Motif ID: SRF.p3

Z-value: 2.759


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRFchr6_+_432468970.322.2e-01Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_34603290 10.753 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr20_+_34603311 10.663 MYL9
myosin, light chain 9, regulatory
chr15_-_32875040 8.511 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr17_-_44026042 6.229 NM_002147
HOXB5
homeobox B5
chr19_-_40939756 5.214 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr11_+_116575249 4.443 NM_001001522
NM_003186
TAGLN

transgelin

chr12_+_74160779 4.365 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr17_-_44026321 3.936 HOXB5
homeobox B5
chr1_+_221955876 3.866 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr5_+_137829077 3.579 NM_001964
EGR1
early growth response 1
chr9_+_91409746 3.521 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr5_-_33928049 3.424 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr10_+_31650069 3.388 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr9_+_36126710 3.353 NM_022343
GLIPR2
GLI pathogenesis-related 2
chr9_-_78710698 3.275 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr6_+_116939500 3.256 NM_153711
FAM26E
family with sequence similarity 26, member E
chr5_-_33927724 3.234 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr9_+_36126667 2.974 GLIPR2
GLI pathogenesis-related 2
chr22_+_29810981 2.842 SMTN
smoothelin
chr6_-_109882116 2.841 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr12_+_50731457 2.748 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr2_+_42128521 2.666 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr3_+_189413414 2.649 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_-_16217025 2.563 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr2_-_128149112 2.383 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr1_-_227636462 2.196 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr10_+_112247614 2.071 NM_004419
DUSP5
dual specificity phosphatase 5
chr5_+_88220846 1.929


chr14_-_52487558 1.928 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr11_-_65424434 1.902 FOSL1
FOS-like antigen 1
chr7_-_5536783 1.874 ACTB
actin, beta
chr19_+_59064795 1.871 MYADM
myeloid-associated differentiation marker
chr11_-_65424385 1.824 FOSL1
FOS-like antigen 1
chr6_+_151603201 1.815 AKAP12
A kinase (PRKA) anchor protein 12
chr11_-_118799058 1.809 THY1
Thy-1 cell surface antigen
chr2_+_88148413 1.759 NM_198274
SMYD1
SET and MYND domain containing 1
chr19_+_977608 1.738 CNN2
calponin 2
chr19_+_59064471 1.710 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr17_-_1336073 1.709 MYO1C
myosin IC
chr10_-_131652364 1.691 EBF3
early B-cell factor 3
chr5_-_141981083 1.659 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr19_+_977555 1.658 CNN2
calponin 2
chr11_-_65424436 1.644 NM_005438
FOSL1
FOS-like antigen 1
chr3_-_101077605 1.615 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr19_+_977601 1.614 CNN2
calponin 2
chr13_-_98757634 1.561 NM_004951
GPR183
G protein-coupled receptor 183
chr17_+_30498948 1.530 NM_001033576
NM_173167
UNC45B

unc-45 homolog B (C. elegans)

chr10_-_90702490 1.523 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr1_-_240228987 1.520 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr7_+_142788480 1.510 NM_001010972
NM_003461
ZYX

