Motif ID: PRDM1.p3

Z-value: 2.270


Transcription factors associated with PRDM1.p3:

Gene SymbolEntrez IDGene Name
PRDM1 639 PR domain containing 1, with ZNF domain

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRDM1chr6_+_106653429-0.224.2e-01Click!


Activity profile for motif PRDM1.p3.

activity profile for motif PRDM1.p3


Sorted Z-values histogram for motif PRDM1.p3

Sorted Z-values for motif PRDM1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_16717887 8.062 BNC2
basonuclin 2
chr11_-_104344473 6.232 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr22_-_28972683 6.216 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr16_+_55580910 6.187 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr4_+_142777172 5.955 NM_000585
NM_172174
IL15

interleukin 15

chr6_-_112682401 5.454 LAMA4
laminin, alpha 4
chr6_-_112682459 5.239 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr17_+_6600080 5.089 XAF1
XIAP associated factor 1
chr3_-_115825742 4.895 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr11_+_32069183 4.551 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr2_-_189752575 4.531 NM_000393
COL5A2
collagen, type V, alpha 2
chr6_-_112682038 4.468 LAMA4
laminin, alpha 4
chr17_+_6599879 3.927 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr6_-_112682573 3.776 LAMA4
laminin, alpha 4
chr11_-_85107569 3.737 NM_206929
SYTL2
synaptotagmin-like 2
chr4_+_146623405 3.712 NM_001003688
SMAD1
SMAD family member 1
chr4_+_14985272 3.239 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr10_-_44200458 3.140 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr16_-_71650034 2.889 NM_001164766
ZFHX3
zinc finger homeobox 3
chr6_-_105691235 2.851 NM_007073
BVES
blood vessel epicardial substance
chr1_+_160868932 2.818 DDR2
discoidin domain receptor tyrosine kinase 2
chr3_+_8518539 2.810 LMCD1
LIM and cysteine-rich domains 1
chr17_-_45626364 2.752


chr8_-_23596346 2.726 NM_006167
NKX3-1
NK3 homeobox 1
chr1_-_111548440 2.615 DENND2D
DENN/MADD domain containing 2D
chr12_+_6431437 2.555 NM_018009
TAPBPL
TAP binding protein-like
chr16_+_49333513 2.503 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr3_+_8518508 2.502 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr16_+_49333461 2.499 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr21_-_34820916 2.438 NM_203418
RCAN1
regulator of calcineurin 1
chr10_+_63478974 2.424 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr8_-_145132551 2.400 PARP10
poly (ADP-ribose) polymerase family, member 10
chr17_+_3326045 2.342 NM_000049
ASPA
aspartoacylase
chr9_+_108665168 2.325 NM_021224
ZNF462
zinc finger protein 462
chr8_+_134272463 2.294 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr8_-_145132582 2.266 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr2_-_19421852 2.257 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr6_-_105691675 2.212 BVES
blood vessel epicardial substance
chr6_-_32919751 2.205 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr7_-_92301147 2.194 NM_001259
CDK6
cyclin-dependent kinase 6
chr8_-_79880095 2.188 NM_000880
IL7
interleukin 7
chr1_+_160868822 2.183 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr8_+_144711619 2.163 NM_024736
GSDMD
gasdermin D
chr4_+_187227302 2.134 NM_003265
TLR3
toll-like receptor 3
chr5_-_142795269 2.085 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr3_+_120495906 2.056 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr21_+_25856311 2.024 MIR155HG
MIR155 host gene (non-protein coding)
chr10_-_131652007 1.994 NM_001005463
EBF3
early B-cell factor 3
chr3_+_189354167 1.934 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr3_-_8518327 1.916 LOC100288428
hypothetical LOC100288428
chr2_+_205118801 1.852 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr14_-_68329407 1.847 NM_004926
ZFP36L1
zinc finger protein 36, C3H type-like 1
chr5_+_131774478 1.792 NM_001013717
C5orf56
chromosome 5 open reading frame 56
chr4_+_37569093 1.766 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr3_-_189354510 1.741 LOC339929
hypothetical LOC339929
chr3_-_49826221 1.720 UBA7
ubiquitin-like modifier activating enzyme 7
chr2_+_205118961 1.711 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr19_+_40931285 1.618 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr9_+_136673464 1.607 NM_000093
COL5A1
collagen, type V, alpha 1
chr4_-_153523113 1.594 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr21_-_42219849 1.551 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr10_+_114126004 1.517 ACSL5
acyl-CoA synthetase long-chain family member 5
chr8_+_97575071 1.516 SDC2
syndecan 2
chr15_-_40537002 1.505 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr10_+_114125955 1.502 ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_-_49826360 1.498 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr14_-_68332942 1.415 NM_207442
C14orf181
chromosome 14 open reading frame 181
chr10_+_114125927 1.375 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr22_-_34886727 1.344 NM_145640
APOL3
apolipoprotein L, 3
chr8_+_97575196 1.339 SDC2
syndecan 2
chr6_+_127481740 1.326 NM_032784
RSPO3
R-spondin 3 homolog (Xenopus laevis)
chrX_+_102770547 1.275 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr8_+_97575052 1.271 NM_002998
SDC2
syndecan 2
chr19_-_23370066 1.261 NM_003430
ZNF91
zinc finger protein 91
chr15_+_68971835 1.240 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr2_+_230989114 1.231 NM_001080391
NM_003113
SP100

