Motif ID: GTF2I.p2

Z-value: 1.955


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2Ichr7_+_73709991-0.711.9e-03Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_68470585 5.242 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr9_+_108665168 4.207 NM_021224
ZNF462
zinc finger protein 462
chr12_-_113606322 3.974 NM_005996
NM_016569
TBX3

T-box 3

chr2_-_227371698 3.803 NM_005544
IRS1
insulin receptor substrate 1
chr4_-_177950658 3.512 NM_005429
VEGFC
vascular endothelial growth factor C
chr1_+_156229934 3.365 KIRREL
kin of IRRE like (Drosophila)
chr11_+_12355600 3.362 NM_018222
PARVA
parvin, alpha
chr22_-_34566210 3.209 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr1_-_20685314 3.197 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr19_-_36531958 3.108 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr1_-_20684858 3.061 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr22_-_34566276 2.949 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr16_-_63713382 2.912 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr2_-_19421852 2.802 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr11_-_66897584 2.787 NM_013246
CLCF1
cardiotrophin-like cytokine factor 1
chr16_-_63713485 2.777 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr16_-_63713466 2.773 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr3_-_187025438 2.609 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr1_-_72521079 2.451


chr6_-_10520592 2.424 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr9_+_138341752 2.380 NM_001145638
NM_015597
GPSM1

G-protein signaling modulator 1

chr21_-_27139563 2.349 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr21_-_27139143 2.344 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr17_+_58058774 2.291 MRC2
mannose receptor, C type 2
chr2_+_36436316 2.285 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr11_-_56846246 2.236 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr3_-_187025501 2.233 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr6_-_10520264 2.231 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr10_+_20145350 2.209 NM_032812
PLXDC2
plexin domain containing 2
chr11_-_78829342 2.199 NM_001098816
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
chr14_+_85069217 2.178


chr1_-_212791188 2.176 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr19_-_56178882 2.163 NM_139277
NM_005046
KLK7

kallikrein-related peptidase 7

chr11_-_66898223 2.130 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr18_+_44319365 2.114 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr1_-_212791597 2.037 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr1_-_212791467 2.028 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr1_-_72520735 2.011 NM_173808
NEGR1
neuronal growth regulator 1
chr3_-_121652183 1.974 NM_007085
FSTL1
follistatin-like 1
chr1_+_221955876 1.949 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr1_+_156229686 1.917 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr17_+_58058783 1.897 MRC2
mannose receptor, C type 2
chr11_-_122571198 1.887 NM_024769
CLMP
CXADR-like membrane protein
chr11_-_122571046 1.875 CLMP
CXADR-like membrane protein
chr10_-_33663777 1.833 NM_001024628
NM_001024629
NM_003873
NRP1


neuropilin 1


chr10_-_126839546 1.831 NM_001083914
CTBP2
C-terminal binding protein 2
chr3_+_37878647 1.810 NM_001008392
NM_005808
CTDSPL

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

chr9_-_16860719 1.800 NM_017637
BNC2
basonuclin 2
chr1_+_162795538 1.798 PBX1
pre-B-cell leukemia homeobox 1
chr12_+_55201854 1.772 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr22_-_34566367 1.772 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr22_-_34754343 1.771 NM_001082578
NM_001082579
RBFOX2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr17_+_58058479 1.763 NM_006039
MRC2
mannose receptor, C type 2
chr2_-_164300758 1.761 NM_018086
FIGN
fidgetin
chr4_-_158111916 1.750 PDGFC
platelet derived growth factor C
chr4_-_158111995 1.750 NM_016205
PDGFC
platelet derived growth factor C
chr12_-_51912101 1.735 NM_000966
RARG
retinoic acid receptor, gamma
chr12_+_6363482 1.730 NM_002342
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr1_+_85819004 1.728 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr5_-_178704934 1.714 ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr3_+_189354167 1.710 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr18_-_21184824 1.702


