Motif ID: ESR1.p2

Z-value: 2.583


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESR1chr6_+_152053323-0.505.0e-02Click!


Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_29322993 3.097 NM_001003682
TMEM200B
transmembrane protein 200B
chr18_+_75825563 3.011 NM_001136180
HSBP1L1
heat shock factor binding protein 1-like 1
chr10_+_115428924 2.567 NM_033340
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr8_+_16929116 2.355 NM_181723
EFHA2
EF-hand domain family, member A2
chr7_+_1543644 2.271 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr22_-_41447214 2.095 A4GALT
alpha 1,4-galactosyltransferase
chr3_-_129690056 1.929 NM_001145661
GATA2
GATA binding protein 2
chr4_+_184257337 1.803 NM_024949
WWC2
WW and C2 domain containing 2
chr16_-_73842884 1.780 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr4_+_151218862 1.743 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr6_+_107917965 1.713 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr17_-_30724732 1.695 NM_001104587
NM_001104588
NM_001104589
NM_001104590
NM_152270
SLFN11




schlafen family member 11




chr9_-_83493415 1.600 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chrX_+_117745551 1.583 NM_001560
IL13RA1
interleukin 13 receptor, alpha 1
chr13_+_75108450 1.568 LMO7
LIM domain 7
chr2_+_36436316 1.555 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr14_+_99273751 1.502 EML1
echinoderm microtubule associated protein like 1
chr22_-_41446740 1.494 NM_017436
A4GALT
alpha 1,4-galactosyltransferase
chr9_+_136673464 1.486 NM_000093
COL5A1
collagen, type V, alpha 1
chr7_+_45894480 1.462 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr17_-_37793885 1.451 NM_213662
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr9_-_85342868 1.448 NM_174938
FRMD3
FERM domain containing 3
chr17_-_37794102 1.432 STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr11_-_1549719 1.431 NM_004420
DUSP8
dual specificity phosphatase 8
chr19_-_40939756 1.429 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr5_+_178219519 1.418 NM_058230
ZNF354B
zinc finger protein 354B
chr12_-_69317441 1.382 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr17_+_71892538 1.370 SPHK1
sphingosine kinase 1
chr12_-_123568781 1.342


chr2_+_219354692 1.337 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr17_+_71893014 1.329 SPHK1
sphingosine kinase 1
chr3_+_16901455 1.327 NM_001144382
PLCL2
phospholipase C-like 2
chr13_-_27967215 1.307 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr2_+_238200922 1.301 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr3_+_52504391 1.286 NM_015136
STAB1
stabilin 1
chr14_+_73073570 1.285 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr7_+_1536847 1.285 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr17_+_71892271 1.269 NM_001142601
NM_021972
NM_182965
SPHK1


sphingosine kinase 1


chr7_+_2638156 1.267 TTYH3
tweety homolog 3 (Drosophila)
chr11_-_72530605 1.260 NM_014824
FCHSD2
FCH and double SH3 domains 2
chr5_-_1165106 1.258 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr17_-_37794017 1.255 NM_003150
NM_139276
STAT3

signal transducer and activator of transcription 3 (acute-phase response factor)

chr19_+_15079141 1.251 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr1_+_179148935 1.240 NM_020950
KIAA1614
KIAA1614
chr7_+_44110470 1.227 NM_001129
AEBP1
AE binding protein 1
chr17_+_71892781 1.226 NM_001142602
SPHK1
sphingosine kinase 1
chr17_-_45562112 1.188 NM_174920
SAMD14
sterile alpha motif domain containing 14
chr2_+_242398954 1.184 NEU4
sialidase 4
chr1_-_92124201 1.165 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr16_+_4361775 1.165 NM_138440
VASN
vasorin
chr13_-_32822759 1.161 STARD13
StAR-related lipid transfer (START) domain containing 13
chr6_-_117193505 1.155 NM_001085480
FAM162B
family with sequence similarity 162, member B
chr19_-_8581559 1.152 NM_030957
ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr19_-_10475083 1.150 KEAP1
kelch-like ECH-associated protein 1
chr16_+_54072969 1.146 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr2_+_242398832 1.136 NM_001167600
NM_001167601
NEU4

