Motif ID: TFAP4.p2

Z-value: 1.626


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP4chr16_-_42630560.371.6e-01Click!


Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_154873344 2.281 CNKSR3
CNKSR family member 3
chr6_-_154873480 2.043 CNKSR3
CNKSR family member 3
chr8_+_97575370 1.843 SDC2
syndecan 2
chr1_+_78126787 1.756 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr3_-_87122936 1.642 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr9_-_128924782 1.611 ANGPTL2
angiopoietin-like 2
chr9_+_133154896 1.598 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr1_-_925332 1.557 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr9_-_128924706 1.552 ANGPTL2
angiopoietin-like 2
chr6_-_154873396 1.477 NM_173515
CNKSR3
CNKSR family member 3
chr17_-_36451189 1.461 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr9_-_128924819 1.420 NM_012098
ANGPTL2
angiopoietin-like 2
chr1_-_56817568 1.392 PPAP2B
phosphatidic acid phosphatase type 2B
chr8_+_97575244 1.380 SDC2
syndecan 2
chr9_-_83493415 1.272 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr1_-_225572419 1.232 NM_003607
NM_014826
CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)

chr5_+_129268352 1.231 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr5_+_176726918 1.221 RGS14
regulator of G-protein signaling 14
chr4_+_4912272 1.208 NM_002448
MSX1
msh homeobox 1
chr3_-_87122958 1.198 VGLL3
vestigial like 3 (Drosophila)
chr8_+_97575071 1.157 SDC2
syndecan 2
chr1_-_56817717 1.153 PPAP2B
phosphatidic acid phosphatase type 2B
chr6_+_129245978 1.125 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr8_+_104452877 1.115 CTHRC1
collagen triple helix repeat containing 1
chr8_-_145090892 1.114 NM_201381
PLEC
plectin
chr8_-_13178399 1.091 DLC1
deleted in liver cancer 1
chr17_+_14145051 1.088 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr12_+_79995927 1.052 NM_024560
ACSS3
acyl-CoA synthetase short-chain family member 3
chr7_-_27136876 1.051 NM_002141
HOXA4
homeobox A4
chr8_-_13178327 1.023


chr17_-_74432671 1.010 TIMP2
TIMP metallopeptidase inhibitor 2
chr11_-_65395248 0.975 EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr15_+_72006015 0.951 LOXL1
lysyl oxidase-like 1
chr10_-_126839056 0.935 NM_001329
CTBP2
C-terminal binding protein 2
chr3_-_126088530 0.926 ITGB5
integrin, beta 5
chr6_+_37245860 0.923 NM_002648
PIM1
pim-1 oncogene
chr5_-_178704934 0.911 ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr11_+_67534364 0.909 NM_000694
NM_001030010
ALDH3B1

aldehyde dehydrogenase 3 family, member B1

chr11_-_47427263 0.905 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr9_+_115265827 0.900 NM_017790
RGS3
regulator of G-protein signaling 3
chr17_+_78286687 0.900 NM_022158
FN3K
fructosamine 3 kinase
chr17_-_36436979 0.899 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr17_-_74432800 0.898 TIMP2
TIMP metallopeptidase inhibitor 2
chr2_-_216944911 0.891 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr11_+_67534371 0.882 ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr1_+_43769065 0.876 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr1_+_17817397 0.873 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr10_-_76831430 0.871 NM_032772
ZNF503
zinc finger protein 503
chr8_+_98857190 0.865 LAPTM4B
lysosomal protein transmembrane 4 beta
chr12_+_62523648 0.863


