Motif ID: HNF4A_NR2F1,2.p2

Z-value: 7.381


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF4Achr20_+_424634190.893.3e-06Click!
NR2F2chr15_+_94670160-0.421.0e-01Click!
NR2F1chr5_+_92946348-0.165.6e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_69950782 13.948 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr9_-_126309510 13.896 NM_004959
 NR5A1
nuclear receptor subfamily 5, group A, member 1
chr6_+_131190237 12.879 NM_001195597
 LOC285733
hypothetical LOC285733
chr9_-_14858974 12.809 FREM1
FRAS1 related extracellular matrix 1
chr17_+_24394281 12.607 PIPOX
pipecolic acid oxidase
chr5_-_42847716 11.814 NM_001085486
NM_001093726
NM_005410
 SEPP1


selenoprotein P, plasma, 1


chr14_-_23847000 11.534 CIDEB
cell death-inducing DFFA-like effector b
chr2_+_241193492 11.439 NM_001195381
NM_001195382
 GPR35

G protein-coupled receptor 35

chr1_-_167822248 11.437 F5
coagulation factor V (proaccelerin, labile factor)
chr14_-_23847024 11.143 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_23846993 10.926 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_23846904 10.874 CIDEB
cell death-inducing DFFA-like effector b
chr12_+_51783554 10.854 SOAT2
sterol O-acyltransferase 2
chr10_-_101831579 10.684 NM_001308
 CPN1
carboxypeptidase N, polypeptide 1
chr12_+_51783540 10.679 NM_003578
 SOAT2
sterol O-acyltransferase 2
chr14_-_93924873 9.971 NM_000295
 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr16_-_86527608 9.875 NM_001739
 CA5A
carbonic anhydrase VA, mitochondrial
chr2_-_74606819 9.781 NM_133637
 DQX1
DEAQ box RNA-dependent ATPase 1
chr6_+_31731647 9.649 NM_019101
 APOM
apolipoprotein M
chr9_-_129752687 9.522 NM_203305
 FAM102A
family with sequence similarity 102, member A

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
1.62 2.81e-02 GO:0032787 monocarboxylic acid metabolic process
1.49 4.19e-04 GO:0006082 organic acid metabolic process
1.49 7.61e-04 GO:0019752 carboxylic acid metabolic process
1.49 7.61e-04 GO:0043436 oxoacid metabolic process
1.47 1.08e-03 GO:0042180 cellular ketone metabolic process
1.44 2.76e-04 GO:0055114 oxidation-reduction process
1.26 5.25e-04 GO:0042221 response to chemical stimulus
1.26 5.48e-03 GO:0044281 small molecule metabolic process
1.23 1.64e-02 GO:0065008 regulation of biological quality
1.11 3.27e-03 GO:0008152 metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
1.63 2.68e-03 GO:0005743 mitochondrial inner membrane
1.57 6.42e-03 GO:0019866 organelle inner membrane
1.54 6.95e-04 GO:0005740 mitochondrial envelope
1.49 7.59e-03 GO:0031966 mitochondrial membrane
1.45 5.69e-04 GO:0044429 mitochondrial part
1.44 6.24e-05 GO:0005626 insoluble fraction
1.42 3.06e-04 GO:0005624 membrane fraction
1.39 6.13e-03 GO:0031967 organelle envelope
1.38 6.18e-05 GO:0000267 cell fraction
1.38 6.73e-03 GO:0031975 envelope
1.30 9.51e-04 GO:0005739 mitochondrion
1.11 1.93e-03 GO:0044444 cytoplasmic part
1.08 1.42e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
1.51 2.46e-05 GO:0016491 oxidoreductase activity