zyxin

chr3_-_46879883 1.457 NM_000258
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr17_+_3326045 1.449 NM_000049
ASPA
aspartoacylase
chr10_+_88418147 1.409 NM_001171610
LDB3
LIM domain binding 3
chr19_+_977582 1.405 CNN2
calponin 2
chr19_+_977624 1.373 CNN2
calponin 2
chr6_-_105691675 1.327 BVES
blood vessel epicardial substance
chr14_-_73296643 1.312 NM_194278
C14orf43
chromosome 14 open reading frame 43
chr19_+_977627 1.292 CNN2
calponin 2
chr1_+_165866127 1.288 RCSD1
RCSD domain containing 1
chr7_+_142788521 1.248 ZYX
zyxin
chr1_-_11830328 1.246 NM_006172
NPPA
natriuretic peptide A
chr5_-_178983241 1.240 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr15_+_72006015 1.240 LOXL1
lysyl oxidase-like 1
chr1_+_179324458 1.238 IER5
immediate early response 5
chr7_+_142788566 1.234 ZYX
zyxin
chrX_-_11194015 1.231 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr16_+_55523526 1.228 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr7_+_142788569 1.223 ZYX
zyxin
chr4_+_14985272 1.222 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr7_-_5536704 1.216 NM_001101
ACTB
actin, beta
chr5_+_92944680 1.185 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr10_-_64246080 1.179 EGR2
early growth response 2
chr15_-_63147350 1.174 NM_016563
RASL12
RAS-like, family 12
chr1_+_165865953 1.171 NM_052862
RCSD1
RCSD domain containing 1
chr20_+_32610161 1.162 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr2_+_87536106 1.152 NCRNA00152
non-protein coding RNA 152
chr19_+_2427122 1.135 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr7_+_142788517 1.106 ZYX
zyxin
chr15_-_53369261 1.070 NM_183235
RAB27A
RAB27A, member RAS oncogene family
chr6_+_151602787 1.052 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr1_-_89303478 1.043 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible, 67kDa
chr7_+_94123612 1.034 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr17_+_16259636 1.030 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr5_+_60663842 1.009 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr10_+_6226909 0.989 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr6_-_159386007 0.983 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr3_+_150675117 0.981 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr10_+_6226884 0.970 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chrX_+_153318662 0.954 GDI1
GDP dissociation inhibitor 1
chr10_+_88418243 0.948 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr9_+_18464090 0.941 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr7_-_94123308 0.924 SGCE
sarcoglycan, epsilon
chr1_-_152431175 0.909 NM_152263
TPM3
tropomyosin 3
chr12_-_90029672 0.895 NM_002345
LUM
lumican
chr11_-_57038891 0.893 NM_001198810
SLC43A1
solute carrier family 43, member 1
chr4_+_156899575 0.884 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr7_+_142788579 0.879 ZYX
zyxin
chr5_+_137829065 0.854 EGR1
early growth response 1
chr5_-_178983281 0.854 NM_005520
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr1_-_31618405 0.847 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr17_+_16259573 0.845 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr2_+_100545827 0.831 NM_024065
PDCL3
phosducin-like 3
chr22_+_24468110 0.820 NM_032608
MYO18B
myosin XVIIIB
chr17_+_39990124 0.807 NM_001466
FZD2
frizzled homolog 2 (Drosophila)
chr1_-_166373434 0.798 GPR161
G protein-coupled receptor 161
chr7_-_107430566 0.781 NM_002291
LAMB1
laminin, beta 1
chr3_+_145173329 0.780 NM_173552
C3orf58
chromosome 3 open reading frame 58
chr17_-_4831644 0.778 NM_001171166
NM_015099
CAMTA2

calmodulin binding transcription activator 2

chr3_-_9809357 0.776 NM_006354
NM_133480
TADA3

transcriptional adaptor 3

chr7_-_94123362 0.751 SGCE
sarcoglycan, epsilon
chr10_+_6226764 0.748 NM_001145443
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr17_+_16259812 0.743 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr11_+_74950893 0.731 SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr22_-_35114001 0.715 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr14_-_73296387 0.714 C14orf43
chromosome 14 open reading frame 43
chr7_-_94123413 0.705 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr1_-_150599105 0.702 NM_001014342
FLG2
filaggrin family member 2
chr7_-_526005 0.691 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr17_-_77094375 0.688 NM_001614
ACTG1
actin, gamma 1
chr10_+_123912930 0.678 TACC2
transforming, acidic coiled-coil containing protein 2
chr5_+_140730014 0.673 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr1_-_166373351 0.652 GPR161
G protein-coupled receptor 161
chr12_-_48902692 0.636 NM_001113547
LIMA1
LIM domain and actin binding 1
chr7_-_5535726 0.631 ACTB
actin, beta
chr18_-_42804531 0.628 NM_145653
TCEB3C
transcription elongation factor B polypeptide 3C (elongin A3)
chr7_+_142788730 0.624 ZYX
zyxin
chr1_+_113064711 0.619 NM_001004440
NM_182759
FAM19A3

