Motif ID: HSF1,2.p2

Z-value: 1.167


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HSF2chr6_+_1227624490.253.5e-01Click!
HSF1chr8_+_1454862450.058.6e-01Click!


Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_152366970 2.008 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr10_+_94584449 1.801 NM_001013848
EXOC6
exocyst complex component 6
chr20_+_19818209 1.567 NM_018993
RIN2
Ras and Rab interactor 2
chrX_-_33139349 1.553 NM_004006
DMD
dystrophin
chr7_+_134114957 1.549 CALD1
caldesmon 1
chr7_+_134114701 1.382 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr6_+_151688327 1.370 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr11_+_12265022 1.312 NM_032867
MICALCL
MICAL C-terminal like
chr14_+_62740878 1.312 NM_020663
RHOJ
ras homolog gene family, member J
chr10_-_116434102 1.255 ABLIM1
actin binding LIM protein 1
chr2_-_188127294 1.248 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr10_-_116434364 1.226 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr2_-_188127430 1.192 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr2_-_192419896 1.153 SDPR
serum deprivation response
chr7_+_134114912 1.121 CALD1
caldesmon 1
chr19_+_15079141 1.080 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr13_+_48582389 1.043 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr7_-_80386258 1.001 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr3_-_64648703 0.965 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr3_-_115585178 0.944 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr20_-_17487480 0.936 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr12_+_74160779 0.917 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr5_-_148422799 0.916 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr7_-_80386602 0.876 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr12_-_119172339 0.848 NM_025157
PXN
paxillin
chr12_-_14887648 0.830 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr3_-_113842350 0.827 CCDC80
coiled-coil domain containing 80
chr2_-_189752575 0.823 NM_000393
COL5A2
collagen, type V, alpha 2
chr12_-_68369322 0.813 NM_152439
BEST3
bestrophin 3
chr10_+_122206455 0.811 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr3_+_195336625 0.795 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr10_+_104525877 0.791 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr4_-_22126437 0.790 NM_145290
GPR125
G protein-coupled receptor 125
chr2_+_202379442 0.785 NM_139158
CDK15
cyclin-dependent kinase 15
chr6_+_116939500 0.782 NM_153711
FAM26E
family with sequence similarity 26, member E
chr8_-_110689396 0.762 SYBU
syntabulin (syntaxin-interacting)
chr2_+_66516196 0.759 MEIS1
Meis homeobox 1
chr2_-_224611568 0.736 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr3_+_30623376 0.735 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr6_+_129245978 0.678 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr4_+_108965167 0.654 NM_001136258
SGMS2
sphingomyelin synthase 2
chr2_-_192420168 0.643 NM_004657
SDPR
serum deprivation response
chr9_+_130719034 0.634 LRRC8A
leucine rich repeat containing 8 family, member A
chr12_+_118100977 0.628 NM_014365
HSPB8
heat shock 22kDa protein 8
chr2_-_162808123 0.617 NM_004460
FAP
fibroblast activation protein, alpha
chr19_+_50041424 0.612 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr4_+_128773529 0.611 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr7_+_120416680 0.608 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chr6_+_31190505 0.608 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr3_-_113842553 0.606 CCDC80
coiled-coil domain containing 80
chr1_+_54786394 0.603 NM_015547
NM_147161
ACOT11

acyl-CoA thioesterase 11

chr8_+_40130143 0.589 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr2_+_28469850 0.576 FOSL2
FOS-like antigen 2
chr6_+_153060722 0.572 NM_025107
MYCT1
myc target 1
chr11_-_111287657 0.571 NM_001885
CRYAB
crystallin, alpha B
chr11_+_27019084 0.567 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr6_-_111995213 0.565 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chrX_-_102828238 0.563 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr15_+_60838053 0.560 TLN2
talin 2
chr2_+_159533329 0.557 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chrX_+_80344253 0.555 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr3_+_195336631 0.553 HES1
hairy and enhancer of split 1, (Drosophila)
chr5_+_36644187 0.551 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_+_12652427 0.551 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr18_-_51219880 0.549 TCF4
transcription factor 4
chr18_-_45630154 0.545 MYO5B
myosin VB
chr2_-_105421661 0.539 NM_201557
FHL2
four and a half LIM domains 2
chr2_-_158439868 0.536 NM_001105
ACVR1
activin A receptor, type I
chr8_+_70541412 0.529 NM_001128204
NM_015170
SULF1

