Motif ID: NKX3-2.p2

Z-value: 2.620


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-2chr4_-_13155135-0.458.3e-02Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_17585462 6.744 VSNL1
visinin-like 1
chr2_-_70634129 5.230 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr2_+_17585287 3.955 NM_003385
VSNL1
visinin-like 1
chr10_+_24795446 3.417 KIAA1217
KIAA1217
chr11_-_119513429 3.273 TRIM29
tripartite motif containing 29
chr10_+_24795465 3.217 KIAA1217
KIAA1217
chr5_+_52812236 3.180 NM_006350
NM_013409
FST

follistatin

chrX_-_107568211 3.027 NM_033641
COL4A6
collagen, type IV, alpha 6
chr16_-_80602546 2.951 NM_145168
SDR42E1
short chain dehydrogenase/reductase family 42E, member 1
chr6_+_54819527 2.950 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr20_+_51023159 2.940 TSHZ2
teashirt zinc finger homeobox 2
chr5_+_52812165 2.883 FST
follistatin
chr8_+_120289735 2.390 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr11_-_119513948 2.366 TRIM29
tripartite motif containing 29
chr12_+_4253143 2.286 NM_001759
CCND2
cyclin D2
chr11_+_66580861 2.240 NM_014578
RHOD
ras homolog gene family, member D
chr11_-_119499188 2.192 TRIM29
tripartite motif containing 29
chr11_-_119514058 2.186 NM_012101
TRIM29
tripartite motif containing 29
chr20_-_42249631 2.141 NM_020433
NM_175913
JPH2

junctophilin 2

chr12_-_51200347 2.124 NM_000424
KRT5
keratin 5
chr18_+_40514772 2.047 NM_015559
SETBP1
SET binding protein 1
chr11_-_119514011 2.039 TRIM29
tripartite motif containing 29
chr1_+_199519202 2.035 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr1_+_35020425 1.949 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr10_-_105604942 1.930 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr13_+_75232797 1.903 NM_015842
LMO7
LIM domain 7
chr2_-_238861830 1.841 NM_022817
PER2
period homolog 2 (Drosophila)
chr8_+_102574012 1.823 GRHL2
grainyhead-like 2 (Drosophila)
chr1_+_86662356 1.777 NM_006536
CLCA2
chloride channel accessory 2
chr16_+_55963883 1.723 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr17_+_7289086 1.722 NM_000747
CHRNB1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr2_+_98070026 1.712 NM_144992
VWA3B
von Willebrand factor A domain containing 3B
chr16_+_55963899 1.695 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr8_+_102573837 1.692 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr1_-_94779727 1.692 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr8_+_32905027 1.688


chr5_+_68746694 1.678 NM_001038603
MARVELD2
MARVEL domain containing 2
chr10_-_98021144 1.674 NM_001114094
NM_013314
BLNK

B-cell linker

chr1_+_46418786 1.616 TSPAN1
tetraspanin 1
chr20_+_19903778 1.610 RIN2
Ras and Rab interactor 2
chr1_-_24342158 1.606 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr5_+_56507029 1.567 NM_001127235
GPBP1
GC-rich promoter binding protein 1
chr9_+_77695334 1.564 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr12_+_94861201 1.502 NM_152435
AMDHD1
amidohydrolase domain containing 1
chr6_-_112001590 1.476 NM_001164282
TRAF3IP2
TRAF3 interacting protein 2
chr8_+_123863075 1.474 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr10_-_116276651 1.421 NM_006720
ABLIM1
actin binding LIM protein 1
chr20_-_51633042 1.408 NM_006526
ZNF217
zinc finger protein 217
chr2_-_160764819 1.395 NM_000888
ITGB6
integrin, beta 6
chr8_+_123863169 1.385 ZHX2
zinc fingers and homeoboxes 2
chr12_+_52618815 1.354 NM_017410
HOXC13
homeobox C13
chr1_-_6368324 1.337 NM_181864
ACOT7
acyl-CoA thioesterase 7
chr4_+_169789327 1.337 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr21_+_38550739 1.319 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr12_-_6355165 1.311 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr11_-_77411933 1.308 NM_023930
KCTD14
potassium channel tetramerisation domain containing 14
chr10_+_59942874 1.298 NM_001080512
BICC1
bicaudal C homolog 1 (Drosophila)
chr19_-_6671585 1.286 NM_000064
C3
complement component 3
chr6_+_139055244 1.269 FLJ46906
hypothetical LOC441172
chr3_-_191522886 1.260 NM_021101
CLDN1
claudin 1
chr1_+_208178160 1.248 NM_001146261
NM_001146262
NM_001146264
NM_153262
SYT14