family with sequence similarity 19 (chemokine (C-C motif)-like), member A3

chr2_-_105421661 0.618 NM_201557
FHL2
four and a half LIM domains 2
chr7_+_94123672 0.616 PEG10
paternally expressed 10
chr11_-_8982107 0.612 NM_020645
NRIP3
nuclear receptor interacting protein 3
chr17_-_36181927 0.603 NM_181539
KRT26
keratin 26
chr1_-_166373159 0.598 GPR161
G protein-coupled receptor 161
chr2_-_160972606 0.588 RBMS1
RNA binding motif, single stranded interacting protein 1
chr4_+_86918882 0.584 ARHGAP24
Rho GTPase activating protein 24
chr2_-_30883775 0.583 NM_144575
CAPN13
calpain 13
chr10_+_75427853 0.580 NM_003373
NM_014000
VCL

vinculin

chr19_+_39402167 0.580 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr3_+_150675169 0.574 TM4SF4
transmembrane 4 L six family member 4
chr11_+_46339691 0.569 NM_001105540
DGKZ
diacylglycerol kinase, zeta
chr17_-_77094426 0.555 ACTG1
actin, gamma 1
chr17_-_4831388 0.543 NM_001171167
NM_001171168
CAMTA2

calmodulin binding transcription activator 2

chr22_+_24468168 0.540 MYO18B
myosin XVIIIB
chr9_-_4290028 0.532 NM_001042413
GLIS3
GLIS family zinc finger 3
chr10_-_64246129 0.530 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr3_-_158704056 0.517 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr12_+_60940404 0.515 NM_006313
USP15
ubiquitin specific peptidase 15
chr15_-_63147228 0.508 RASL12
RAS-like, family 12
chr14_-_93512818 0.506 ASB2
ankyrin repeat and SOCS box containing 2
chr3_+_25445071 0.505 RARB
retinoic acid receptor, beta
chr14_-_93512647 0.491 ASB2
ankyrin repeat and SOCS box containing 2
chr2_-_105381855 0.475 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr1_-_148080888 0.465 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr2_-_231697999 0.465 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr2_-_40593074 0.464 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr18_+_9698299 0.461 RAB31
RAB31, member RAS oncogene family
chr2_+_87536174 0.453 NCRNA00152
non-protein coding RNA 152
chr14_+_73775927 0.447 NM_182894
VSX2
visual system homeobox 2
chr19_-_63550712 0.445 A1BG
alpha-1-B glycoprotein
chr3_-_9809065 0.444 TADA3
transcriptional adaptor 3
chr17_-_36456949 0.433 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr4_+_24406182 0.424 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr7_+_111908143 0.405 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr20_+_155898 0.404 NM_080831
DEFB129
defensin, beta 129
chr19_-_50975603 0.400 NM_001081563
DMPK
dystrophia myotonica-protein kinase
chr12_-_8656705 0.387 NM_020661
AICDA
activation-induced cytidine deaminase
chr4_+_81337663 0.382 NM_001099403
PRDM8
PR domain containing 8
chr17_-_1335763 0.376 NM_001080950
MYO1C
myosin IC
chr11_-_64402629 0.368 NM_006795
EHD1
EH-domain containing 1
chr2_-_207739815 0.366 KLF7
Kruppel-like factor 7 (ubiquitous)
chr19_+_53650577 0.364 NM_013348
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr18_-_63333487 0.354 DSEL
dermatan sulfate epimerase-like
chr1_+_27972269 0.349 NM_177424
STX12
syntaxin 12
chr18_-_42804291 0.346 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chrX_-_99873728 0.343 NM_001129896
SYTL4
synaptotagmin-like 4
chr5_+_169749068 0.343


