Motif ID: EVI1.p2

Z-value: 1.604


Transcription factors associated with EVI1.p2:

Gene SymbolEntrez IDGene Name
EVI1 2122 ecotropic viral integration site 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MECOMchr3_-_170864111-0.224.1e-01Click!


Activity profile for motif EVI1.p2.

activity profile for motif EVI1.p2


Sorted Z-values histogram for motif EVI1.p2

Sorted Z-values for motif EVI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EVI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_50025115 3.351 NM_001166478
DEFB133
defensin, beta 133
chrX_-_119095544 2.695 NM_001099685
NM_032498
RHOXF2B
RHOXF2
Rhox homeobox family, member 2B
Rhox homeobox family, member 2
chr15_+_64661560 2.591


chr8_-_38127489 2.329 NM_000349
STAR
steroidogenic acute regulatory protein
chr6_+_105511615 2.199 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr22_+_43451351 2.013 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr4_+_111053488 1.788 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr12_-_9804682 1.755 NM_001781
CD69
CD69 molecule
chr17_-_64462976 1.742 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr12_-_8110268 1.727 C3AR1
complement component 3a receptor 1
chr11_+_93940121 1.719 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr15_-_100280784 1.611 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr1_+_58899 1.567 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr12_-_8110196 1.520 NM_004054
C3AR1
complement component 3a receptor 1
chr2_+_157822355 1.402 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chrX_-_11194015 1.394 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr6_-_41276901 1.384 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr12_+_112344529 1.346 NM_138432
SDSL
serine dehydratase-like
chr14_+_54291255 1.322 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chr8_-_17812151 1.309


chr4_-_40212670 1.301 NM_019027
RBM47
RNA binding motif protein 47
chr7_+_106292975 1.264 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr17_+_53769562 1.253 LOC100506779
hypothetical LOC100506779
chr1_-_32054164 1.218 NM_144569
SPOCD1
SPOC domain containing 1
chr1_+_202033273 1.206 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr7_+_106292932 1.165 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr1_+_152560179 1.143 NM_080429
AQP10
aquaporin 10
chr11_-_33848061 1.132 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_5247948 1.124 NM_005330
HBE1
hemoglobin, epsilon 1
chr11_-_33848013 1.118 LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_33847937 1.089 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr7_+_106293112 1.069 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr2_-_144994349 1.066 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr6_-_11887265 1.059 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr7_-_130069399 1.011 NM_138693
KLF14
Kruppel-like factor 14
chr5_+_139856688 1.002 ANKHD1
ankyrin repeat and KH domain containing 1
chr8_-_110724594 0.996 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr2_-_144991386 0.977 ZEB2
zinc finger E-box binding homeobox 2
chr3_-_180467483 0.955 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr5_+_140719773 0.943 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr12_+_56802 0.901 NM_015232
IQSEC3
IQ motif and Sec7 domain 3
chr6_-_49712483 0.896 NM_000324
RHAG
Rh-associated glycoprotein
chr9_-_99746923 0.895 NM_018437
HEMGN
hemogen
chr19_+_61624 0.884 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr17_-_59437782 0.876 NM_000873
ICAM2
intercellular adhesion molecule 2
chr17_+_53769659 0.866 LOC100506779
hypothetical LOC100506779
chr17_-_39822366 0.865 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr1_+_12325632 0.854 VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr1_+_181028016 0.850 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr6_-_53638464 0.827 NM_001003760
KLHL31
kelch-like 31 (Drosophila)
chr16_+_33168191 0.825 NM_001099687
TP53TG3B
TP53 target 3B
chr11_-_64520964 0.814 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr11_+_64694200 0.811 NM_001008778
SPDYC
speedy homolog C (Xenopus laevis)
chr12_-_48017223 0.810 NM_001008223
C1QL4
complement component 1, q subcomponent-like 4
chr11_-_47467094 0.808 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr14_-_62638336 0.803 NM_172376
KCNH5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr16_+_20682812 0.791 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr17_-_37599953 0.782 NM_001142622
NM_001142623
NM_032484
GHDC


GH3 domain containing


chr11_+_59580705 0.767 MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr1_+_179269183 0.766 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr16_+_33111656 0.766 NM_001099687
TP53TG3B
TP53 target 3B
chr11_+_59580630 0.763 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr11_-_85108030 0.759 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr7_-_16471817 0.758 NM_015464
SOSTDC1
sclerostin domain containing 1
chr2_+_169637255 0.745 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr5_+_171553780 0.740 NM_001171183
EFCAB9
EF-hand calcium binding domain 9
chrX_+_154880439 0.735 NM_002186
IL9R
interleukin 9 receptor
chr1_+_203503214 0.729 TMCC2
transmembrane and coiled-coil domain family 2
chr1_-_153537810 0.719 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr8_-_17986690 0.719 NM_001127505
NM_004315
ASAH1

