Motif ID: ATF2.p2

Z-value: 1.368


Transcription factors associated with ATF2.p2:

Gene SymbolEntrez IDGene Name
ATF2 1386 activating transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF2chr2_-_175741096-0.107.1e-01Click!


Activity profile for motif ATF2.p2.

activity profile for motif ATF2.p2


Sorted Z-values histogram for motif ATF2.p2

Sorted Z-values for motif ATF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_19863716 2.537 RIN2
Ras and Rab interactor 2
chr20_-_55718351 2.160 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr1_+_29435534 2.129 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chr16_-_53520208 2.055 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr5_+_66160359 1.927 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr4_-_187884721 1.906


chr2_+_54638957 1.878 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr21_-_42060266 1.510 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr20_-_14266200 1.438 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr4_+_85723080 1.428 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr21_-_42060334 1.420 RIPK4
receptor-interacting serine-threonine kinase 4
chr1_-_16355013 1.412 NM_004431
EPHA2
EPH receptor A2
chr11_-_117628211 1.406 NM_198275
MPZL3
myelin protein zero-like 3
chr12_+_52680143 1.391 NM_006897
HOXC9
homeobox C9
chr4_+_75529716 1.362 NM_001657
AREG
amphiregulin
chr5_+_73145098 1.251 RGNEF
190 kDa guanine nucleotide exchange factor
chr3_+_42107711 1.141 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr7_-_41709191 1.127 NM_002192
INHBA
inhibin, beta A
chr13_+_75232797 1.125 NM_015842
LMO7
LIM domain 7
chr5_+_36642213 1.122 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr1_+_154297588 1.117 NM_020387
RAB25
RAB25, member RAS oncogene family
chr1_-_208046011 1.089 NM_006147
IRF6
interferon regulatory factor 6
chr4_-_153820535 1.057 NM_152680
TMEM154
transmembrane protein 154
chr13_-_47885248 1.044 LPAR6
lysophosphatidic acid receptor 6
chr22_-_42589543 1.044 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr4_+_75699652 1.039 NM_001657
AREG
amphiregulin
chr13_-_47885018 1.020 LPAR6
lysophosphatidic acid receptor 6
chr12_+_55201854 1.014 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr22_+_39583001 1.004 NM_022098
XPNPEP3
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
chr5_-_94442941 0.997 MCTP1
multiple C2 domains, transmembrane 1
chr20_-_55718982 0.996 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr21_-_34820916 0.958 NM_203418
RCAN1
regulator of calcineurin 1
chr5_-_94443300 0.946 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr6_+_148705421 0.935 NM_015278
SASH1
SAM and SH3 domain containing 1
chr11_+_12652427 0.912 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr5_+_36642424 0.874 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_147266257 0.840 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr2_-_220116508 0.827 NM_024536
CHPF
chondroitin polymerizing factor
chr17_+_54124952 0.822 NM_002876
NM_058216
RAD51C

RAD51 homolog C (S. cerevisiae)

chr6_+_134800533 0.819 LOC154092
hypothetical LOC154092
chr12_+_52665196 0.806 NM_017409
HOXC10
homeobox C10
chr6_-_127822227 0.801 NM_014702
KIAA0408
KIAA0408
chr21_+_38550739 0.798 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr13_-_43908937 0.796 TSC22D1
TSC22 domain family, member 1
chr6_-_47385205 0.786 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr2_-_224611568 0.779 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr20_+_55718619 0.776


chr4_-_111777584 0.776 PITX2
paired-like homeodomain 2
chr12_-_123568781 0.772


chr19_-_56919032 0.771 NM_001523
HAS1
hyaluronan synthase 1
chr5_-_64813459 0.763 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr3_+_189354167 0.758 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_+_85300580 0.758 NM_145172
WDR63
WD repeat domain 63
chr12_+_79625538 0.756 NM_002469
MYF6
myogenic factor 6 (herculin)
chr14_+_62740878 0.753 NM_020663
RHOJ
ras homolog gene family, member J
chr4_-_186693574 0.752 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr17_+_54124928 0.751 RAD51C
RAD51 homolog C (S. cerevisiae)
chr10_+_63803921 0.747 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr2_-_31491057 0.743 XDH
xanthine dehydrogenase
chr2_-_31491102 0.735 NM_000379
XDH
xanthine dehydrogenase
chrX_-_15198093 0.733 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr3_-_12561962 0.730 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr1_-_152431175 0.728 NM_152263
TPM3
tropomyosin 3
chr5_-_1935764 0.723 NM_016358
IRX4
iroquois homeobox 4
chr17_+_35148084 0.722 NM_001030002
GRB7
growth factor receptor-bound protein 7
chr11_-_123353607 0.721 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr2_-_216009015 0.702 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr4_-_111777651 0.700 PITX2
paired-like homeodomain 2
chrX_-_83644054 0.699 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr6_-_47385313 0.697 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr20_+_55718718 0.695