sulfatase 1

chr6_-_109521969 0.528 NM_014454
SESN1
sestrin 1
chr9_-_74757735 0.527 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr15_+_94670160 0.516 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr15_+_45263517 0.515 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr13_+_75232797 0.506 NM_015842
LMO7
LIM domain 7
chr16_+_3055639 0.502 NM_001012634
IL32
interleukin 32
chr3_-_113842652 0.498 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr16_+_3055640 0.497 IL32
interleukin 32
chr1_+_143807876 0.496 SEC22B
SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
chr21_+_30724442 0.491 NM_181600
KRTAP13-4
keratin associated protein 13-4
chr18_-_44723116 0.486 NM_001190823
SMAD7
SMAD family member 7
chr1_+_176577228 0.485 NM_004841
RASAL2
RAS protein activator like 2
chr6_+_10663934 0.483 NM_001491
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr1_+_45046740 0.482 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr18_+_30427279 0.478 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chrX_+_80344215 0.475 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr3_-_124893875 0.473 MYLK
myosin light chain kinase
chr14_-_69953433 0.470 NM_018373
SYNJ2BP
synaptojanin 2 binding protein
chr5_-_159672060 0.468 NM_024565
CCNJL
cyclin J-like
chr13_+_96672541 0.467 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr3_-_71262405 0.466 FOXP1
forkhead box P1
chr8_-_72436832 0.465 EYA1
eyes absent homolog 1 (Drosophila)
chr4_-_159313167 0.465 NM_016613
FAM198B
family with sequence similarity 198, member B
chr6_+_46728590 0.461 NM_004277
SLC25A27
solute carrier family 25, member 27
chr12_+_10351683 0.460 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr12_+_49604782 0.452 NM_014033
METTL7A
methyltransferase like 7A
chr4_-_75183700 0.448 CXCL2
chemokine (C-X-C motif) ligand 2
chr16_+_3055313 0.448 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr11_-_5419358 0.445 NM_001005288
OR51I1
olfactory receptor, family 51, subfamily I, member 1
chr2_+_28469864 0.441 FOSL2
FOS-like antigen 2
chr4_-_75123193 0.440 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr1_-_151848039 0.440 S100A16
S100 calcium binding protein A16
chr2_+_222871109 0.438 NM_153038
CCDC140
coiled-coil domain containing 140
chr16_+_3055642 0.437 NM_001012632
NM_001012636
IL32

interleukin 32

chr12_+_49605010 0.436 METTL7A
methyltransferase like 7A
chr10_+_53744043 0.432 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr6_-_56615544 0.430 NM_001723
NM_015548
DST

dystonin

chr16_+_3055602 0.429 NM_001012635
IL32
interleukin 32
chr3_+_46514488 0.427 NM_031440
RTP3
receptor (chemosensory) transporter protein 3
chr13_-_32658215 0.424 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_-_75641587 0.423 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr3_+_113061218 0.421 NM_001134439
PHLDB2
pleckstrin homology-like domain, family B, member 2
chrX_-_43717864 0.418 NM_000266
NDP
Norrie disease (pseudoglioma)
chr2_+_69093641 0.418 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr16_+_68516401 0.417 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr3_+_184453907 0.415 B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr18_+_3441589 0.413 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr12_+_13240868 0.413 NM_001423
EMP1
epithelial membrane protein 1
chr1_-_78217278 0.412 FUBP1
far upstream element (FUSE) binding protein 1
chr3_-_71262426 0.412 FOXP1
forkhead box P1
chr3_-_15814678 0.409 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr4_-_101658094 0.406 NM_001159694
NM_016242
EMCN