synaptotagmin XIV



chr10_-_116276560 1.245 ABLIM1
actin binding LIM protein 1
chr11_+_34599227 1.229 EHF
ets homologous factor
chr2_-_139254273 1.220 NM_007226
NXPH2
neurexophilin 2
chr11_+_34599163 1.212 NM_012153
EHF
ets homologous factor
chr3_-_145049853 1.206 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr1_-_24311212 1.192 NM_152372
MYOM3
myomesin family, member 3
chr5_+_149960820 1.179 NM_001166208
SYNPO
synaptopodin
chr3_+_106568430 1.171 ALCAM
activated leukocyte cell adhesion molecule
chr2_-_197499584 1.168 NM_024989
PGAP1
post-GPI attachment to proteins 1
chr10_-_29963906 1.164 NM_021738
SVIL
supervillin
chr3_+_138159396 1.158 NM_144717
IL20RB
interleukin 20 receptor beta
chr9_+_111582317 1.155 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr12_+_52806103 1.142 LOC400043
hypothetical LOC400043
chr2_-_109728958 1.140 NM_144710
NM_178584
SEPT10

septin 10

chr1_-_207892296 1.137 NM_001127641
LAMB3
laminin, beta 3
chr18_+_59405513 1.137 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr8_-_122722674 1.125 NM_005328
HAS2
hyaluronan synthase 2
chr2_+_218790364 1.106 NM_005731
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr15_-_72513311 1.088 NM_001146029
NM_003612
SEMA7A

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

chr4_+_183302105 1.077 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr3_+_106568334 1.077 NM_001627
ALCAM
activated leukocyte cell adhesion molecule
chr1_+_107484151 1.074 NM_001113226
NM_001113228
NM_014917
NTNG1


netrin G1


chr1_+_232107170 1.073 NM_173508
SLC35F3
solute carrier family 35, member F3
chr4_+_108965167 1.071 NM_001136258
SGMS2
sphingomyelin synthase 2
chr12_+_3470685 1.068 NM_019854
PRMT8
protein arginine methyltransferase 8
chr3_-_188936941 1.067 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr19_-_4468715 1.064 NM_001080400
PLIN4
perilipin 4
chr2_+_228386800 1.062 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr1_+_26728846 1.060 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr11_-_117628211 1.057 NM_198275
MPZL3
myelin protein zero-like 3
chr5_+_174084137 1.052 NM_002449
MSX2
msh homeobox 2
chr10_-_123343761 1.047 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr10_-_116154212 1.043 AFAP1L2
actin filament associated protein 1-like 2
chr3_-_48607596 1.037 NM_000094
COL7A1
collagen, type VII, alpha 1
chr5_+_96023926 1.033 CAST
calpastatin
chr21_+_38550533 1.025 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr3_+_106568243 1.024 ALCAM
activated leukocyte cell adhesion molecule
chr10_+_20145350 1.024 NM_032812
PLXDC2
plexin domain containing 2
chr2_+_63131466 1.023 NM_014562
OTX1
orthodenticle homeobox 1
chr11_+_101488380 1.017 NM_001195045
YAP1
Yes-associated protein 1
chr11_+_63412562 1.014 NM_017490
MARK2
MAP/microtubule affinity-regulating kinase 2
chr12_-_51173238 1.006 NM_005554
KRT6A
keratin 6A
chr10_+_86174665 1.004 FAM190B
family with sequence similarity 190, member B
chr18_+_27332024 1.002 NM_001943
DSG2
desmoglein 2
chr6_+_41712907 1.001 MDFI
MyoD family inhibitor
chr12_+_32546243 0.998 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr8_-_17702991 0.995


