Motif ID: TFEB.p2

Z-value: 2.249


Transcription factors associated with TFEB.p2:

Gene SymbolEntrez IDGene Name
TFEB 7942 transcription factor EB

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFEBchr6_-_41781655-0.485.9e-02Click!


Activity profile for motif TFEB.p2.

activity profile for motif TFEB.p2


Sorted Z-values histogram for motif TFEB.p2

Sorted Z-values for motif TFEB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFEB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_27162688 8.339 NM_006896
HOXA7
homeobox A7
chr5_+_34692124 6.175 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr2_+_223625105 5.575 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr5_+_34692239 5.422 RAI14
retinoic acid induced 14
chr5_+_34692352 5.130 NM_001145520
RAI14
retinoic acid induced 14
chr1_-_68470585 4.849 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr10_-_14090459 4.827 FRMD4A
FERM domain containing 4A
chr9_-_16860719 4.816 NM_017637
BNC2
basonuclin 2
chr22_+_34107051 4.535 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr6_+_87921980 4.515 NM_015021
ZNF292
zinc finger protein 292
chr2_+_85834111 4.469 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr22_+_34107087 4.456 HMOX1
heme oxygenase (decycling) 1
chr1_-_152459667 4.439 C1orf43
chromosome 1 open reading frame 43
chr13_+_112999462 4.328 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chr7_-_47588652 4.109 TNS3
tensin 3
chr6_-_80713589 3.987 NM_022726
ELOVL4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr7_-_47588160 3.976 TNS3
tensin 3
chrX_-_34585287 3.747 NM_031442
TMEM47
transmembrane protein 47
chr1_-_152459506 3.688 C1orf43
chromosome 1 open reading frame 43
chr1_+_201364050 3.677 ADORA1
adenosine A1 receptor
chr1_+_148521852 3.673 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr9_-_16860664 3.580 BNC2
basonuclin 2
chr7_-_47588266 3.514 TNS3
tensin 3
chr1_-_197173159 3.466 LOC100131234
familial acute myelogenous leukemia related factor
chr11_+_120399966 3.439 NM_001130047
NM_152715
TBCEL

tubulin folding cofactor E-like

chr3_+_114948550 3.426 NM_001690
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr3_-_172109119 3.419 NM_020390
EIF5A2
eukaryotic translation initiation factor 5A2
chr11_-_47427263 3.418 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr16_-_69277355 3.381 NM_138383
MTSS1L
metastasis suppressor 1-like
chr1_+_152459918 3.334 NM_014847
UBAP2L
ubiquitin associated protein 2-like
chrX_+_100692071 3.327 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr19_+_10625896 3.324 NM_001137673
NM_004516
NM_012218
NM_017620
NM_153464
ILF3




interleukin enhancer binding factor 3, 90kDa




chr13_-_20533703 3.301 NM_014572
LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr19_+_54149843 3.292 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr13_+_112999538 3.259 LAMP1
lysosomal-associated membrane protein 1
chr4_+_120167721 3.198 SYNPO2
synaptopodin 2
chrX_-_114703273 3.193


chr7_+_4781784 3.147 NM_014855
KIAA0415
KIAA0415
chr1_+_66772393 3.071 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr7_+_27191534 3.025 HOXA11-AS1
HOXA11 antisense RNA 1 (non-protein coding)
chr17_-_44026042 2.994 NM_002147
HOXB5
homeobox B5
chr3_-_172109075 2.992 EIF5A2
eukaryotic translation initiation factor 5A2
chr19_+_54149941 2.979 BAX
BCL2-associated X protein
chrX_+_102749489 2.948 NM_001006933
NM_032926
TCEAL3

transcription elongation factor A (SII)-like 3

chr6_-_33822659 2.936 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr11_-_8849485 2.932 ST5
suppression of tumorigenicity 5
chr7_+_27102197 2.908


chr3_+_33293915 2.899 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr7_-_27191287 2.867 NM_005523
HOXA11
homeobox A11
chr11_-_85457736 2.860 PICALM
phosphatidylinositol binding clathrin assembly protein
chr18_+_75967902 2.859 NM_014913
ADNP2
ADNP homeobox 2
chr16_+_31132842 2.855 NM_001008274
TRIM72
tripartite motif containing 72
chr1_-_152459697 2.854 NM_001098616
NM_015449
NM_138740
C1orf43


chromosome 1 open reading frame 43


chr13_+_112999590 2.833 LAMP1
lysosomal-associated membrane protein 1
chr13_-_20533629 2.831 LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr11_+_101485946 2.829 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr1_-_94475840 2.758 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr2_+_238060602 2.749 NM_001042467
NM_024101
MLPH