sialidase 4

chr4_+_1842947 1.131 WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr1_-_92124064 1.120 TGFBR3
transforming growth factor, beta receptor III
chr11_-_118716244 1.113 MFRP
membrane frizzled-related protein
chrX_-_2428963 1.107 NM_145177
NM_001171136
NM_004729
DHRSX
ZBED1

dehydrogenase/reductase (SDR family) X-linked
zinc finger, BED-type containing 1

chr7_-_139987044 1.096 DENND2A
DENN/MADD domain containing 2A
chr22_-_19122047 1.095 SCARF2
scavenger receptor class F, member 2
chr6_-_11152340 1.087 NM_017770
ELOVL2
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
chr3_+_195889845 1.085 FAM43A
family with sequence similarity 43, member A
chr16_+_658081 1.070 NM_138769
RHOT2
ras homolog gene family, member T2
chr3_+_171558143 1.067 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr6_+_148705421 1.061 NM_015278
SASH1
SAM and SH3 domain containing 1
chr10_+_81882477 1.050 PLAC9
placenta-specific 9
chr3_-_66633534 1.044 NM_015541
LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr10_+_81882409 1.040 PLAC9
placenta-specific 9
chr10_+_129595289 1.040 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr5_-_92982927 1.038


chr8_+_21980315 1.033 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr1_+_15352800 1.030 NM_001136218
NM_018022
TMEM51

transmembrane protein 51

chr18_+_18003401 1.029 NM_005257
GATA6
GATA binding protein 6
chr7_-_47588160 1.026 TNS3
tensin 3
chr11_-_116213511 1.026 NM_000039
APOA1
apolipoprotein A-I
chr20_+_4077466 1.011 SMOX
spermine oxidase
chr3_+_171558188 0.994 SKIL
SKI-like oncogene
chr20_-_24986501 0.993 ACSS1
acyl-CoA synthetase short-chain family member 1
chr7_-_47588266 0.987 TNS3
tensin 3
chr9_+_132579088 0.985 NM_007313
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr19_+_59062937 0.983 NM_001020819
NM_138373
MYADM

myeloid-associated differentiation marker

chr13_+_50694364 0.979 NM_145019
FAM124A
family with sequence similarity 124A
chr13_-_107317460 0.977 NM_001080396
FAM155A
family with sequence similarity 155, member A
chr15_-_50375143 0.972 NM_018728
MYO5C
myosin VC
chr19_-_10474767 0.972 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chr19_+_59062962 0.967 MYADM
myeloid-associated differentiation marker
chr6_+_3696224 0.967


chr17_-_75808680 0.965 NM_000199
SGSH
N-sulfoglucosamine sulfohydrolase
chr9_-_16860719 0.952 NM_017637
BNC2
basonuclin 2
chr16_+_658158 0.937 RHOT2
ras homolog gene family, member T2
chr12_+_130979729 0.937 NM_001002019
NM_025215
PUS1

pseudouridylate synthase 1

chr22_-_19122107 0.936 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr2_+_219354948 0.935 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr1_+_6537924 0.933 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chrX_-_2857351 0.929 NM_001669
NM_009589
ARSD

arylsulfatase D

chr10_-_105410840 0.929


chr7_-_29995809 0.926 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr19_+_58733144 0.925 NM_001079906
ZNF331
zinc finger protein 331
chr15_+_30797466 0.924 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr11_+_128067598 0.923 NM_001167681
FLI1
Friend leukemia virus integration 1
chr3_+_171558215 0.922 SKIL
SKI-like oncogene
chrX_-_2857315 0.920 ARSD
arylsulfatase D
chr12_+_50592379 0.914 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr10_+_81882237 0.909 NM_001012973
PLAC9
placenta-specific 9
chr19_+_40224457 0.909 HPN
hepsin
chr10_-_30388439 0.905 NM_020848
KIAA1462
KIAA1462
chr9_+_136673534 0.905 COL5A1
collagen, type V, alpha 1
chr20_-_39199936 0.902


