Motif ID: FOXO1,3,4.p2

Z-value: 1.687


Transcription factors associated with FOXO1,3,4.p2:

Gene SymbolEntrez IDGene Name
FOXO1 2308 forkhead box O1
FOXO3 2309 forkhead box O3
FOXO4 4303 forkhead box O4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXO3chr6_+_1089877030.514.3e-02Click!
FOXO4chrX_+_70232362-0.078.0e-01Click!
FOXO1chr13_-_401386070.078.1e-01Click!


Activity profile for motif FOXO1,3,4.p2.

activity profile for motif FOXO1,3,4.p2


Sorted Z-values histogram for motif FOXO1,3,4.p2

Sorted Z-values for motif FOXO1,3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXO1,3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_32578513 3.480 FGD4
FYVE, RhoGEF and PH domain containing 4
chr10_+_86174665 3.299 FAM190B
family with sequence similarity 190, member B
chr6_-_152744143 3.249 SYNE1
spectrin repeat containing, nuclear envelope 1
chr5_+_66160359 3.132 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr6_-_48186868 2.786 C6orf138
chromosome 6 open reading frame 138
chr7_+_134114957 2.743 CALD1
caldesmon 1
chr4_-_186934059 2.693 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr5_-_58607673 2.644 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_+_120167264 2.571 SYNPO2
synaptopodin 2
chr5_-_59100194 2.513 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr9_+_74956614 2.464 ANXA1
annexin A1
chr9_+_130719034 2.421 LRRC8A
leucine rich repeat containing 8 family, member A
chr4_+_26194643 2.321 NM_018317
TBC1D19
TBC1 domain family, member 19
chrX_-_19598912 2.266 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr13_-_98428244 2.191 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr9_+_102231616 2.187 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr6_-_105734535 2.150 NM_022361
POPDC3
popeye domain containing 3
chr2_-_162808123 2.089 NM_004460
FAP
fibroblast activation protein, alpha
chr4_+_120167721 1.974 SYNPO2
synaptopodin 2
chr5_+_36644187 1.968 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_-_152744022 1.966 SYNE1
spectrin repeat containing, nuclear envelope 1
chr7_+_75892187 1.901 NM_001110354
ZP3
zona pellucida glycoprotein 3 (sperm receptor)
chr4_-_159311959 1.892 FAM198B
family with sequence similarity 198, member B
chr3_+_100840129 1.862 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr9_+_119506428 1.825 TLR4
toll-like receptor 4
chr8_-_13178399 1.792 DLC1
deleted in liver cancer 1
chr9_-_16717887 1.721 BNC2
basonuclin 2
chr2_-_192419896 1.701 SDPR
serum deprivation response
chr9_+_119506446 1.681 TLR4
toll-like receptor 4
chr9_+_119506274 1.670 NM_138554
TLR4
toll-like receptor 4
chr11_+_113436438 1.670 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr4_-_152368492 1.669 SH3D19
SH3 domain containing 19
chr4_+_86968069 1.669 ARHGAP24
Rho GTPase activating protein 24
chr9_+_112470871 1.652 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr13_+_92677012 1.649 NM_005708
GPC6
glypican 6
chr8_-_13178327 1.648


chr1_+_162795538 1.639 PBX1
pre-B-cell leukemia homeobox 1
chr8_+_70567634 1.632 SULF1
sulfatase 1
chr16_+_54070302 1.606 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr9_+_74956601 1.531 ANXA1
annexin A1
chr5_-_125958503 1.517 NM_001182
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr1_-_7998265 1.509 ERRFI1
ERBB receptor feedback inhibitor 1
chr9_+_5500544 1.493 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr6_-_117853710 1.477 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr2_-_192420168 1.457 NM_004657
SDPR
serum deprivation response
chr10_-_29963847 1.419


chr9_+_696744 1.413 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr7_+_18515440 1.412 HDAC9
histone deacetylase 9
chr7_-_158304062 1.401 ESYT2
extended synaptotagmin-like protein 2
chr7_+_134114912 1.399 CALD1
caldesmon 1
chr19_-_54557450 1.383 NM_003598
TEAD2
TEA domain family member 2
chr7_+_18515488 1.358 HDAC9
histone deacetylase 9
chr6_+_131498540 1.355 AKAP7
A kinase (PRKA) anchor protein 7
chr5_-_125956996 1.318 ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr6_-_131333173 1.272 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr5_+_125786975 1.263 GRAMD3
GRAM domain containing 3
chr7_-_94902149 1.258 NM_000305
NM_001018161
PON2