chr13_-_37341859 0.833 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr3_-_9786583 0.832 CAMK1
calcium/calmodulin-dependent protein kinase I
chrX_+_117993342 0.823 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr18_-_53621277 0.814 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr10_-_30388439 0.806 NM_020848
KIAA1462
KIAA1462
chr3_-_12983959 0.802 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr4_-_24523605 0.795 NM_001130726
CCDC149
coiled-coil domain containing 149
chr8_+_97575317 0.788 SDC2
syndecan 2
chr5_-_58370693 0.785 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr10_+_80498782 0.781 NM_020338
ZMIZ1
zinc finger, MIZ-type containing 1
chr3_-_9786623 0.774 CAMK1
calcium/calmodulin-dependent protein kinase I
chr3_-_187025501 0.769 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr15_-_53822468 0.767 NM_173814
PRTG
protogenin
chr6_+_45498354 0.758 RUNX2
runt-related transcription factor 2
chr7_-_16427471 0.756 NM_001101417
NM_001101426
ISPD

isoprenoid synthase domain containing

chr5_-_178705036 0.755 NM_014244
NM_021599
ADAMTS2

ADAM metallopeptidase with thrombospondin type 1 motif, 2

chr9_+_139292094 0.752 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr8_+_106400322 0.752 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr22_-_19122047 0.752 SCARF2
scavenger receptor class F, member 2
chr16_-_65984836 0.747 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr1_-_151848039 0.742 S100A16
S100 calcium binding protein A16
chr22_-_20235372 0.741 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr4_+_72271218 0.740 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr14_-_22521544 0.732 NM_032876
JUB
jub, ajuba homolog (Xenopus laevis)
chr15_-_38420414 0.719 NM_207380
C15orf52
chromosome 15 open reading frame 52
chr1_-_56817802 0.714 PPAP2B
phosphatidic acid phosphatase type 2B
chr4_+_81406765 0.713 NM_004464
NM_033143
FGF5

fibroblast growth factor 5

chr9_+_89530896 0.709 CTSL1
cathepsin L1
chr3_+_124268545 0.703 NM_006810
PDIA5
protein disulfide isomerase family A, member 5
chr3_-_9786628 0.703 NM_003656
CAMK1
calcium/calmodulin-dependent protein kinase I
chr9_+_89530848 0.699 CTSL1
cathepsin L1
chr14_-_51605695 0.698 NM_007361
NID2
nidogen 2 (osteonidogen)
chr12_-_53099277 0.688 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr20_+_2743613 0.687 NM_080739
C20orf141
chromosome 20 open reading frame 141
chr1_+_238321794 0.687 NM_020066
FMN2
formin 2
chr14_+_20608179 0.687 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr16_-_73842884 0.686 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr14_-_51605487 0.683 NID2
nidogen 2 (osteonidogen)
chr8_+_98856984 0.682 NM_018407
LAPTM4B
lysosomal protein transmembrane 4 beta
chr9_+_89530838 0.682 CTSL1
cathepsin L1
chr16_-_71650034 0.674 NM_001164766
ZFHX3
zinc finger homeobox 3
chr1_-_22136263 0.671 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr3_-_187025438 0.667 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr14_-_51605461 0.667 NID2
nidogen 2 (osteonidogen)
chr2_-_220144511 0.663 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr10_+_81882477 0.663 PLAC9
placenta-specific 9
chr9_+_89530793 0.660 NM_001912
NM_145918
CTSL1

cathepsin L1

chr8_+_97575196 0.659 SDC2
syndecan 2
chr4_+_55218663 0.658 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr22_-_19122107 0.657 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr11_+_133444175 0.656 JAM3
junctional adhesion molecule 3
chr4_+_78089931 0.655 SEPT11
septin 11
chr10_+_81882237 0.655 NM_001012973
PLAC9
placenta-specific 9
chr2_-_161058550 0.651 NM_002897
NM_016836
RBMS1

