Motif ID: TCF4_dimer.p2

Z-value: 4.183


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF4chr18_-_512198800.638.9e-03Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_49996353 10.893 NM_003068
 SNAI2
snail homolog 2 (Drosophila)
chr8_-_41641881 8.957 NM_001142445
NM_020478
NM_020480
 ANK1


ankyrin 1, erythrocytic


chr3_-_87122936 8.135 NM_016206
 VGLL3
vestigial like 3 (Drosophila)
chr1_+_46151845 7.709 MAST2
microtubule associated serine/threonine kinase 2
chr2_+_219991342 7.579 NM_001927
 DES
desmin
chr11_-_47427263 7.530 NM_005055
NM_032645
 RAPSN

receptor-associated protein of the synapse

chr4_-_177427252 6.988 NM_080874
 ASB5
ankyrin repeat and SOCS box containing 5
chr1_+_201364050 6.916 ADORA1
adenosine A1 receptor
chr1_+_181259317 6.873


chr2_-_175337386 6.810 NM_000079
NM_001039523
 CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr9_-_35679799 6.767 TPM2
tropomyosin 2 (beta)
chr15_+_72006015 6.753 LOXL1
lysyl oxidase-like 1
chr9_-_35679902 6.450 NM_003289
NM_213674
 TPM2

tropomyosin 2 (beta)

chr19_+_10597167 6.354 NM_020428
 SLC44A2
solute carrier family 44, member 2
chrX_-_13866366 6.039


chr2_+_85834111 5.831 NM_032827
 ATOH8
atonal homolog 8 (Drosophila)
chr2_+_205118961 5.779 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr3_-_87122958 5.776 VGLL3
vestigial like 3 (Drosophila)
chr2_+_205118801 5.757 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr10_+_11100111 5.743 CELF2
CUGBP, Elav-like family member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 47 entries
enrichment   p-value GO term description
1.75 1.10e-05 GO:0007517 muscle organ development
1.64 5.35e-06 GO:0061061 muscle structure development
1.54 2.26e-04 GO:0022603 regulation of anatomical structure morphogenesis
1.53 2.09e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.51 3.16e-04 GO:0007411 axon guidance
1.45 7.04e-03 GO:0044057 regulation of system process
1.44 1.10e-03 GO:0007409 axonogenesis
1.43 8.84e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.42 1.80e-03 GO:0048812 neuron projection morphogenesis
1.40 1.89e-04 GO:0048666 neuron development
1.39 2.08e-03 GO:0000904 cell morphogenesis involved in differentiation
1.37 1.81e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.37 6.94e-03 GO:0031175 neuron projection development
1.36 7.25e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.35 3.07e-04 GO:0030182 neuron differentiation
1.34 3.10e-02 GO:0032990 cell part morphogenesis
1.34 4.33e-02 GO:0048858 cell projection morphogenesis
1.32 7.11e-05 GO:0048468 cell development
1.32 1.52e-02 GO:0032989 cellular component morphogenesis
1.31 1.81e-04 GO:0022008 neurogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
2.39 3.98e-02 GO:0031594 neuromuscular junction
1.91 3.97e-06 GO:0043292 contractile fiber
1.91 1.31e-05 GO:0044449 contractile fiber part
1.91 1.35e-04 GO:0030017 sarcomere
1.89 1.57e-05 GO:0030016 myofibril
1.65 4.99e-02 GO:0005924 cell-substrate adherens junction
1.62 4.50e-03 GO:0005912 adherens junction
1.45 3.46e-03 GO:0015629 actin cytoskeleton
1.44 3.82e-02 GO:0016323 basolateral plasma membrane
1.40 1.20e-02 GO:0005578 proteinaceous extracellular matrix
1.39 4.59e-03 GO:0031012 extracellular matrix
1.33 1.28e-03 GO:0030054 cell junction
1.33 3.66e-02 GO:0045202 synapse
1.24 1.26e-02 GO:0005626 insoluble fraction
1.22 8.26e-05 GO:0005856 cytoskeleton
1.21 2.07e-02 GO:0044430 cytoskeletal part
1.14 2.42e-02 GO:0044459 plasma membrane part
1.14 2.99e-02 GO:0005829 cytosol
1.08 1.06e-06 GO:0005737 cytoplasm
1.08 4.48e-03 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.79 4.72e-02 GO:0005201 extracellular matrix structural constituent
1.43 5.95e-03 GO:0003779 actin binding
1.32 7.43e-03 GO:0008092 cytoskeletal protein binding
1.09 2.53e-05 GO:0005515 protein binding