chr15_+_90197884 1.696 NM_001145044
NM_013272
SLCO3A1

solute carrier organic anion transporter family, member 3A1

chr1_-_68071635 1.679 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr1_-_150232900 1.676 S100A10
S100 calcium binding protein A10
chr6_+_45498354 1.676 RUNX2
runt-related transcription factor 2
chr2_+_100802923 1.666 NM_002518
NPAS2
neuronal PAS domain protein 2
chr10_+_114699953 1.659 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr10_-_126839056 1.629 NM_001329
CTBP2
C-terminal binding protein 2
chr3_-_64648703 1.617 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr12_+_52618815 1.607 NM_017410
HOXC13
homeobox C13
chr6_-_75972473 1.599 COL12A1
collagen, type XII, alpha 1
chrX_+_73557809 1.584 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr5_+_135392482 1.578 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr1_-_150233337 1.557 NM_002966
S100A10
S100 calcium binding protein A10
chr7_+_115952279 1.552 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr4_-_140696740 1.536 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr7_+_115952325 1.508 CAV1
caveolin 1, caveolae protein, 22kDa
chr8_-_122722674 1.499 NM_005328
HAS2
hyaluronan synthase 2
chrX_-_54538591 1.499 FGD1
FYVE, RhoGEF and PH domain containing 1
chr19_+_46416975 1.476 AXL
AXL receptor tyrosine kinase
chr11_-_27697768 1.467 NM_001143807
BDNF
brain-derived neurotrophic factor
chr4_-_158111504 1.459 PDGFC
platelet derived growth factor C
chr1_+_162795328 1.455 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr20_+_51023159 1.443 TSHZ2
teashirt zinc finger homeobox 2
chr16_+_56219802 1.435 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr7_-_32077504 1.426 NM_001191059
NM_005020
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr4_-_102487649 1.404 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr9_-_16860664 1.403 BNC2
basonuclin 2
chr19_-_242168 1.393 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr8_+_22513043 1.385 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr15_+_41597097 1.369 NM_002373
MAP1A
microtubule-associated protein 1A
chr1_+_202308814 1.367 NM_005686
SOX13
SRY (sex determining region Y)-box 13
chr2_+_85213884 1.366 NM_031283
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr6_+_1335067 1.359 NM_001452
FOXF2
forkhead box F2
chr3_-_31997738 1.358 OSBPL10
oxysterol binding protein-like 10
chr1_-_240754620 1.358 NM_152666
PLD5
phospholipase D family, member 5
chr1_+_199884152 1.348 NAV1
neuron navigator 1
chr13_-_32822759 1.347 STARD13
StAR-related lipid transfer (START) domain containing 13
chr22_-_35914200 1.341 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr4_+_30331289 1.320 PCDH7
protocadherin 7
chr19_-_54557450 1.318 NM_003598
TEAD2
TEA domain family member 2
chr7_-_27120015 1.309 HOXA3
homeobox A3
chr6_-_80713589 1.299 NM_022726
ELOVL4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr5_-_2804768 1.288 NM_001134222
NM_033267
IRX2

iroquois homeobox 2

chr7_+_73506172 1.285 GTF2IRD1
GTF2I repeat domain containing 1
chr4_+_184257337 1.271 NM_024949
WWC2
WW and C2 domain containing 2
chr19_-_60573552 1.261 NM_000641
IL11
interleukin 11
chr9_-_14304036 1.258 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr11_+_129823667 1.255 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr18_-_51406359 1.240 TCF4
transcription factor 4
chr6_+_45498262 1.229 RUNX2
runt-related transcription factor 2
chr7_-_27136876 1.226 NM_002141
HOXA4
homeobox A4
chr5_-_38881636 1.218


chr5_+_135392624 1.214 TGFBI
transforming growth factor, beta-induced, 68kDa
chr6_-_153494076 1.214 NM_012419
RGS17
regulator of G-protein signaling 17
chr1_-_208046011 1.211 NM_006147
IRF6
interferon regulatory factor 6
chr12_-_6354650 1.206 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr5_+_38881719 1.206 NM_003999
OSMR
oncostatin M receptor
chr1_+_199884072 1.199 NM_020443
NAV1
neuron navigator 1
chr7_-_28186671 1.193 JAZF1
JAZF zinc finger 1
chr14_+_22375632 1.191 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr4_+_30330963 1.190 NM_001173523
NM_002589
NM_032456
NM_032457
PCDH7