SP100 nuclear antigen

chr10_+_18469611 1.220 NM_201593
NM_201596
NM_201597
NM_001167945
NM_201571
NM_201572
CACNB2





calcium channel, voltage-dependent, beta 2 subunit





chr9_-_8723893 1.194 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr8_+_97575244 1.171 SDC2
syndecan 2
chr6_+_32919873 1.167


chr2_+_205118710 1.158 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr17_+_17339059 1.155


chr2_+_230989177 1.135 SP100
SP100 nuclear antigen
chr6_+_32929902 1.096 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr10_+_91051685 1.072 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr11_-_85108030 1.062 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr11_+_93501811 1.036 PANX1
pannexin 1
chr12_+_11694172 1.011 ETV6
ets variant 6
chr1_-_2486313 0.991 NM_003820
TNFRSF14
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr5_+_49998528 0.989 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chrX_-_62921937 0.966 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chrX_+_102770303 0.954 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chr9_+_18464138 0.949 ADAMTSL1
ADAMTS-like 1
chr9_+_111582317 0.941 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr11_-_40271086 0.928 LRRC4C
leucine rich repeat containing 4C
chr6_-_101018271 0.890 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr6_+_30018287 0.871 NM_002116
HLA-A
major histocompatibility complex, class I, A
chr3_-_11598829 0.860 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr2_-_230792844 0.852 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr14_+_23675233 0.832 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr1_-_152847256 0.822 ADAR
adenosine deaminase, RNA-specific
chr11_+_93501791 0.816 PANX1
pannexin 1
chr11_-_40272239 0.797 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr14_+_23675206 0.796 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr11_-_786175 0.774 NM_024698
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr11_+_5602782 0.768 NM_021616
TRIM34
tripartite motif containing 34
chr9_+_96806235 0.767 C9orf3
chromosome 9 open reading frame 3
chr10_+_91082218 0.767 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr3_+_176059763 0.745 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr1_-_8406288 0.736 NM_001042682
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr1_+_2975590 0.733 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr2_+_230989150 0.729 SP100
SP100 nuclear antigen
chr9_+_119506428 0.718 TLR4
toll-like receptor 4
chr11_+_93501708 0.711 NM_015368
PANX1
pannexin 1
chr1_-_197173159 0.708 LOC100131234
familial acute myelogenous leukemia related factor
chr11_+_64946848 0.698


chr20_+_13924263 0.685 MACROD2
MACRO domain containing 2
chr20_-_5048443 0.680 NM_182649
PCNA
proliferating cell nuclear antigen
chr2_-_202216451 0.678 NM_001044385
ALS2CR4
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4
chr4_-_48477021 0.671 FRYL
FRY-like
chr2_+_230900121 0.667 NM_138402
SP140L
SP140 nuclear body protein-like
chr12_-_54996098 0.663 NM_001190991
NM_014255
CNPY2