endomucin

chr6_+_134800533 0.405 LOC154092
hypothetical LOC154092
chr2_-_75641535 0.405 FAM176A
family with sequence similarity 176, member A
chr6_-_161614962 0.403 NM_020133
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr5_-_94443300 0.400 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chrX_+_86659370 0.399 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr21_-_34820916 0.397 NM_203418
RCAN1
regulator of calcineurin 1
chr17_+_21249040 0.394 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chr3_+_113061296 0.393 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr6_+_146906520 0.392 NM_006834
RAB32
RAB32, member RAS oncogene family
chr3_+_69871252 0.389 NM_198159
MITF
microphthalmia-associated transcription factor
chr13_+_96672705 0.388 MBNL2
muscleblind-like 2 (Drosophila)
chr4_+_77575276 0.387 NM_020859
SHROOM3
shroom family member 3
chr1_+_20788027 0.387 NM_001785
CDA
cytidine deaminase
chr4_-_74307637 0.385 ANKRD17
ankyrin repeat domain 17
chr18_+_54013575 0.381 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr10_+_71232281 0.379 COL13A1
collagen, type XIII, alpha 1
chr3_+_113061330 0.376 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr5_+_140454382 0.372 NM_018936
PCDHB2
protocadherin beta 2
chr1_+_150749943 0.372 NM_178438
LCE5A
late cornified envelope 5A
chr5_-_92942680 0.371 FLJ42709
hypothetical LOC441094
chr6_-_109522207 0.369 SESN1
sestrin 1
chrX_+_135106578 0.366 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr20_+_29656744 0.365 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr14_-_51605695 0.361 NM_007361
NID2
nidogen 2 (osteonidogen)
chr5_-_94442941 0.360 MCTP1
multiple C2 domains, transmembrane 1
chrX_-_2892288 0.359 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr14_+_88360690 0.356 NM_144596
NM_198309
NM_198310
TTC8


tetratricopeptide repeat domain 8


chr22_-_34564611 0.353 RPL41P5
ribosomal protein L41 pseudogene 5
chr3_-_113841448 0.352 CCDC80
coiled-coil domain containing 80
chr7_+_102340579 0.352 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr8_-_13018123 0.352 NM_001164271
DLC1
deleted in liver cancer 1
chr7_-_83662152 0.352 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr1_-_199657468 0.351 NM_003281
TNNI1
troponin I type 1 (skeletal, slow)
chr3_+_52504410 0.350 STAB1
stabilin 1
chr22_+_39583001 0.349 NM_022098
XPNPEP3
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
chr15_-_72981595 0.346 C15orf17
chromosome 15 open reading frame 17
chr7_+_105304445 0.344 LOC100506768
CDHR3
hypothetical LOC100506768
cadherin-related family member 3
chr9_-_13269562 0.344 MPDZ
multiple PDZ domain protein
chr21_-_35181956 0.340 RUNX1
runt-related transcription factor 1
chr6_-_46728188 0.337 NM_016593
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr14_-_22610572 0.337 ACIN1
apoptotic chromatin condensation inducer 1
chr8_-_37847095 0.334 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr4_+_120167264 0.331 SYNPO2
synaptopodin 2
chr11_-_104344473 0.329 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr7_-_92615593 0.329 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr1_-_45045543 0.326 NM_001013632
TCTEX1D4
Tctex1 domain containing 4
chr8_-_72436519 0.326 EYA1
eyes absent homolog 1 (Drosophila)
chr10_-_131652007 0.325 NM_001005463
EBF3
early B-cell factor 3
chr14_+_85066207 0.324 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr14_-_22610610 0.324 NM_001164816
NM_001164817
ACIN1