protocadherin 7



chr9_+_35528890 1.190 RUSC2
RUN and SH3 domain containing 2
chr5_+_38881716 1.189 NM_001168355
OSMR
oncostatin M receptor
chr7_-_78920806 1.187 NM_012301
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr19_+_60487578 1.175 BRSK1
BR serine/threonine kinase 1
chr7_+_33911636 1.173 NM_133468
BMPER
BMP binding endothelial regulator
chr15_-_69194854 1.172 NM_001102658
CT62
cancer/testis antigen 62
chr2_-_166358792 1.168 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr5_+_52812165 1.146 FST
follistatin
chr12_-_47468985 1.143 NM_020983
ADCY6
adenylate cyclase 6
chr19_-_242335 1.142 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr1_-_32940943 1.141 NM_001161708
NM_030786
SYNC

syncoilin, intermediate filament protein

chr17_+_45488356 1.141 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr6_+_45497796 1.134 NM_004348
RUNX2
runt-related transcription factor 2
chr22_+_44277354 1.132 NM_001996
NM_006485
NM_006486
NM_006487
FBLN1



fibulin 1



chr14_+_22375656 1.130 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr14_+_22375753 1.127 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr10_-_105604942 1.122 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr18_-_44189625 1.113 ZBTB7C
zinc finger and BTB domain containing 7C
chr14_+_22375747 1.113 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr4_-_115120251 1.109 NM_024590
ARSJ
arylsulfatase family, member J
chr8_+_22078817 1.106 BMP1
bone morphogenetic protein 1
chr3_+_61522310 1.102 PTPRG
protein tyrosine phosphatase, receptor type, G
chr9_+_35528628 1.102 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr1_-_29322993 1.099 NM_001003682
TMEM200B
transmembrane protein 200B
chr5_+_38882017 1.098 OSMR
oncostatin M receptor
chr9_-_112381593 1.093 NM_153366
SVEP1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr6_+_149109841 1.092 NM_005715
UST
uronyl-2-sulfotransferase
chr8_-_93184629 1.090 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr4_-_122063118 1.078 NM_018699
PRDM5
PR domain containing 5
chr5_+_52812236 1.071 NM_006350
NM_013409
FST

follistatin

chr5_+_92944680 1.070 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr2_-_56004366 1.064 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr17_-_43977273 1.057 NM_002145
HOXB2
homeobox B2
chr1_+_201862845 1.054 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr7_+_105304445 1.051 LOC100506768
CDHR3
hypothetical LOC100506768
cadherin-related family member 3
chr22_-_28972683 1.043 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr2_+_188864975 1.041 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr14_-_60185659 1.025 NM_005982
SIX1
SIX homeobox 1
chr8_+_30361485 1.020 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr2_+_85834111 1.010 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr9_+_117955890 1.009 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr14_-_104507862 1.007 AHNAK2
AHNAK nucleoprotein 2
chr22_+_29974314 1.005 NM_001031801
NM_016733
LIMK2

LIM domain kinase 2

chr8_-_116750427 1.005 TRPS1
trichorhinophalangeal syndrome I
chr19_+_38979502 1.003 NM_001129994
NM_001129995
NM_024076
KCTD15


potassium channel tetramerisation domain containing 15


chr16_-_71650034 1.003 NM_001164766
ZFHX3
zinc finger homeobox 3
chr1_-_32940850 1.000 SYNC
syncoilin, intermediate filament protein
chr12_-_6354818 1.000 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr3_+_113061330 1.000 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr7_-_105304159 0.999 NM_020725
NM_152749
ATXN7L1

ataxin 7-like 1

chr3_+_113061296 0.998 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr5_-_146813343 0.995 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr3_+_113061218 0.993 NM_001134439
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr2_-_161058550 0.993 NM_002897
NM_016836
RBMS1

