Motif ID: NFKB1_REL_RELA.p2

Z-value: 4.389


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFKB1chr4_+_1036418540.721.6e-03Click!
RELchr2_+_609622790.683.5e-03Click!
RELAchr11_-_651870030.683.8e-03Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_104145421 10.283 NM_002502
 NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr19_-_6542012 7.956 CD70
CD70 molecule
chr2_+_219453487 7.433 NM_025216
 WNT10A
wingless-type MMTV integration site family, member 10A
chr10_+_104144218 6.628 NM_001077493
NM_001077494
 NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr20_-_4743768 6.023 NM_170774
 RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr19_+_4180494 5.616 NM_005755
 EBI3
Epstein-Barr virus induced 3
chr2_-_231498184 5.469 NM_005683
 GPR55
G protein-coupled receptor 55
chr1_-_207891264 5.343 NM_001017402
 LAMB3
laminin, beta 3
chr8_-_70909754 5.231 NM_030958
 SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr2_-_162883062 4.947 NM_022168
 IFIH1
interferon induced with helicase C domain 1
chr19_+_3087026 4.904 NM_002068
 GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr6_+_116798791 4.865 NM_013352
 DSE
dermatan sulfate epimerase
chr17_+_35277942 4.761 NM_198844
NM_199321
 ZPBP2

zona pellucida binding protein 2

chr1_-_207892420 4.548 NM_000228
 LAMB3
laminin, beta 3
chr11_+_101693403 4.346 NM_001165
NM_182962
 BIRC3

baculoviral IAP repeat containing 3

chr12_-_55790355 4.342 NM_001178079
 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr1_-_24386324 4.304 NM_170743
NM_173064
NM_173065
 IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr14_-_95250155 4.177 NM_001098725
NM_021966
 TCL1A

T-cell leukemia/lymphoma 1A

chr6_+_32713160 4.081 NM_002122
 HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr19_-_6542082 4.057 CD70
CD70 molecule

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 67 entries
enrichment   p-value GO term description
5.13 1.54e-02 GO:0060330 regulation of response to interferon-gamma
5.13 1.54e-02 GO:0060334 regulation of interferon-gamma-mediated signaling pathway
4.64 4.85e-02 GO:0060603 mammary gland duct morphogenesis
4.40 2.14e-03 GO:0060443 mammary gland morphogenesis
3.11 2.52e-03 GO:0034130 toll-like receptor 1 signaling pathway
3.11 2.52e-03 GO:0034134 toll-like receptor 2 signaling pathway
2.99 3.09e-03 GO:0002699 positive regulation of immune effector process
2.95 4.01e-03 GO:0034142 toll-like receptor 4 signaling pathway
2.94 7.32e-03 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
2.94 3.48e-02 GO:0034138 toll-like receptor 3 signaling pathway
2.87 2.55e-03 GO:0002224 toll-like receptor signaling pathway
2.82 1.53e-02 GO:0008063 Toll signaling pathway
2.76 3.62e-03 GO:0002758 innate immune response-activating signal transduction
2.74 6.52e-03 GO:0002221 pattern recognition receptor signaling pathway
2.70 5.66e-03 GO:0002218 activation of innate immune response
2.68 3.81e-02 GO:0034341 response to interferon-gamma
2.48 4.37e-05 GO:0045088 regulation of innate immune response
2.45 5.88e-04 GO:0002697 regulation of immune effector process
2.44 1.60e-04 GO:0051251 positive regulation of lymphocyte activation
2.44 4.24e-02 GO:0070663 regulation of leukocyte proliferation

Gene overrepresentation in compartment category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
9.75 5.14e-03 GO:0033256 I-kappaB/NF-kappaB complex
1.25 3.42e-02 GO:0005829 cytosol
1.24 4.47e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.64 1.78e-02 GO:0004674 protein serine/threonine kinase activity
1.50 4.62e-02 GO:0004672 protein kinase activity
1.49 1.74e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.45 3.47e-02 GO:0016301 kinase activity
1.42 2.70e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups