.270 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr17_-_64568641 0.270 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr11_-_30910074 0.270 NM_020869
DCDC5
doublecortin domain containing 5
chr20_+_56919233 0.269 GNAS
GNAS complex locus
chr16_+_11346812 0.269 C16orf75
chromosome 16 open reading frame 75
chr11_-_16953135 0.268 RPL36A
ribosomal protein L36a
chr1_+_50348052 0.266 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr16_-_68317868 0.266 NQO1
NAD(P)H dehydrogenase, quinone 1
chr3_+_120799411 0.265 NM_015900
PLA1A
phospholipase A1 member A
chr4_+_71283383 0.265 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr19_+_63508526 0.263 LOC100506584
hypothetical protein LOC100506584
chr4_-_176970372 0.262 GPM6A
glycoprotein M6A
chr6_-_55848317 0.262 NM_021073
BMP5
bone morphogenetic protein 5
chr4_+_74497998 0.261 ALB
albumin
chr2_+_201806410 0.261 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr17_-_5078773 0.258 NM_207103
C17orf87
chromosome 17 open reading frame 87
chrX_+_115215985 0.257 NM_000686
AGTR2
angiotensin II receptor, type 2
chrX_+_90977115 0.257 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr11_+_123625632 0.257 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr17_+_24394043 0.253 NM_016518
PIPOX
pipecolic acid oxidase
chr9_-_94206648 0.253 NM_014057
NM_033014
OGN

osteoglycin

chr1_-_3556420 0.251 NM_017818
WDR8
WD repeat domain 8
chr3_+_162697289 0.251 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr17_+_23818922 0.249


chr10_-_52315436 0.248 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr6_+_10629550 0.247 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr5_+_67622242 0.246 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr10_+_7785290 0.245 ITIH2
inter-alpha (globulin) inhibitor H2
chr6_-_55848346 0.245 BMP5
bone morphogenetic protein 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.77 2.97e-21 GO:0007608 sensory perception of smell
3.55 1.12e-20 GO:0007606 sensory perception of chemical stimulus
2.40 2.21e-12 GO:0007600 sensory perception
1.79 2.65e-09 GO:0003008 system process
1.87 1.87e-08 GO:0050877 neurological system process
1.33 2.16e-06 GO:0032501 multicellular organismal process
1.26 3.64e-05 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.38 1.42e-07 GO:0005886 plasma membrane
1.38 1.61e-07 GO:0071944 cell periphery
1.43 1.42e-03 GO:0005576 extracellular region
1.22 2.19e-03 GO:0031224 intrinsic to membrane
1.22 2.66e-03 GO:0016021 integral to membrane
1.18 1.08e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.85 7.59e-22 GO:0004984 olfactory receptor activity
2.56 1.33e-16 GO:0004930 G-protein coupled receptor activity
2.01 1.11e-11 GO:0004888 transmembrane receptor activity
1.79 4.72e-10 GO:0004872 receptor activity
1.62 6.78e-08 GO:0004871 signal transducer activity
1.62 6.78e-08 GO:0060089 molecular transducer activity
8.84 1.21e-02 GO:0004522 pancreatic ribonuclease activity
6.38 3.07e-02 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
7.18 4.94e-02 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters