Motif ID: TFAP2B.p2

Z-value: 3.823


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Bchr6_+_50894397-0.351.8e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_5533967 6.173 NM_012307
 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr19_+_39664706 4.813 NM_001080436
 WTIP
Wilms tumor 1 interacting protein
chr2_-_127580975 4.465 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
 BIN1









bridging integrator 1









chr7_-_139987044 4.424 DENND2A
DENN/MADD domain containing 2A
chr20_+_56701224 4.122 NM_024663
 NPEPL1
aminopeptidase-like 1
chr5_+_10617431 3.846 NM_001164440
 ANKRD33B
ankyrin repeat domain 33B
chr11_+_93917214 3.474 FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chrX_+_9943793 3.458 NM_015691
 WWC3
WWC family member 3
chr2_-_160972606 3.419 RBMS1
RNA binding motif, single stranded interacting protein 1
chr3_-_130807865 3.396 NM_015103
 PLXND1
plexin D1
chr16_-_79395379 3.382 NM_152342
 CDYL2
chromodomain protein, Y-like 2
chr19_-_1518875 3.288 NM_001174118
NM_203304
 MEX3D

mex-3 homolog D (C. elegans)

chr7_+_1536847 3.264 NM_002360
 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr9_-_38059082 3.067 SHB
Src homology 2 domain containing adaptor protein B
chr17_+_78630793 3.039 NM_001004431
 METRNL
meteorin, glial cell differentiation regulator-like
chr22_-_48607449 2.991 BRD1
bromodomain containing 1
chr14_+_105012106 2.905 NM_001312
 CRIP2
cysteine-rich protein 2
chr17_-_74432800 2.799 TIMP2
TIMP metallopeptidase inhibitor 2
chr1_+_148388870 2.767 PLEKHO1
pleckstrin homology domain containing, family O member 1
chr19_+_16296632 2.702 NM_016270
 KLF2
Kruppel-like factor 2 (lung)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 123 entries
enrichment   p-value GO term description
1.76 3.91e-02 GO:0007173 epidermal growth factor receptor signaling pathway
1.68 2.95e-03 GO:0007265 Ras protein signal transduction
1.57 4.10e-05 GO:0048011 nerve growth factor receptor signaling pathway
1.54 3.67e-02 GO:0031344 regulation of cell projection organization
1.51 3.23e-04 GO:0030036 actin cytoskeleton organization
1.47 1.45e-02 GO:0045786 negative regulation of cell cycle
1.46 1.35e-04 GO:0060284 regulation of cell development
1.45 8.58e-08 GO:0000904 cell morphogenesis involved in differentiation
1.44 3.15e-04 GO:0007411 axon guidance
1.44 1.26e-02 GO:0050767 regulation of neurogenesis
1.43 2.51e-07 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.43 1.89e-05 GO:0007409 axonogenesis
1.43 1.27e-04 GO:0051056 regulation of small GTPase mediated signal transduction
1.42 4.90e-08 GO:0000902 cell morphogenesis
1.42 2.78e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.41 2.48e-05 GO:0048812 neuron projection morphogenesis
1.41 9.39e-03 GO:0030029 actin filament-based process
1.40 8.81e-08 GO:0032989 cellular component morphogenesis
1.40 6.10e-04 GO:0007264 small GTPase mediated signal transduction
1.39 1.36e-07 GO:0007167 enzyme linked receptor protein signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 20 of 47 entries
enrichment   p-value GO term description
2.07 4.39e-03 GO:0000118 histone deacetylase complex
2.04 2.18e-03 GO:0017053 transcriptional repressor complex
2.01 3.02e-05 GO:0031256 leading edge membrane
1.73 4.50e-02 GO:0030426 growth cone
1.72 4.07e-02 GO:0030427 site of polarized growth
1.71 2.43e-06 GO:0005912 adherens junction
1.66 1.62e-03 GO:0030055 cell-substrate junction
1.64 3.16e-06 GO:0031252 cell leading edge
1.64 5.09e-03 GO:0005924 cell-substrate adherens junction
1.63 1.06e-02 GO:0005925 focal adhesion
1.61 4.09e-05 GO:0070161 anchoring junction
1.39 2.58e-03 GO:0015629 actin cytoskeleton
1.36 4.65e-02 GO:0005635 nuclear envelope
1.34 2.21e-02 GO:0005773 vacuole
1.33 4.21e-07 GO:0044451 nucleoplasm part
1.30 1.15e-11 GO:0005654 nucleoplasm
1.30 2.12e-02 GO:0043005 neuron projection
1.29 2.73e-18 GO:0044428 nuclear part
1.28 5.64e-14 GO:0031981 nuclear lumen
1.25 1.39e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
1.56 4.20e-03 GO:0003714 transcription corepressor activity
1.49 9.35e-06 GO:0008134 transcription factor binding
1.42 2.90e-05 GO:0000988 protein binding transcription factor activity
1.42 2.90e-05 GO:0000989 transcription factor binding transcription factor activity
1.42 3.51e-04 GO:0016563 transcription activator activity
1.41 4.16e-05 GO:0003712 transcription cofactor activity
1.40 2.07e-03 GO:0016564 transcription repressor activity
1.35 1.27e-02 GO:0003779 actin binding
1.32 2.47e-04 GO:0008092 cytoskeletal protein binding
1.32 2.48e-03 GO:0030695 GTPase regulator activity
1.31 6.09e-03 GO:0019904 protein domain specific binding
1.31 1.12e-02 GO:0004674 protein serine/threonine kinase activity
1.30 8.23e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.26 6.41e-04 GO:0016301 kinase activity
1.26 1.14e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.26 1.17e-02 GO:0004672 protein kinase activity
1.25 7.17e-05 GO:0030528 transcription regulator activity
1.25 2.16e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.25 2.06e-03 GO:0019899 enzyme binding
1.24 1.69e-04 GO:0001071 nucleic acid binding transcription factor activity