chr10_-_95350949 0.693 NM_006744
RBP4
retinol binding protein 4, plasma
chr17_-_4589387 0.685 CXCL16
chemokine (C-X-C motif) ligand 16
chr3_-_8518327 0.677 LOC100288428
hypothetical LOC100288428
chr11_-_118693021 0.677 NM_006500
MCAM
melanoma cell adhesion molecule
chr8_-_72437020 0.660 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr5_-_138238891 0.660 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chr6_+_148705646 0.659 SASH1
SAM and SH3 domain containing 1
chr8_-_72436832 0.659 EYA1
eyes absent homolog 1 (Drosophila)
chr13_+_96672541 0.654 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr3_-_21767819 0.652 NM_024697
ZNF385D
zinc finger protein 385D
chr3_+_151608673 0.650 TSC22D2
TSC22 domain family, member 2
chr1_-_114925734 0.644 NM_005872
BCAS2
breast carcinoma amplified sequence 2
chr5_-_138238877 0.643 LRRTM2
leucine rich repeat transmembrane neuronal 2
chr21_+_38550533 0.636 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chrX_+_107569671 0.634 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr2_+_219991342 0.625 NM_001927
DES
desmin
chr3_+_62279707 0.625 C3orf14
chromosome 3 open reading frame 14
chr2_+_154436670 0.620 NM_052917
GALNT13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr8_-_116750277 0.616 NM_014112
TRPS1
trichorhinophalangeal syndrome I
chr17_-_38978772 0.615 NM_001986
ETV4
ets variant 4
chr9_+_130684248 0.605 LRRC8A
leucine rich repeat containing 8 family, member A
chr8_-_42184194 0.603 PLAT
plasminogen activator, tissue
chr6_-_15356865 0.601


chr17_-_8092098 0.595 NM_025099
CTC1
CTS telomere maintenance complex component 1
chr13_-_47885653 0.593 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr8_-_42184350 0.585 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr4_-_153493133 0.583 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr1_+_210275735 0.573 DTL
denticleless homolog (Drosophila)
chr8_+_128875902 0.572 PVT1
Pvt1 oncogene (non-protein coding)
chr17_+_69939806 0.572 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr9_+_130684189 0.571 NM_001127245
NM_019594
LRRC8A

leucine rich repeat containing 8 family, member A

chr17_-_8092078 0.568 CTC1
CTS telomere maintenance complex component 1
chr8_-_10734700 0.566 NM_017884
PINX1
PIN2/TERF1 interacting, telomerase inhibitor 1
chr2_-_216008689 0.560 FN1
fibronectin 1
chr2_+_148319033 0.555 NM_001616
ACVR2A
activin A receptor, type IIA
chr14_+_67156386 0.547 ARG2
arginase, type II
chr15_-_61461127 0.547 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr4_+_145786622 0.547 NM_022475
HHIP
hedgehog interacting protein
chr17_-_53847937 0.546 RNF43
ring finger protein 43
chr6_-_47385604 0.546 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr2_+_220116986 0.541 NM_001005209
TMEM198
transmembrane protein 198
chr11_-_111255020 0.541 FDXACB1
ferredoxin-fold anticodon binding domain containing 1
chr2_-_188021117 0.540 NM_005795
CALCRL
calcitonin receptor-like
chr6_-_47385470 0.538 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr15_-_81412354 0.538 NM_004839
NM_199330
NM_199331
NM_199332
HOMER2



homer homolog 2 (Drosophila)



chr1_-_199635057 0.537 LAD1
ladinin 1
chr10_-_116276560 0.532 ABLIM1
actin binding LIM protein 1
chr5_-_138238953 0.529 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr2_+_219779737 0.528 NM_138802
ZFAND2B
zinc finger, AN1-type domain 2B
chr18_+_45342398 0.526 NM_006033
LIPG
lipase, endothelial
chr6_-_47385599 0.525 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr6_-_99904251 0.524 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr12_-_14887648 0.522 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chrX_-_15198509 0.520 NM_001168531
ASB9
ankyrin repeat and SOCS box containing 9
chr4_-_100704156 0.519 NM_001134665
NM_001134666
RG9MTD2

RNA (guanine-9-) methyltransferase domain containing 2

chr21_-_35343331 0.519 RUNX1
runt-related transcription factor 1
chr12_+_70119785 0.515 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr21_-_35343500 0.515 RUNX1
runt-related transcription factor 1
chr2_+_10969513 0.513 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr21_-_35343448 0.512 RUNX1
runt-related transcription factor 1
chr8_+_94999167 0.512 NM_001161778
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr14_+_67156323 0.512 NM_001172
ARG2
arginase, type II
chr21_-_35343456 0.510 NM_001754
RUNX1
runt-related transcription factor 1
chr7_-_129379947 0.510 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

chr21_-_35343428 0.507 RUNX1
runt-related transcription factor 1
chr19_-_52308848 0.505 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr4_-_54119102 0.505 LNX1
ligand of numb-protein X 1
chr12_-_121946561 0.503


chrX_+_49718954 0.503 NM_000084
CLCN5
chloride channel 5
chrX_+_101910713 0.501 LOC100287765
hypothetical LOC100287765
chr14_-_49122813 0.496 NM_001030001
NM_001032
RPS29