apoptotic chromatin condensation inducer 1

chr17_+_65677255 0.323 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr3_-_188946168 0.320 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr1_-_148175345 0.319 MTMR11
myotubularin related protein 11
chr11_+_65027721 0.318


chr6_+_10803141 0.316 NM_017906
PAK1IP1
PAK1 interacting protein 1
chr14_-_51605487 0.315 NID2
nidogen 2 (osteonidogen)
chr14_-_51605461 0.314 NID2
nidogen 2 (osteonidogen)
chr8_-_38505331 0.313 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr14_-_51605515 0.311 NID2
nidogen 2 (osteonidogen)
chr5_-_146813343 0.309 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr7_+_129771865 0.308 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr6_+_28342766 0.306 NM_001023560
NM_001111039
NM_152736
ZNF187


zinc finger protein 187


chr1_+_194887630 0.306 NM_000186
NM_001014975
CFH

complement factor H

chr17_+_35425139 0.305 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr1_-_148174722 0.304 NM_181873
MTMR11
myotubularin related protein 11
chr14_+_54104383 0.304 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr7_-_158304062 0.303 ESYT2
extended synaptotagmin-like protein 2
chr10_+_24795446 0.302 KIAA1217
KIAA1217
chr7_+_142790047 0.300 ZYX
zyxin
chr9_-_72673753 0.300 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr14_+_104218487 0.300


chr13_-_30634031 0.300 NM_006644
HSPH1
heat shock 105kDa/110kDa protein 1
chr12_+_11694172 0.299 ETV6
ets variant 6
chr13_+_47705493 0.299 ITM2B
integral membrane protein 2B
chr21_+_29439768 0.299 C21orf7
chromosome 21 open reading frame 7
chrX_-_21686079 0.298 NM_014332
SMPX
small muscle protein, X-linked
chr18_+_18003401 0.297 NM_005257
GATA6
GATA binding protein 6
chr6_+_158358067 0.296 NM_001178088
SYNJ2
synaptojanin 2
chr12_-_84754289 0.296 NM_005447
RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.89 5.71e-06 GO:0072358 cardiovascular system development
1.89 5.71e-06 GO:0072359 circulatory system development
1.89 9.29e-06 GO:0048646 anatomical structure formation involved in morphogenesis
1.44 5.75e-05 GO:0009653 anatomical structure morphogenesis
1.24 7.05e-04 GO:0007275 multicellular organismal development
1.56 1.97e-03 GO:0007155 cell adhesion
1.56 1.97e-03 GO:0022610 biological adhesion
1.92 2.89e-03 GO:0001944 vasculature development
1.51 3.11e-03 GO:0040011 locomotion
1.24 4.23e-03 GO:0048856 anatomical structure development
1.21 5.35e-03 GO:0032502 developmental process
1.93 6.74e-03 GO:0001568 blood vessel development
1.25 7.06e-03 GO:0048731 system development
1.16 1.39e-02 GO:0032501 multicellular organismal process
1.95 1.45e-02 GO:0007507 heart development
1.59 1.89e-02 GO:0006928 cellular component movement
2.41 2.29e-02 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
1.20 3.49e-02 GO:0071840 cellular component organization or biogenesis
1.21 3.58e-02 GO:0016043 cellular component organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.51 1.71e-05 GO:0044421 extracellular region part
2.32 5.25e-03 GO:0044420 extracellular matrix part
1.68 7.23e-03 GO:0031012 extracellular matrix
1.44 1.12e-02 GO:0005615 extracellular space
2.96 1.25e-02 GO:0031983 vesicle lumen
1.26 1.52e-02 GO:0005576 extracellular region
2.00 3.52e-02 GO:0005912 adherens junction
1.39 4.02e-02 GO:0042995 cell projection
1.28 4.96e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 8.17e-04 GO:0005515 protein binding
5.75 3.55e-02 GO:0048185 activin binding