Motif ID: HBP1_HMGB_SSRP1_UBTF.p2

Z-value: 4.300


Transcription factors associated with HBP1_HMGB_SSRP1_UBTF.p2:

Gene SymbolEntrez IDGene Name
HBP1 26959 HMG-box transcription factor 1
HMGB2 3148 high-mobility group box 2
HMGB3 3149 high-mobility group box 3
SSRP1 6749 structure specific recognition protein 1
UBTF 7343 upstream binding transcription factor, RNA polymerase I

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
UBTFchr17_-_39651189-0.811.3e-04Click!
HBP1chr7_+_1065966410.811.7e-04Click!
SSRP1chr11_-_568599000.476.5e-02Click!
HMGB3chrX_+_1499024150.351.8e-01Click!
HMGB2chr4_-_174491270-0.146.1e-01Click!


Activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2.

activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2


Sorted Z-values histogram for motif HBP1_HMGB_SSRP1_UBTF.p2

Sorted Z-values for motif HBP1_HMGB_SSRP1_UBTF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HBP1_HMGB_SSRP1_UBTF.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_134114957 17.805 CALD1
caldesmon 1
chr7_+_134114912 17.231 CALD1
caldesmon 1
chr7_-_27186400 16.686 NM_153715
 HOXA10
homeobox A10
chr6_+_12398514 16.008 NM_001168319
NM_001955
 EDN1

endothelin 1

chr11_-_85107569 15.474 NM_206929
 SYTL2
synaptotagmin-like 2
chr11_-_85108030 13.797 NM_001162952
NM_206930
 SYTL2

synaptotagmin-like 2

chr13_-_73605914 13.631 NM_007249
 KLF12
Kruppel-like factor 12
chr16_+_85169615 12.871 NM_005250
 FOXL1
forkhead box L1
chr13_-_98428244 12.738 NM_001130048
NM_001130050
 DOCK9

dedicator of cytokinesis 9

chr5_-_111119846 12.688 NM_001142483
 C5orf13
chromosome 5 open reading frame 13
chr8_-_72436519 12.380 EYA1
eyes absent homolog 1 (Drosophila)
chr13_-_73606362 11.495 KLF12
Kruppel-like factor 12
chr8_-_108579270 11.308 NM_001146
 ANGPT1
angiopoietin 1
chr13_-_109757442 10.750 NM_001845
 COL4A1
collagen, type IV, alpha 1
chr2_-_162808123 10.700 NM_004460
 FAP
fibroblast activation protein, alpha
chr4_+_86918882 10.666 ARHGAP24
Rho GTPase activating protein 24
chr1_-_197173159 10.546 LOC100131234
familial acute myelogenous leukemia related factor
chr6_-_111995213 10.499 NM_001164283
 TRAF3IP2
TRAF3 interacting protein 2
chr5_-_16989371 10.276 NM_012334
 MYO10
myosin X
chr7_-_27171673 10.155 NM_152739
 HOXA9
homeobox A9

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 93 entries
enrichment   p-value GO term description
4.04 2.77e-02 GO:0016339 calcium-dependent cell-cell adhesion
3.47 2.31e-02 GO:0001952 regulation of cell-matrix adhesion
3.36 4.40e-07 GO:0030336 negative regulation of cell migration
3.36 4.40e-07 GO:2000146 negative regulation of cell motility
3.21 9.27e-07 GO:0051271 negative regulation of cellular component movement
2.98 7.00e-03 GO:0010810 regulation of cell-substrate adhesion
2.96 1.08e-05 GO:0040013 negative regulation of locomotion
2.56 1.93e-02 GO:0048706 embryonic skeletal system development
2.53 3.28e-05 GO:0007156 homophilic cell adhesion
2.48 3.23e-03 GO:0035107 appendage morphogenesis
2.48 3.23e-03 GO:0035108 limb morphogenesis
2.46 2.59e-03 GO:0048736 appendage development
2.46 2.59e-03 GO:0060173 limb development
2.36 5.11e-03 GO:0006469 negative regulation of protein kinase activity
2.27 6.34e-08 GO:0001568 blood vessel development
2.26 1.55e-08 GO:0001944 vasculature development
2.24 1.78e-02 GO:0033673 negative regulation of kinase activity
2.21 9.84e-07 GO:0030334 regulation of cell migration
2.18 1.73e-06 GO:2000145 regulation of cell motility
2.18 4.56e-05 GO:0048514 blood vessel morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
8.08 1.39e-02 GO:0071437 invadopodium
3.68 1.34e-03 GO:0042641 actomyosin
3.47 2.75e-02 GO:0001725 stress fiber
2.89 1.59e-05 GO:0030027 lamellipodium
2.55 7.11e-05 GO:0030055 cell-substrate junction
2.53 2.83e-04 GO:0005925 focal adhesion
2.41 9.26e-04 GO:0005924 cell-substrate adherens junction
2.39 9.80e-06 GO:0005912 adherens junction
2.29 2.16e-03 GO:0044420 extracellular matrix part
2.21 9.14e-05 GO:0070161 anchoring junction
2.16 1.08e-02 GO:0030016 myofibril
2.15 1.66e-02 GO:0044449 contractile fiber part
2.12 1.68e-04 GO:0031252 cell leading edge
2.04 3.65e-02 GO:0043292 contractile fiber
1.88 4.23e-05 GO:0005578 proteinaceous extracellular matrix
1.77 1.29e-04 GO:0031012 extracellular matrix
1.77 2.03e-02 GO:0016323 basolateral plasma membrane
1.70 1.31e-02 GO:0015629 actin cytoskeleton
1.61 9.71e-05 GO:0030054 cell junction
1.32 2.01e-03 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
2.87 4.45e-02 GO:0008013 beta-catenin binding
2.55 1.16e-02 GO:0005089 Rho guanyl-nucleotide exchange factor activity
2.21 1.58e-02 GO:0017124 SH3 domain binding
1.89 2.92e-05 GO:0003779 actin binding
1.75 1.31e-06 GO:0008092 cytoskeletal protein binding
1.51 2.60e-03 GO:0005509 calcium ion binding
1.45 2.11e-04 GO:0030528 transcription regulator activity
1.44 6.32e-04 GO:0001071 nucleic acid binding transcription factor activity
1.44 6.32e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.14 7.85e-05 GO:0005515 protein binding
1.06 1.77e-02 GO:0005488 binding