RNA binding motif, single stranded interacting protein 1

chr19_-_18912112 0.643 NM_001145722
NM_001145721
HOMER3

homer homolog 3 (Drosophila)

chr18_+_7557313 0.627 NM_001105244
NM_002845
PTPRM

protein tyrosine phosphatase, receptor type, M

chr19_+_60691671 0.626 NM_001144950
NM_001195267
SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

chr2_-_161058120 0.624 RBMS1
RNA binding motif, single stranded interacting protein 1
chr9_+_89530943 0.620 CTSL1
cathepsin L1
chr6_-_132314004 0.619 NM_001901
CTGF
connective tissue growth factor
chr15_-_30798417 0.618


chr8_-_48813236 0.618 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr1_+_148788410 0.616 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr3_+_150191884 0.615 NM_001184720
NM_001184721
NM_004130
GYG1


glycogenin 1


chr2_-_220144427 0.612 OBSL1
obscurin-like 1
chr10_+_4858321 0.608 NM_001040177
AKR1E2
aldo-keto reductase family 1, member E2
chr3_-_50335113 0.597 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chr8_+_97575052 0.591 NM_002998
SDC2
syndecan 2
chr16_+_3295433 0.590 NM_153028
ZNF75A
zinc finger protein 75a
chr12_-_53099203 0.582 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr11_-_106394039 0.582 NM_000855
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr1_-_925215 0.581 HES4
hairy and enhancer of split 4 (Drosophila)
chr5_+_135392624 0.579 TGFBI
transforming growth factor, beta-induced, 68kDa
chr10_-_126839000 0.561 CTBP2
C-terminal binding protein 2
chr8_-_145099963 0.557 NM_201379
PLEC
plectin
chr7_+_45894480 0.553 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr11_+_101485946 0.553 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr2_+_70981233 0.552 VAX2
ventral anterior homeobox 2
chr1_-_94475504 0.552 ARHGAP29
Rho GTPase activating protein 29
chr15_-_35180656 0.546 NM_002399
MEIS2
Meis homeobox 2
chr2_+_70981223 0.539 NM_012476
VAX2
ventral anterior homeobox 2
chr1_+_200429740 0.533 NM_001017403
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr2_+_238200922 0.532 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr5_+_135392482 0.531 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr4_+_114433551 0.526 ANK2
ankyrin 2, neuronal
chr15_+_72005839 0.526 NM_005576
LOXL1
lysyl oxidase-like 1
chr19_-_60412624 0.525 NM_001161440
NM_002842
PTPRH

protein tyrosine phosphatase, receptor type, H

chr12_-_105057940 0.524 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr11_+_133444029 0.524 NM_032801
JAM3
junctional adhesion molecule 3
chr1_+_53300410 0.522 NM_153703
PODN
podocan
chr13_+_23451919 0.522 SPATA13
spermatogenesis associated 13
chr17_+_71892538 0.521 SPHK1
sphingosine kinase 1
chr12_-_46499834 0.519 NM_001098416
NM_015401
HDAC7

histone deacetylase 7

chr1_+_77520315 0.519 NM_174858
AK5
adenylate kinase 5
chr1_-_8008979 0.517 NM_018948
ERRFI1
ERBB receptor feedback inhibitor 1
chr2_-_217267742 0.517 IGFBP5
insulin-like growth factor binding protein 5
chr14_+_23908141 0.517 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr3_-_126088819 0.516 NM_002213
ITGB5
integrin, beta 5
chr2_-_158440587 0.514 NM_001111067
ACVR1
activin A receptor, type I
chr11_-_65860450 0.514 NM_004292
RIN1
Ras and Rab interactor 1
chr1_+_77520190 0.513 AK5
adenylate kinase 5
chr18_-_63334902 0.511 NM_032160
DSEL
dermatan sulfate epimerase-like
chr19_-_9982041 0.510 NM_015719
COL5A3
collagen, type V, alpha 3
chr8_+_9450800 0.509 TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr15_+_72005864 0.507 LOXL1
lysyl oxidase-like 1
chr11_-_310925 0.507 IFITM3
interferon induced transmembrane protein 3 (1-8U)
chr3_-_95175282 0.507 PROS1
protein S (alpha)
chr2_-_110665188 0.504 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr15_+_72005875 0.500 LOXL1
lysyl oxidase-like 1
chr5_+_115326035 0.500 NM_173800
AQPEP
laeverin
chr2_+_110013297 0.497 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr13_+_23451838 0.494