chr3_+_185762233 0.989 NM_004443
EPHB3
EPH receptor B3
chr18_-_26996742 0.986 NM_004948
NM_024421
DSC1

desmocollin 1

chr2_+_54638957 0.977 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr11_+_35117408 0.974 CD44
CD44 molecule (Indian blood group)
chr21_-_42060334 0.970 RIPK4
receptor-interacting serine-threonine kinase 4
chr16_-_31054321 0.965 PRSS8
protease, serine, 8
chr3_-_137395966 0.962 NM_001145417
MSL2
male-specific lethal 2 homolog (Drosophila)
chr16_-_31054563 0.942 NM_002773
PRSS8
protease, serine, 8
chr11_+_35117391 0.942 CD44
CD44 molecule (Indian blood group)
chr22_-_44015248 0.930 NM_001009880
KIAA0930
KIAA0930
chr3_-_110155237 0.920 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr15_+_38923914 0.915 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr12_+_12857516 0.910 NM_016355
NM_201224
DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

chr15_-_81743198 0.907 BNC1
basonuclin 1
chr20_-_42249146 0.902 JPH2
junctophilin 2
chr17_-_78391178 0.901 NM_024702
ZNF750
zinc finger protein 750
chr14_-_53491019 0.900 NM_130851
BMP4
bone morphogenetic protein 4
chrX_-_15198093 0.897 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr10_+_5126613 0.891 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr10_+_5126589 0.885 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr5_+_96023479 0.885 NM_001190442
CAST
calpastatin
chr3_+_112876212 0.884 NM_001185106
NM_153268
PLCXD2

phosphatidylinositol-specific phospholipase C, X domain containing 2

chr5_+_38882017 0.869 OSMR
oncostatin M receptor
chr5_+_66160359 0.868 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr2_+_109729176 0.858 NM_023016
ANKRD57
ankyrin repeat domain 57
chr5_+_96023627 0.852 NM_001042440
CAST
calpastatin
chr20_+_42273013 0.849 LOC100505783
hypothetical LOC100505783
chr5_-_149772563 0.848 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr1_+_26728839 0.842 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr18_-_28304392 0.842 NM_022751
FAM59A
family with sequence similarity 59, member A
chr1_-_219982016 0.839 DUSP10
dual specificity phosphatase 10
chr10_+_5126556 0.833 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr3_+_113061218 0.827 NM_001134439
PHLDB2
pleckstrin homology-like domain, family B, member 2
chrX_-_31194867 0.824 NM_004015
NM_004016
NM_004017
NM_004018
NM_004019
DMD




dystrophin




chr10_+_96295511 0.821 NM_018063
HELLS
helicase, lymphoid-specific
chr19_+_44590345 0.821 ZFP36
zinc finger protein 36, C3H type, homolog (mouse)
chr11_-_6212421 0.817 FAM160A2
family with sequence similarity 160, member A2
chr16_+_67236730 0.817 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr15_-_57452361 0.816 NM_004998
MYO1E
myosin IE
chr14_-_49848538 0.813 NM_024884
L2HGDH
L-2-hydroxyglutarate dehydrogenase
chr10_+_24537725 0.806 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr16_+_67236699 0.803 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr9_-_21984329 0.798 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr19_+_627346 0.794 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr10_+_4995453 0.794 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr11_-_6212449 0.789 FAM160A2
family with sequence similarity 160, member A2
chr21_-_42060266 0.788 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr12_+_81604752 0.785 TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr1_-_219982049 0.781 DUSP10
dual specificity phosphatase 10
chr16_+_65790514 0.781 NM_024712
ELMO3
engulfment and cell motility 3
chr6_+_29963485 0.778


chr15_-_72513053 0.774 NM_001146030
SEMA7A
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr3_+_113061330 0.773 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr6_-_128883125 0.773 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr15_-_57452345 0.772 MYO1E
myosin IE
chr16_-_45562840 0.771 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr14_-_64479198 0.771 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr1_-_159257567 0.771 F11R
F11 receptor
chr11_-_6212467 0.770 NM_001098794
NM_032127
FAM160A2