melanophilin

chr13_-_109236897 2.702 NM_003749
IRS2
insulin receptor substrate 2
chr1_-_151775221 2.692 NM_014624
S100A6
S100 calcium binding protein A6
chr7_+_28415495 2.679 LOC401317
hypothetical LOC401317
chr13_-_35818603 2.664 NM_001142296
NM_015087
SPG20

spastic paraplegia 20 (Troyer syndrome)

chr7_+_17304707 2.659 NM_001621
AHR
aryl hydrocarbon receptor
chr13_-_73605914 2.656 NM_007249
KLF12
Kruppel-like factor 12
chr11_+_119701047 2.623 NM_001198670
NM_001198671
NM_001198672
NM_001198673
NM_001198674
NM_001198675
NM_174926
TMEM136






transmembrane protein 136






chr19_+_54149963 2.595 BAX
BCL2-associated X protein
chr2_+_187266899 2.591 NM_177454
FAM171B
family with sequence similarity 171, member B
chr4_+_120167770 2.555 SYNPO2
synaptopodin 2
chr5_-_131160589 2.548 FNIP1
folliculin interacting protein 1
chr9_-_89779413 2.547 NM_001039803
NM_001170639
NM_001170640
NM_012119
NM_178432
CDK20




cyclin-dependent kinase 20




chr19_-_52710129 2.526 NM_003827
NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr18_+_9126742 2.524 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chrX_+_102518064 2.508 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr2_-_192767844 2.496 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr19_+_10625987 2.493 ILF3
interleukin enhancer binding factor 3, 90kDa
chr6_+_151603201 2.485 AKAP12
A kinase (PRKA) anchor protein 12
chr2_-_133144094 2.477 LYPD1
LY6/PLAUR domain containing 1
chr12_-_54409107 2.458 NM_001040034
NM_001780
CD63

CD63 molecule

chr9_-_37566248 2.435 NM_012166
FBXO10
F-box protein 10
chr3_+_114948591 2.435 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr12_+_52653176 2.429 NM_014212
HOXC11
homeobox C11
chr19_-_10625449 2.409 LOC147727
hypothetical LOC147727
chr11_+_32993973 2.407 NM_001077242
DEPDC7
DEP domain containing 7
chr7_+_4781803 2.395 KIAA0415
KIAA0415
chr3_-_188946168 2.375 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr3_+_129927723 2.372 RAB7A
RAB7A, member RAS oncogene family
chr1_+_68070573 2.364


chr4_+_71806538 2.350 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr5_-_172687798 2.338 STC2
stanniocalcin 2
chr3_+_51403760 2.322 NM_013286
RBM15B
RNA binding motif protein 15B
chr13_-_95094920 2.308 NM_014934
NM_198968
DZIP1

DAZ interacting protein 1

chr15_-_38000379 2.305 NM_007223
GPR176
G protein-coupled receptor 176
chr21_-_35343500 2.282 RUNX1
runt-related transcription factor 1
chr10_+_52420936 2.278 NM_001098512
PRKG1
protein kinase, cGMP-dependent, type I
chr1_-_33669190 2.277 PHC2
polyhomeotic homolog 2 (Drosophila)
chr4_+_128773529 2.276 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr11_-_85457753 2.274 NM_001008660
NM_007166
PICALM

phosphatidylinositol binding clathrin assembly protein

chr3_+_129927726 2.268 RAB7A
RAB7A, member RAS oncogene family
chr7_+_27102508 2.255


chr21_-_35343456 2.254 NM_001754
RUNX1
runt-related transcription factor 1
chr5_+_52812165 2.252 FST
follistatin
chr19_-_52709975 2.242 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr5_-_131160614 2.236 NM_001008738
NM_133372
FNIP1

folliculin interacting protein 1

chr7_-_27171648 2.227 HOXA9
homeobox A9
chr7_-_27171673 2.218 NM_152739
HOXA9
homeobox A9
chr7_-_27102049 2.211 NM_005522
NM_153620
HOXA1

homeobox A1

chr5_-_159730196 2.209 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr21_-_35343448 2.203 RUNX1
runt-related transcription factor 1
chr12_+_52806103 2.195 LOC400043
hypothetical LOC400043
chr3_+_129927716 2.193 RAB7A
RAB7A, member RAS oncogene family
chr3_-_188945921 2.176 BCL6
B-cell CLL/lymphoma 6
chr21_-_35343428 2.170 RUNX1
runt-related transcription factor 1
chr22_+_36928972 2.130 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr7_+_97748959 2.121 BRI3
brain protein I3
chr6_+_151603264 2.111


chr17_-_43977273 2.110 NM_002145
HOXB2
homeobox B2
chr7_-_27171600 2.107 HOXA9
homeobox A9
chr3_+_129927714 2.103 RAB7A
RAB7A, member RAS oncogene family
chr3_+_114948600 2.101 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr12_-_54409059 2.088 CD63
CD63 molecule
chrX_+_102498035 2.087 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr3_+_134239860 2.081 NM_001136469
NM_023943
TMEM108

transmembrane protein 108

chr13_-_35818491 2.059 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr9_-_72218098 2.044 KLF9
Kruppel-like factor 9
chr1_-_151775087 2.044 S100A6
S100 calcium binding protein A6
chr5_+_72957736 2.038 NM_001080479
NM_001177693
RGNEF

