Motif ID: NANOG.p2

Z-value: 1.063


Transcription factors associated with NANOG.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NANOGchr12_+_78332610.165.6e-01Click!


Activity profile for motif NANOG.p2.

activity profile for motif NANOG.p2


Sorted Z-values histogram for motif NANOG.p2

Sorted Z-values for motif NANOG.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_51025604 3.548 NM_001042481
FRMD6
FERM domain containing 6
chr2_+_17861266 3.238 NM_001105569
MSGN1
mesogenin 1
chr13_-_40491491 1.644 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_-_40491405 1.618 ELF1
E74-like factor 1 (ets domain transcription factor)
chr10_-_105835525 1.614 COL17A1
collagen, type XVII, alpha 1
chr6_+_34314545 1.564 NM_145905
HMGA1
high mobility group AT-hook 1
chr10_-_105835609 1.461 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr12_-_15005761 1.360 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr10_-_13789628 1.284 FRMD4A
FERM domain containing 4A
chr14_+_77939845 1.217 NM_004796
NRXN3
neurexin 3
chr7_+_128802719 1.213 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr18_+_19826734 1.213 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr22_-_39189369 1.198 MKL1
megakaryoblastic leukemia (translocation) 1
chr12_-_51114372 1.141 NM_004693
KRT75
keratin 75
chr2_+_170742900 1.131 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr2_+_157822355 1.112 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chrX_+_134482212 1.092 NM_182540
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr15_+_38849450 1.077 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr3_+_123279439 1.065 NM_006889
CD86
CD86 molecule
chr3_+_161040439 1.048 SCHIP1
schwannomin interacting protein 1
chr10_+_11246934 1.044 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr17_-_53849888 1.034 RNF43
ring finger protein 43
chr1_+_165565006 1.027 POU2F1
POU class 2 homeobox 1
chr3_+_161040343 1.020 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr11_-_58736897 0.981 NM_001039396
MPEG1
macrophage expressed 1
chr7_+_50318801 0.956 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr1_+_165564904 0.940 NM_001198783
POU2F1
POU class 2 homeobox 1
chr6_-_32605898 0.935 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr8_-_10550026 0.914 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr12_+_25096472 0.892 NM_006152
LRMP
lymphoid-restricted membrane protein
chr12_-_51200347 0.866 NM_000424
KRT5
keratin 5
chr11_-_110755112 0.856 POU2AF1
POU class 2 associating factor 1
chr12_+_25096755 0.833 LRMP
lymphoid-restricted membrane protein
chr1_+_196874839 0.825 PTPRC
protein tyrosine phosphatase, receptor type, C
chr11_-_56951628 0.822 NM_017611
SLC43A3
solute carrier family 43, member 3
chr7_-_25234582 0.816 NM_022150
NPVF
neuropeptide VF precursor
chr1_+_196874759 0.811 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr2_+_108604111 0.809 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr1_+_180836050 0.806


chr11_-_118405288 0.803 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr17_-_53849929 0.795 NM_017763
RNF43
ring finger protein 43
chr6_-_32665409 0.791 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr13_-_93929719 0.789 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr7_+_113853790 0.787 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr11_-_83071084 0.782 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chrX_+_134482387 0.778 DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr3_-_57209319 0.708 NM_003865
HESX1
HESX homeobox 1
chr3_-_145049853 0.705 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr17_-_78391178 0.703 NM_024702
ZNF750
zinc finger protein 750
chr10_+_82290554 0.701 NM_001145719
SH2D4B
SH2 domain containing 4B
chr18_+_27281729 0.691 NM_001944
DSG3
desmoglein 3
chr17_-_36165050 0.689 NM_181534
KRT25
keratin 25
chr16_-_21221872 0.685 NM_001014444
NM_001888
CRYM

crystallin, mu

chr13_-_83354474 0.651 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr13_-_83354425 0.631 SLITRK1
SLIT and NTRK-like family, member 1
chr11_+_58146721 0.630 NM_000614
CNTF
ciliary neurotrophic factor
chr6_+_34312906 0.619 HMGA1
high mobility group AT-hook 1
chr18_+_54039730 0.618 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr3_+_154362726 0.615 RAP2B
RAP2B, member of RAS oncogene family
chr4_+_77575276 0.609 NM_020859
SHROOM3
shroom family member 3
chr6_-_26343139 0.589 NM_005320
HIST1H1D
histone cluster 1, H1d
chr13_-_98708549 0.584 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr1_-_42157077 0.582 NM_001127714
NM_024503
HIVEP3

