Motif ID: HSF1,2.p2

Z-value: 1.167


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HSF2chr6_+_1227624490.253.5e-01Click!
HSF1chr8_+_1454862450.058.6e-01Click!


Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_152366970 2.008 NM_001009555
NM_001128923
 SH3D19

SH3 domain containing 19

chr10_+_94584449 1.801 NM_001013848
 EXOC6
exocyst complex component 6
chr20_+_19818209 1.567 NM_018993
 RIN2
Ras and Rab interactor 2
chrX_-_33139349 1.553 NM_004006
 DMD
dystrophin
chr7_+_134114957 1.549 CALD1
caldesmon 1
chr7_+_134114701 1.382 NM_004342
NM_033138
NM_033157
 CALD1


caldesmon 1


chr6_+_151688327 1.370 NM_144497
 AKAP12
A kinase (PRKA) anchor protein 12
chr11_+_12265022 1.312 NM_032867
 MICALCL
MICAL C-terminal like
chr14_+_62740878 1.312 NM_020663
 RHOJ
ras homolog gene family, member J
chr10_-_116434102 1.255 ABLIM1
actin binding LIM protein 1
chr2_-_188127294 1.248 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr10_-_116434364 1.226 NM_001003407
NM_001003408
 ABLIM1

actin binding LIM protein 1

chr2_-_188127430 1.192 NM_001032281
NM_006287
 TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr2_-_192419896 1.153 SDPR
serum deprivation response
chr7_+_134114912 1.121 CALD1
caldesmon 1
chr19_+_15079141 1.080 NM_033025
 SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr13_+_48582389 1.043 NM_014923
 FNDC3A
fibronectin type III domain containing 3A
chr7_-_80386258 1.001 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr3_-_64648703 0.965 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr3_-_115585178 0.944 NM_001164342
 ZBTB20
zinc finger and BTB domain containing 20

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
2.41 2.29e-02 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
1.95 1.45e-02 GO:0007507 heart development
1.93 6.74e-03 GO:0001568 blood vessel development
1.92 2.89e-03 GO:0001944 vasculature development
1.89 5.71e-06 GO:0072358 cardiovascular system development
1.89 5.71e-06 GO:0072359 circulatory system development
1.89 9.29e-06 GO:0048646 anatomical structure formation involved in morphogenesis
1.59 1.89e-02 GO:0006928 cellular component movement
1.56 1.97e-03 GO:0007155 cell adhesion
1.56 1.97e-03 GO:0022610 biological adhesion
1.51 3.11e-03 GO:0040011 locomotion
1.44 5.75e-05 GO:0009653 anatomical structure morphogenesis
1.25 7.06e-03 GO:0048731 system development
1.24 7.05e-04 GO:0007275 multicellular organismal development
1.24 4.23e-03 GO:0048856 anatomical structure development
1.21 5.35e-03 GO:0032502 developmental process
1.21 3.58e-02 GO:0016043 cellular component organization
1.20 3.49e-02 GO:0071840 cellular component organization or biogenesis
1.16 1.39e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
2.96 1.25e-02 GO:0031983 vesicle lumen
2.32 5.25e-03 GO:0044420 extracellular matrix part
2.00 3.52e-02 GO:0005912 adherens junction
1.68 7.23e-03 GO:0031012 extracellular matrix
1.51 1.71e-05 GO:0044421 extracellular region part
1.44 1.12e-02 GO:0005615 extracellular space
1.39 4.02e-02 GO:0042995 cell projection
1.28 4.96e-02 GO:0005856 cytoskeleton
1.26 1.52e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
5.75 3.55e-02 GO:0048185 activin binding
1.13 8.17e-04 GO:0005515 protein binding