190 kDa guanine nucleotide exchange factor

chr3_+_134239906 2.035 TMEM108
transmembrane protein 108
chr5_-_131160608 2.035 FNIP1
folliculin interacting protein 1
chr8_+_1759502 2.023 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr1_+_11788889 2.022 CLCN6
chloride channel 6
chr15_-_71712711 2.018 NM_001161363
NM_001161364
NM_012428
NM_017455
NPTN



neuroplastin



chr7_-_27149750 2.016 NM_019102
HOXA5
homeobox A5
chr1_-_151775119 2.015 S100A6
S100 calcium binding protein A6
chr6_-_109810354 2.003 CD164
CD164 molecule, sialomucin
chrX_-_106846924 2.000 NM_004089
TSC22D3
TSC22 domain family, member 3
chr1_-_94475504 1.995 ARHGAP29
Rho GTPase activating protein 29
chr5_-_72780107 1.971 NM_004472
FOXD1
forkhead box D1
chr3_+_4996096 1.970 NM_003670
BHLHE40
basic helix-loop-helix family, member e40
chr2_-_196744546 1.968 NM_004226
STK17B
serine/threonine kinase 17b
chr1_+_216585298 1.965 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr16_-_65742323 1.956 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr11_+_119701214 1.944 TMEM136
transmembrane protein 136
chrX_+_102471769 1.940 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr12_-_54409015 1.939 CD63
CD63 molecule
chr3_+_129927668 1.937 NM_004637
RAB7A
RAB7A, member RAS oncogene family
chr1_+_11788827 1.932 CLCN6
chloride channel 6
chrX_-_100801472 1.909 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr6_+_151688327 1.905 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr5_-_131160541 1.886 FNIP1
folliculin interacting protein 1
chr3_+_4996141 1.879 BHLHE40
basic helix-loop-helix family, member e40
chr16_-_4837266 1.871 NM_032569
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr12_-_54409067 1.860 CD63
CD63 molecule
chr1_-_202595666 1.851 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr13_-_35818396 1.849 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr16_+_28893525 1.828 NM_001142448
NM_001142449
NM_001142450
NM_001142451
NM_032038
SPIN1
SPNS1




spindlin 1
spinster homolog 1 (Drosophila)




chr1_-_239587090 1.820 NM_002924
RGS7
regulator of G-protein signaling 7
chr2_-_183611470 1.818 NM_013436
NM_205842
NCKAP1

NCK-associated protein 1

chr18_+_54682261 1.815 ZNF532
zinc finger protein 532
chr18_+_75968133 1.811 ADNP2
ADNP homeobox 2
chr1_-_153195188 1.801 NM_020524
PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr20_+_43953372 1.797 CTSA
cathepsin A
chr5_+_52812236 1.775 NM_006350
NM_013409
FST

follistatin

chr20_-_43953036 1.769 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chr2_-_196744507 1.758 STK17B
serine/threonine kinase 17b
chr6_-_109810396 1.755 NM_001142401
NM_001142402
NM_001142403
NM_001142404
NM_006016
CD164




CD164 molecule, sialomucin




chr17_-_33043514 1.738 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr17_-_44043361 1.738 NM_004502
HOXB7
homeobox B7
chr16_-_57276108 1.737 NM_018231
SLC38A7
solute carrier family 38, member 7
chr17_-_44022595 1.727 HOXB3
homeobox B3
chr1_-_153195219 1.711 PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr2_+_238712101 1.711 NM_198582
KLHL30
kelch-like 30 (Drosophila)
chr8_+_133856738 1.709 NM_016018
NM_032205
NM_198513
PHF20L1


