Motif ID: SPIB.p2

Z-value: 4.186


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPIBchr19_+_556140060.766.1e-04Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_15005761 10.607 NM_001175
 ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr17_+_44643067 8.462 ABI3
ABI family, member 3
chr17_-_40843530 7.165 ARHGAP27
Rho GTPase activating protein 27
chr6_-_32268267 6.407 GPSM3
G-protein signaling modulator 3
chr2_-_175207521 5.936 NM_003387
 WIPF1
WAS/WASL interacting protein family, member 1
chr17_-_44642934 5.381 NM_001198754
 GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chrX_+_48427137 5.144 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr11_+_63864263 4.882 NM_032251
 CCDC88B
coiled-coil domain containing 88B
chrX_+_48427103 4.834 NM_000377
 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr6_-_11490487 4.721 NM_001142393
 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr19_+_3129735 4.644 NM_003775
 S1PR4
sphingosine-1-phosphate receptor 4
chr19_-_40925151 4.577 NM_024660
 TMEM149
transmembrane protein 149
chr14_+_99601517 4.577 EVL
Enah/Vasp-like
chr14_+_99601498 4.544 NM_016337
 EVL
Enah/Vasp-like
chr7_+_128367961 4.521 NM_001098627
 IRF5
interferon regulatory factor 5
chr6_-_32742265 4.499 NM_002123
 HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr17_+_37693090 4.262 NM_003152
 STAT5A
signal transducer and activator of transcription 5A
chr6_-_159386007 4.243 NM_054114
NM_138810
NM_152133
 TAGAP


T-cell activation RhoGTPase activating protein


chr6_-_32268615 4.028 GPSM3
G-protein signaling modulator 3
chr3_-_113701073 4.022 NM_001085357
NM_181780
 BTLA

B and T lymphocyte associated


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 35 entries
enrichment   p-value GO term description
1.92 1.53e-02 GO:0050851 antigen receptor-mediated signaling pathway
1.84 1.40e-03 GO:0050870 positive regulation of T cell activation
1.83 1.42e-02 GO:0042110 T cell activation
1.81 1.76e-04 GO:0051251 positive regulation of lymphocyte activation
1.79 3.16e-04 GO:0050863 regulation of T cell activation
1.78 1.52e-04 GO:0050867 positive regulation of cell activation
1.76 3.76e-04 GO:0002696 positive regulation of leukocyte activation
1.73 1.37e-04 GO:0051249 regulation of lymphocyte activation
1.69 8.21e-05 GO:0050865 regulation of cell activation
1.68 2.12e-04 GO:0002694 regulation of leukocyte activation
1.68 3.82e-03 GO:0046649 lymphocyte activation
1.65 1.68e-02 GO:0002764 immune response-regulating signaling pathway
1.64 3.00e-02 GO:0002757 immune response-activating signal transduction
1.61 3.14e-03 GO:0045321 leukocyte activation
1.45 8.18e-04 GO:0001775 cell activation
1.45 2.99e-03 GO:0002684 positive regulation of immune system process
1.44 7.64e-13 GO:0002376 immune system process
1.43 3.40e-06 GO:0006955 immune response
1.40 1.46e-04 GO:0002682 regulation of immune system process
1.39 4.92e-02 GO:0050776 regulation of immune response

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
2.83 2.14e-02 GO:0070603 SWI/SNF-type complex
1.93 4.85e-02 GO:0030117 membrane coat
1.93 4.85e-02 GO:0048475 coated membrane
1.53 1.43e-02 GO:0016604 nuclear body
1.37 3.41e-03 GO:0030529 ribonucleoprotein complex
1.31 4.57e-07 GO:0005654 nucleoplasm
1.25 8.96e-07 GO:0031981 nuclear lumen
1.22 4.66e-06 GO:0044428 nuclear part
1.19 1.22e-04 GO:0031974 membrane-enclosed lumen
1.18 2.87e-04 GO:0043233 organelle lumen
1.18 5.41e-04 GO:0070013 intracellular organelle lumen
1.18 1.56e-03 GO:0005829 cytosol
1.13 9.10e-07 GO:0005634 nucleus
1.11 1.10e-04 GO:0044422 organelle part
1.11 1.31e-04 GO:0044446 intracellular organelle part
1.08 2.88e-05 GO:0043227 membrane-bounded organelle
1.08 3.44e-05 GO:0043231 intracellular membrane-bounded organelle
1.07 2.30e-05 GO:0043226 organelle
1.07 2.42e-05 GO:0043229 intracellular organelle
1.06 3.10e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
1.39 3.42e-02 GO:0003712 transcription cofactor activity
1.39 3.92e-02 GO:0000988 protein binding transcription factor activity
1.39 3.92e-02 GO:0000989 transcription factor binding transcription factor activity
1.32 5.47e-04 GO:0003723 RNA binding
1.17 1.68e-05 GO:0003676 nucleic acid binding
1.16 1.36e-02 GO:0003677 DNA binding
1.12 5.57e-10 GO:0005515 protein binding
1.05 1.18e-04 GO:0005488 binding