Motif ID: PAX2.p2

Z-value: 1.041


Transcription factors associated with PAX2.p2:

Gene SymbolEntrez IDGene Name
PAX2 5076 paired box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX2chr10_+_1024953270.048.9e-01Click!


Activity profile for motif PAX2.p2.

activity profile for motif PAX2.p2


Sorted Z-values histogram for motif PAX2.p2

Sorted Z-values for motif PAX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_60663842 1.990 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr6_-_18230829 1.357 NM_198586
NHLRC1
NHL repeat containing 1
chr8_-_13178399 1.238 DLC1
deleted in liver cancer 1
chr10_+_128583984 1.066 NM_001380
DOCK1
dedicator of cytokinesis 1
chr8_-_13178327 1.025


chr13_-_32757835 0.966 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_-_192767494 0.957 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr12_-_113330574 0.905 NM_000192
NM_080717
TBX5

T-box 5

chr2_-_216008689 0.890 FN1
fibronectin 1
chr10_+_102662675 0.882 FAM178A
family with sequence similarity 178, member A
chr17_+_14145051 0.867 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr15_-_68781662 0.861 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr3_+_114948550 0.859 NM_001690
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr9_+_119506446 0.855 TLR4
toll-like receptor 4
chr1_-_197173159 0.850 LOC100131234
familial acute myelogenous leukemia related factor
chr13_-_20533703 0.837 NM_014572
LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr10_+_102782151 0.835 SFXN3
sideroflexin 3
chr11_+_101485946 0.794 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr10_+_102782156 0.787 SFXN3
sideroflexin 3
chr9_-_37566248 0.772 NM_012166
FBXO10
F-box protein 10
chr9_-_109291866 0.748 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr7_-_27162688 0.747 NM_006896
HOXA7
homeobox A7
chr2_-_216009015 0.712 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr3_+_114948600 0.669 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr2_-_216944911 0.669 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr2_+_223625105 0.662 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr3_+_114948591 0.655 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr6_+_17501589 0.654 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr4_-_177950658 0.654 NM_005429
VEGFC
vascular endothelial growth factor C
chr3_+_30622905 0.649 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr13_-_20533629 0.644 LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr17_+_56831951 0.634 NM_005994
TBX2
T-box 2
chr7_+_116099648 0.631 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr12_+_15926554 0.629 NM_007178
STRAP
serine/threonine kinase receptor associated protein
chr1_-_152459667 0.629 C1orf43
chromosome 1 open reading frame 43
chr20_-_47965393 0.623 SPATA2
spermatogenesis associated 2
chr5_+_52812236 0.622 NM_006350
NM_013409
FST

follistatin

chr5_+_52812165 0.621 FST
follistatin
chr18_-_44729700 0.608 NM_001190822
SMAD7
SMAD family member 7
chr8_-_119192985 0.607 NM_000127
EXT1
exostosin 1
chr9_-_21999270 0.602 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr12_+_15926681 0.600 STRAP
serine/threonine kinase receptor associated protein
chr5_+_14493905 0.597 TRIO
triple functional domain (PTPRF interacting)
chr2_+_228045121 0.596 NM_001135187
NM_001135188
NM_001135189
NM_004504
AGFG1



ArfGAP with FG repeats 1



chr16_-_65984836 0.574 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr14_+_95575319 0.572 C14orf132
chromosome 14 open reading frame 132
chr15_+_41597097 0.568 NM_002373
MAP1A
microtubule-associated protein 1A
chr21_-_27261276 0.558 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr10_-_93382735 0.536 PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr16_+_30952382 0.531 NM_004604
STX4
syntaxin 4
chr8_+_67787444 0.530 NM_001033578
SGK3
serum/glucocorticoid regulated kinase family, member 3
chr7_-_121571472 0.529 NM_005763
AASS
aminoadipate-semialdehyde synthase
chr1_+_181259317 0.524