family with sequence similarity 160, member A2

chr15_-_57452357 0.770 MYO1E
myosin IE
chr2_+_101981888 0.768 NM_173343
IL1R2
interleukin 1 receptor, type II
chr3_+_113061296 0.768 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr1_+_26728827 0.767 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_-_158306570 0.764 NM_002241
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr5_-_149772528 0.760


chr7_+_29200636 0.759 NM_004067
CHN2
chimerin (chimaerin) 2
chr9_-_34448477 0.757 NM_001184940
NM_001184941
NM_001184942
NM_001184943
NM_001184944
NM_001184945
NM_147202
C9orf25






chromosome 9 open reading frame 25






chr4_+_113958652 0.754 NM_001127493
ANK2
ankyrin 2, neuronal
chr18_+_50646616 0.749 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr1_-_219982081 0.744 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr10_-_5035967 0.744 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr12_-_15757114 0.737 EPS8
epidermal growth factor receptor pathway substrate 8
chr18_+_19826734 0.736 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr12_-_56447090 0.735 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr2_+_219141761 0.733 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr1_-_207892420 0.729 NM_000228
LAMB3
laminin, beta 3
chr9_-_21984379 0.728 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr12_+_32578513 0.715 FGD4
FYVE, RhoGEF and PH domain containing 4
chr14_+_20636935 0.712 NM_001146683
C14orf176
chromosome 14 open reading frame 176
chr14_+_51397134 0.711 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr14_-_20636909 0.710 NM_001101672
ZNF219
zinc finger protein 219
chr14_+_51397166 0.709 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr1_-_207891264 0.709 NM_001017402
LAMB3
laminin, beta 3
chrX_-_20194629 0.707 NM_004586
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr14_+_20580224 0.705 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr6_+_30018287 0.705 NM_002116
HLA-A
major histocompatibility complex, class I, A
chr20_-_42272709 0.705 C20orf111
chromosome 20 open reading frame 111
chr14_-_101841222 0.705 NM_014226
RAGE
renal tumor antigen
chr2_+_201099093 0.704 NM_001160033
NM_001160046
NM_152524
SGOL2


shugoshin-like 2 (S. pombe)


chr2_-_25048276 0.704 NM_001198559
NM_016544
DNAJC27

DnaJ (Hsp40) homolog, subfamily C, member 27

chr12_-_15706340 0.702 EPS8
epidermal growth factor receptor pathway substrate 8
chr12_+_106236281 0.701 NM_001018072
BTBD11
BTB (POZ) domain containing 11

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 6.28e-06 GO:0009987 cellular process
1.17 1.28e-05 GO:0043170 macromolecule metabolic process
1.17 5.88e-05 GO:0044260 cellular macromolecule metabolic process
1.26 2.46e-03 GO:0010467 gene expression
1.11 4.66e-03 GO:0044238 primary metabolic process
1.10 7.98e-03 GO:0008152 metabolic process
1.28 2.37e-02 GO:0033036 macromolecule localization
1.18 3.19e-02 GO:0048518 positive regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 2.87e-05 GO:0005737 cytoplasm
1.06 3.35e-04 GO:0005622 intracellular
1.06 4.04e-04 GO:0044424 intracellular part
1.07 1.79e-03 GO:0043229 intracellular organelle
1.07 2.07e-03 GO:0043226 organelle
1.08 3.75e-03 GO:0043231 intracellular membrane-bounded organelle
1.08 5.01e-03 GO:0043227 membrane-bounded organelle
1.20 8.58e-03 GO:0070013 intracellular organelle lumen
1.22 1.02e-02 GO:0031981 nuclear lumen
1.19 1.07e-02 GO:0043233 organelle lumen
1.19 1.22e-02 GO:0031974 membrane-enclosed lumen
1.10 1.75e-02 GO:0044444 cytoplasmic part
1.25 2.25e-02 GO:0005654 nucleoplasm
2.36 2.51e-02 GO:0034708 methyltransferase complex
2.36 2.51e-02 GO:0035097 histone methyltransferase complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 1.68e-07 GO:0005515 protein binding