RNA binding motif, single stranded interacting protein 1

chr17_+_30594192 0.990 NM_144975
SLFN5
schlafen family member 5
chr10_-_33663305 0.984 NRP1
neuropilin 1
chr1_+_182622987 0.979 C1orf21
chromosome 1 open reading frame 21
chr8_-_116750277 0.978 NM_014112
TRPS1
trichorhinophalangeal syndrome I
chr22_-_26527469 0.978 NM_002430
MN1
meningioma (disrupted in balanced translocation) 1
chr12_-_24606616 0.978 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr5_-_59100194 0.969 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_+_15957832 0.966 NM_017556
FBLIM1
filamin binding LIM protein 1
chr7_-_28186867 0.964 NM_175061
JAZF1
JAZF zinc finger 1
chr1_-_150232927 0.959 S100A10
S100 calcium binding protein A10
chr11_-_8849485 0.958 ST5
suppression of tumorigenicity 5
chr7_-_5429702 0.955 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr1_-_225572419 0.953 NM_003607
NM_014826
CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)

chr5_-_72780107 0.951 NM_004472
FOXD1
forkhead box D1
chr21_+_38550533 0.948 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr17_-_40263124 0.942 NM_005497
GJC1
gap junction protein, gamma 1, 45kDa
chr7_+_93862137 0.942 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr14_-_60260211 0.941 NM_017420
SIX4
SIX homeobox 4
chr14_-_60260780 0.940 SIX4
SIX homeobox 4
chr18_-_51406841 0.939 NM_001083962
NM_003199
TCF4