canopy 2 homolog (zebrafish)

chr7_+_134114957 0.658 CALD1
caldesmon 1
chr1_+_32438788 0.655 NM_024296
CCDC28B
coiled-coil domain containing 28B
chr1_-_142536082 0.633


chr11_-_104411065 0.632 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr15_-_53996597 0.625 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr8_-_41641881 0.618 NM_001142445
NM_020478
NM_020480
ANK1


ankyrin 1, erythrocytic


chr20_+_13924014 0.607 NM_080676
MACROD2
MACRO domain containing 2
chr7_+_134114701 0.605 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chrX_-_106248706 0.603 NM_001171080
NM_018301
RBM41

RNA binding motif protein 41

chr11_+_64946820 0.602 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr1_-_7998265 0.583 ERRFI1
ERBB receptor feedback inhibitor 1
chr6_-_32920167 0.571 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr6_+_127481496 0.563 RSPO3
R-spondin 3 homolog (Xenopus laevis)
chr8_-_23768242 0.552 NM_003155
STC1
stanniocalcin 1
chr3_+_51951314 0.546 NM_001003931
NM_005485
PARP3

poly (ADP-ribose) polymerase family, member 3

chr1_-_152847301 0.541 NM_001111
NM_015840
NM_015841
ADAR


adenosine deaminase, RNA-specific


chr1_+_210848592 0.535 NM_001040619
NM_001674
ATF3

activating transcription factor 3

chr12_+_100795480 0.529 DRAM1
DNA-damage regulated autophagy modulator 1
chr10_+_69539255 0.524 NM_032578
MYPN
myopalladin
chr20_+_56904042 0.510 GNAS
GNAS complex locus
chr1_-_146398501 0.506 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr11_+_63060848 0.502 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr9_-_72926333 0.494 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr7_-_86686754 0.487 NM_024315
C7orf23
chromosome 7 open reading frame 23
chr14_+_23982017 0.475


chr14_-_23981493 0.474 NM_020195
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr4_-_48477038 0.464 NM_015030
FRYL
FRY-like
chr8_-_42184350 0.463 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr13_+_30207690 0.462 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr12_-_54995923 0.461 CNPY2
canopy 2 homolog (zebrafish)
chr17_+_38412267 0.448 NM_005533
IFI35
interferon-induced protein 35
chr3_+_51952326 0.444 PARP3
poly (ADP-ribose) polymerase family, member 3
chr19_+_20138991 0.435 NM_052852
ZNF486
zinc finger protein 486
chr22_-_30018329 0.429 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr15_+_65245546 0.422 NM_001145104
SMAD3
SMAD family member 3
chr1_-_219982081 0.420 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr14_+_23771464 0.419 NM_001002000
NM_001002001
GMPR2

guanosine monophosphate reductase 2

chr19_-_52427698 0.416 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr12_-_47605478 0.412 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr1_+_149638633 0.411 NM_002796
PSMB4
proteasome (prosome, macropain) subunit, beta type, 4
chr17_+_75851984 0.407


