Motif ID: GLI1..3.p2

Z-value: 1.381


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
GLI1 2735 glioma-associated oncogene homolog 1 (zinc finger protein)
GLI2 2736 GLI-Kruppel family member GLI2
GLI3 2737 GLI-Kruppel family member GLI3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GLI2chr2_+_121271336-0.185.1e-01Click!
GLI3chr7_-_42243142-0.175.4e-01Click!
GLI1chr12_+_561401840.165.5e-01Click!


Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_15436333 1.251 NM_022904
RASAL3
RAS protein activator like 3
chr22_-_49317408 1.180 ODF3B
outer dense fiber of sperm tails 3B
chr6_+_44076281 1.174 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr16_+_48865521 1.141 ADCY7
adenylate cyclase 7
chr11_-_60880799 0.985 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr12_-_3732614 0.954 NM_001144958
NM_001144959
NM_032680
EFCAB4B


EF-hand calcium binding domain 4B


chr2_-_6923215 0.936 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr19_-_46551172 0.901 TGFB1
transforming growth factor, beta 1
chr12_-_3732478 0.899 EFCAB4B
EF-hand calcium binding domain 4B
chr2_-_231498184 0.890 NM_005683
GPR55
G protein-coupled receptor 55
chr19_+_3129735 0.876 NM_003775
S1PR4
sphingosine-1-phosphate receptor 4
chr11_-_72057755 0.845 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr1_-_209818675 0.844 NM_021194
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr19_-_46551359 0.841 TGFB1
transforming growth factor, beta 1
chr19_+_10404110 0.840 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr12_+_110328126 0.807 NM_005475
SH2B3
SH2B adaptor protein 3
chr19_+_13124870 0.794 IER2
immediate early response 2
chr17_+_37693090 0.745 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr1_+_154389945 0.744 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr12_-_113330574 0.729 NM_000192
NM_080717
TBX5

T-box 5

chr1_-_209818576 0.727 SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr1_+_148388719 0.723 NM_016274
PLEKHO1
pleckstrin homology domain containing, family O member 1
chr17_-_3766441 0.687 P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr9_+_4480193 0.676 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr6_-_32892705 0.670 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr19_+_13124889 0.661 IER2
immediate early response 2
chr7_+_119700924 0.656 NM_012281
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr1_-_210939727 0.655


chr1_+_11646735 0.651 NM_018438
FBXO6
F-box protein 6
chr17_-_3766708 0.645 NM_002558
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr7_-_23476156 0.614


chr19_-_46551093 0.588 TGFB1
transforming growth factor, beta 1
chr2_+_19932101 0.581 FLJ12334
hypothetical LOC400946
chr16_+_66236512 0.576 NM_001013838
RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr6_+_3009120 0.570 RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1
chr16_-_11588525 0.566 LITAF
lipopolysaccharide-induced TNF factor
chr9_+_139292094 0.564 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr2_+_96355661 0.562 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr21_-_46428768 0.557 C21orf56
chromosome 21 open reading frame 56
chr1_+_40715465 0.557 ZNF642
zinc finger protein 642
chr12_-_56422120 0.555 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr11_+_22171150 0.552 NM_001142649
NM_213599
ANO5

anoctamin 5

chr16_+_66236559 0.550 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr16_+_29581783 0.550 NM_001030288
SPN
sialophorin
chr19_-_52307642 0.549


chr14_-_73296387 0.548 C14orf43
chromosome 14 open reading frame 43
chr3_+_47004457 0.539 NBEAL2
neurobeachin-like 2
chr17_-_37794102 0.538 STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr16_+_88305743 0.534 LOC100128881
hypothetical LOC100128881
chr12_+_6915698 0.531


chr6_+_83129641 0.531 NM_006670
TPBG
trophoblast glycoprotein
chr8_-_41774296 0.531 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chr4_-_105635499 0.527 CXXC4
CXXC finger protein 4
chr20_+_30103642 0.524 NM_001172129
NM_001172130
NM_001172131
NM_001172132
NM_001172133
NM_002110
HCK