chr10_-_93382779 0.519 PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr22_+_34107087 0.516 HMOX1
heme oxygenase (decycling) 1
chr1_+_77520190 0.513 AK5
adenylate kinase 5
chr14_+_23653848 0.511 DCAF11
DDB1 and CUL4 associated factor 11
chr16_+_56219802 0.511 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr16_+_30952350 0.509 STX4
syntaxin 4
chr17_+_72795567 0.505 NM_001113492
SEPT9
septin 9
chr2_-_217267742 0.504 IGFBP5
insulin-like growth factor binding protein 5
chr16_-_69277355 0.503 NM_138383
MTSS1L
metastasis suppressor 1-like
chr14_+_23653745 0.503 NM_001163484
DCAF11
DDB1 and CUL4 associated factor 11
chr5_-_83715947 0.502 EDIL3
EGF-like repeats and discoidin I-like domains 3
chr5_+_80292313 0.500 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr11_+_101291134 0.499 KIAA1377
KIAA1377
chr12_+_15926743 0.498 STRAP
serine/threonine kinase receptor associated protein
chr1_-_152459697 0.495 NM_001098616
NM_015449
NM_138740
C1orf43


chromosome 1 open reading frame 43


chr20_-_47965443 0.488 SPATA2
spermatogenesis associated 2
chr16_+_639278 0.485 NM_145294
WDR90
WD repeat domain 90
chr9_-_13269562 0.485 MPDZ
multiple PDZ domain protein
chr6_+_116939500 0.483 NM_153711
FAM26E
family with sequence similarity 26, member E
chr1_+_152459918 0.481 NM_014847
UBAP2L
ubiquitin associated protein 2-like
chr18_-_53621277 0.480 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr1_-_154205675 0.480 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr12_+_79634820 0.478 NM_005593
MYF5
myogenic factor 5
chr2_+_228045053 0.476 AGFG1
ArfGAP with FG repeats 1
chr16_-_27468717 0.476 GTF3C1
general transcription factor IIIC, polypeptide 1, alpha 220kDa
chrX_-_34585287 0.475 NM_031442
TMEM47
transmembrane protein 47
chr3_-_36961539 0.474 NM_014831
TRANK1
tetratricopeptide repeat and ankyrin repeat containing 1
chr12_-_57600336 0.473 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr11_+_120399966 0.472 NM_001130047
NM_152715
TBCEL

tubulin folding cofactor E-like

chr19_-_42098758 0.467 NM_001171979
ZNF829
zinc finger protein 829
chr8_-_13416554 0.467 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr14_+_23653819 0.466 NM_025230
DCAF11
DDB1 and CUL4 associated factor 11
chr11_+_101290930 0.466 NM_020802
KIAA1377
KIAA1377
chr22_+_34107051 0.465 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr20_+_43952997 0.465 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A


chr9_+_119506274 0.458 NM_138554
TLR4
toll-like receptor 4
chr1_-_152459506 0.458 C1orf43
chromosome 1 open reading frame 43
chr1_-_68470585 0.450 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr8_-_82186832 0.446 NM_018440
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr4_+_108965167 0.445 NM_001136258
SGMS2
sphingomyelin synthase 2
chr6_+_148705421 0.444 NM_015278
SASH1
SAM and SH3 domain containing 1
chrX_-_106846684 0.442 TSC22D3
TSC22 domain family, member 3
chr7_+_28415495 0.440 LOC401317
hypothetical LOC401317
chr6_-_109810396 0.436 NM_001142401
NM_001142402
NM_001142403
NM_001142404
NM_006016
CD164