transcription factor 4

chr5_+_17270781 0.936 BASP1
brain abundant, membrane attached signal protein 1
chr16_+_12902955 0.933 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr14_+_74815233 0.925 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.19 4.65e-29 GO:0050794 regulation of cellular process
1.17 4.85e-27 GO:0050789 regulation of biological process
1.16 6.35e-26 GO:0065007 biological regulation
1.27 4.28e-25 GO:0032502 developmental process
1.32 1.45e-24 GO:0048731 system development
1.29 2.87e-23 GO:0048856 anatomical structure development
1.27 2.09e-22 GO:0007275 multicellular organismal development
1.43 2.60e-21 GO:0009653 anatomical structure morphogenesis
1.42 1.53e-19 GO:0007399 nervous system development
1.24 8.70e-19 GO:0023052 signaling
1.25 2.54e-18 GO:0007165 signal transduction
1.28 1.39e-17 GO:0048518 positive regulation of biological process
1.51 3.89e-17 GO:0022008 neurogenesis
1.51 5.89e-16 GO:0048699 generation of neurons
1.29 8.06e-16 GO:0048522 positive regulation of cellular process
1.35 2.79e-15 GO:0023051 regulation of signaling
1.20 7.54e-15 GO:0051716 cellular response to stimulus
1.38 8.36e-15 GO:0009966 regulation of signal transduction
1.29 1.16e-13 GO:0048523 negative regulation of cellular process
1.29 1.64e-13 GO:0048869 cellular developmental process
1.29 3.63e-13 GO:0030154 cell differentiation
1.61 2.69e-12 GO:0031175 neuron projection development
1.64 2.74e-12 GO:0048812 neuron projection morphogenesis
1.08 3.05e-12 GO:0009987 cellular process
1.26 6.24e-12 GO:0048519 negative regulation of biological process
1.29 6.62e-12 GO:0048583 regulation of response to stimulus
1.54 1.50e-11 GO:0000902 cell morphogenesis
1.58 2.54e-11 GO:0032990 cell part morphogenesis
1.51 2.83e-11 GO:0030030 cell projection organization
1.52 3.00e-11 GO:0032989 cellular component morphogenesis
1.49 3.09e-11 GO:0030182 neuron differentiation
1.54 3.73e-11 GO:0048666 neuron development
1.58 3.73e-11 GO:0048858 cell projection morphogenesis
1.56 2.45e-10 GO:0000904 cell morphogenesis involved in differentiation
1.61 3.63e-10 GO:0007409 axonogenesis
1.27 3.82e-10 GO:0048513 organ development
1.60 4.53e-10 GO:0048667 cell morphogenesis involved in neuron differentiation
1.48 9.23e-10 GO:0007167 enzyme linked receptor protein signaling pathway
1.39 4.23e-09 GO:0048468 cell development
1.39 4.78e-09 GO:0050793 regulation of developmental process
1.43 7.17e-09 GO:2000026 regulation of multicellular organismal development
1.40 9.14e-09 GO:0051128 regulation of cellular component organization
1.18 5.64e-08 GO:0016043 cellular component organization
1.32 8.15e-08 GO:0010604 positive regulation of macromolecule metabolic process
1.30 1.04e-07 GO:0009893 positive regulation of metabolic process
1.17 2.61e-07 GO:0071840 cellular component organization or biogenesis
1.29 2.85e-07 GO:0051239 regulation of multicellular organismal process
1.41 2.95e-07 GO:0045595 regulation of cell differentiation
1.30 3.72e-07 GO:0031325 positive regulation of cellular metabolic process
1.36 3.88e-07 GO:0009888 tissue development
1.24 4.10e-07 GO:0007166 cell surface receptor linked signaling pathway
1.64 5.48e-07 GO:0061061 muscle structure development
1.32 6.84e-07 GO:0010646 regulation of cell communication
1.17 8.90e-07 GO:0060255 regulation of macromolecule metabolic process
1.16 9.72e-07 GO:0031323 regulation of cellular metabolic process
1.15 1.89e-06 GO:0019222 regulation of metabolic process
1.27 2.39e-06 GO:0035556 intracellular signal transduction
1.32 3.13e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.45 3.15e-06 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.57 3.22e-06 GO:0060284 regulation of cell development
1.32 3.65e-06 GO:0032879 regulation of localization
1.18 3.65e-06 GO:0071842 cellular component organization at cellular level
1.39 3.66e-06 GO:0010628 positive regulation of gene expression
1.57 4.25e-06 GO:0001501 skeletal system development
1.12 4.40e-06 GO:0032501 multicellular organismal process
1.46 6.35e-06 GO:0072358 cardiovascular system development
1.46 6.35e-06 GO:0072359 circulatory system development
1.15 6.68e-06 GO:0080090 regulation of primary metabolic process
1.52 7.14e-06 GO:0051056 regulation of small GTPase mediated signal transduction
1.56 1.09e-05 GO:0022603 regulation of anatomical structure morphogenesis
1.81 1.43e-05 GO:0034330 cell junction organization
1.39 2.19e-05 GO:0009887 organ morphogenesis
2.13 2.99e-05 GO:0022612 gland morphogenesis
1.17 3.03e-05 GO:0071841 cellular component organization or biogenesis at cellular level
1.35 3.90e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
1.38 4.32e-05 GO:0045893 positive regulation of transcription, DNA-dependent
1.29 5.73e-05 GO:0032268 regulation of cellular protein metabolic process
2.11 6.41e-05 GO:2000027 regulation of organ morphogenesis
1.66 7.42e-05 GO:0044087 regulation of cellular component biogenesis
1.36 7.65e-05 GO:0051254 positive regulation of RNA metabolic process
1.44 7.83e-05 GO:0051094 positive regulation of developmental process
1.35 8.53e-05 GO:0019220 regulation of phosphate metabolic process
