Motif ID: SRF.p3

Z-value: 2.759


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRFchr6_+_432468970.322.2e-01Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_34603290 10.753 NM_006097
NM_181526
 MYL9

myosin, light chain 9, regulatory

chr20_+_34603311 10.663 MYL9
myosin, light chain 9, regulatory
chr15_-_32875040 8.511 NM_005159
 ACTC1
actin, alpha, cardiac muscle 1
chr17_-_44026042 6.229 NM_002147
 HOXB5
homeobox B5
chr19_-_40939756 5.214 NM_144617
 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr11_+_116575249 4.443 NM_001001522
NM_003186
 TAGLN

transgelin

chr12_+_74160779 4.365 NM_006851
 GLIPR1
GLI pathogenesis-related 1
chr17_-_44026321 3.936 HOXB5
homeobox B5
chr1_+_221955876 3.866 NM_001146068
 CAPN2
calpain 2, (m/II) large subunit
chr5_+_137829077 3.579 NM_001964
 EGR1
early growth response 1
chr9_+_91409746 3.521 NM_006705
 GADD45G
growth arrest and DNA-damage-inducible, gamma
chr5_-_33928049 3.424 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr10_+_31650069 3.388 NM_001128128
NM_001174094
 ZEB1

zinc finger E-box binding homeobox 1

chr9_+_36126710 3.353 NM_022343
 GLIPR2
GLI pathogenesis-related 2
chr9_-_78710698 3.275 NM_015225
 PRUNE2
prune homolog 2 (Drosophila)
chr6_+_116939500 3.256 NM_153711
 FAM26E
family with sequence similarity 26, member E
chr5_-_33927724 3.234 NM_030955
 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr9_+_36126667 2.974 GLIPR2
GLI pathogenesis-related 2
chr22_+_29810981 2.842 SMTN
smoothelin
chr6_-_109882116 2.841 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
9.18 1.22e-04 GO:0007015 actin filament organization
7.07 9.94e-07 GO:0006936 muscle contraction
6.90 4.30e-07 GO:0003012 muscle system process
4.93 2.47e-03 GO:0007517 muscle organ development
4.38 3.78e-04 GO:0030029 actin filament-based process
4.18 7.09e-03 GO:0030036 actin cytoskeleton organization
4.05 4.95e-03 GO:0061061 muscle structure development
1.95 2.21e-03 GO:0030154 cell differentiation
1.89 4.95e-03 GO:0048869 cellular developmental process
1.86 3.21e-02 GO:0048513 organ development
1.81 6.10e-04 GO:0048731 system development
1.80 2.37e-05 GO:0007275 multicellular organismal development
1.79 6.56e-06 GO:0032502 developmental process
1.77 3.47e-04 GO:0048856 anatomical structure development
1.58 4.52e-05 GO:0032501 multicellular organismal process
1.46 6.25e-04 GO:0050896 response to stimulus
1.34 5.35e-03 GO:0065007 biological regulation
1.34 1.17e-02 GO:0050789 regulation of biological process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
21.47 4.97e-03 GO:0031672 A band
19.94 7.16e-07 GO:0001725 stress fiber
19.03 1.17e-07 GO:0042641 actomyosin
18.61 1.32e-06 GO:0032432 actin filament bundle
10.27 2.15e-02 GO:0005884 actin filament
10.18 9.48e-04 GO:0031674 I band
9.27 1.38e-08 GO:0044449 contractile fiber part
9.26 2.64e-07 GO:0030017 sarcomere
9.08 4.32e-09 GO:0043292 contractile fiber
9.03 2.02e-08 GO:0030016 myofibril
8.73 6.54e-04 GO:0016459 myosin complex
7.05 2.88e-04 GO:0005925 focal adhesion
6.71 4.53e-04 GO:0005924 cell-substrate adherens junction
6.46 6.40e-04 GO:0030055 cell-substrate junction
6.35 1.18e-11 GO:0015629 actin cytoskeleton
5.16 1.88e-03 GO:0005912 adherens junction
4.66 4.91e-03 GO:0070161 anchoring junction
2.65 2.55e-09 GO:0005856 cytoskeleton
2.43 1.82e-04 GO:0044430 cytoskeletal part
1.72 1.23e-03 GO:0043228 non-membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
13.96 4.75e-03 GO:0017022 myosin binding
3.98 1.42e-04 GO:0003779 actin binding
2.97 1.08e-03 GO:0008092 cytoskeletal protein binding
1.38 1.98e-04 GO:0005515 protein binding
1.17 9.78e-03 GO:0005488 binding