N-acylsphingosine amidohydrolase (acid ceramidase) 1

chr11_+_123625632 0.713 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr2_+_99344060 0.709 EIF5B
eukaryotic translation initiation factor 5B
chr3_-_143230124 0.706 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr6_-_29081015 0.702 NM_001010877
ZNF311
zinc finger protein 311
chr18_-_53438854 0.701


chr7_-_75876830 0.694 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr2_-_175207521 0.686 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr11_-_118405288 0.681 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr1_-_180624494 0.679 GLUL
glutamate-ammonia ligase
chr16_-_45562840 0.675 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr1_-_47468029 0.654 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr6_+_38798529 0.644 NM_001371
DNAH8
dynein, axonemal, heavy chain 8
chr21_+_29322100 0.643 USP16
ubiquitin specific peptidase 16
chr7_+_90731671 0.642 NM_003505
FZD1
frizzled homolog 1 (Drosophila)
chr17_-_35774467 0.634 NM_152219
GJD3
gap junction protein, delta 3, 31.9kDa
chr7_+_90731614 0.632 FZD1
frizzled homolog 1 (Drosophila)
chr1_+_108904493 0.629 NM_001010883
FAM102B
family with sequence similarity 102, member B
chr1_+_179269766 0.628 MR1
major histocompatibility complex, class I-related
chr20_-_45418818 0.622 NM_012408
NM_183047
NM_183048
ZMYND8


zinc finger, MYND-type containing 8


chr7_-_75794919 0.617 YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr8_-_101384633 0.615 NM_015435
RNF19A
ring finger protein 19A
chr4_+_123311207 0.615 NM_015312
KIAA1109
KIAA1109
chr11_-_113935789 0.613 NM_152315
FAM55A
family with sequence similarity 55, member A
chr6_+_142510034 0.613 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr11_-_10487212 0.607 NM_001190702
MTRNR2L8
MT-RNR2-like 8
chr16_+_2807228 0.607 PRSS21
protease, serine, 21 (testisin)
chr6_+_31623370 0.606 NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr1_-_148854503 0.602


chr11_+_46339691 0.601 NM_001105540
DGKZ
diacylglycerol kinase, zeta
chr2_-_188127430 0.600 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr1_+_179269761 0.593 MR1
major histocompatibility complex, class I-related
chr1_-_180822686 0.592 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr7_+_142053693 0.590 NM_001190487
MTRNR2L6
MT-RNR2-like 6
chr2_-_144991556 0.578 ZEB2
zinc finger E-box binding homeobox 2
chrX_-_23955223 0.576 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr22_+_21340757 0.574


chr13_+_96592051 0.559 MBNL2
muscleblind-like 2 (Drosophila)
chr7_+_129634935 0.558 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr2_+_43919606 0.557 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr1_+_179269689 0.554 MR1
major histocompatibility complex, class I-related
chr7_-_112545840 0.554 LOC401397
hypothetical LOC401397
chr1_-_180624380 0.549 GLUL
glutamate-ammonia ligase
chr11_+_113671744 0.548 NM_006169
NNMT
nicotinamide N-methyltransferase
chr7_+_123036312 0.547 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr12_-_94469357 0.542 NM_032147
USP44
ubiquitin specific peptidase 44
chr5_-_79982584 0.542 NM_001190470
MTRNR2L2
MT-RNR2-like 2
chr2_+_102401580 0.542 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr19_+_10642648 0.540 ILF3
interleukin enhancer binding factor 3, 90kDa
chr1_+_144124547 0.540 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chrX_-_101581504 0.537 NM_022053
NXF2
nuclear RNA export factor 2
chr4_-_90197140 0.535 NM_014883
FAM13A
family with sequence similarity 13, member A
chr2_-_39310176 0.535 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr11_+_65023218 0.534


chr1_+_28134090 0.529 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr1_+_15675182 0.527 NM_015849
CELA2B
chymotrypsin-like elastase family, member 2B
chr6_-_31797434 0.526 NM_025261
LY6G6C
lymphocyte antigen 6 complex, locus G6C
chr1_+_160868932 0.525 DDR2
discoidin domain receptor tyrosine kinase 2
chr10_-_48426868 0.523 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr22_+_38652555 0.522 GRAP2
GRB2-related adaptor protein 2
chr22_-_25343959 0.522 NM_001887
CRYBB1
crystallin, beta B1
chr9_+_34642125 0.520 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chr9_+_114671635 0.520 SNX30
sorting nexin family member 30
chr5_+_71438796 0.514 NM_005909
MAP1B
microtubule-associated protein 1B
chr12_-_49708279 0.509 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr1_+_144152864 0.509 TXNIP
thioredoxin interacting protein
chr6_-_31789824 0.507


chr11_-_28086263 0.506 KIF18A
kinesin family member 18A
chr1_+_111217244 0.502 NM_000560
CD53
CD53 molecule
chr9_+_95886558 0.499 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr6_+_31623331 0.494 NM_001144961
NM_005007
NFKBIL1