hemopoietic cell kinase





chr16_+_56134037 0.523 GPR114
G protein-coupled receptor 114
chr11_-_65841077 0.522 NM_020404
CD248
CD248 molecule, endosialin
chr16_+_56134077 0.519 NM_153837
GPR114
G protein-coupled receptor 114
chr11_+_32870935 0.518 NM_001076786
QSER1
glutamine and serine rich 1
chr20_-_44612619 0.517 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr16_-_87570716 0.513 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr1_+_32251988 0.505 NM_006559
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr11_-_3035172 0.505 NM_001014437
NM_001194997
NM_001751
NM_139273
CARS



cysteinyl-tRNA synthetase



chr1_+_199259664 0.503


chr1_+_148090804 0.502 NM_021059
NM_001005464
HIST2H3C
HIST2H3A
histone cluster 2, H3c
histone cluster 2, H3a
chr6_+_31647854 0.497 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr19_-_43800374 0.497 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr1_-_45081190 0.490 NM_001166292
NM_003738
PTCH2

patched 2

chr7_-_148212336 0.487 NM_004456
NM_152998
EZH2

enhancer of zeste homolog 2 (Drosophila)

chr7_-_148212312 0.484 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr7_-_99871981 0.482 NM_145030
C7orf47
chromosome 7 open reading frame 47
chr7_-_23476497 0.478 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr19_+_3317536 0.477 NM_005597
NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr19_-_19590438 0.476 NM_025245
PBX4
pre-B-cell leukemia homeobox 4
chr19_-_11477689 0.474 NM_138783
ZNF653
zinc finger protein 653
chr1_-_54644269 0.474 SSBP3
single stranded DNA binding protein 3
chr21_-_46428728 0.474 C21orf56
chromosome 21 open reading frame 56
chr3_-_120761092 0.470 NM_005191
CD80
CD80 molecule
chr18_+_75825563 0.469 NM_001136180
HSBP1L1
heat shock factor binding protein 1-like 1
chr6_-_32929570 0.468 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr10_+_80672842 0.466 ZMIZ1
zinc finger, MIZ-type containing 1
chr3_+_16901455 0.463 NM_001144382
PLCL2
phospholipase C-like 2
chrX_-_1615999 0.457 NM_178129
P2RY8
CRLF2
purinergic receptor P2Y, G-protein coupled, 8
cytokine receptor-like factor 2
chr20_+_44180355 0.457 CD40
CD40 molecule, TNF receptor superfamily member 5
chr17_+_77582774 0.456 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr14_+_92188546 0.454 RIN3
Ras and Rab interactor 3
chr11_-_404975 0.451 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr19_+_2240996 0.451


chr12_-_101396459 0.450 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr7_+_149699185 0.447 NM_014374
REPIN1
replication initiator 1
chr1_-_158815850 0.447 CD84
CD84 molecule
chr22_-_49317873 0.446 NM_001014440
ODF3B
outer dense fiber of sperm tails 3B
chr17_-_39632845 0.444 ATXN7L3
ataxin 7-like 3
chr19_+_10900419 0.443 NM_138358
C19orf52
chromosome 19 open reading frame 52
chr7_+_68702252 0.442 AUTS2
autism susceptibility candidate 2
chr1_-_180840016 0.440 NM_002928
RGS16
regulator of G-protein signaling 16
chr19_+_3317575 0.438 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chrX_+_48427103 0.437 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr20_-_24986501 0.436 ACSS1
acyl-CoA synthetase short-chain family member 1
chr17_+_4795128 0.434 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr22_-_17545872 0.433 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr19_+_10900502 0.433 C19orf52
chromosome 19 open reading frame 52
chr11_-_85053709 0.432 CREBZF
CREB/ATF bZIP transcription factor
chr16_-_3049336 0.431


chr11_-_64268126 0.430 NM_001098671
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr19_+_63670148 0.426 NM_014347
ZNF324
zinc finger protein 324
chr19_+_3317589 0.425 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr14_-_106330781 0.423 IGHV5-78
immunoglobulin heavy variable 5-78 pseudogene
chr17_-_71272811 0.423 NM_000154
GALK1
galactokinase 1
chr8_+_27238964 0.422 NM_173176
PTK2B
PTK2B protein tyrosine kinase 2 beta
chr22_-_17546276 0.422 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr3_-_109292444 0.421 NM_001777
NM_198793
CD47

