Motif ID: HIC1.p2

Z-value: 5.793


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_19051040.766.1e-04Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_101485946 11.780 NM_001130145
NM_001195044
NM_006106
 YAP1


Yes-associated protein 1


chr13_-_109757442 10.059 NM_001845
 COL4A1
collagen, type IV, alpha 1
chr13_+_109757593 9.313 NM_001846
 COL4A2
collagen, type IV, alpha 2
chr2_+_9532087 6.725 NM_001039613
 IAH1
isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)
chr14_+_105012106 6.695 NM_001312
 CRIP2
cysteine-rich protein 2
chrX_+_9943793 6.319 NM_015691
 WWC3
WWC family member 3
chr12_+_26003218 6.005 NM_001164748
NM_007211
 RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr2_-_160972606 5.935 RBMS1
RNA binding motif, single stranded interacting protein 1
chr4_-_24523605 5.776 NM_001130726
 CCDC149
coiled-coil domain containing 149
chr1_-_85703198 5.310 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr14_+_92049396 5.258 NM_024832
 RIN3
Ras and Rab interactor 3
chr6_+_3696224 5.081


chr3_+_61522310 5.056 PTPRG
protein tyrosine phosphatase, receptor type, G
chr4_-_177950658 4.956 NM_005429
 VEGFC
vascular endothelial growth factor C
chr3_+_11171213 4.905 NM_001098212
 HRH1
histamine receptor H1
chr7_-_81910956 4.857 NM_000722
 CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr9_-_135847106 4.848 NM_001134398
NM_003371
 VAV2

vav 2 guanine nucleotide exchange factor

chr13_+_97593711 4.757 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr14_+_54104099 4.709 SAMD4A
sterile alpha motif domain containing 4A
chr2_+_235525355 4.700 NM_014521
 SH3BP4
SH3-domain binding protein 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 157 entries
enrichment   p-value GO term description
2.40 2.11e-03 GO:0030509 BMP signaling pathway
1.94 2.12e-02 GO:0007173 epidermal growth factor receptor signaling pathway
1.88 1.10e-03 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
1.82 2.35e-03 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.77 3.52e-02 GO:0010720 positive regulation of cell development
1.74 3.24e-02 GO:0035023 regulation of Rho protein signal transduction
1.73 1.63e-13 GO:0048667 cell morphogenesis involved in neuron differentiation
1.73 3.81e-13 GO:0007409 axonogenesis
1.73 2.67e-03 GO:0016311 dephosphorylation
1.72 2.55e-13 GO:0048812 neuron projection morphogenesis
1.72 4.79e-02 GO:0006469 negative regulation of protein kinase activity
1.70 5.62e-09 GO:0007411 axon guidance
1.70 2.04e-02 GO:0006470 protein dephosphorylation
1.69 8.67e-14 GO:0000904 cell morphogenesis involved in differentiation
1.66 2.84e-12 GO:0031175 neuron projection development
1.66 3.15e-05 GO:0046578 regulation of Ras protein signal transduction
1.65 3.20e-12 GO:0048858 cell projection morphogenesis
1.64 9.86e-14 GO:0048666 neuron development
1.64 2.56e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.63 9.61e-12 GO:0032990 cell part morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
1.93 7.53e-08 GO:0005912 adherens junction
1.92 1.64e-02 GO:0031256 leading edge membrane
1.91 1.31e-03 GO:0030027 lamellipodium
1.83 1.11e-07 GO:0031252 cell leading edge
1.83 6.42e-07 GO:0070161 anchoring junction
1.81 2.51e-03 GO:0005925 focal adhesion
1.80 1.31e-03 GO:0030055 cell-substrate junction
1.76 5.49e-03 GO:0005924 cell-substrate adherens junction
1.76 2.26e-02 GO:0001726 ruffle
1.41 2.48e-02 GO:0015629 actin cytoskeleton
1.34 5.67e-04 GO:0030054 cell junction
1.25 2.16e-03 GO:0005794 Golgi apparatus
1.21 2.44e-06 GO:0005829 cytosol
1.17 4.11e-02 GO:0005856 cytoskeleton
1.12 8.62e-16 GO:0005737 cytoplasm
1.12 2.03e-07 GO:0044444 cytoplasmic part
1.12 3.28e-07 GO:0005634 nucleus
1.10 6.66e-24 GO:0005622 intracellular
1.10 7.14e-24 GO:0044424 intracellular part
1.10 6.17e-13 GO:0043226 organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 38 entries
enrichment   p-value GO term description
2.40 1.94e-04 GO:0046332 SMAD binding
1.89 1.67e-02 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.84 4.77e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.78 1.63e-03 GO:0051020 GTPase binding
1.76 3.28e-02 GO:0017016 Ras GTPase binding
1.74 2.33e-02 GO:0031267 small GTPase binding
1.71 2.57e-04 GO:0005085 guanyl-nucleotide exchange factor activity
1.69 6.00e-04 GO:0004721 phosphoprotein phosphatase activity
1.59 9.21e-05 GO:0016791 phosphatase activity
1.58 6.93e-04 GO:0004842 ubiquitin-protein ligase activity
1.57 2.10e-06 GO:0042578 phosphoric ester hydrolase activity
1.57 2.66e-03 GO:0000975 regulatory region DNA binding
1.57 2.66e-03 GO:0001067 regulatory region nucleic acid binding
1.57 2.66e-03 GO:0044212 transcription regulatory region DNA binding
1.56 6.55e-03 GO:0010843 promoter binding
1.53 1.76e-04 GO:0005083 small GTPase regulator activity
1.52 2.20e-04 GO:0008134 transcription factor binding
1.52 3.61e-03 GO:0019787 small conjugating protein ligase activity
1.51 1.53e-03 GO:0016881 acid-amino acid ligase activity
1.50 5.10e-07 GO:0060589 nucleoside-triphosphatase regulator activity