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

chr9_+_124072947 0.493 NM_199177
MRRF
mitochondrial ribosome recycling factor
chr16_-_4795160 0.487 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr9_+_95886625 0.486 PTPDC1
protein tyrosine phosphatase domain containing 1
chr11_-_123772456 0.485 NM_001005467
OR8B3
olfactory receptor, family 8, subfamily B, member 3
chr11_+_59564323 0.482 NM_173801
PLAC1L
placenta-specific 1-like
chr12_+_49634048 0.482 NM_001109619
HIGD1C
HIG1 hypoxia inducible domain family, member 1C
chr1_+_47674275 0.481 NM_004474
FOXD2
forkhead box D2
chr2_+_169631777 0.475 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr10_+_49279647 0.472 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr7_+_139750311 0.472 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr15_+_39839866 0.468 MGA
MAX gene associated
chr22_-_37214480 0.467 NM_001098505
NM_030881
DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

chr8_+_110443881 0.464 NM_177531
PKHD1L1
polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
chr11_+_28086373 0.464 NM_001113528
NM_152636
METTL15

methyltransferase like 15

chr4_-_75066533 0.463 NM_002619
PF4
platelet factor 4
chr7_-_137271191 0.463 CREB3L2
cAMP responsive element binding protein 3-like 2
chr19_-_50688310 0.460 NM_206901
RTN2
reticulon 2
chr8_-_91164100 0.460 NM_004929
CALB1
calbindin 1, 28kDa
chr15_-_35178888 0.459 NM_172316
MEIS2
Meis homeobox 2
chr11_-_28086277 0.457 NM_031217
KIF18A
kinesin family member 18A
chr1_+_3658821 0.456 NM_152492
CCDC27
coiled-coil domain containing 27
chr11_-_28086222 0.455 KIF18A
kinesin family member 18A
chr2_-_144994038 0.448 ZEB2
zinc finger E-box binding homeobox 2
chr1_+_160868822 0.442 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr17_+_73511843 0.440 NM_001142640
NM_018996
TNRC6C

trinucleotide repeat containing 6C

chr15_+_55298908 0.439 NM_207040
TCF12
transcription factor 12
chr12_-_69434598 0.439 NM_130846
PTPRR
protein tyrosine phosphatase, receptor type, R
chr11_-_133599079 0.438 NCAPD3
non-SMC condensin II complex, subunit D3
chr5_+_121493113 0.438 NM_207317
ZNF474
zinc finger protein 474
chr20_+_35445350 0.437 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr3_-_161584137 0.437 NM_001190242
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chr6_+_135558744 0.436 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr19_-_45022993 0.436 FBL
fibrillarin
chr6_-_150109324 0.435 NM_198887
NUP43
nucleoporin 43kDa
chr6_-_6632197 0.434


chr21_+_37714470 0.433 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr19_-_60241424 0.432 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr7_-_13992351 0.432 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr1_-_171838802 0.428 NM_178527
SLC9A11
solute carrier family 9, member 11
chr12_-_101396459 0.425 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr22_+_21543671 0.425 IGLV4-3
immunoglobulin lambda variable 4-3
chr16_+_14187965 0.424 MKL2
MKL/myocardin-like 2
chr7_-_112545847 0.423 LOC401397
hypothetical LOC401397
chr6_+_154373323 0.422 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr12_-_69434650 0.422 PTPRR
protein tyrosine phosphatase, receptor type, R
chr12_-_53044495 0.416 NM_020370
GPR84
G protein-coupled receptor 84
chr5_-_41249270 0.413 NM_000065
C6
complement component 6
chr3_+_23904086 0.413 UBE2E1
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
chr16_-_4794749 0.413 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr12_-_101036407 0.412 NM_024057
NUP37
nucleoporin 37kDa
chr16_+_7322751 0.410 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr15_-_62460622 0.408 NM_001029989
NM_014736
KIAA0101

KIAA0101

chr22_-_25344037 0.399 CRYBB1
crystallin, beta B1
chr6_-_99955987 0.396 SFRS18
splicing factor, arginine/serine-rich 18
chr3_-_25658829 0.395 TOP2B
topoisomerase (DNA) II beta 180kDa
chr16_+_31446703 0.395 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr1_-_152431175 0.394 NM_152263
TPM3
tropomyosin 3
chr7_-_112513379 0.394 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr1_-_33110668 0.391 NM_001171941
FNDC5
fibronectin type III domain containing 5
chr7_-_112515068 0.387 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.41 4.25e-08 GO:0007608 sensory perception of smell
2.19 2.13e-06 GO:0007606 sensory perception of chemical stimulus
1.54 1.34e-05 GO:0003008 system process
1.26 2.53e-05 GO:0032501 multicellular organismal process
1.73 3.26e-04 GO:0007600 sensory perception
1.45 2.60e-02 GO:0050877 neurological system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.27 8.96e-05 GO:0005886 plasma membrane
1.26 9.82e-05 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.52 1.25e-09 GO:0004984 olfactory receptor activity
1.67 4.32e-04 GO:0004930 G-protein coupled receptor activity
1.41 4.09e-02 GO:0004888 transmembrane receptor activity