CD47 molecule

chr20_-_48686832 0.420 NM_080829
FAM65C
family with sequence similarity 65, member C
chr20_+_61655934 0.417


chr7_+_68701704 0.416 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr20_+_44180296 0.415 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr12_-_55316350 0.413 NM_013449
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr22_-_17546296 0.413 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr6_+_26129885 0.411 NM_003538
HIST1H4A
histone cluster 1, H4a
chr17_-_37793885 0.409 NM_213662
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr19_-_10900086 0.408 NM_024029
YIPF2
Yip1 domain family, member 2
chr16_+_85101605 0.408 NM_001451
FOXF1
forkhead box F1
chr7_-_148212310 0.407 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr22_-_17546234 0.406 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr16_+_66153810 0.405 NM_001191022
NM_006565
CTCF

CCCTC-binding factor (zinc finger protein)

chr7_-_148212230 0.403 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr6_+_83130220 0.402 TPBG
trophoblast glycoprotein
chr11_+_63766163 0.402 NM_057092
FKBP2
FK506 binding protein 2, 13kDa
chr22_-_40652724 0.401 NM_052945
TNFRSF13C
tumor necrosis factor receptor superfamily, member 13C
chr7_+_73826244 0.400 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr20_-_43974092 0.398 NM_006227
NM_182676
PLTP

phospholipid transfer protein

chr16_+_30102231 0.395 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr19_+_12763285 0.394 JUNB
jun B proto-oncogene
chr16_+_55950195 0.393 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr7_-_1034453 0.393 C7orf50
chromosome 7 open reading frame 50
chr6_+_27885692 0.391 NM_003536
HIST1H3H
histone cluster 1, H3h
chr1_+_36394044 0.390 MAP7D1
MAP7 domain containing 1
chr3_+_38010081 0.390 NM_015873
VILL
villin-like
chr19_-_44518465 0.389 GMFG
glia maturation factor, gamma
chr8_+_27238979 0.388 NM_173175
PTK2B
PTK2B protein tyrosine kinase 2 beta
chr3_-_53055078 0.388 NM_001005158
NM_016329
SFMBT1

Scm-like with four mbt domains 1

chr1_-_111544820 0.387 DENND2D
DENN/MADD domain containing 2D
chr6_-_32929390 0.385 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr5_-_1647617 0.383 SDHAP3
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3
chr11_+_75157450 0.380 DGAT2
diacylglycerol O-acyltransferase 2
chr22_-_48437081 0.379 C22orf34
chromosome 22 open reading frame 34
chr1_-_111544603 0.379


chrX_+_12719394 0.378 NM_001039091
NM_002765
PRPS2

phosphoribosyl pyrophosphate synthetase 2

chr12_-_31368347 0.378 FAM60A
family with sequence similarity 60, member A
chr7_+_6380614 0.377 NM_006908
NM_018890
RAC1

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

chr7_-_148212292 0.376 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr19_+_60851207 0.375 CCDC106
coiled-coil domain containing 106
chr20_-_34102250 0.374 LOC647979
hypothetical LOC647979
chr18_+_2896178 0.373 EMILIN2
elastin microfibril interfacer 2
chr16_+_30583278 0.372 NM_001105079
FBRS
fibrosin
chr19_+_19640604 0.372 NM_033204
ZNF101
zinc finger protein 101
chr22_+_18090118 0.372 SEPT5-GP1BB
SEPT5-GP1BB read-through transcript
chr1_-_1300385 0.371 AURKAIP1
aurora kinase A interacting protein 1
chr17_-_44641741 0.371 NM_031498
NM_001198755
NM_001198756
GNGT2


guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2


chr9_+_8848130 0.370


chr1_-_11909042 0.367 NM_138346
KIAA2013
KIAA2013
chr16_+_85101734 0.367 FOXF1
forkhead box F1
chr7_-_99518294 0.365 ZNF3
zinc finger protein 3
chr7_+_149733309 0.365


chr16_+_30102426 0.364 CORO1A
coronin, actin binding protein, 1A
chr19_-_46551607 0.363 TGFB1
transforming growth factor, beta 1
chr8_-_144731498 0.363 NAPRT1
nicotinate phosphoribosyltransferase domain containing 1
chr7_+_87095640 0.363 NM_001134405
NM_001134406
NM_138290
RUNDC3B


RUN domain containing 3B


chr19_-_11477395 0.360 ZNF653
zinc finger protein 653
chr22_+_18388633 0.359 C22orf25
chromosome 22 open reading frame 25
chr22_-_49041786 0.356 MAPK12
mitogen-activated protein kinase 12
chr7_+_101978777 0.355 NM_001166339
NM_001031618
SPDYE2L
SPDYE2
WBSCR19-like protein 3
speedy homolog E2 (Xenopus laevis)
chr7_-_126819953 0.355 NM_176814
ZNF800
zinc finger protein 800
chr9_+_115151632 0.353 NM_017688
BSPRY
B-box and SPRY domain containing
chr17_-_37794017 0.351 NM_003150
NM_139276
STAT3

signal transducer and activator of transcription 3 (acute-phase response factor)

chr19_+_55844446 0.347 NM_001195076
LOC342918
hypothetical protein LOC342918
chr19_-_53832381 0.347 NM_001352
DBP
D site of albumin promoter (albumin D-box) binding protein
chr10_+_99488223 0.346 NM_001002261
ZFYVE27
zinc finger, FYVE domain containing 27
chr2_+_182030173 0.345 ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr16_+_1979959 0.345 NM_004209
SYNGR3
synaptogyrin 3
chr5_-_131854325 0.344 NM_002198
IRF1
interferon regulatory factor 1
chr22_-_49042065 0.343 NM_002969
MAPK12
mitogen-activated protein kinase 12
chr9_+_130259006 0.342 NM_153437
ODF2
outer dense fiber of sperm tails 2
chr11_-_65187003 0.342 NM_001145138
NM_021975
RELA

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

chr2_+_182030510 0.340 ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr19_-_48977247 0.338 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr9_+_130258256 0.338 ODF2
outer dense fiber of sperm tails 2
chr9_+_138677197 0.338 NM_201446
NM_016215
EGFL7

EGF-like-domain, multiple 7

chr17_-_4831644 0.334 NM_001171166
NM_015099
CAMTA2

calmodulin binding transcription activator 2

chr1_+_22224571 0.331 HSPC157
hypothetical LOC29092
chr5_-_149515331 0.331 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr12_-_120502483 0.330 NM_001005366
KDM2B
lysine (K)-specific demethylase 2B
chr21_+_34963557 0.330 NM_053277
CLIC6
chloride intracellular channel 6
chr11_-_64268841 0.329 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr5_+_122452739 0.329 NM_001136239
PRDM6
PR domain containing 6
chr7_+_149842850 0.329 NM_153236
GIMAP7
GTPase, IMAP family member 7
chr3_+_196870099 0.329 SDHAP2
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2
chr11_+_44074322 0.326 NM_000401
EXT2
exostosin 2
chr16_-_87297525 0.325 NM_001171816
RNF166
ring finger protein 166
chr5_-_1165106 0.324 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr19_-_1601246 0.323 NM_001136139
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.70 2.32e-03 GO:0016568 chromatin modification
1.58 7.18e-03 GO:0006325 chromatin organization
1.54 2.26e-02 GO:0007596 blood coagulation
1.54 2.26e-02 GO:0050817 coagulation
1.53 3.02e-02 GO:0007599 hemostasis

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 1.58e-05 GO:0005515 protein binding
2.86 4.26e-02 GO:0003823 antigen binding