CD164 molecule, sialomucin




chr20_-_47965474 0.435 NM_006038
SPATA2
spermatogenesis associated 2
chr2_+_42249896 0.433 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr14_-_23653965 0.432 NRL
neural retina leucine zipper
chr5_+_80292213 0.432 RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr18_+_7557313 0.431 NM_001105244
NM_002845
PTPRM

protein tyrosine phosphatase, receptor type, M

chr6_+_127629677 0.426 NM_030963
RNF146
ring finger protein 146
chr12_-_57600564 0.424 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr14_+_23654161 0.423 DCAF11
DDB1 and CUL4 associated factor 11
chr12_-_79855580 0.422 LIN7A
lin-7 homolog A (C. elegans)
chr2_-_227372574 0.422 IRS1
insulin receptor substrate 1
chr4_-_23500706 0.422 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr11_-_8695974 0.420 ST5
suppression of tumorigenicity 5
chr9_-_98421894 0.419 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr5_-_121440704 0.418 NM_001178102
LOX
lysyl oxidase
chr1_-_59020875 0.416 JUN
jun proto-oncogene
chr16_-_65742323 0.415 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr10_-_3817205 0.414 KLF6
Kruppel-like factor 6
chr13_+_47776026 0.413 RB1
retinoblastoma 1
chrX_-_102205736 0.413 BEX1
brain expressed, X-linked 1
chr22_+_36928972 0.412 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr5_+_15553768 0.411 FBXL7
F-box and leucine-rich repeat protein 7
chr17_+_77529070 0.411 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr4_-_77354011 0.410 NM_005506
SCARB2
scavenger receptor class B, member 2
chr8_+_103889733 0.410 FLJ45248
FLJ45248 protein
chr12_-_90096275 0.407 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr2_+_238200922 0.404 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr1_-_20685314 0.401 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr16_+_87765661 0.397 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr15_-_71712711 0.395 NM_001161363
NM_001161364
NM_012428
NM_017455
NPTN



neuroplastin



chr2_-_160362914 0.395 CD302
CD302 molecule
chr12_+_50731457 0.394 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr10_-_93382837 0.393 NM_005398
PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr6_+_87921980 0.392 NM_015021
ZNF292
zinc finger protein 292
chr9_+_77695334 0.391 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr7_-_81910740 0.390 CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr20_-_49818268 0.389 ATP9A
ATPase, class II, type 9A
chr2_+_173000590 0.380 ITGA6
integrin, alpha 6
chr11_+_43658718 0.380 NM_016142
HSD17B12
hydroxysteroid (17-beta) dehydrogenase 12
chr19_-_61680510 0.375 NM_022103
ZNF667
zinc finger protein 667
chr1_+_181258952 0.374 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr17_-_75385371 0.373 NM_020649
CBX8
chromobox homolog 8
chrX_+_102518064 0.371 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr1_+_152644471 0.370 IL6R
interleukin 6 receptor
chr3_+_44878380 0.369 NM_144638
TMEM42
transmembrane protein 42
chr9_+_119506428 0.369 TLR4
toll-like receptor 4
chrX_-_102205752 0.369 NM_018476
BEX1
brain expressed, X-linked 1
chr9_-_89779413 0.366 NM_001039803
NM_001170639
NM_001170640
NM_012119
NM_178432
CDK20




cyclin-dependent kinase 20




chr4_-_77353713 0.366 SCARB2
scavenger receptor class B, member 2
chr4_+_77446906 0.365 STBD1
starch binding domain 1
chr13_+_112999462 0.365 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chr11_-_8849485 0.364 ST5
suppression of tumorigenicity 5
chr2_+_173000552 0.362 NM_000210
NM_001079818
ITGA6

integrin, alpha 6

chr1_-_112083387 0.362 NM_019099
C1orf183
chromosome 1 open reading frame 183
chr17_+_7416780 0.361 NM_001416
EIF4A1
eukaryotic translation initiation factor 4A1
chrX_+_149282097 0.361 NM_001177465
MAMLD1
mastermind-like domain containing 1
chr9_+_102380156 0.360 NM_001018116
MURC
muscle-related coiled-coil protein
chr8_+_67787206 0.359 SGK3
serum/glucocorticoid regulated kinase family, member 3
chr7_+_27102508 0.356