chr1_-_219982016 0.400 DUSP10
dual specificity phosphatase 10
chr12_-_54996044 0.398 CNPY2
canopy 2 homolog (zebrafish)
chr1_+_210848763 0.395 ATF3
activating transcription factor 3
chr2_-_191587128 0.393 STAT1
signal transducer and activator of transcription 1, 91kDa
chr4_+_86918882 0.392 ARHGAP24
Rho GTPase activating protein 24
chr12_+_120055013 0.392 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr8_-_143805371 0.379 LOC100288181
hypothetical LOC100288181
chr13_+_30207668 0.376 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr9_+_119506446 0.373 TLR4
toll-like receptor 4
chr1_-_219982049 0.369 DUSP10
dual specificity phosphatase 10
chr20_+_18396030 0.366 NM_006466
POLR3F
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chrX_-_100999204 0.364 NM_032946
NXF5
nuclear RNA export factor 5
chrX_-_106248674 0.361 RBM41
RNA binding motif protein 41
chr11_-_92570693 0.358 NM_152313
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr12_+_100795213 0.353 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr7_+_134483305 0.343 NM_018295
TMEM140
transmembrane protein 140
chr5_+_161209969 0.329 NM_001127647
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr6_-_25044156 0.327 FAM65B
family with sequence similarity 65, member B
chr11_-_4371463 0.322 NM_003141
TRIM21
tripartite motif containing 21
chr10_+_123744131 0.321 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_-_142535878 0.321 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr1_+_210848726 0.319 ATF3
activating transcription factor 3
chr13_-_109600709 0.316 COL4A1
collagen, type IV, alpha 1
chr11_-_56137553 0.314 NM_001004740
OR5M1
olfactory receptor, family 5, subfamily M, member 1
chr7_-_11643113 0.314 THSD7A
thrombospondin, type I, domain containing 7A
chr2_-_224611568 0.302 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr9_+_122890394 0.302 NM_007018
CEP110
centrosomal protein 110kDa
chr8_-_93144366 0.299 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr17_-_78000890 0.295 NM_001193655
C17orf62
chromosome 17 open reading frame 62
chr14_-_23771401 0.282 NM_006156
NEDD8
neural precursor cell expressed, developmentally down-regulated 8
chr12_+_53809731 0.281 NM_001005243
OR9K2
olfactory receptor, family 9, subfamily K, member 2
chr3_+_115099007 0.274 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr19_+_54669629 0.269 FLT3LG
fms-related tyrosine kinase 3 ligand
chr9_-_34700062 0.269 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr7_+_89681069 0.263 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr21_+_42807052 0.262 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr15_-_78050515 0.260 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
12.43 1.34e-06 GO:0060337 type I interferon-mediated signaling pathway
12.43 1.34e-06 GO:0071357 cellular response to type I interferon
12.24 1.60e-06 GO:0034340 response to type I interferon
5.72 7.97e-05 GO:0019221 cytokine-mediated signaling pathway
4.05 1.64e-04 GO:0045087 innate immune response
2.95 2.45e-04 GO:0006955 immune response
2.43 2.88e-04 GO:0002376 immune system process
5.16 3.09e-04 GO:0071345 cellular response to cytokine stimulus
5.92 4.09e-04 GO:0009615 response to virus
2.69 7.18e-04 GO:0051704 multi-organism process
2.74 1.16e-03 GO:0006952 defense response
2.53 1.68e-03 GO:0009892 negative regulation of metabolic process
2.88 1.73e-03 GO:0002682 regulation of immune system process
2.60 2.18e-03 GO:0031324 negative regulation of cellular metabolic process
2.57 2.79e-03 GO:0010605 negative regulation of macromolecule metabolic process
3.51 3.02e-03 GO:0051707 response to other organism
2.89 4.21e-03 GO:0071310 cellular response to organic substance
3.18 4.26e-03 GO:0009607 response to biotic stimulus
10.22 6.12e-03 GO:0032479 regulation of type I interferon production
1.79 1.11e-02 GO:0048522 positive regulation of cellular process
3.72 1.79e-02 GO:0034097 response to cytokine stimulus
7.10 2.07e-02 GO:0043900 regulation of multi-organism process
3.82 2.55e-02 GO:0001817 regulation of cytokine production
6.84 2.73e-02 GO:0045637 regulation of myeloid cell differentiation
2.46 2.99e-02 GO:0006508 proteolysis
3.35 3.35e-02 GO:0044419 interspecies interaction between organisms
20.02 4.45e-02 GO:0032728 positive regulation of interferon-beta production

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.68 4.75e-02 GO:0000502 proteasome complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
21.56 5.66e-03 GO:0001530 lipopolysaccharide binding
4.17 1.59e-02 GO:0005126 cytokine receptor binding
2.60 2.22e-02 GO:0008233 peptidase activity
2.56 4.04e-02 GO:0070011 peptidase activity, acting on L-amino acid peptides
13.35 4.33e-02 GO:0004298 threonine-type endopeptidase activity
13.35 4.33e-02 GO:0070003 threonine-type peptidase activity