chr11_+_71221893 0.342 NM_001002035
DEFB108B
defensin, beta 108B
chr12_+_51931636 0.338 NM_001170790
MFSD5
major facilitator superfamily domain containing 5
chr6_+_144654565 0.336 NM_007124
UTRN
utrophin
chr18_-_42810446 0.331 NM_145653
TCEB3C
transcription elongation factor B polypeptide 3C (elongin A3)
chr16_+_29984611 0.330 ALDOA
aldolase A, fructose-bisphosphate
chr12_-_46405477 0.329 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr3_+_9809776 0.326 NM_001198780
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr4_+_120276386 0.321 NM_016599
MYOZ2
myozenin 2
chr9_+_115396020 0.316 NM_144489
RGS3
regulator of G-protein signaling 3
chr16_+_31390567 0.312 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr16_+_29984647 0.299 ALDOA
aldolase A, fructose-bisphosphate
chr15_+_79276273 0.297 NM_001172128
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr7_+_94123556 0.295 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chrX_-_37591760 0.293 NM_006520
DYNLT3
dynein, light chain, Tctex-type 3
chr6_-_73991895 0.290 NM_001126063
KHDC1L
KH homology domain containing 1-like
chr7_-_5535432 0.287 ACTB
actin, beta
chr19_-_15204767 0.274 NM_001142886
EPHX3
epoxide hydrolase 3
chr11_-_30562324 0.274 MPPED2
metallophosphoesterase domain containing 2
chr14_-_101623097 0.271 HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chrX_-_37591703 0.267 DYNLT3
dynein, light chain, Tctex-type 3
chr6_+_158322875 0.265 NM_003898
SYNJ2
synaptojanin 2
chr7_+_71937980 0.264 SBDSP1
Shwachman-Bodian-Diamond syndrome pseudogene 1
chr19_+_62593000 0.264 NM_001172773
NM_152909
ZNF548

zinc finger protein 548

chr16_+_30015899 0.264


chr5_-_39461054 0.255 NM_001343
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.90 4.30e-07 GO:0003012 muscle system process
7.07 9.94e-07 GO:0006936 muscle contraction
1.79 6.56e-06 GO:0032502 developmental process
1.80 2.37e-05 GO:0007275 multicellular organismal development
1.58 4.52e-05 GO:0032501 multicellular organismal process
9.18 1.22e-04 GO:0007015 actin filament organization
1.77 3.47e-04 GO:0048856 anatomical structure development
4.38 3.78e-04 GO:0030029 actin filament-based process
1.81 6.10e-04 GO:0048731 system development
1.46 6.25e-04 GO:0050896 response to stimulus
1.95 2.21e-03 GO:0030154 cell differentiation
4.93 2.47e-03 GO:0007517 muscle organ development
4.05 4.95e-03 GO:0061061 muscle structure development
1.89 4.95e-03 GO:0048869 cellular developmental process
1.34 5.35e-03 GO:0065007 biological regulation
4.18 7.09e-03 GO:0030036 actin cytoskeleton organization
1.34 1.17e-02 GO:0050789 regulation of biological process
1.86 3.21e-02 GO:0048513 organ development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.35 1.18e-11 GO:0015629 actin cytoskeleton
2.65 2.55e-09 GO:0005856 cytoskeleton
9.08 4.32e-09 GO:0043292 contractile fiber
9.27 1.38e-08 GO:0044449 contractile fiber part
9.03 2.02e-08 GO:0030016 myofibril
19.03 1.17e-07 GO:0042641 actomyosin
9.26 2.64e-07 GO:0030017 sarcomere
19.94 7.16e-07 GO:0001725 stress fiber
18.61 1.32e-06 GO:0032432 actin filament bundle
2.43 1.82e-04 GO:0044430 cytoskeletal part
7.05 2.88e-04 GO:0005925 focal adhesion
6.71 4.53e-04 GO:0005924 cell-substrate adherens junction
6.46 6.40e-04 GO:0030055 cell-substrate junction
8.73 6.54e-04 GO:0016459 myosin complex
10.18 9.48e-04 GO:0031674 I band
1.72 1.23e-03 GO:0043228 non-membrane-bounded organelle
1.72 1.23e-03 GO:0043232 intracellular non-membrane-bounded organelle
5.16 1.88e-03 GO:0005912 adherens junction
4.66 4.91e-03 GO:0070161 anchoring junction
21.47 4.97e-03 GO:0031672 A band
10.27 2.15e-02 GO:0005884 actin filament

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.98 1.42e-04 GO:0003779 actin binding
1.38 1.98e-04 GO:0005515 protein binding
2.97 1.08e-03 GO:0008092 cytoskeletal protein binding
13.96 4.75e-03 GO:0017022 myosin binding
1.17 9.78e-03 GO:0005488 binding