Motif ID: GTF2I.p2

Z-value: 1.955


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2Ichr7_+_73709991-0.711.9e-03Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_68470585 5.242 NM_001002292
NM_001193334
NM_024911
 WLS


wntless homolog (Drosophila)


chr9_+_108665168 4.207 NM_021224
 ZNF462
zinc finger protein 462
chr12_-_113606322 3.974 NM_005996
NM_016569
 TBX3

T-box 3

chr2_-_227371698 3.803 NM_005544
 IRS1
insulin receptor substrate 1
chr4_-_177950658 3.512 NM_005429
 VEGFC
vascular endothelial growth factor C
chr1_+_156229934 3.365 KIRREL
kin of IRRE like (Drosophila)
chr11_+_12355600 3.362 NM_018222
 PARVA
parvin, alpha
chr22_-_34566210 3.209 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr1_-_20685314 3.197 NM_018584
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr19_-_36531958 3.108 NM_020856
 TSHZ3
teashirt zinc finger homeobox 3
chr1_-_20684858 3.061 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr22_-_34566276 2.949 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr16_-_63713382 2.912 NM_001797
 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr2_-_19421852 2.802 NM_145260
 OSR1
odd-skipped related 1 (Drosophila)
chr11_-_66897584 2.787 NM_013246
 CLCF1
cardiotrophin-like cytokine factor 1
chr16_-_63713485 2.777 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr16_-_63713466 2.773 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr3_-_187025438 2.609 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr1_-_72521079 2.451


chr6_-_10520592 2.424 NM_001032280
 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 171 entries
enrichment   p-value GO term description
2.55 4.07e-03 GO:0060688 regulation of morphogenesis of a branching structure
2.30 2.26e-02 GO:0034332 adherens junction organization
2.13 2.99e-05 GO:0022612 gland morphogenesis
2.11 6.41e-05 GO:2000027 regulation of organ morphogenesis
1.88 2.33e-03 GO:0045216 cell-cell junction organization
1.87 1.01e-04 GO:0035023 regulation of Rho protein signal transduction
1.81 1.43e-05 GO:0034330 cell junction organization
1.80 1.51e-04 GO:0034329 cell junction assembly
1.67 1.68e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.66 7.42e-05 GO:0044087 regulation of cellular component biogenesis
1.66 2.35e-02 GO:0022604 regulation of cell morphogenesis
1.65 4.64e-03 GO:0031344 regulation of cell projection organization
1.64 2.74e-12 GO:0048812 neuron projection morphogenesis
1.64 5.48e-07 GO:0061061 muscle structure development
1.64 3.03e-02 GO:0060537 muscle tissue development
1.64 4.80e-02 GO:0010975 regulation of neuron projection development
1.63 5.07e-04 GO:0007517 muscle organ development
1.63 4.46e-02 GO:0048705 skeletal system morphogenesis
1.61 2.69e-12 GO:0031175 neuron projection development
1.61 3.63e-10 GO:0007409 axonogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
1.75 2.36e-03 GO:0005925 focal adhesion
1.71 4.59e-05 GO:0005912 adherens junction
1.70 5.85e-03 GO:0005924 cell-substrate adherens junction
1.69 6.09e-06 GO:0031252 cell leading edge
1.68 4.00e-02 GO:0001726 ruffle
1.67 5.70e-05 GO:0070161 anchoring junction
1.67 9.57e-03 GO:0030055 cell-substrate junction
1.63 1.05e-03 GO:0045211 postsynaptic membrane
1.52 8.85e-03 GO:0030424 axon
1.49 1.14e-02 GO:0030425 dendrite
1.48 1.96e-06 GO:0045202 synapse
1.47 3.50e-06 GO:0043005 neuron projection
1.47 4.19e-03 GO:0016323 basolateral plasma membrane
1.43 4.69e-08 GO:0030054 cell junction
1.43 1.17e-04 GO:0031012 extracellular matrix
1.42 3.40e-03 GO:0044456 synapse part
1.42 4.91e-03 GO:0015629 actin cytoskeleton
1.41 4.10e-03 GO:0005578 proteinaceous extracellular matrix
1.37 4.57e-03 GO:0009986 cell surface
1.34 1.53e-07 GO:0042995 cell projection

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
2.05 5.67e-05 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.83 1.26e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.50 2.76e-05 GO:0016563 transcription activator activity
1.43 4.17e-03 GO:0005083 small GTPase regulator activity
1.40 1.28e-07 GO:0043565 sequence-specific DNA binding
1.35 4.16e-04 GO:0008092 cytoskeletal protein binding
1.33 5.97e-08 GO:0001071 nucleic acid binding transcription factor activity
1.33 5.97e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.32 1.82e-02 GO:0030695 GTPase regulator activity
1.31 2.88e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.28 1.73e-05 GO:0030528 transcription regulator activity
1.23 2.42e-03 GO:0005102 receptor binding
1.22 2.11e-02 GO:0030234 enzyme regulator activity
1.16 2.41e-25 GO:0005515 protein binding
1.07 1.19e-14 GO:0005488 binding