chr5_-_159730196 0.356 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr4_-_111763655 0.354 NM_000325
PITX2
paired-like homeodomain 2
chr19_+_16296632 0.353 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr14_+_23654307 0.353 NM_181357
DCAF11
DDB1 and CUL4 associated factor 11
chr4_-_156517394 0.352 MAP9
microtubule-associated protein 9
chr11_-_8788765 0.352 NM_213618
ST5
suppression of tumorigenicity 5
chr4_-_77353778 0.352 SCARB2
scavenger receptor class B, member 2
chr6_+_123152044 0.352 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr7_-_81910956 0.351 NM_000722
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chrX_+_99785818 0.350 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr11_+_110916629 0.350 LAYN
layilin
chr12_+_63958949 0.349 NM_001193461
MSRB3
methionine sulfoxide reductase B3
chr10_-_3817418 0.348 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr16_+_27468942 0.348 NM_015202
KIAA0556
KIAA0556
chr11_+_69165065 0.347 CCND1
cyclin D1
chr5_+_122452739 0.345 NM_001136239
PRDM6
PR domain containing 6
chr7_+_27102197 0.345


chr10_+_11100111 0.344 CELF2
CUGBP, Elav-like family member 2
chr9_-_90983501 0.343 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr12_+_63958689 0.343 NM_001031679
NM_001193460
NM_198080
MSRB3


methionine sulfoxide reductase B3


chr10_+_53744043 0.342 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr8_+_11599119 0.341 NM_002052
GATA4
GATA binding protein 4
chr4_-_156517423 0.340 MAP9
microtubule-associated protein 9
chr2_-_20115269 0.339 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chr19_-_18912112 0.339 NM_001145722
NM_001145721
HOMER3

homer homolog 3 (Drosophila)

chr6_-_84994032 0.338 NM_014895
KIAA1009
KIAA1009
chr1_-_233879617 0.338 NM_001098722
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chr4_-_77353760 0.337 SCARB2
scavenger receptor class B, member 2
chr2_-_64734544 0.337 NM_014755
SERTAD2
SERTA domain containing 2
chr20_-_6051860 0.336 FERMT1
fermitin family member 1
chr10_-_62373828 0.334 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chrX_-_106846924 0.334 NM_004089
TSC22D3
TSC22 domain family, member 3
chr5_+_148766632 0.334 LOC728264
hypothetical LOC728264
chr11_+_69165119 0.333 CCND1
cyclin D1
chr2_+_85683473 0.333 USP39
ubiquitin specific peptidase 39
chr10_-_105427898 0.332 SH3PXD2A
SH3 and PX domains 2A
chr16_-_10581944 0.331 NM_001424
EMP2
epithelial membrane protein 2
chr2_-_196744546 0.330 NM_004226
STK17B
serine/threonine kinase 17b
chr1_+_152644292 0.330 NM_000565
NM_181359
IL6R

interleukin 6 receptor

chr3_+_11153778 0.329 NM_001098213
HRH1
histamine receptor H1
chr2_-_85683268 0.329 NM_001031738
TMEM150A
transmembrane protein 150A
chr9_-_126309510 0.329 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr22_+_34025872 0.327 TOM1
target of myb1 (chicken)
chr17_+_30594192 0.326 NM_144975
SLFN5
schlafen family member 5
chr1_-_37792414 0.325 NM_024700
SNIP1
Smad nuclear interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.37 3.92e-04 GO:0033036 macromolecule localization
1.44 6.58e-03 GO:0046907 intracellular transport
1.23 1.31e-02 GO:0048522 positive regulation of cellular process
1.20 4.13e-02 GO:0048518 positive regulation of biological process
1.33 4.65e-02 GO:0051649 establishment of localization in cell

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 3.42e-06 GO:0005622 intracellular
1.08 6.66e-06 GO:0044424 intracellular part
1.09 5.55e-03 GO:0005737 cytoplasm
1.07 1.40e-02 GO:0043229 intracellular organelle
1.07 1.49e-02 GO:0043226 organelle
1.11 4.81e-02 GO:0005634 nucleus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 3.24e-07 GO:0005515 protein binding
2.68 1.38e-02 GO:0003707 steroid hormone receptor activity
1.06 1.95e-02 GO:0005488 binding
2.54 3.69e-02 GO:0004879 ligand-dependent nuclear receptor activity