human immunodeficiency virus type I enhancer binding protein 3

chr11_-_123353607 0.577 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr1_-_42156957 0.568 HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr18_+_54039818 0.567 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr13_+_23042722 0.566 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr3_-_152517204 0.563 NM_023915
GPR87
G protein-coupled receptor 87
chr3_+_113200696 0.562 NM_001008273
TAGLN3
transgelin 3
chrX_+_55951280 0.558


chr9_-_5294579 0.547 NM_005059
NM_134441
RLN2

relaxin 2

chr18_+_54039779 0.541 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr5_+_169713458 0.529 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr2_-_98646367 0.526 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr6_+_32713160 0.525 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr6_+_44076281 0.524 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr2_-_55090759 0.513 NM_007008
RTN4
reticulon 4
chr3_+_190990142 0.507 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr12_+_45896511 0.503 FAM113B
family with sequence similarity 113, member B
chr1_-_42156913 0.502


chr3_-_110155237 0.499 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr18_+_55718171 0.492 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr13_+_108079570 0.480 NM_001198950
MYO16
myosin XVI
chr5_-_56814310 0.477 NM_001017992
ACTBL2
actin, beta-like 2
chr14_+_75907442 0.475 NM_004452
ESRRB
estrogen-related receptor beta
chr14_-_56342097 0.472 NM_172337
OTX2
orthodenticle homeobox 2
chr3_-_120861959 0.470 NM_022135
POPDC2
popeye domain containing 2
chr7_-_13992351 0.460 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr19_+_40632456 0.459 NM_005306
FFAR2
free fatty acid receptor 2
chr17_-_39094787 0.458 NM_001040002
MEOX1
mesenchyme homeobox 1
chr6_-_112033752 0.452 TRAF3IP2
TRAF3 interacting protein 2
chr10_-_123346148 0.450 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr18_-_26996742 0.444 NM_004948
NM_024421
DSC1

desmocollin 1

chr11_+_59979857 0.444 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr3_+_113200275 0.443 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr4_-_40631397 0.437 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr1_+_158636987 0.431 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr1_-_230717850 0.428 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr1_-_108032645 0.423 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr18_+_13601664 0.421 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr12_+_47205681 0.418 NM_001005203
OR8S1
olfactory receptor, family 8, subfamily S, member 1
chr9_+_129066576 0.414 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr1_-_149004852 0.407 CTSS
cathepsin S
chr6_-_32742265 0.402 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr3_+_138132006 0.401 NM_001190796
NCK1
NCK adaptor protein 1
chr17_-_74244539 0.398


chr4_-_83566246 0.398 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr6_-_42798286 0.397 NM_000322
PRPH2
peripherin 2 (retinal degeneration, slow)
chr6_-_116973465 0.395 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr7_+_63411813 0.394 ZNF736
zinc finger protein 736
chr4_+_110968594 0.383 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr8_+_32905027 0.376


chr4_+_169250281 0.370 NM_007193
ANXA10
annexin A10
chr8_-_102029997 0.369 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr2_+_113542017 0.367 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chrX_-_116991728 0.366 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chr5_-_168204430 0.365


chr7_+_116447527 0.363 ST7
suppression of tumorigenicity 7
chr11_-_119514058 0.358 NM_012101
TRIM29
tripartite motif containing 29
chr1_+_42920635 0.356 NM_004559
YBX1
Y box binding protein 1
chr13_+_47948586 0.355 RB1
retinoblastoma 1
chr19_+_7874701 0.355 MAP2K7
mitogen-activated protein kinase kinase 7
chr6_-_112033775 0.355 TRAF3IP2
TRAF3 interacting protein 2
chr6_+_88026338 0.352 ZNF292
zinc finger protein 292
chr12_+_8167494 0.349 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chr19_-_56147971 0.342 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr10_+_47216925 0.342 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr1_+_50342168 0.340 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_-_149004916 0.338 NM_004079
CTSS
cathepsin S
chr3_+_2528272 0.337 CNTN4
contactin 4
chr18_+_18989786 0.337 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr6_+_34312979 0.335 HMGA1
high mobility group AT-hook 1
chr7_-_107930170 0.332 PNPLA8
patatin-like phospholipase domain containing 8
chr5_-_169657395 0.330 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr6_+_135544214 0.330 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chrX_-_10761729 0.330 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr8_+_26206648 0.329 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr22_+_38652555 0.329 GRAP2
GRB2-related adaptor protein 2
chr17_-_9635325 0.327 NM_001105571
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr20_+_58004811 0.321 NM_021810
CDH26
cadherin 26
chr15_-_75259714 0.320 PEAK1
NKF3 kinase family member
chr3_+_157877146 0.319 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr19_-_51829778 0.319 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr2_-_166638376 0.316 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chr11_+_7574992 0.314 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr11_-_123695302 0.313 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr14_+_69307914 0.312 SRSF5
serine/arginine-rich splicing factor 5
chr17_-_38529638 0.308 NM_007298
BRCA1
breast cancer 1, early onset
chr11_+_10433241 0.308 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr11_+_65164167 0.306 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr21_-_30460841 0.302 NM_012131
CLDN17
claudin 17
chr13_+_110637173 0.300 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr11_+_123986661 0.300 NM_052959
PANX3
pannexin 3
chr17_-_9870292 0.298 NM_001130831
GAS7
growth arrest-specific 7
chr6_+_34312633 0.297 HMGA1
high mobility group AT-hook 1
chr12_+_45896318 0.297 NM_138371
FAM113B
family with sequence similarity 113, member B
chr22_+_44828338 0.297