PHD finger protein 20-like 1


chr6_-_109810310 1.692 CD164
CD164 molecule, sialomucin
chr6_+_151603346 1.690 AKAP12
A kinase (PRKA) anchor protein 12
chr3_-_45858566 1.672 NM_020347
LZTFL1
leucine zipper transcription factor-like 1
chr10_-_32257693 1.663 ARHGAP12
Rho GTPase activating protein 12
chr2_-_192767494 1.663 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr17_-_7471832 1.659 NM_133491
SAT2
spermidine/spermine N1-acetyltransferase family member 2
chrX_+_101862297 1.655 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr4_+_159909626 1.655 NM_020840
FNIP2
folliculin interacting protein 2
chr8_+_75066117 1.643 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr10_-_32257768 1.635 NM_018287
ARHGAP12
Rho GTPase activating protein 12
chr12_+_54396099 1.610 BLOC1S1-RDH5
BLOC1S1
BLOC1S1-RDH5 read-through transcript
biogenesis of lysosomal organelles complex-1, subunit 1
chr6_-_109810296 1.603 CD164
CD164 molecule, sialomucin
chr9_-_89779180 1.598 CDK20
cyclin-dependent kinase 20
chr7_+_97748914 1.596 NM_001159491
NM_015379
BRI3

brain protein I3

chr1_-_203557379 1.592 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr17_-_35510431 1.592 NM_021724
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr12_+_120840829 1.591 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr12_-_57600336 1.582 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr18_+_12397894 1.581 NM_001142405
NM_006553
SLMO1

slowmo homolog 1 (Drosophila)

chr7_-_130443379 1.579 FLJ43663
hypothetical LOC378805
chrX_-_13866451 1.571 GPM6B
glycoprotein M6B
chr3_+_44878380 1.562 NM_144638
TMEM42
transmembrane protein 42
chr17_-_17081217 1.557 NM_144606
NM_144997
FLCN

folliculin

chr6_-_109810246 1.553 CD164
CD164 molecule, sialomucin
chr7_-_6278662 1.548 NM_004227
CYTH3
cytohesin 3
chr3_-_4483939 1.541 SUMF1
sulfatase modifying factor 1
chr4_+_159909658 1.533 FNIP2
folliculin interacting protein 2
chr9_+_114953087 1.528 SLC31A2
solute carrier family 31 (copper transporters), member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.92 7.56e-06 GO:0008104 protein localization
1.80 1.42e-05 GO:0033036 macromolecule localization
1.88 9.53e-04 GO:0015031 protein transport
7.11 1.26e-03 GO:0015682 ferric iron transport
7.11 1.26e-03 GO:0033572 transferrin transport
1.84 1.82e-03 GO:0045184 establishment of protein localization
1.68 1.91e-03 GO:0051641 cellular localization
5.33 3.11e-03 GO:0007033 vacuole organization
4.78 4.38e-03 GO:0048704 embryonic skeletal system morphogenesis
3.05 6.34e-03 GO:0009952 anterior/posterior pattern formation
4.05 6.85e-03 GO:0048706 embryonic skeletal system development
1.82 9.29e-03 GO:0046907 intracellular transport
2.04 1.10e-02 GO:0034613 cellular protein localization
3.24 1.17e-02 GO:0048705 skeletal system morphogenesis
2.02 1.30e-02 GO:0070727 cellular macromolecule localization
7.47 4.42e-02 GO:0032006 regulation of TOR signaling cascade
6.32 4.56e-02 GO:0007040 lysosome organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.32 8.30e-11 GO:0005773 vacuole
1.17 4.62e-09 GO:0044424 intracellular part
1.16 6.81e-08 GO:0005622 intracellular
1.20 9.89e-08 GO:0043226 organelle
1.20 1.13e-07 GO:0043229 intracellular organelle
3.98 1.18e-07 GO:0005774 vacuolar membrane
1.22 1.23e-07 GO:0043227 membrane-bounded organelle
1.22 1.61e-07 GO:0043231 intracellular membrane-bounded organelle
3.81 3.50e-07 GO:0044437 vacuolar part
2.53 3.96e-07 GO:0005768 endosome
2.93 2.55e-06 GO:0000323 lytic vacuole
2.93 2.55e-06 GO:0005764 lysosome
2.93 7.06e-06 GO:0010008 endosome membrane
2.90 8.65e-06 GO:0044440 endosomal part
3.83 3.82e-05 GO:0005770 late endosome
1.28 4.41e-05 GO:0044422 organelle part
1.28 7.25e-05 GO:0044446 intracellular organelle part
3.41 8.82e-05 GO:0005769 early endosome
1.25 1.26e-04 GO:0044444 cytoplasmic part
4.67 4.25e-04 GO:0031902 late endosome membrane
3.53 5.68e-04 GO:0005765 lysosomal membrane
8.54 6.02e-04 GO:0033176 proton-transporting V-type ATPase complex
1.17 1.37e-03 GO:0005737 cytoplasm
1.23 4.90e-03 GO:0005634 nucleus
3.60 5.43e-03 GO:0042470 melanosome
3.60 5.43e-03 GO:0048770 pigment granule
1.41 8.51e-03 GO:0044428 nuclear part
1.72 2.43e-02 GO:0044451 nucleoplasm part
8.89 4.66e-02 GO:0030897 HOPS complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.22 1.41e-04 GO:0005515 protein binding