1.35 8.53e-05 GO:0051174 regulation of phosphorus metabolic process
1.28 9.50e-05 GO:0051246 regulation of protein metabolic process
1.87 1.01e-04 GO:0035023 regulation of Rho protein signal transduction
1.33 1.10e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.80 1.51e-04 GO:0034329 cell junction assembly
1.50 1.89e-04 GO:0007411 axon guidance
1.34 2.07e-04 GO:0042325 regulation of phosphorylation
1.30 2.19e-04 GO:0009891 positive regulation of biosynthetic process
1.54 2.55e-04 GO:0051960 regulation of nervous system development
1.28 2.58e-04 GO:0042127 regulation of cell proliferation
1.30 2.88e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.52 3.17e-04 GO:0001944 vasculature development
1.35 3.37e-04 GO:0001932 regulation of protein phosphorylation
1.27 3.54e-04 GO:0010941 regulation of cell death
1.32 4.03e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29 4.46e-04 GO:0008219 cell death
1.33 4.78e-04 GO:0009790 embryo development
1.63 5.07e-04 GO:0007517 muscle organ development
1.55 5.26e-04 GO:0046578 regulation of Ras protein signal transduction
1.26 5.28e-04 GO:0043067 regulation of programmed cell death
1.50 6.31e-04 GO:0051130 positive regulation of cellular component organization
1.37 6.71e-04 GO:0023056 positive regulation of signaling
1.29 7.71e-04 GO:0016265 death
1.33 8.33e-04 GO:0009719 response to endogenous stimulus
1.30 1.15e-03 GO:0031399 regulation of protein modification process
1.40 1.52e-03 GO:0023057 negative regulation of signaling
1.36 1.81e-03 GO:0010647 positive regulation of cell communication
1.48 1.83e-03 GO:0048729 tissue morphogenesis
1.25 1.85e-03 GO:0042981 regulation of apoptosis
1.88 2.33e-03 GO:0045216 cell-cell junction organization
1.45 2.36e-03 GO:0071495 cellular response to endogenous stimulus
1.41 2.42e-03 GO:0009968 negative regulation of signal transduction
1.28 2.56e-03 GO:0040011 locomotion
1.52 2.62e-03 GO:0050767 regulation of neurogenesis
1.38 2.96e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.39 3.12e-03 GO:0010648 negative regulation of cell communication
1.41 3.54e-03 GO:0007264 small GTPase mediated signal transduction
1.36 3.68e-03 GO:0009967 positive regulation of signal transduction
1.30 3.86e-03 GO:0051049 regulation of transport
2.55 4.07e-03 GO:0060688 regulation of morphogenesis of a branching structure
1.32 4.45e-03 GO:0009725 response to hormone stimulus
1.65 4.64e-03 GO:0031344 regulation of cell projection organization
1.36 6.20e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.35 7.36e-03 GO:0006935 chemotaxis
1.35 7.36e-03 GO:0042330 taxis
1.41 7.62e-03 GO:0048598 embryonic morphogenesis
1.08 7.79e-03 GO:0050896 response to stimulus
1.46 8.30e-03 GO:0040012 regulation of locomotion
1.37 8.44e-03 GO:0032583 regulation of gene-specific transcription
1.51 1.13e-02 GO:0002009 morphogenesis of an epithelium
1.28 1.15e-02 GO:0012501 programmed cell death
1.33 1.24e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.46 1.34e-02 GO:0035295 tube development
1.33 1.48e-02 GO:0051253 negative regulation of RNA metabolic process
1.30 1.49e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.50 1.54e-02 GO:0051129 negative regulation of cellular component organization
1.30 1.68e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.67 1.68e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.27 1.69e-02 GO:0016192 vesicle-mediated transport
1.15 1.73e-02 GO:0042221 response to chemical stimulus
1.14 1.75e-02 GO:0010468 regulation of gene expression
1.50 2.08e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.54 2.09e-02 GO:0048732 gland development
1.33 2.11e-02 GO:0048585 negative regulation of response to stimulus
1.28 2.24e-02 GO:0006915 apoptosis
2.30 2.26e-02 GO:0034332 adherens junction organization
1.66 2.35e-02 GO:0022604 regulation of cell morphogenesis
1.28 2.58e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.52 2.61e-02 GO:0045664 regulation of neuron differentiation
1.40 2.61e-02 GO:0007389 pattern specification process
1.33 2.91e-02 GO:0007417 central nervous system development
1.40 2.91e-02 GO:0045597 positive regulation of cell differentiation
1.28 2.93e-02 GO:0009890 negative regulation of biosynthetic process
1.64 3.03e-02 GO:0060537 muscle tissue development
1.09 3.07e-02 GO:0043170 macromolecule metabolic process
1.10 3.17e-02 GO:0044260 cellular macromolecule metabolic process
1.45 3.20e-02 GO:0001568 blood vessel development
1.29 3.38e-02 GO:0071310 cellular response to organic substance
1.42 3.40e-02 GO:0032870 cellular response to hormone stimulus
1.43 3.40e-02 GO:0051270 regulation of cellular component movement
1.36 3.48e-02 GO:0007243 intracellular protein kinase cascade
1.36 3.48e-02 GO:0023014 signal transduction via phosphorylation event
1.23 3.71e-02 GO:0009605 response to external stimulus
1.45 4.33e-02 GO:0030334 regulation of cell migration
1.63 4.46e-02 GO:0048705 skeletal system morphogenesis
1.44 4.51e-02 GO:2000145 regulation of cell motility
1.64 4.80e-02 GO:0010975 regulation of neuron projection development
1.15 4.80e-02 GO:0065008 regulation of biological quality
1.22 4.84e-02 GO:0007154 cell communication