chr2_-_220144254 0.491 OBSL1
obscurin-like 1
chr2_-_73193419 0.489 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr12_-_53099269 0.489 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr1_+_176329578 0.488 RASAL2
RAS protein activator like 2
chr16_+_15435825 0.487 NM_033201
C16orf45
chromosome 16 open reading frame 45
chr1_-_159435440 0.486 NM_005099
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr17_-_74433048 0.484 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr1_-_93919789 0.484 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr5_+_131657964 0.484 NM_003059
SLC22A4
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
chr14_-_91483757 0.484 NM_006329
FBLN5
fibulin 5
chr1_-_39871226 0.482 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr1_-_182273114 0.482 GLT25D2
glycosyltransferase 25 domain containing 2
chr12_+_105873803 0.482 C12orf23
chromosome 12 open reading frame 23
chr16_-_87405817 0.482 NM_000485
NM_001030018
APRT

adenine phosphoribosyltransferase

chr10_+_102749597 0.479 LZTS2
leucine zipper, putative tumor suppressor 2
chr14_-_24588916 0.479 NM_014178
STXBP6
syntaxin binding protein 6 (amisyn)
chr5_-_121440704 0.478 NM_001178102
LOX
lysyl oxidase
chr4_+_8322358 0.476 NM_053044
HTRA3
HtrA serine peptidase 3
chr7_+_16652282 0.476 NM_001159767
NM_014038
BZW2

basic leucine zipper and W2 domains 2

chr8_-_145187553 0.476 NM_017570
OPLAH
5-oxoprolinase (ATP-hydrolysing)
chr4_+_78089879 0.475 NM_018243
SEPT11
septin 11
chr7_+_100037817 0.475 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr19_+_21056792 0.472 NM_182515
ZNF714
zinc finger protein 714
chr1_+_145479805 0.471 NM_004326
BCL9
B-cell CLL/lymphoma 9
chr1_+_26220852 0.471 NM_004455
EXTL1
exostoses (multiple)-like 1
chr11_-_310775 0.471 NM_021034
IFITM3
interferon induced transmembrane protein 3 (1-8U)
chr8_+_37773991 0.469 GPR124
G protein-coupled receptor 124
chr20_-_17610704 0.468 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr11_-_35503720 0.467 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr22_+_19699441 0.467 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr16_+_2226468 0.466 NM_001374
DNASE1L2
deoxyribonuclease I-like 2
chr11_+_834062 0.462 NM_001025234
TSPAN4
tetraspanin 4
chr5_-_136862130 0.462 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr13_-_109757442 0.462 NM_001845
COL4A1
collagen, type IV, alpha 1
chr6_-_75972286 0.461 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr1_-_21868380 0.457 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr20_+_48241334 0.455 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr10_-_76831545 0.455 ZNF503
zinc finger protein 503

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.19 3.38e-04 GO:0023052 signaling
1.12 4.88e-04 GO:0050789 regulation of biological process
1.20 9.07e-04 GO:0007165 signal transduction
1.12 2.16e-03 GO:0050794 regulation of cellular process
1.18 2.41e-03 GO:0032502 developmental process
1.31 4.78e-03 GO:0009966 regulation of signal transduction
1.10 6.14e-03 GO:0065007 biological regulation
1.18 9.51e-03 GO:0007275 multicellular organismal development
1.45 1.29e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.16 1.41e-02 GO:0051716 cellular response to stimulus
1.27 1.73e-02 GO:0023051 regulation of signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.41 1.78e-02 GO:0030054 cell junction
2.14 3.10e-02 GO:0045095 keratin filament

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.09 4.73e-02 GO:0005515 protein binding