ribosomal protein S29

chr5_+_99898922 0.496 NM_198507
FAM174A
family with sequence similarity 174, member A
chr19_-_53814173 0.492 NM_000979
RPL18
ribosomal protein L18
chr6_-_106880300 0.490 NM_004849
ATG5
ATG5 autophagy related 5 homolog (S. cerevisiae)
chr4_-_54119123 0.489 LNX1
ligand of numb-protein X 1
chr7_+_38184444 0.489 NM_032016
STARD3NL
STARD3 N-terminal like
chr19_+_50041424 0.488 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr1_+_119484529 0.487


chr13_+_96672705 0.484 MBNL2
muscleblind-like 2 (Drosophila)
chr4_+_120167264 0.482 SYNPO2
synaptopodin 2
chr11_-_8788765 0.481 NM_213618
ST5
suppression of tumorigenicity 5
chr10_-_64698831 0.480 NM_004241
JMJD1C
jumonji domain containing 1C
chr14_+_101346032 0.480 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr7_+_38184393 0.476 STARD3NL
STARD3 N-terminal like
chr9_-_168913 0.476 NM_001145355
NM_001145356
NM_018491
CBWD2
CBWD1


COBW domain containing 2
COBW domain containing 1


chr18_-_35634247 0.475 LOC647946
hypothetical LOC647946
chrX_+_43399101 0.474 MAOA
monoamine oxidase A
chr3_+_63928459 0.473 NM_001128149
ATXN7
ataxin 7
chr12_+_12935619 0.471 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr1_+_210275752 0.465 DTL
denticleless homolog (Drosophila)
chr4_+_113958652 0.464 NM_001127493
ANK2
ankyrin 2, neuronal
chr22_-_27787793 0.459 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr5_+_159276317 0.459 NM_000679
ADRA1B
adrenergic, alpha-1B-, receptor
chr1_+_51855343 0.454 OSBPL9
oxysterol binding protein-like 9
chr6_-_47385605 0.452 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr2_-_142605010 0.452 LRP1B
low density lipoprotein receptor-related protein 1B
chr2_+_113911737 0.451 NM_172003
CBWD2
CBWD1
COBW domain containing 2
COBW domain containing 1
chr17_+_30938433 0.449 AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr1_-_227710619 0.448 NUP133
nucleoporin 133kDa
chr17_+_30938391 0.448 NM_001030006
NM_001282
AP2B1

adaptor-related protein complex 2, beta 1 subunit

chr17_-_34263487 0.446 NM_000978
SNORA21
RPL23
small nucleolar RNA, H/ACA box 21
ribosomal protein L23
chr9_-_69729918 0.445 CBWD5
COBW domain containing 5
chr11_+_9552809 0.443 NM_001143976
WEE1
WEE1 homolog (S. pombe)
chr14_+_67156405 0.441 ARG2
arginase, type II
chr12_+_54838408 0.438 MYL6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr8_+_61753793 0.436 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr12_+_52653176 0.436 NM_014212
HOXC11
homeobox C11
chr8_+_26204997 0.432 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr11_+_111255157 0.429 NM_022761
C11orf1
chromosome 11 open reading frame 1
chr19_+_50041400 0.427 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr1_-_151614681 0.425 NM_005621
S100A12
S100 calcium binding protein A12
chr7_+_116447499 0.423 ST7
suppression of tumorigenicity 7
chr15_-_61460967 0.420 CA12
carbonic anhydrase XII
chr9_-_126573349 0.419 NM_001489
NM_033334
NR6A1

nuclear receptor subfamily 6, group A, member 1

chr21_-_35343065 0.418 RUNX1
runt-related transcription factor 1
chr4_-_54119159 0.415 NM_032622
LNX1
ligand of numb-protein X 1
chr19_-_411995 0.415 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr5_+_99899133 0.414 FAM174A
family with sequence similarity 174, member A
chr8_-_10734792 0.413 PINX1
PIN2/TERF1 interacting, telomerase inhibitor 1
chr1_-_219982016 0.411 DUSP10
dual specificity phosphatase 10
chr1_-_227710700 0.411 NM_018230
NUP133
nucleoporin 133kDa
chr22_-_39582616 0.409 NM_003932
ST13
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
chr17_-_38979178 0.408 NM_001079675
ETV4
ets variant 4
chr3_+_186563529 0.408 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr19_-_62043867 0.406 NM_001146326
NM_001146327
NM_015363
NM_001146184
NM_001146185
NM_001146187
NM_006210
ZIM2


PEG3



zinc finger, imprinted 2


paternally expressed 3



chr17_+_39741306 0.405 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr4_-_96689373 0.405 NM_003728
UNC5C
unc-5 homolog C (C. elegans)
chr1_+_242281175 0.402 NM_205768
ZNF238
zinc finger protein 238
chr6_+_148705817 0.400 SASH1
SAM and SH3 domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.32 2.83e-02 GO:0048856 anatomical structure development
1.10 4.05e-02 GO:0009987 cellular process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 6.78e-04 GO:0005515 protein binding
1.09 8.30e-03 GO:0005488 binding