paraoxonase 2

chr10_+_91077581 1.251 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr11_+_101488380 1.240 NM_001195045
YAP1
Yes-associated protein 1
chr3_+_156280497 1.227 MME
membrane metallo-endopeptidase
chr4_+_124540114 1.206 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr2_-_160764819 1.205 NM_000888
ITGB6
integrin, beta 6
chr3_+_156280539 1.205 MME
membrane metallo-endopeptidase
chr8_-_134378630 1.204 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr9_+_74956494 1.199 NM_000700
ANXA1
annexin A1
chr12_+_52665196 1.191 NM_017409
HOXC10
homeobox C10
chr9_-_109291575 1.176 KLF4
Kruppel-like factor 4 (gut)
chr11_-_85074848 1.176 NM_152723
CCDC89
coiled-coil domain containing 89
chr4_-_177353707 1.156 NM_144644
SPATA4
spermatogenesis associated 4
chr22_+_24468110 1.150 NM_032608
MYO18B
myosin XVIIIB
chr5_+_98132898 1.149 NM_001012761
RGMB
RGM domain family, member B
chr22_+_24468168 1.134 MYO18B
myosin XVIIIB
chr4_+_86918870 1.129 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr21_+_29439768 1.117 C21orf7
chromosome 21 open reading frame 7
chr1_+_86662356 1.115 NM_006536
CLCA2
chloride channel accessory 2
chr7_+_111908143 1.102 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr1_-_115039614 1.101 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr6_+_136214495 1.094 NM_018945
PDE7B
phosphodiesterase 7B
chr12_+_55201854 1.079 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr2_+_138438277 1.078 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr8_-_133841988 1.078 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr3_-_71262426 1.073 FOXP1
forkhead box P1
chr3_+_156280604 1.065 NM_007288
MME
membrane metallo-endopeptidase
chr6_-_56615544 1.065 NM_001723
NM_015548
DST

dystonin

chr6_+_123152044 1.060 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr3_-_170347019 1.059 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr3_-_71262405 1.056 FOXP1
forkhead box P1
chr14_-_74669864 1.055 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr11_-_8695974 1.055 ST5
suppression of tumorigenicity 5
chr6_-_127822227 1.050 NM_014702
KIAA0408
KIAA0408
chr3_-_170346760 1.036 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr6_+_121798443 1.032 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr1_+_162795328 1.032 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr12_-_50871953 1.026 NM_001081492
NM_182507
KRT80

keratin 80

chr13_-_37341859 1.011 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr4_+_86918882 0.997 ARHGAP24
Rho GTPase activating protein 24
chr10_+_24795465 0.992 KIAA1217
KIAA1217
chr10_+_24795446 0.987 KIAA1217
KIAA1217
chr8_+_70567581 0.982 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr12_+_119224506 0.982 NM_012240
SIRT4
sirtuin 4
chr8_+_19215279 0.979 NM_001174160
NM_022071
NM_001174159
SH2D4A


SH2 domain containing 4A


chr12_-_6356783 0.972 NM_001159575
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr9_+_12764988 0.968 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr1_-_56817823 0.964 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_56817568 0.962 PPAP2B
phosphatidic acid phosphatase type 2B
chr13_-_35818491 0.953 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr9_-_36266930 0.948 NM_001128227
NM_001190388
GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chr9_+_129900637 0.941 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr12_-_27126721 0.938 NM_001080406
C12orf71
chromosome 12 open reading frame 71
chr3_+_190990142 0.929 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr2_-_151052391 0.926 NM_005168
RND3
Rho family GTPase 3
chr2_-_189752575 0.921 NM_000393
COL5A2
collagen, type V, alpha 2
chr5_+_140546839 0.920 NM_019119
PCDHB9
protocadherin beta 9
chr9_-_14769530 0.919 NM_001177704
FREM1
FRAS1 related extracellular matrix 1
chr1_+_161308318 0.907 NM_001113380
RGS4
regulator of G-protein signaling 4
chr13_-_35818396 0.906 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr11_+_36572615 0.900 NM_138787
C11orf74
chromosome 11 open reading frame 74
chr8_-_130868315 0.900 NM_031415
GSDMC
gasdermin C
chr3_+_139550368 0.899 MRAS
muscle RAS oncogene homolog
chr1_+_144236398 0.894 ITGA10
integrin, alpha 10
chr13_-_47885018 0.890 LPAR6
lysophosphatidic acid receptor 6
chr3_+_156280772 0.890 NM_007289
MME
membrane metallo-endopeptidase
chr3_-_58497913 0.888 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr3_-_150533948 0.886 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chrX_+_102498035 0.880 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr7_+_120416103 0.872 C7orf58
chromosome 7 open reading frame 58
chr11_+_114054409 0.870 NM_182495
FAM55B
family with sequence similarity 55, member B
chr20_+_44771532 0.869 NM_030777
SLC2A10
solute carrier family 2 (facilitated glucose transporter), member 10
chr12_-_8706533 0.868 MFAP5
microfibrillar associated protein 5
chr16_+_68516401 0.854 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr6_-_80303822 0.850 NM_001122769
NM_181714
LCA5