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 4.00e-09 GO:0005737 cytoplasm
1.43 4.69e-08 GO:0030054 cell junction
1.21 7.80e-08 GO:0044459 plasma membrane part
1.34 1.53e-07 GO:0042995 cell projection
1.48 1.96e-06 GO:0045202 synapse
1.47 3.50e-06 GO:0043005 neuron projection
1.20 4.09e-06 GO:0005829 cytosol
1.05 4.78e-06 GO:0005622 intracellular
1.69 6.09e-06 GO:0031252 cell leading edge
1.23 8.40e-06 GO:0005856 cytoskeleton
1.05 1.17e-05 GO:0044424 intracellular part
1.71 4.59e-05 GO:0005912 adherens junction
1.67 5.70e-05 GO:0070161 anchoring junction
1.43 1.17e-04 GO:0031012 extracellular matrix
1.63 1.05e-03 GO:0045211 postsynaptic membrane
1.24 1.59e-03 GO:0005794 Golgi apparatus
1.31 1.81e-03 GO:0044431 Golgi apparatus part
1.75 2.36e-03 GO:0005925 focal adhesion
1.42 3.40e-03 GO:0044456 synapse part
1.41 4.10e-03 GO:0005578 proteinaceous extracellular matrix
1.47 4.19e-03 GO:0016323 basolateral plasma membrane
1.37 4.57e-03 GO:0009986 cell surface
1.42 4.91e-03 GO:0015629 actin cytoskeleton
1.70 5.85e-03 GO:0005924 cell-substrate adherens junction
1.52 8.85e-03 GO:0030424 axon
1.67 9.57e-03 GO:0030055 cell-substrate junction
1.49 1.14e-02 GO:0030425 dendrite
1.33 2.14e-02 GO:0044463 cell projection part
1.12 2.39e-02 GO:0043228 non-membrane-bounded organelle
1.12 2.39e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.07 3.25e-02 GO:0044444 cytoplasmic part
1.68 4.00e-02 GO:0001726 ruffle
1.22 4.55e-02 GO:0031982 vesicle
1.11 4.62e-02 GO:0043234 protein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 2.41e-25 GO:0005515 protein binding
1.07 1.19e-14 GO:0005488 binding
1.33 5.97e-08 GO:0001071 nucleic acid binding transcription factor activity
1.33 5.97e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.40 1.28e-07 GO:0043565 sequence-specific DNA binding
1.28 1.73e-05 GO:0030528 transcription regulator activity
1.50 2.76e-05 GO:0016563 transcription activator activity
2.05 5.67e-05 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.35 4.16e-04 GO:0008092 cytoskeletal protein binding
1.83 1.26e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.23 2.42e-03 GO:0005102 receptor binding
1.43 4.17e-03 GO:0005083 small GTPase regulator activity
1.32 1.82e-02 GO:0030695 GTPase regulator activity
1.22 2.11e-02 GO:0030234 enzyme regulator activity
1.31 2.88e-02 GO:0060589 nucleoside-triphosphatase regulator activity