chr5_-_37285160 0.901 NM_023073
C5orf42
chromosome 5 open reading frame 42
chr7_+_44110527 0.896 AEBP1
AE binding protein 1
chr21_+_32167175 0.896 NM_014586
HUNK
hormonally up-regulated Neu-associated kinase
chr6_-_154873396 0.894 NM_173515
CNKSR3
CNKSR family member 3
chr22_+_42651018 0.894 PNPLA3
patatin-like phospholipase domain containing 3
chr16_+_64958060 0.892 CDH5
cadherin 5, type 2 (vascular endothelium)
chr8_+_22465368 0.891 SORBS3
sorbin and SH3 domain containing 3
chr20_+_23279372 0.887 NM_013248
NXT1
NTF2-like export factor 1
chr11_-_70641267 0.884 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr1_-_11029882 0.884 MASP2
mannan-binding lectin serine peptidase 2
chr4_-_57671307 0.882 IGFBP7
insulin-like growth factor binding protein 7
chr1_+_15955719 0.882 FBLIM1
filamin binding LIM protein 1
chr14_+_105012106 0.874 NM_001312
CRIP2
cysteine-rich protein 2
chr6_+_148705646 0.868 SASH1
SAM and SH3 domain containing 1
chr17_+_77261477 0.863 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr20_+_4077409 0.860 NM_175839
NM_175840
NM_175841
NM_175842
SMOX



spermine oxidase



chr19_-_14447163 0.853 NM_000955
PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr7_+_128615948 0.846 NM_005631
SMO
smoothened homolog (Drosophila)
chr7_+_2409731 0.845 NM_018641
CHST12
carbohydrate (chondroitin 4) sulfotransferase 12
chr16_-_3014226 0.840 NM_001002017
NM_001002018
NM_017885
HCFC1R1


host cell factor C1 regulator 1 (XPO1 dependent)


chr14_+_105063975 0.839 NM_025268
TMEM121
transmembrane protein 121
chr17_-_8006979 0.836 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr3_-_186353421 0.836 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chr4_-_89299034 0.834 NM_004827
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr5_+_176446425 0.832 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr10_+_122206455 0.826 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr2_+_100802923 0.826 NM_002518
NPAS2
neuronal PAS domain protein 2
chr19_-_14447122 0.822 PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr1_+_3360880 0.822 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr16_-_265868 0.820 NM_003834
NM_183337
RGS11

regulator of G-protein signaling 11

chr16_+_67017 0.814 NM_001015054
MPG
N-methylpurine-DNA glycosylase
chr6_-_154873480 0.812 CNKSR3
CNKSR family member 3
chr10_-_62883213 0.811 NM_178505
TMEM26
transmembrane protein 26
chr15_-_93671314 0.806 LOC400456
hypothetical LOC400456
chr19_-_41191423 0.803 NM_001039876
C19orf46
chromosome 19 open reading frame 46
chr12_-_132042920 0.802 NM_183238
NM_001164715
ZNF605

zinc finger protein 605

chr16_+_64958025 0.800 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr3_-_135231417 0.799 SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr6_+_30002084 0.795