Leber congenital amaurosis 5

chr12_-_8706637 0.847 NM_003480
MFAP5
microfibrillar associated protein 5
chr9_+_129900590 0.842 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr18_-_20105900 0.842 OSBPL1A
oxysterol binding protein-like 1A
chr2_+_36777336 0.842 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr5_-_151046638 0.841 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr7_+_120415958 0.839 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr1_-_23393808 0.835 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr1_-_159474503 0.834 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr18_-_21184824 0.834


chr10_-_99151003 0.828 NM_001145114
NM_015179
RRP12

ribosomal RNA processing 12 homolog (S. cerevisiae)

chr17_-_17816425 0.827 NM_001033551
NM_001082968
TOM1L2

target of myb1-like 2 (chicken)

chr1_-_56817802 0.827 PPAP2B
phosphatidic acid phosphatase type 2B
chr3_-_150569574 0.825 TM4SF1
transmembrane 4 L six family member 1
chr1_-_24342158 0.824 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr2_+_54411574 0.818 NM_001100396
C2orf73
chromosome 2 open reading frame 73
chr1_-_199732323 0.815 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr6_+_134800533 0.810 LOC154092
hypothetical LOC154092
chr12_-_8706746 0.805 MFAP5
microfibrillar associated protein 5
chr1_-_229071957 0.802 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr1_+_144236346 0.797 NM_003637
ITGA10
integrin, alpha 10
chr1_+_20788027 0.795 NM_001785
CDA
cytidine deaminase
chr11_+_112337199 0.792 NM_000615
NM_001076682
NM_181351
NCAM1


neural cell adhesion molecule 1


chr2_+_174968701 0.789 NM_001193528
NM_024583
SCRN3

secernin 3

chr3_-_113842652 0.782 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr12_+_12935222 0.781 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr3_+_42176662 0.780 NM_014965
TRAK1
trafficking protein, kinesin binding 1
chr8_+_12847521 0.758 NM_020844
KIAA1456
KIAA1456
chr9_-_8723893 0.758 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr10_-_105835525 0.757 COL17A1
collagen, type XVII, alpha 1
chr7_-_13997574 0.757 NM_001163148
ETV1
ets variant 1
chr3_-_113842553 0.755 CCDC80
coiled-coil domain containing 80
chr16_+_54072969 0.755 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr6_+_36752244 0.754 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr2_-_200033445 0.754 SATB2
SATB homeobox 2
chr2_+_36777406 0.749 VIT
vitrin
chr13_-_47885248 0.746 LPAR6
lysophosphatidic acid receptor 6
chr3_+_62280435 0.745 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr2_-_165768798 0.737 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr5_+_178419938 0.736 NM_014594
ZNF354C
zinc finger protein 354C
chr12_+_79625538 0.735 NM_002469
MYF6
myogenic factor 6 (herculin)
chr17_+_3326045 0.730 NM_000049
ASPA
aspartoacylase
chr5_+_125786717 0.729 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr11_+_834445 0.727 NM_001025237
TSPAN4
tetraspanin 4
chr1_-_56817717 0.727 PPAP2B
phosphatidic acid phosphatase type 2B
chr2_+_12774264 0.720 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr15_-_70288071 0.718 PKM2
pyruvate kinase, muscle
chr6_+_52393763 0.716 NM_001172420
EFHC1
EF-hand domain (C-terminal) containing 1
chr15_-_37999519 0.716


chr6_+_108988797 0.714 FOXO3
forkhead box O3
chr13_-_73605914 0.708 NM_007249
KLF12
Kruppel-like factor 12
chr21_+_36429079 0.708 NM_001236
CBR3
carbonyl reductase 3
chr2_+_189547358 0.705 COL3A1
collagen, type III, alpha 1
chr17_-_15495534 0.698 TRIM16
tripartite motif containing 16
chr9_-_74757735 0.696 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr2_+_174968751 0.695 SCRN3
secernin 3
chr2_+_202379442 0.692 NM_139158
CDK15
cyclin-dependent kinase 15
chr4_+_187227302 0.684 NM_003265
TLR3
toll-like receptor 3
chr17_+_1612056 0.679 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr3_-_15814678 0.677 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr9_+_130722994 0.675 NM_001100876
NM_174933
PHYHD1

phytanoyl-CoA dioxygenase domain containing 1

chr20_-_29751755 0.675


chr17_-_36469869 0.672 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr2_+_135526304 0.671 NM_001172435
NM_012233
RAB3GAP1

RAB3 GTPase activating protein subunit 1 (catalytic)

chr5_-_58688428 0.670 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr15_-_40537002 0.667 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr10_+_11087345 0.663 CELF2
CUGBP, Elav-like family member 2
chr15_+_97010219 0.662 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr13_+_96672705 0.654 MBNL2
muscleblind-like 2 (Drosophila)
chr8_+_107807415 0.653 NM_001198534
NM_001198535
OXR1

oxidation resistance 1


Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.65 8.69e-04 GO:0044420 extracellular matrix part
2.85 1.49e-02 GO:0005604 basement membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
11.07 4.49e-02 GO:0047023 androsterone dehydrogenase activity