chr11_-_16380967 0.296 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr7_-_129379947 0.296 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

chr7_+_129693938 0.296 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr12_-_51065629 0.295 NM_033045
KRT84
keratin 84
chr15_-_74091817 0.294 NM_138573
NRG4
neuregulin 4
chrX_-_19727828 0.292 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr3_+_89239494 0.291 EPHA3
EPH receptor A3
chr1_+_50347188 0.290 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_+_50348052 0.290 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr8_+_24354387 0.289 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr6_-_112034166 0.286 NM_001164281
NM_147686
TRAF3IP2

TRAF3 interacting protein 2

chr3_-_122862391 0.284 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr10_-_21475493 0.278 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr1_-_6341553 0.278 NM_181866
ACOT7
acyl-CoA thioesterase 7
chr1_-_150328153 0.276 NM_001008536
TCHHL1
trichohyalin-like 1
chr10_+_49279647 0.276 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr12_-_55614311 0.276 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr12_+_14429499 0.275 ATF7IP
activating transcription factor 7 interacting protein
chr11_+_20005704 0.275 NAV2
neuron navigator 2
chr12_-_14740694 0.275 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr2_+_161980865 0.275 NM_006593
TBR1
T-box, brain, 1
chrX_-_133620103 0.273 NM_021796
PLAC1
placenta-specific 1
chr17_+_22823151 0.272 NM_014238
KSR1
kinase suppressor of ras 1
chr3_+_154362714 0.270 NM_002886
RAP2B
RAP2B, member of RAS oncogene family
chr1_+_196874867 0.269 PTPRC
protein tyrosine phosphatase, receptor type, C
chrX_+_110252960 0.269 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr16_+_55373241 0.266 NUP93
nucleoporin 93kDa
chrX_+_41191630 0.265 NM_022567
NYX
nyctalopin
chr9_-_85773899 0.261 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr12_-_107551783 0.261 NM_003006
SELPLG
selectin P ligand
chr7_+_18501876 0.260 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr6_+_34312641 0.259 HMGA1
high mobility group AT-hook 1
chr3_-_122862447 0.257 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr5_+_115415061 0.254 NM_001195581
LOC644100
hypothetical LOC644100
chr7_-_36992221 0.254 NM_130442
ELMO1
engulfment and cell motility 1
chr9_-_14076901 0.253 NFIB
nuclear factor I/B
chr9_+_12683385 0.251 NM_000550
TYRP1
tyrosinase-related protein 1
chr5_+_125786975 0.251 GRAMD3
GRAM domain containing 3
chr7_-_104696678 0.250 NM_182691
SRPK2
SRSF protein kinase 2
chr15_-_53349775 0.250 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr10_+_11247243 0.246 CELF2
CUGBP, Elav-like family member 2
chr11_+_117762432 0.244 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr18_+_59726183 0.244 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.35 2.36e-05 GO:0032501 multicellular organismal process
2.08 3.94e-05 GO:0007600 sensory perception
1.70 4.33e-05 GO:0003008 system process
1.73 5.60e-04 GO:0050877 neurological system process
1.35 4.84e-02 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
10.55 2.94e-03 GO:0042613 MHC class II protein complex
2.80 1.47e-02 GO:0005882 intermediate filament
3.69 2.59e-02 GO:0045095 keratin filament
2.55 3.51e-02 GO:0045111 intermediate filament cytoskeleton
1.26 4.86e-02 GO:0005886 plasma membrane
12.30 4.88e-02 GO:0033162 melanosome membrane
12.30 4.88e-02 GO:0045009 chitosome

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.88 8.42e-04 GO:0004930 G-protein coupled receptor activity
1.52 6.67e-03 GO:0004872 receptor activity
1.59 1.39e-02 GO:0004888 transmembrane receptor activity