chr10_-_62882930 0.794 TMEM26
transmembrane protein 26
chr12_+_120132319 0.793 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr13_+_109757593 0.792 NM_001846
COL4A2
collagen, type IV, alpha 2
chr9_-_16860664 0.790 BNC2
basonuclin 2
chr19_-_10091534 0.789 NM_003755
EIF3G
eukaryotic translation initiation factor 3, subunit G
chr3_-_197201497 0.787 SDHAP1
SDHAP2
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2
chr13_+_97593411 0.787 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chrX_+_135057202 0.786 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr9_+_137532294 0.786 NM_016034
MRPS2
mitochondrial ribosomal protein S2
chr8_-_145090892 0.784 NM_201381
PLEC
plectin
chr3_+_52504410 0.784 STAB1
stabilin 1
chr2_-_25328452 0.782 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr3_-_170970296 0.781 NM_032487
ARPM1
actin related protein M1
chr4_-_122837590 0.779 NM_001154
ANXA5
annexin A5
chr12_+_120132233 0.776 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr12_+_130979696 0.774 NM_001002020
PUS1
pseudouridylate synthase 1
chr19_+_40224480 0.771 HPN
hepsin
chr5_+_148766632 0.770 LOC728264
hypothetical LOC728264
chr16_-_65984836 0.769 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr17_+_77261440 0.765 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr2_+_205118710 0.762 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr5_+_150380325 0.758 GPX3
glutathione peroxidase 3 (plasma)
chr9_-_13269562 0.756 MPDZ
multiple PDZ domain protein
chr10_-_133971136 0.756 NM_173575
STK32C
serine/threonine kinase 32C
chr6_-_154873344 0.754 CNKSR3
CNKSR family member 3
chr21_+_45649719 0.751


chr3_-_66634031 0.748 LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr16_+_28893525 0.747 NM_001142448
NM_001142449
NM_001142450
NM_001142451
NM_032038
SPIN1
SPNS1




spindlin 1
spinster homolog 1 (Drosophila)




chr16_+_88512769 0.744 MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr5_+_179180447 0.741 NM_003900
SQSTM1
sequestosome 1
chr14_+_105024301 0.736 NM_001311
CRIP1
cysteine-rich protein 1 (intestinal)
chr11_-_900793 0.735 CHID1
chitinase domain containing 1
chr12_-_79855618 0.733 NM_004664
LIN7A
lin-7 homolog A (C. elegans)
chr1_-_27113018 0.733 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr3_+_99934227 0.733 NM_006100
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr20_+_61842880 0.729 SLC2A4RG
SLC2A4 regulator
chr5_+_179180509 0.728 SQSTM1
sequestosome 1
chr22_+_42651007 0.724 PNPLA3
patatin-like phospholipase domain containing 3
chr17_+_77261401 0.722 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr3_-_173010921 0.719 NM_001130081
NM_002662
PLD1

phospholipase D1, phosphatidylcholine-specific

chr17_+_77261457 0.717


chr10_+_123862430 0.716 TACC2
transforming, acidic coiled-coil containing protein 2
chr5_-_43593277 0.715 NM_183323
PAIP1
poly(A) binding protein interacting protein 1
chr1_+_148388719 0.711 NM_016274
PLEKHO1
pleckstrin homology domain containing, family O member 1
chr4_-_122837501 0.710 ANXA5
annexin A5
chr4_-_122837579 0.709 ANXA5
annexin A5
chrX_-_2428579 0.709 NM_001171135
ZBED1
zinc finger, BED-type containing 1
chr22_+_42650951 0.706 NM_025225
PNPLA3
patatin-like phospholipase domain containing 3
chr4_+_4912272 0.706 NM_002448
MSX1
msh homeobox 1
chr5_+_179180517 0.703 SQSTM1
sequestosome 1
chr18_-_5533967 0.703 NM_012307
EPB41L3
erythrocyte membrane protein band 4.1-like 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.81 3.20e-02 GO:0032870 cellular response to hormone stimulus
1.13 3.88e-02 GO:0050794 regulation of cellular process
1.89 4.28e-02 GO:0030036 actin cytoskeleton organization
1.48 4.38e-02 GO:0031399 regulation of protein modification process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.71 3.86e-02 GO:0015629 actin cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 1.60e-09 GO:0005515 protein binding
1.09 1.61e-06 GO:0005488 binding
1.51 3.53e-03 GO:0019899 enzyme binding
1.79 5.00e-03 GO:0003779 actin binding
2.50 4.44e-02 GO:0031625 ubiquitin protein ligase binding